Telomerase in cutaneous carcinogenesis.

abstract：BACKGROUND:Systemic sclerosis (SSc) is a chronic autoimmune disease characterized by inflammation and fibrosis. Our previous research has indicated that Sirtuin1 (Sirt1) plays a role in the regulation of TNF-α-induced inflammation; however, whether Sirt1 may inhibit the progress of SSc by blocking inflammation remains ...

journal_title：Journal of dermatological science

authors： Zhu X,Chu H,Jiang S,Liu Q,Liu L,Xue Y,Zheng S,Wan W,Qiu J,Wang J,Zou H

更新日期：2017-08-01 00:00:00

abstract：:This study reports on the isolation and characterization of a cDNA clone, regulated by androgen transcriptionally, in male Golden hamsters' flank organs. Previous studies have reported on the cloning of an androgen-dependent gene, FAR-17a, from the same hamster organ. After castration, the FAR-17c transcription rate d...

journal_title：Journal of dermatological science

authors： Ideta R,Seki T,Adachi K

更新日期：1995-03-01 00:00:00

abstract：:The CC-chemokine TARC is known to be a ligand for the CCR4 receptor which in turn is known to be expressed selectively on the Th(2)-subset of lymphocytes. Atopic dermatitis is generally believed to be a Th(2)-type disease, and TARC has been shown to be expressed in the skin lesions of a murine model of AD. IL-10 is an...

journal_title：Journal of dermatological science

authors： Vestergaard C,Kirstejn N,Gesser B,Mortensen JT,Matsushima K,Larsen CG

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND:Th17 is a newly identified effector T cell lineage which plays a central role in many human inflammatory diseases and experimental animal models. Epicutaneous sensitization with a protein antigen has been proven to induce a Th2-predominant immune response and lead to development of atopic diseases in a murin...

journal_title：Journal of dermatological science

authors： Wang LF,Chiu HC,Hsu CJ,Liu CY,Hsueh YH,Miaw SC

更新日期：2009-06-01 00:00:00

abstract：:Transdermal system(s) bearing captopril were developed using a low temperature casting method and aqueous based polymers viz., eudragit RL-100 and polyvinyl pyrrolidone (PVP). The developed system(s) were subjected to an in vitro characterization study. The results were compared with the transdermal systems of the sam...

journal_title：Journal of dermatological science

authors： Dubey BK,Katare OP,Singh R,Jain SK

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND:Our previous study showed that T cells in skin lesions of human atopic dermatitis (AD) had oligoclonal accumulation, indicating the involvement of antigen-specific immune reactions at those sites. Recently, NC/Nga mice, which develop skin lesions similar to AD, have been proposed as a model for that disease....

journal_title：Journal of dermatological science

authors： Matsuoka A,Kato T,Soma Y,Takahama H,Nakamura M,Matsuoka H,Mizoguchi M

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND:Netherton syndrome (NS) is a rare but severe type of ichthyosis characterized by atopy, allergies, and potentially lethal skin overdesquamation associated with highly elevated proteolytic activities in LEKTI-deficient epidermis. NS symptoms are recapitulated in Spink5-/- mouse where the gene encoding Lekti h...

journal_title：Journal of dermatological science

authors： Zingkou E,Pampalakis G,Charla E,Nauroy P,Kiritsi D,Sotiropoulou G

更新日期：2019-07-01 00:00:00

abstract：:Extracted human terminal and vellus hair follicles were prepared by EDTA and examined by light and electron microscopes. These samples were morphologically well preserved and enabled us to observe 3-dimensional (3-D) views of the outer surfaces of hair follicles. Interestingly, the bulge areas of terminal and vellus h...

journal_title：Journal of dermatological science

authors： Narisawa Y,Hashimoto K,Kohda H

更新日期：1994-07-01 00:00:00

abstract：:Genetically engineered mouse models are invaluable to investigators in nearly all areas of biomedical research. The use of genetically engineered mice has allowed researchers to explore fundamental functions of genes in a mammal that shares substantial similarities with human physiology and pathology. Genetically engi...

journal_title：Journal of dermatological science

authors： Chen J,Roop DR

更新日期：2008-10-01 00:00:00

abstract：:DS-Nh (DS Nh/+) mice spontaneously develop dermatitis when they are housed in a conventional environment. In this study, we analyzed the clinical and histopathological features of dermatitis in DS-Nh mice, which is characterized by erythema, edema, and erosion on the face, neck, chest and flexor surfaces of their fore...

journal_title：Journal of dermatological science

authors： Hikita I,Yoshioka T,Mizoguchi T,Tsukahara K,Tsuru K,Nagai H,Hirasawa T,Tsuruta Y,Suzuki R,Ichihashi M,Horikawa T

