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Genetic predisposition to bullous pemphigoid.

Abstract：

:Bullous pemphigoid (BP) is a common autoimmune blistering skin disease that mainly affects elderly patients. Although BP risk is strongly influenced by age, genetic factors are also important determinants of this disease. Many genomic regions, especially in the HLA-II region, have been found to influence BP susceptibility through targeted sequencing studies. However, the relationship between non-HLA regions and BP susceptibility remains poorly understood and the identification of functional variants and key genes within these association regions remains a major challenge. In this review, we summarize the genetic predisposition to BP through an overview of the research history in this field.

journal_name

J Dermatol Sci

journal_title

Journal of dermatological science

authors

Zhang J,Wang G

doi

10.1016/j.jdermsci.2020.05.010

subject

Has Abstract

pub_date

2020-11-01 00:00:00

pages

86-91

issue

2

eissn

0923-1811

issn

1873-569X

pii

S0923-1811(20)30178-X

journal_volume

100

pub_type

杂志文章,评审

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