当前位置： SCI文献检索 > JOURNAL OF DERMATOLOGICAL SCIENCE期刊下所有文献 > Neutrophil elastase contributes to extracellular matrix damage induced by chronic low-dose UV irradiation in a hairless mouse photoaging model.

Neutrophil elastase contributes to extracellular matrix damage induced by chronic low-dose UV irradiation in a hairless mouse photoaging model.

Abstract：

BACKGROUND:Repeated exposure to ultraviolet (UV) rays damages skin connective tissue, which is thought to be associated with wrinkle formation. We hypothesized that repeated mild inflammation may cause the connective tissue alterations in photoaging. OBJECTIVE:To clarify the behavior of neutrophils and neutrophil elastase (NE) activity in the photoaging process and to examine the mechanisms of connective tissue damage resulting from NE in photoaging. METHODS:Mouse dorsal skin was irradiated with a suberythemal dose of UVB three times a week. After 5 or 10 weeks of irradiation, neutrophils were investigated by light microscopy and transmission electron microscopy. NE activity was examined by in situ zymography. Activation of proMMP-2 and proMMP-1 by NE both in the purified enzyme and in human skin fibroblast culture was examined by gelatin zymography or immunoblotting respectively. RESULTS:Both neutrophil infiltration and NE activity were elevated in photoaging. Furthermore, activated MMP-2 and MMP-1 were increased by NE treatment in a dose-dependent manner. CONCLUSIONS:In the present study, we demonstrated that neutrophil infiltration and NE activity are elevated in the chronic UVB-irradiated skin of hairless mice and we confirmed the involvement of NE in MMP activation. These data suggest that NE indirectly plays a role in skin photoaging through MMP activation.

journal_name

J Dermatol Sci

journal_title

Journal of dermatological science

authors

Takeuchi H,Gomi T,Shishido M,Watanabe H,Suenobu N

doi

10.1016/j.jdermsci.2010.09.001

subject

Has Abstract

pub_date

2010-12-01 00:00:00

pages

151-8

issue

3

eissn

0923-1811

issn

1873-569X

pii

S0923-1811(10)00290-2

journal_volume

60

pub_type

杂志文章

相关文献

JOURNAL OF DERMATOLOGICAL SCIENCE文献大全
  • Clinical analysis of anti-cardiolipin.beta 2 glycoprotein 1 antibody positive patients in anti-phospholipid syndrome.

    abstract：:Clinical analysis was performed on anti-cardiolipin x beta2 glycoprotein 1 (ACL x beta2 GP1) antibody positive patients with collagen vascular diseases. Nine patients out of 89 showed positive aCL x beta2 GP1 antibody which was a relatively lower percentage compared to that of othoffanti-phospholipid antibodies, such ...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/0923-1811(94)00380-w

    authors： Katayama I,Nishioka K,Otoyama K

    更新日期：1995-05-01 00:00:00

  • Effect of growth factors on dermal fibroblast contraction in normal skin and hypertrophic scar.

    abstract：:We have examined the effects of four 'exogenous' growth factors, i.e. PDGF-BB (5 ng/ml), TGF-beta1 (5 ng/ml), bFGF (10 ng/ml) and EGF (10 ng/ml) on the contraction of floating collagen type I lattices populated by human normal skin (NS) and hypertrophic scar (HS) fibroblasts (FPCL). Only TGF-beta1 enhanced the contrac...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(96)00571-3

    authors： Yang CC,Lin SD,Yu HS

    更新日期：1997-02-01 00:00:00

  • A lamellar body mimetic system for the treatment of oxazolone-induced atopic dermatitis in hairless mice.

    abstract：BACKGROUND:Atopic dermatitis is a common skin disease characterized by a Th2 cell-dominant inflammatory infiltrate, elevated serum IgE levels and impaired epidermal barrier function. It is associated to abnormal epidermal lamellar body secretion, producing alteration in lipid composition and extracellular lamellar memb...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2018.01.010

    authors： Moner V,Fernández E,Calpena AC,Garcia-Herrera A,Cócera M,López O

    更新日期：2018-05-01 00:00:00

  • The atopic dermatitis-like lesion and the associated MRSA infection and barrier dysfunction can be alleviated by 2,4-dimethoxy-6-methylbenzene-1,3-diol from Antrodia camphorata.

