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Activation of fibroblast proliferation by Werner's syndrome fibroblast-conditioned medium.

Abstract：

:The effects of Werner's syndrome (WS) fibroblast-conditioned medium on cell proliferation and collagen production of normal fibroblasts were studied using four WS fibroblast strains. The conditioned medium from the WS fibroblasts brought about activation of normal fibroblast proliferation, whereas, that from late passage normal fibroblasts and fibroblasts from aged donors' skin did not. Collagen and non-collagenous protein synthesis in normal fibroblasts were increased by the addition of conditioned medium from the WS fibroblasts, but the relative rates of collagen synthesis and non-collagenous protein synthesis were unaltered. These results suggest that activation of fibroblast proliferation by conditioned medium is one of the characteristics of WS fibroblasts.

journal_name

J Dermatol Sci

journal_title

Journal of dermatological science

authors

Hatamochi A,Arakawa M,Takeda K,Ueki H

doi

10.1016/0923-1811(94)90097-3

subject

Has Abstract

pub_date

1994-06-01 00:00:00

pages

210-6

issue

3

eissn

0923-1811

issn

1873-569X

pii

0923-1811(94)90097-3

journal_volume

7

pub_type

杂志文章

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