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND:The tetracycline (Tet) responsive system is a valuable tool that is routinely used in a wide variety of mammalian cells for regulatable expression of gene products. However, technical difficulties such as harsh selection conditions and extensive screening processes to identify suitably responsive clones limi...

journal_title：Journal of dermatological science

authors： Nagarajan P,Sinha S

更新日期：2008-01-01 00:00:00

abstract：:We have examined the effects of four 'exogenous' growth factors, i.e. PDGF-BB (5 ng/ml), TGF-beta1 (5 ng/ml), bFGF (10 ng/ml) and EGF (10 ng/ml) on the contraction of floating collagen type I lattices populated by human normal skin (NS) and hypertrophic scar (HS) fibroblasts (FPCL). Only TGF-beta1 enhanced the contrac...

journal_title：Journal of dermatological science

authors： Yang CC,Lin SD,Yu HS

更新日期：1997-02-01 00:00:00

abstract：BACKGROUND:Trichloroethylene (TCE) is an industrial solvent which can cause severe generalized dermatitis, i.e., occupational TCE hypersensitivity syndrome. Reactivation of latent human herpesvirus 6 (HHV6) can occur in such patients, which has made TCE known as a causative chemical of drug-induced hypersensitivity syn...

journal_title：Journal of dermatological science

authors： Kamijima M,Wang H,Yamanoshita O,Ito Y,Xia L,Yanagiba Y,Chen C,Okamura A,Huang Z,Qiu X,Song X,Cai T,Liu L,Ge Y,Deng Y,Naito H,Yoshikawa T,Tohyama M,Li L,Huang H,Nakajima T

更新日期：2013-12-01 00:00:00

abstract：:Members of the transforming growth factor-beta (TGF-beta) superfamily are pleiotropic cytokines that have the ability to regulate numerous cell functions, including proliferation, differentiation, apoptosis, epithelial-mesenchymal transition, and production of extracellular matrix, allowing them to play an important r...

journal_title：Journal of dermatological science

authors： Schiller M,Javelaud D,Mauviel A

更新日期：2004-08-01 00:00:00

abstract：BACKGROUND:UV radiation from sunlight is a potent environmental risk factor in skin cancer pathogenesis. UVA is the major portion of UV light reaching the earth surface ( approximately 95%) and it is reported to lead to benign and malignant tumor formation. UVA-mediated cellular damage occurs primarily through the rele...

journal_title：Journal of dermatological science

authors： Svobodová A,Zdarilová A,Malisková J,Mikulková H,Walterová D,Vostalová J

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND:Telomere shortening has been implicated in cellular senescence, which may cause certain aging phenotypes. OBJECTIVE:To reveal whether telomere shortening is associated with chronological aging and/or photoaging of the skin, we measured telomere length in the epidermis and in the dermis from sun-protected an...

journal_title：Journal of dermatological science

authors： Sugimoto M,Yamashita R,Ueda M

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND:Psoriasis is a chronic inflammatory dermatosis that has been associated with various cardiovascular and metabolic comorbidities, including myocardial infarction, stroke, and diabetes mellitus. Recently, there are studies reporting the association of psoriasis with renal diseases. OBJECTIVE:To evaluate the r...

journal_title：Journal of dermatological science

authors： Chi CC,Wang J,Chen YF,Wang SH,Chen FL,Tung TH

更新日期：2015-06-01 00:00:00

abstract：:Hair follicles reconstitute themselves though the hair cycle, suggesting the presence of intrinsic stem cells. In contrast to the previous belief that stem cells reside in the bulbar region of hair follicles, stem cells were detected in the bulge area, a contiguous part of outer root sheath, that provides the insertio...

journal_title：Journal of dermatological science

authors： Ohyama M

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:Glycolic acid (GA) has been widely used in cosmetic agents and superficial chemical peeling in recent years. It has long been concerned that UV irradiation would enhance the photosensitivity of GA on human skin. Therefore, it is mandatory to explore the biologic effects of concomitant exposure of GA and UV i...

journal_title：Journal of dermatological science

authors： Lai WW,Hsiao YP,Chung JG,Wei YH,Cheng YW,Yang JH

更新日期：2011-12-01 00:00:00

abstract：:Cyclosporin A (CsA), a cyclic endecapeptide, is a T cell-specific immunosuppressant and is successfully used in the field of organ transplantation. Another T cell-specific immunosuppressant, FK506, a more recently discovered macrolide antibiotic, is effective against graft rejection at much lower doses than CsA. Altho...