    abstract：BACKGROUND:Atopic dermatitis (AD) is an inflammatory skin disease with an associated barrier dysfunction and Staphylococcus aureus infection. The mainstay steroid and calcineurin inhibitor therapy shows some adverse effects. 2,4-Dimethoxy-6-methylbenzene-1,3-diol (DMD) is a benzenoid isolated from Antrodia camphorata. ...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2018.09.002

    authors： Yang SC,Huang TH,Chiu CH,Chou WL,Alalaiwe A,Yeh YC,Su KW,Fang JY

    更新日期：2018-11-01 00:00:00

  • Inflammatory papillomatous hyperplasia and epidermal necrosis in a transgenic rat for HIV-1.

    abstract：BACKGROUND:Skin lesions commonly affect AIDS patients. The pathogenesis of certain dermatologic disorders primarily associated to HIV-1 is unclear, and better forms of therapy for these conditions need to be discovered. Transgenic animal models represent a novel approach for the study of these disorders and for the que...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2008.08.015

    authors： Cedeno-Laurent F,Bryant J,Fishelevich R,Jones OD,Deng A,Eng ML,Gaspari AA,Trujillo JR

    更新日期：2009-02-01 00:00:00

  • Cloning of the hamster androgen receptor gene.

    abstract：:Flank organs of male Golden Syrian hamsters contain sebaceous glands and hair follicles whose morphology and function are highly dependent on androgen, which makes these organs a useful model to study androgen action. In order to investigate molecular mechanisms of androgen action, we cloned a cDNA encoding the hamste...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(00)00172-9

    authors： Shiba K,Hamaguchi T,Kataoka K,Yamaguchi Y,Handa H,Adachi K

    更新日期：2001-07-01 00:00:00

  • The production of superantigenic exotoxins by coagulase-negative staphylococci isolated from human skin lesions.

    abstract：:We examined the production of superantigenic exotoxins in 136 coagulase-negative staphylococci isolated from various skin lesions in humans using a reversed passive latex agglutination test (Denka Seiken). As a control we examined the same in 50 Staphylococcus aureus strains isolated from non-infective skin ulcers in ...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(00)00122-5

    authors： Akiyama H,Yamasaki O,Tada J,Arata J

    更新日期：2000-11-01 00:00:00

  • Superantigen-induced cytokine expression in organ-cultured human skin.

    abstract：:Bacterial superantigen such as staphylococcal enterotoxin B (SEB) induced strong ICAM-1 expression in organ-cultured human keratinocytes. Other superantigens (SEA, SEC1, SEC2) but not mite antigen (Dermatophagoides) also induced ICAM-1 expression both at protein and mRNA level. In contrast to ICAM-1, vascular endothel...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/0923-1811(95)00426-2

    authors： Matsunaga T,Katayama I,Yokozeki H,Nishioka K

    更新日期：1996-02-01 00:00:00

  • FK506 and cyclosporin A inhibit growth factor-stimulated human keratinocyte proliferation by blocking cells in the G0/G1 phases of the cell cycle.

    abstract：:FK506, a new immunosuppressive agent, is effective in treating patients with psoriasis. A major feature of psoriasis vulgaris is the hyperproliferation of keratinocytes together with inflammation. To determine the effect of FK506 or cyclosporin A (CsA) on the keratinocyte cell cycle, flow cytometry and the growth fact...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/0923-1811(95)00480-7

    authors： Karashima T,Hachisuka H,Sasai Y

    更新日期：1996-09-01 00:00:00

  • Update on contact dermatitis 2007: Medical pearls from the annual meeting of the British Contact Dermatitis Society at the annual meeting of the British Association of Dermatologists.

    abstract：:Contact dermatitis is an integral part of dermatology. Many patients affected by contact dermatitis suffer significant morbidity and require prompt diagnosis and treatment. Here we give an overview of contact dermatitis related presentations made during the British Contact Dermatitis Society at 87th annual meeting of ...

