当前位置： SCI文献检索 > JOURNAL OF DERMATOLOGICAL SCIENCE期刊下所有文献 > Surgical damage to the lymphatic system promotes tumor growth via impaired adaptive immune response.

Surgical damage to the lymphatic system promotes tumor growth via impaired adaptive immune response.

Abstract：

BACKGROUND:Both lymph nodes (LNs) and lymphatic channels from primary sites to regional LNs are critical for initiation of adaptive immunity. However, as LNs are common metastatic sites in skin cancers, LN biopsies or dissections are frequently performed. In addition, reconstructive skin flaps after tumor resection may damage lymphatic flow from primary sites to regional LNs. OBJECTIVE:This study was designed to investigate the effect on tumor progression by such surgeries. METHODS:We developed a mouse model that simulates LNs dissection or skin flap that blocks lymphatic flow from primary sites to regional LNs and monitored tumor progression. RESULTS:As a poor immunogenic tumor line, the growth of inoculated B16F10 melanoma into syngeneic C57BL/6 mice was not affected by these surgeries. However, the growth of the same cell line in allogenic Balb/c mice was accelerated while immune cell infiltration (CD4+ and CD8+ T cells) into the tumor was reduced by these surgeries. In addition, both cytotoxicity against B16F10 melanoma and numbers of apoptotic tumor cells were diminished by these surgeries. Similarly, tumor growth of the immunogenic MC38 cell line in syngeneic C57BL/6 mice was accelerated and immune cell infiltration and apoptotic tumor cells were reduced by these surgeries. CONCLUSION:These results strongly indicate that surgical damage of the lymphatic system may promote tumor progression via impaired adaptive immune response.

journal_name

J Dermatol Sci

journal_title

Journal of dermatological science

authors

Nakamura Y,Fujisawa Y,Okiyama N,Watanabe R,Tanaka R,Ishitsuka Y,Tahara H,Fujimoto M

doi

10.1016/j.jdermsci.2017.12.016

subject

Has Abstract

pub_date

2018-04-01 00:00:00

pages

46-51

issue

1

eissn

0923-1811

issn

1873-569X

pii

S0923-1811(17)31020-4

journal_volume

90

pub_type

杂志文章

相关文献

JOURNAL OF DERMATOLOGICAL SCIENCE文献大全
  • Unfolded protein response in keratinocytes: impact on normal and abnormal keratinization.

    abstract：:The unfolded protein response (UPR) is a signaling pathway from the endoplasmic reticulum (ER) to the nucleus that protects cells from stress caused by misfolded or unfolded proteins. As such, ER stress is an ongoing challenge for all cells, given the central biologic importance of secretion as part of normal physiolo...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章,评审

    doi：10.1016/j.jdermsci.2012.12.002

    authors： Sugiura K

    更新日期：2013-03-01 00:00:00

  • Inflammatory papillomatous hyperplasia and epidermal necrosis in a transgenic rat for HIV-1.

    abstract：BACKGROUND:Skin lesions commonly affect AIDS patients. The pathogenesis of certain dermatologic disorders primarily associated to HIV-1 is unclear, and better forms of therapy for these conditions need to be discovered. Transgenic animal models represent a novel approach for the study of these disorders and for the que...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2008.08.015

    authors： Cedeno-Laurent F,Bryant J,Fishelevich R,Jones OD,Deng A,Eng ML,Gaspari AA,Trujillo JR

    更新日期：2009-02-01 00:00:00

  • In vivo optical coherence tomography of basal cell carcinoma.

    abstract：BACKGROUND:Optical coherence tomography (OCT) is a promising non-invasive imaging technique that has not systematically been studied in skin cancer such as basal cell carcinoma (BCC). OBJECTIVE:We aimed, first, to describe the in vivo histologic features of BCC by using OCT, and second, to find out whether it is possi...

    journal_title：Journal of dermatological science

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.jdermsci.2006.11.012

    authors： Gambichler T,Orlikov A,Vasa R,Moussa G,Hoffmann K,Stücker M,Altmeyer P,Bechara FG

    更新日期：2007-03-01 00:00:00

  • A study of anti-carbonic anhydrase II antibodies in rheumatic autoimmune diseases.

