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A novel niche for skin derived precursors in non-follicular skin.

Abstract：

BACKGROUND:Skin derived precursors (SKP) comprise a subset of specialized dermal cells that can be distinguished from fibroblast by their capacity for spheroidal growth. Recent investigations have shown that hair follicles constitute a niche for this cell type, but their localization and their definite function in non-follicular skin remains largely unknown. OBJECTIVE:To identify the dermal niche of non-follicular SKPs and to analyze whether functional aspects correlate with this localization. METHODS:SKPs were isolated from separate anatomical regions of human abdominal skin. Fluorescence activated cell sorting then was used to obtain a pure population of non-follicular SKPs. Functional characterization of these cells was performed applying differentiation and proliferation assays. Information on specific in vivo functions was derived from histological evaluation of quantity and localization patterns. RESULTS:Sphere forming capacity and differentiation assays show that SKPs reside in the papillary part of the dermis. Further delineation revealed that the dermal capillaries represent a niche for these cells which subsequently could be isolated by FACS utilizing a perivascular marker. Whereas functional properties described for follicular SKPs could also be detected in the perivascular SKP population, histological analyses additionally point to a cross-talk with epidermal stem cells and a reduction during chronological aging. CONCLUSION:Our data show that SKPs isolated from non-follicular skin originate from a perivascular niche. Compared to their follicular counterparts, no functional differences could be observed upon cultivation, but ex vivo analyses also point to unique functions and a contribution to the phenotype of aged skin.

journal_name

J Dermatol Sci

journal_title

Journal of dermatological science

authors

Ruetze M,Knauer T,Gallinat S,Wenck H,Achterberg V,Maerz A,Deppert W,Knott A

doi

10.1016/j.jdermsci.2012.10.007

subject

Has Abstract

pub_date

2013-02-01 00:00:00

pages

132-9

issue

2

eissn

0923-1811

issn

1873-569X

pii

S0923-1811(12)00317-9

journal_volume

69

pub_type

杂志文章

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