    journal_title：Journal of dermatological science

    pub_type：

    doi：10.1016/j.jdermsci.2008.02.002

    authors： Alexandroff AB,Gawkrodger DJ

    更新日期：2008-09-01 00:00:00

  • Prognostic factors in 105 Japanese cases of mycosis fungoides and Sézary syndrome: clusterin expression as a novel prognostic factor.

    abstract：BACKGROUND:The analysis of prognostic factors in Japanese cases of cutaneous T-cell lymphoma (CTCL) is scarce. Clusterin is a ubiquitous 80kDa heterodimeric glycoprotein expressed on tumor cells of systemic and primary cutaneous anaplastic large cell lymphoma. The expression of clusterin in mycosis fungoides (MF) and S...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2013.04.020

    authors： Tobisawa S,Honma M,Ishida-Yamamoto A,Saijo Y,Iizuka H

    更新日期：2013-09-01 00:00:00

  • Failure to detect paramyxovirus RNA in the skin of connective tissue disease.

    abstract：:Etiology of connective tissue disease is unknown. The association of infectious agents has been suspected serologically, ultrastructurally and recently by means of molecular biological techniques. We extracted RNA from lesions of 25 discoid lupus erythematosus, 9 systemic LE, and 3 systemic sclerosis biopsies, and rev...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/0923-1811(95)00422-x

    authors： Fujiwara H,Fujiwara K,Yotsumoto S,Hashimoto K

    更新日期：1996-01-01 00:00:00

  • Crystalloid inclusion bodies of the endothelial cells in human fetal skin blood vessels and human umbilical cord vessels: a possible relationship to Weibel-Palade bodies?

    abstract：:Crystalloid inclusion bodies (CIB) of the endothelial cells (EC) were investigated in blood vessels of human fetal skin and the umbilical cord by electron- and immunoelectron microscopy. They were found in up to 15% of the investigated EC in various types of vessels. Their sizes ranged from 0.2 microns to 0.6 microns ...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/0923-1811(91)90020-x

    authors： Tronnier M,Hashimoto K,Setoyama M,Predeteanu GS

    更新日期：1991-03-01 00:00:00

  • Loss of skin elasticity precedes to rapid increase of wrinkle levels.

    abstract：BACKGROUND:Decreased skin elasticity is considered as a factor that promotes wrinkle formation. However, the relationship between decreased skin elasticity and the formation of wrinkles is not fully understood. OBJECTIVE:The purpose of this study is to characterize the relationship between skin elasticity and wrinkle ...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2007.05.002

    authors： Fujimura T,Haketa K,Hotta M,Kitahara T

    更新日期：2007-09-01 00:00:00

  • Synergistic phototoxic effects of glycolic acid in a human keratinocyte cell line (HaCaT).

    abstract：BACKGROUND:Glycolic acid (GA) has been widely used in cosmetic agents and superficial chemical peeling in recent years. It has long been concerned that UV irradiation would enhance the photosensitivity of GA on human skin. Therefore, it is mandatory to explore the biologic effects of concomitant exposure of GA and UV i...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2011.09.001

    authors： Lai WW,Hsiao YP,Chung JG,Wei YH,Cheng YW,Yang JH

    更新日期：2011-12-01 00:00:00

  • Understanding age-induced alterations to the biomechanical barrier function of human stratum corneum.

    abstract：BACKGROUND:The appearance and function of human skin are dramatically altered with aging, resulting in higher rates of severe xerosis and other skin complaints. The outermost layer of the epidermis, the stratum corneum (SC), is responsible for the biomechanical barrier function of skin and is also adversely transformed...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2015.07.016

    authors： Biniek K,Kaczvinsky J,Matts P,Dauskardt RH

    更新日期：2015-11-01 00:00:00

  • Regulation of keratinocyte differentiation by O-GlcNAcylation.

    abstract：BACKGROUND:O-linked β-N-acetylglucosamine (O-GlcNAc) modification is one of the posttranslational modification, emerging as an important regulatory mechanism in various cellular events. OBJECTIVE:We attempted to investigate whether O-GlcNAcylation is involved in keratinocyte differentiation. METHODS:Immunohistochemis...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2014.04.010

    authors： Sohn KC,Lee EJ,Shin JM,Lim EH,No Y,Lee JY,Yoon TY,Lee YH,Im M,Lee Y,Seo YJ,Lee JH,Kim CD