    abstract：:Autoantibodies to human carbonic anhydrase II (CAII) were screened by ELISA in 109 sera from Asian Japanese patients with systemic lupus erythematosus (SLE), primary Sjögren's syndrome (Sjs), progressive systemic sclerosis (PSS) and dermatomyositis (DM). Anti-CAII antibodies were positive in 24.1% of SLE, 20.0% of pri...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(99)00032-8

    authors： Ono M,Ono M,Watanabe K,Miyashita Y,Inagaki Y,Ueki H

    更新日期：1999-11-01 00:00:00

  • miR-128 targets the CC chemokine ligand 18 gene (CCL18) in cutaneous malignant melanoma progression.

    abstract：BACKGROUND:The CC chemokine ligand 18 (CCL18) has a higher expression in some tumors, while the CCL18 level can be a marker of tumor progression and prognosis. We previously reported that the expression of CCL18 gene was dramatically up-regulated in cutaneous malignant melanoma (CMM) and its expression levels were corr...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2018.06.011

    authors： Song H,Tao Y,Ni N,Zhou X,Xiong J,Zeng X,Xu X,Qi J,Sun J

    更新日期：2018-09-01 00:00:00

  • Genetic variation at IL12B, IL23R and IL23A is associated with psoriasis severity, psoriatic arthritis and type 2 diabetes mellitus.

    abstract：BACKGROUND:Common DNA variants in IL12B, IL23R and IL23A have been associated with an increased susceptibility to psoriasis (Ps) and psoriatic arthritis (PsA). Metabolic comorbidities and cardiovascular risk factors have also been associated to both Ps and PsA. OBJECTIVE:To analyze the effect of single nucleotide poly...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2014.05.010

    authors： Eirís N,González-Lara L,Santos-Juanes J,Queiro R,Coto E,Coto-Segura P

    更新日期：2014-09-01 00:00:00

  • Strategies to enhance epithelial-mesenchymal interactions for human hair follicle bioengineering.

    abstract：:Hair follicle morphogenesis and regeneration depend on intensive but well-orchestrated interactions between epithelial and mesenchymal components. Accordingly, the enhancement of this crosstalk represents a promising approach to achieve successful bioengineering of human hair follicles. The present article summarizes ...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章,评审

    doi：10.1016/j.jdermsci.2013.02.004

    authors： Ohyama M,Veraitch O

    更新日期：2013-05-01 00:00:00

  • Both Th2 and Th1 chemokines (TARC/CCL17, MDC/CCL22, and Mig/CXCL9) are elevated in sera from patients with atopic dermatitis.

    abstract：BACKGROUND:Chemokines and their receptors are important elements for the selective attraction and activation of various subsets of leukocytes. Expression of CXCR3 ligands, such as monokine induced by IFN-gamma (Mig) leads to preferential Th1 recruitment, whereas CCR4 ligands, thymus and activation regulated chemokine (...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2004.01.001

    authors： Shimada Y,Takehara K,Sato S

    更新日期：2004-05-01 00:00:00

  • Increased SS bonds in chronic solar elastosis: a study with N-(7-dimethylamino-4-methyl-3-coumarinyl) maleimide (DACM) stain.

    abstract：:We have studied the distribution of SH groups and SS linkages in solar elastosis, in comparison with that in aged and juvenile sun-unexposed skin, using N-(7-dimethylamino-4-methyl-3-coumarinyl) maleimide (DACM) stain. In heavy solar elastosis we found increased fluorescence for SS bonds in the upper and middle reticu...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/0923-1811(94)90017-5

    authors： Pravatà G,Noto G,Aricò M

    更新日期：1994-02-01 00:00:00

  • Treatment with TNF-α inhibitor rectifies M1 macrophage polarization from blood CD14+ monocytes in patients with psoriasis independent of STAT1 and IRF-1 activation.

    abstract：BACKGROUND:Psoriasis is a systemic inflammatory disease with dramatic responses to TNF-α inhibitors. TNF-α is mainly produced by macrophages. However, how macrophage polarization contributes to psoriasis remains unknown. OBJECTIVE:We aimed to investigate the molecular mechanisms of macrophage polarization in psoriasis...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2018.05.009

    authors： Lin SH,Chuang HY,Ho JC,Lee CH,Hsiao CC

    更新日期：2018-09-01 00:00:00

  • Streptococci isolated from various skin lesions: the interaction with Staphylococcus aureus strains.

