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Differential regulations of matrix metalloproteinases and tissue inhibitors of metalloproteinases in dermal fibroblasts by dibutyril cyclic AMP.

Abstract：

:The influence of dibutyril cyclic AMP (dbcAMP) on the gene expression of matrix metalloproteinases (MMP)-1, MMP-2, MMP-3, tissue inhibitors of metalloproteinases (TIMP)-1 and TIMP-2 was investigated in human skin fibroblasts by northern analyses. The treatment of dbcAMP increased MMP-1 and MMP-3 mRNA levels but decreased TIMP-1 mRNA levels in time and dose dependent manners. Procollagen alpha 1 (I), MMP-2 and TIMP-2 mRNA levels were unaltered by this reagent. Our data indicate that dbcAMP potentially enhances the degradation of extracellular components of connective tissue.

journal_name

J Dermatol Sci

journal_title

Journal of dermatological science

authors

Kuroda K,Shinkai H

doi

10.1016/s0923-1811(97)00035-2

subject

Has Abstract

pub_date

1997-08-01 00:00:00

pages

95-100

issue

2

eissn

0923-1811

issn

1873-569X

pii

S0923181197000352

journal_volume

15

pub_type

杂志文章

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