    更新日期：2014-07-01 00:00:00

  • Non-disulfided pro alpha 1(IV) chain in B16 melanoma cell culture.

    abstract：:We have previously reported that two species of pro alpha 1(IV) collagen chains, disulfided (500 kDa) and non-disulfided (180 kDa), were produced by B16 melanoma cells (J Biochem (1994) 116; 1039-1043). The mechanism by which the non-disulfided pro alpha 1(IV) chain is produced was studied. No significant difference i...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/0923-1811(95)00486-6

    authors： Tajima S,Tokimitsu I

    更新日期：1996-10-01 00:00:00

  • Nuclear expression of IL-33 in epidermal keratinocytes promotes wound healing in mice.

    abstract：BACKGROUND:Skin is the outermost tissue of the human body, and works as a mechanical, chemical, and biological barrier. The epidermis is the uppermost layer of the skin, and keratinocytes constitute the majority of epidermal cells. Wounds are disruptions of skin integrity, and cause tremendous disadvantages to humans; ...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2016.10.008

    authors： Oshio T,Komine M,Tsuda H,Tominaga SI,Saito H,Nakae S,Ohtsuki M

    更新日期：2017-02-01 00:00:00

  • Propionibacterium acnes-induced iNOS and COX-2 protein expression via ROS-dependent NF-κB and AP-1 activation in macrophages.

    abstract：BACKGROUND:Propionibacterium acnes (P. acnes), a gram-positive anaerobic bacterium, plays a critical role in the development of inflammatory lesion as a result of cytokines production by keratinocytes and macrophages activation. However, effect of P. acnes on iNOS/NO and COX-2/PGE2 production in macrophages is still un...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2012.10.009

    authors： Tsai HH,Lee WR,Wang PH,Cheng KT,Chen YC,Shen SC

    更新日期：2013-02-01 00:00:00

  • Hydroquinone-salicylic acid conjugates as novel anti-melasma actives show superior skin targeting compared to the parent drugs.

    abstract：BACKGROUND:Hydroquinone (HQ) and salicylic acid (SA) are drugs for treating melasma through the mechanisms of tyrosinase inhibition and chemical peeling, respectively. Their high frequency of causing skin irritation has led to limited use of both drugs. OBJECTIVES:We designed the new conjugates obtained by joining HQ ...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2014.08.013

    authors： Hsieh PW,Aljuffali IA,Fang CL,Chang SH,Fang JY

    更新日期：2014-11-01 00:00:00

  • Addition of novel degenerate electrical waveform stimulation with photodynamic therapy significantly enhances its cytotoxic effect in keloid fibroblasts: first report of a potential combination therapy.

    abstract：BACKGROUND:We recently reported use of photodynamic therapy (PDT) for treating keloid disease (KD). However, in view of high recurrence rates post any treatment modality, adjuvant therapies should be considered. Additionally, we previously demonstrated the effect of a novel electrical waveform, the degenerate wave (DW)...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2011.08.012

    authors： Sebastian A,Allan E,Allan D,Colthurst J,Bayat A

    更新日期：2011-12-01 00:00:00

  • PPAR gamma is an important transcription factor in 1 alpha,25-dihydroxyvitamin D3-induced involucrin expression.

    abstract：BACKGROUND:1 alpha,25-Dihydroxyvitamin D3 (1 alpha,25(OH)2D3), the active form of vitamin D, suppresses keratinocyte proliferation, promotes keratinocyte differentiation, and induces involucrin expression. Peroxisome proliferation-activated receptors (PPARs) are ligand-activated transcription factors. It has been repor...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2007.10.011

    authors： Dai X,Sayama K,Shirakata Y,Tokumaru S,Yang L,Tohyama M,Hirakawa S,Hanakawa Y,Hashimoto K

    更新日期：2008-04-01 00:00:00

  • Unfolded protein response in keratinocytes: impact on normal and abnormal keratinization.