    abstract：:We isolated 73 streptococcus strains (41 from infections, and 32 from colonization) from various skin diseases between March, 1994, and June, 1998. In 29 out of 41 cases of infective origin, Staphylococcus aureus strains were simultaneously isolated. Twenty-four out of 28 patients with impetigo were suffering from ato...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(98)00043-7

    authors： Akiyama H,Yamasaki O,Kanzaki H,Tada J,Arata J

    更新日期：1999-01-01 00:00:00

  • Sulfhydryl oxidase (SOx) from mouse epidermis: molecular cloning, nucleotide sequence, and expression of recombinant protein in the cultured cells.

    abstract：:Skin sulfhydryl oxidase (SOx) is an enzyme that catalyzes disulfide (S-S) cross-linking through the oxidation of sulfhydryl compounds in the skin. In this study, using the enzyme purified from rat seminal vesicle, we obtained peptide sequences for SOx by mass spectrometry. We then searched for SOx nucleotides correspo...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(02)00061-0

    authors： Matsuba S,Suga Y,Ishidoh K,Hashimoto Y,Takamori K,Kominami E,Wilhelm B,Seitz J,Ogawa H

    更新日期：2002-10-01 00:00:00

  • Epithelial-mesenchymal transition in the skin.

    abstract：:Epithelial-mesenchymal transition (EMT) plays important roles not only in the morphogenesis but also in wound repair, tissue fibrosis and cancer progression. Recently, regulatory mechanism of this process has been elaborately elucidated. EMT can be a new therapeutic target for treating skin ulcer, fibrosing alopecia, ...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章,评审

    doi：10.1016/j.jdermsci.2010.11.015

    authors： Nakamura M,Tokura Y

    更新日期：2011-01-01 00:00:00

  • Tryptophan photo-product FICZ upregulates AHR/MEK/ERK-mediated MMP1 expression: Implications in anti-fibrotic phototherapy.

    abstract：BACKGROUND:Scleroderma is caused by aberrant transforming growth factor-ß signaling. The degradation of extracellular matrix proteins is regulated by matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). Ultraviolet (UV) radiation has been a therapy for scleroderma. 6-Formylindolo[3,2-b]...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2018.04.010

    authors： Murai M,Yamamura K,Hashimoto-Hachiya A,Tsuji G,Furue M,Mitoma C

    更新日期：2018-07-01 00:00:00

  • Crystalloid inclusion bodies of the endothelial cells in human fetal skin blood vessels and human umbilical cord vessels: a possible relationship to Weibel-Palade bodies?

    abstract：:Crystalloid inclusion bodies (CIB) of the endothelial cells (EC) were investigated in blood vessels of human fetal skin and the umbilical cord by electron- and immunoelectron microscopy. They were found in up to 15% of the investigated EC in various types of vessels. Their sizes ranged from 0.2 microns to 0.6 microns ...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/0923-1811(91)90020-x

    authors： Tronnier M,Hashimoto K,Setoyama M,Predeteanu GS

    更新日期：1991-03-01 00:00:00

  • Detection of interferon-gamma mRNA in psoriatic epidermis by polymerase chain reaction.

    abstract：:Psoriatic skin lesions contain HLA-DR positive T lymphocytes, and other activation antigens, which suggest that the T cells may be producing lymphokines. Gamma interferon is produced by activated T cells, and its presence in psoriasis has been inferred by the lesional keratinocyte expression of 3 gamma interferon-indu...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/0923-1811(91)90019-t

    authors： Barker JN,Karabin GD,Stoof TJ,Sarma VJ,Dixit VM,Nickoloff BJ

    更新日期：1991-03-01 00:00:00

  • Rapid identification of Candida albicans and its related species Candida stellatoidea and Candida dubliniensis by a single PCR amplification using primers specific for the repetitive sequence (RPS) of Candida albicans.

