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Butylated hydroxyanisole blocks the inhibitory effects of tumor necrosis factor-alpha on collagen production in human dermal fibroblasts.

Abstract：

:Tumor necrosis factor-alpha (TNF-alpha) has been demonstrated to selectively decrease the production of type I and type III collagens in human dermal fibroblasts. The effects of the commonly used food antioxidants, butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), alpha-tocopherol, propyl gallate, superoxide dismutase (SOD), and catalase on TNF-alpha-induced growth enhancement and collagen metabolism were evaluated in the present study. BHA at concentrations of both 5 x 10(-5) and 10(-4) M inhibited cell proliferation and DNA synthesis induced by 10 ng/ml TNF-alpha in human dermal fibroblasts, while other antioxidants had minimal effects. Further, BHA (5 x 10(-5) M and 10(-4) M) significantly blocked TNF-alpha-induced decreases in collagen synthesis. These results suggest that antioxidants such as BHA may be involved in the modulation of collagen synthesis by TNF-alpha in human dermal fibroblasts.

journal_name

J Dermatol Sci

journal_title

Journal of dermatological science

authors

Taniguchi S,Furukawa M,Kono T,Hisa T,Ishii M,Hamada T

doi

10.1016/0923-1811(95)00463-7

subject

Has Abstract

pub_date

1996-04-01 00:00:00

pages

44-9

issue

1

eissn

0923-1811

issn

1873-569X

pii

0923181195004637

journal_volume

12

pub_type

杂志文章

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