journal_title：Journal of dermatological science

authors： Yamamoto S,Kato R

更新日期：1994-07-01 00:00:00

abstract：BACKGROUND:Propionibacterium acnes (P. acnes), a gram-positive anaerobic bacterium, plays a critical role in the development of inflammatory lesion as a result of cytokines production by keratinocytes and macrophages activation. However, effect of P. acnes on iNOS/NO and COX-2/PGE2 production in macrophages is still un...

journal_title：Journal of dermatological science

authors： Tsai HH,Lee WR,Wang PH,Cheng KT,Chen YC,Shen SC

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:Scleroderma is caused by aberrant transforming growth factor-ß signaling. The degradation of extracellular matrix proteins is regulated by matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). Ultraviolet (UV) radiation has been a therapy for scleroderma. 6-Formylindolo[3,2-b]...

journal_title：Journal of dermatological science

authors： Murai M,Yamamura K,Hashimoto-Hachiya A,Tsuji G,Furue M,Mitoma C

更新日期：2018-07-01 00:00:00

abstract：:We investigated the adherence characteristics of Staphylococcus aureus and coagulase-negative staphylococci (CNS) isolated from various skin lesions by examining hydrophobicity, negative charge, tube adherence, slime production, and promotion of adherence to coverslips by blood proteins. Our results in the present stu...

journal_title：Journal of dermatological science

authors： Akiyama H,Yamasaki O,Kanzaki H,Tada J,Arata J

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND:Aberrant expression of microRNAs (miRNAs) has been implicated in oncogenesis of various tumors and primary cutaneous T cell lymphomas. Dicer, a ribonuclease III-like enzyme is essential for miRNA processing. OBJECTIVE:We initiated a retrospective study to characterize the alterations in the expression profi...

journal_title：Journal of dermatological science

authors： Valencak J,Schmid K,Trautinger F,Wallnöfer W,Muellauer L,Soleiman A,Knobler R,Haitel A,Pehamberger H,Raderer M

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:Atopic dermatitis (AD) is a highly pruritic, chronic inflammatory skin disease associated with hyperreactivity to environmental triggers. Among those, outdoor air pollutants such as particulate matter (PM) have been reported to aggravate pre-existing AD. However, underlying mechanisms of air pollution-induce...

journal_title：Journal of dermatological science

authors： Han RT,Kim HY,Ryu H,Jang W,Cha SH,Kim HY,Lee J,Back SK,Kim HJ,Na HS

更新日期：2018-06-01 00:00:00

abstract：:We developed a new method for evaluating clinical symptoms of psoriasis during the observation period, by adding a parameter of time (the number of days) to the psoriasis area and severity index (PASI). This method was named the evaluation for prognosis with averaged PASI (E-PAP). Using this method, we assessed 14 cas...

journal_title：Journal of dermatological science

authors： Sugai J,Ozawa A,Kawakubo Y,Iizuka M,Miyahara M,Ohkido M

更新日期：1998-01-01 00:00:00

abstract：:Clinical analysis was performed on anti-cardiolipin x beta2 glycoprotein 1 (ACL x beta2 GP1) antibody positive patients with collagen vascular diseases. Nine patients out of 89 showed positive aCL x beta2 GP1 antibody which was a relatively lower percentage compared to that of othoffanti-phospholipid antibodies, such ...

journal_title：Journal of dermatological science

authors： Katayama I,Nishioka K,Otoyama K

更新日期：1995-05-01 00:00:00

abstract：:Hamster flank organs are useful for studying androgen-dependent growth of hair follicles and sebaceous glands. A cDNA clone (FAR-17a) was isolated from the hamster flank organ, whose expression was highly sensitive to androgen. The mRNA level of this gene was reduced after castration but reappeared after testosterone ...

journal_title：Journal of dermatological science

authors： Aoki H,Seki T,Sawada J,Handa H,Adachi K

更新日期：1997-05-01 00:00:00

abstract：BACKGROUND:We recently reported use of photodynamic therapy (PDT) for treating keloid disease (KD). However, in view of high recurrence rates post any treatment modality, adjuvant therapies should be considered. Additionally, we previously demonstrated the effect of a novel electrical waveform, the degenerate wave (DW)...

journal_title：Journal of dermatological science

authors： Sebastian A,Allan E,Allan D,Colthurst J,Bayat A

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:Antimicrobial peptide derived from insulin-like growth factor binding protein-5 (AMP-IBP5) is a potent antimicrobial agent that possesses various immunomodulatory activities. The parent protein of AMP-IBP5, IGFBP-5, has been shown to exert its effects via an insulin-like growth factor-1 receptor-independent ...

journal_title：Journal of dermatological science

authors： Chieosilapatham P,Yue H,Ikeda S,Ogawa H,Niyonsaba F

更新日期：2020-09-01 00:00:00