    abstract：BACKGROUND:Candidiasis is caused by several Candida species, of which Candida stellatoidea and C. dubliniensis are phenotypically close to C. albicans. Although current molecular biology-based techniques can distinguish between C. albicans and C. dubliniensis, a convenient tool that can distinguish C. stellatoidea from...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2005.06.007

    authors： Kanbe T,Kurimoto K,Hattori H,Iwata T,Kikuchi A

    更新日期：2005-10-01 00:00:00

  • Genetic predisposition to bullous pemphigoid.

    abstract：:Bullous pemphigoid (BP) is a common autoimmune blistering skin disease that mainly affects elderly patients. Although BP risk is strongly influenced by age, genetic factors are also important determinants of this disease. Many genomic regions, especially in the HLA-II region, have been found to influence BP susceptibi...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章,评审

    doi：10.1016/j.jdermsci.2020.05.010

    authors： Zhang J,Wang G

    更新日期：2020-11-01 00:00:00

  • Genetic skin diseases related to desmosomes and corneodesmosomes.

    abstract：:The integrity of the epidermis depends on the cohesion between keratinocytes, and desmosomes are the main adhesion structures. When cells become cornified, desmosomes are modified and transformed into corneodesmosomes. Mutations in the genes encoding desmosomal components underlie several skin diseases including palmo...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章,评审

    doi：10.1016/j.jdermsci.2014.02.005

    authors： Ishida-Yamamoto A,Igawa S

    更新日期：2014-05-01 00:00:00

  • Butylated hydroxyanisole blocks the inhibitory effects of tumor necrosis factor-alpha on collagen production in human dermal fibroblasts.

    abstract：:Tumor necrosis factor-alpha (TNF-alpha) has been demonstrated to selectively decrease the production of type I and type III collagens in human dermal fibroblasts. The effects of the commonly used food antioxidants, butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), alpha-tocopherol, propyl gallate, supero...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/0923-1811(95)00463-7

    authors： Taniguchi S,Furukawa M,Kono T,Hisa T,Ishii M,Hamada T

    更新日期：1996-04-01 00:00:00

  • Novel ex vivo disease model for extramammary Paget's disease using the cancer tissue-originated spheroid method.

    abstract：BACKGROUND:Extramammary Paget's disease (EMPD) is a rare skin cancer that frequently occurs in the anogenital region in the elderly. Prognosis in patients with metastatic EMPD is poor as EMPD treatment has advanced little in recent years, primarily because no EMPD cell line has been established. OBJECTIVE:We aimed to ...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2020.07.006

    authors： Arita T,Kondo J,Kaneko Y,Tsutsumi M,Kanemaru M,Matsui M,Arakawa Y,Katoh N,Inoue M,Asai J

    更新日期：2020-09-01 00:00:00

  • Serum squamous cell carcinoma antigen (SCCA)-2 correlates with clinical severity of pediatric atopic dermatitis in Ishigaki cohort.

    abstract：BACKGROUND:We sometimes encounter difficulties in assessing the severity of pediatric atopic dermatitis (AD) using currently available biomarkers such as thymus and activation-regulated chemokine (TARC) due to the higher baseline values in non-AD children. Recent case control studies have indicated the usefulness of sq...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2019.07.005

    authors： Takeuchi S,Furusyo N,Ono J,Azuma Y,Takemura M,Esaki H,Yamamura K,Mitamura Y,Tsuji G,Kiyomatsu-Oda M,Hayashi J,Izuhara K,Furue M

    更新日期：2019-08-01 00:00:00

  • High expression of Dicer reveals a negative prognostic influence in certain subtypes of primary cutaneous T cell lymphomas.

    abstract：BACKGROUND:Aberrant expression of microRNAs (miRNAs) has been implicated in oncogenesis of various tumors and primary cutaneous T cell lymphomas. Dicer, a ribonuclease III-like enzyme is essential for miRNA processing. OBJECTIVE:We initiated a retrospective study to characterize the alterations in the expression profi...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2011.08.011

    authors： Valencak J,Schmid K,Trautinger F,Wallnöfer W,Muellauer L,Soleiman A,Knobler R,Haitel A,Pehamberger H,Raderer M