    abstract：:The unfolded protein response (UPR) is a signaling pathway from the endoplasmic reticulum (ER) to the nucleus that protects cells from stress caused by misfolded or unfolded proteins. As such, ER stress is an ongoing challenge for all cells, given the central biologic importance of secretion as part of normal physiolo...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章,评审

    doi：10.1016/j.jdermsci.2012.12.002

    authors： Sugiura K

    更新日期：2013-03-01 00:00:00

  • Immunohistochemical study of membrane type-matrix metalloproteinases (MT-MMPs) and matrix metalloproteinase-2 (MMP-2) in dermatofibroma and malignant fibrous histiocytoma.

    abstract：:Matrix metalloproteinases (MMPs) play an important role in tumor invasion and metastasis. Enhanced expression of matrix metalloproteinase-2 (MMP-2) has been demonstrated in dermatofibroma (DF) and malignant fibrous histiocytoma (MFH). MMP-2 has been shown to be activated by membrane-type MMPs (MT-MMPs). To study the r...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(01)00159-1

    authors： Ohnishi Y,Ito Y,Tajima S,Ishibashi A,Arai K

    更新日期：2002-02-01 00:00:00

  • Therapeutic effects of streptococcal preparation OK-432 on atopic dermatitis-like lesions in NC/Nga mice: possible shift from a Th2- to Th1-predominance.

    abstract：BACKGROUND:The inducement of Th1 cell-mediated immune response, possibly brought about through bacterial stimulation, may serve to control atopic disorders such as atopic dermatitis (AD). The streptococcal preparation, OK-432, has been shown a potent Th1 inducer through the action of IL-12. NC/Nga mice under ordinary c...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2004.06.006

    authors： Horiuchi Y,Bae S,Katayama I,Nishioka K

    更新日期：2004-09-01 00:00:00

  • Activation of STING signaling accelerates skin wound healing.

    abstract：BACKGROUND:The process of repair after skin injury is precisely regulated by a variety of mediators such as cytokines and chemokines. Recent reports demonstrated that cytoplasmic DNA-sensor cyclic GMP-AMP synthase (cGAS) activates the stimulator of interferon genes (STING) via production of cyclic GMP-AMP (cGAMP) and s...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2019.11.008

    authors： Mizutani Y,Kanbe A,Ito H,Seishima M

    更新日期：2020-01-01 00:00:00

  • Production of epidermal sheets in a serum free culture system: a further appraisal of the role of extracellular calcium.

    abstract：:Rhenwald and Green's technique is currently the standard method for growing stratifying epidermal cell cultures. The serum free system developed in Ham's laboratory (MCDB 153) was designed to grow keratinocyte monolayers in clonogenic conditions. Our aim was to optimize conditions in serum-free MCDB 153 for culturing ...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/0923-1811(92)90044-c

    authors： Boisseau AM,Donatien P,Surlève-Bazeille JE,Amédée J,Harmand MF,Bézian JH,Maleville J,Taieb A

    更新日期：1992-03-01 00:00:00

  • Epidermal basement membrane zone components: ultrastructural distribution and molecular interactions.

    abstract：:The epidermal basement membrane zone (BMZ) comprises a multiprotein complex that aids the attachment of epidermal keratinocytes to the underlying dermis. In the last 5 years, our understanding of epidermal BMZ morphology, structure and function has dramatically improved. A complex network of molecular interactions has...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章,评审

    doi：10.1016/s0923-1811(03)00045-8

    authors： McMillan JR,Akiyama M,Shimizu H

    更新日期：2003-05-01 00:00:00

  • Attenuation of UVA-induced damage to human keratinocytes by silymarin.

    abstract：BACKGROUND:UV radiation from sunlight is a potent environmental risk factor in skin cancer pathogenesis. UVA is the major portion of UV light reaching the earth surface ( approximately 95%) and it is reported to lead to benign and malignant tumor formation. UVA-mediated cellular damage occurs primarily through the rele...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2006.12.009

    authors： Svobodová A,Zdarilová A,Malisková J,Mikulková H,Walterová D,Vostalová J

    更新日期：2007-04-01 00:00:00