    更新日期：2011-12-01 00:00:00

  • TNIP1/ANXA6 and CSMD1 variants interacting with cigarette smoking, alcohol intake affect risk of psoriasis.

    abstract：BACKGROUND:Psoriasis is a common multi-factorial skin disease, in which gene-gene and gene-environment interactions may affect the onset, manifestation and clinical course. OBJECTIVE:To investigate the underlying gene-environment interaction among several established susceptibility genes, cigarette smoking and alcohol...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2013.02.006

    authors： Yin XY,Cheng H,Wang WJ,Wang WJ,Fu HY,Liu LH,Zhang FY,Yang S,Zhang XJ

    更新日期：2013-05-01 00:00:00

  • Sequence analysis and characterization of FAR-17c, an androgen-dependent gene in the flank organs of hamsters.

    abstract：:This study reports on the isolation and characterization of a cDNA clone, regulated by androgen transcriptionally, in male Golden hamsters' flank organs. Previous studies have reported on the cloning of an androgen-dependent gene, FAR-17a, from the same hamster organ. After castration, the FAR-17c transcription rate d...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/0923-1811(94)00357-k

    authors： Ideta R,Seki T,Adachi K

    更新日期：1995-03-01 00:00:00

  • Two- and three-dimensional observations of human terminal and vellus hair follicles.

    abstract：:Extracted human terminal and vellus hair follicles were prepared by EDTA and examined by light and electron microscopes. These samples were morphologically well preserved and enabled us to observe 3-dimensional (3-D) views of the outer surfaces of hair follicles. Interestingly, the bulge areas of terminal and vellus h...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/0923-1811(94)90030-2

    authors： Narisawa Y,Hashimoto K,Kohda H

    更新日期：1994-07-01 00:00:00

  • Synergistic phototoxic effects of glycolic acid in a human keratinocyte cell line (HaCaT).

    abstract：BACKGROUND:Glycolic acid (GA) has been widely used in cosmetic agents and superficial chemical peeling in recent years. It has long been concerned that UV irradiation would enhance the photosensitivity of GA on human skin. Therefore, it is mandatory to explore the biologic effects of concomitant exposure of GA and UV i...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2011.09.001

    authors： Lai WW,Hsiao YP,Chung JG,Wei YH,Cheng YW,Yang JH

    更新日期：2011-12-01 00:00:00

  • JSID Tanioku Memorial Lecture 1996. Genetic disorders of keratins and their associated proteins.

    abstract：:It has recently been demonstrated that genetic defects in keratin genes cause a number of different skin disorders, including epidermolysis bullosa simplex (EBS), epidermolytic hyperkeratosis (EH), the EH form of epidermal nevi, epidermolytic and non-epidermolytic forms of palmoplantar keratoderma (EPPK and PPK) and p...

    journal_title：Journal of dermatological science

    pub_type：

    doi：10.1016/s0923-1811(96)00568-3

    authors： Fuchs E

    更新日期：1996-12-01 00:00:00

  • The antimicrobial peptide derived from insulin-like growth factor-binding protein 5, AMP-IBP5, regulates keratinocyte functions through Mas-related gene X receptors.

    abstract：BACKGROUND:In addition to their microbicidal properties, host defense peptides (HDPs) display various immunomodulatory functions, including keratinocyte production of cytokines/chemokines, proliferation, migration and wound healing. Recently, a novel HDP named AMP-IBP5 (antimicrobial peptide derived from insulin-like g...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2017.05.008

    authors： Chieosilapatham P,Niyonsaba F,Kiatsurayanon C,Okumura K,Ikeda S,Ogawa H

    更新日期：2017-10-01 00:00:00

  • Small cutaneous wounds induce telogen to anagen transition of murine hair follicle stem cells.

    abstract：BACKGROUND:Recent studies suggest that large (>1 cm) diameter circular cutaneous wounds induce follicular neogenesis in mice. However, the effects of non-circular wounds or smaller circular wounds on the hair follicle cycle remain poorly understood. OBJECTIVE:We investigated whether non-circular wounds or smaller (≤1 ...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2010.10.008

    authors： Jiang S,Zhao L,Teklemariam T,Hantash BM

    更新日期：2010-12-01 00:00:00