The role of immunohistochemistry in the diagnosis of the non-lethal forms of junctional epidermolysis bullosa.

abstract：:Telomeres, which exist in eukaryotic chromosome ends in specialized G-rich TTAGGG structure, protect the ends from degradation or fusion. On the other hand, telomerase is a ribonucleoprotein complex enzyme that synthesizes TTAGGG repeat sequences at the ends of eukaryotic chromosomes. Previous studies suggested that t...

journal_title：Journal of dermatological science

authors： Matsui M,Miyasaka J,Hamada K,Ogawa Y,Hiramoto M,Fujimori R,Aioi A

更新日期：2000-02-01 00:00:00

abstract：:Transdermal system(s) bearing captopril were developed using a low temperature casting method and aqueous based polymers viz., eudragit RL-100 and polyvinyl pyrrolidone (PVP). The developed system(s) were subjected to an in vitro characterization study. The results were compared with the transdermal systems of the sam...

journal_title：Journal of dermatological science

authors： Dubey BK,Katare OP,Singh R,Jain SK

更新日期：1995-11-01 00:00:00

abstract：:Atopic dermatitis is regarded as mediated by Th2-type immunity. In fact, it frequently coincides with the elevation of immunoglobulin (Ig)-E in patients' sera. Due to the pivotal role of interleukin (IL)-4 in regulation of IgE, we hypothesized if atopic dermatitis represents a hyper-reactive condition in response to I...

journal_title：Journal of dermatological science

authors： Yamazaki F,Aragane Y,Maeda A,Matsushita K,Ueno K,Yudate T,Kawada A,Tezuka T

更新日期：2002-04-01 00:00:00

abstract：BACKGROUND:1 alpha,25-Dihydroxyvitamin D3 (1 alpha,25(OH)2D3), the active form of vitamin D, suppresses keratinocyte proliferation, promotes keratinocyte differentiation, and induces involucrin expression. Peroxisome proliferation-activated receptors (PPARs) are ligand-activated transcription factors. It has been repor...

journal_title：Journal of dermatological science

authors： Dai X,Sayama K,Shirakata Y,Tokumaru S,Yang L,Tohyama M,Hirakawa S,Hanakawa Y,Hashimoto K

更新日期：2008-04-01 00:00:00

abstract：:Isolated normal human melanocytes became enlarged and more dendritic in association with an increase in the activity of tyrosinase and the amount of b-locus protein when they were cultured with 0.1-10 microM histamine in vitro. However, histamine did not exert a proliferative effect on them. The stimulatory effect of ...

journal_title：Journal of dermatological science

authors： Tomita Y,Maeda K,Tagami H

更新日期：1993-10-01 00:00:00

abstract：BACKGROUND:UV radiation from sunlight is a potent environmental risk factor in skin cancer pathogenesis. UVA is the major portion of UV light reaching the earth surface ( approximately 95%) and it is reported to lead to benign and malignant tumor formation. UVA-mediated cellular damage occurs primarily through the rele...

journal_title：Journal of dermatological science

authors： Svobodová A,Zdarilová A,Malisková J,Mikulková H,Walterová D,Vostalová J

更新日期：2007-04-01 00:00:00

abstract：:In order to investigate the mode of action of testosterone (T) on human hair follicles we studied the metabolism of T and localization of androgen receptors in outer root sheath cells (ORSC) and dermal papilla cells (DPC) from different body sites. T was principally metabolized to androstenedione (delta 4) even in bea...

journal_title：Journal of dermatological science

authors： Itami S,Sonoda T,Kurata S,Takayasu S

更新日期：1994-07-01 00:00:00

abstract：BACKGROUND:Netherton syndrome (NS, MIM 256500) is a potential live threatening autosomal-recessive skin disorder clinically characterized by the trias of congenital erythroderma, hair shaft anomalies and atopic diathesis. It is caused by mutations in the gene SPINK5 resulting in a deficiency of its processed protein na...

journal_title：Journal of dermatological science

authors： Roedl D,Oji V,Buters JT,Behrendt H,Braun-Falco M

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Atopic dermatitis (AD) is a chronic inflammatory skin disease that often cannot be completely controlled by modern medicine. Since multiple factors are intricately involved in the pathogenesis of AD, wide-ranging research is required for further advancement of AD treatment. Epidermal keratinocytes are the fo...

journal_title：Journal of dermatological science

authors： Kumagai A,Kubo T,Kawata K,Kamekura R,Yamashita K,Jitsukawa S,Nagaya T,Sumikawa Y,Himi T,Yamashita T,Ichimiya S

更新日期：2017-11-01 00:00:00

abstract：:Over the last decade, animal models of atopic dermatitis (AD) have received increasing attention. They include NC/Nga mice, a hapten-induced mouse model, and transgenic and knockout mouse models. Although the pathogenesis of skin inflammation elicited in these models and that in AD are not quite the same, it is pertin...

journal_title：Journal of dermatological science

authors： Shiohara T,Hayakawa J,Mizukawa Y

更新日期：2004-10-01 00:00:00

abstract：:As we contemplate the nature of life sciences in the 21st century, we should briefly consider the changes that have occurred in the past century. Surely, the sources of progress of this science in the next century are the advances emerging now. Furthermore, the likely pace of discovery and change in life sciences in t...

journal_title：Journal of dermatological science

authors： Sharp PA

更新日期：2000-12-01 00:00:00

abstract：BACKGROUND:Cisplatin is a potent anticancer drug for treating melanoma. OBJECTIVE:The aim of this study was to evaluate the possibility of using liposomes, for intratumoral distribution in a melanoma, composed of phosphatidylethanolamine (PE), for its cytotoxicity. METHOD:The in vitro drug release, in vitro cytotoxic...

journal_title：Journal of dermatological science

authors： Hwang TL,Lee WR,Hua SC,Fang JY

更新日期：2007-04-01 00:00:00

abstract：:Hamster flank organs are useful for studying androgen-dependent growth of hair follicles and sebaceous glands. A cDNA clone (FAR-17a) was isolated from the hamster flank organ, whose expression was highly sensitive to androgen. The mRNA level of this gene was reduced after castration but reappeared after testosterone ...

journal_title：Journal of dermatological science

authors： Aoki H,Seki T,Sawada J,Handa H,Adachi K

更新日期：1997-05-01 00:00:00

abstract：BACKGROUND:We recently reported that the autoantibodies of anti-p200 pemphigoid sera react with laminin γ1 and renamed this entity as anti-laminin γ1 pemphigoid. However, it has not been clarified whether the anti-laminin γ1 autoantibodies, particularly those to the C-terminal integrin binding site, affect the dermoepi...

journal_title：Journal of dermatological science

authors： Koga H,Ishii N,Dainichi T,Tsuruta D,Hamada T,Ohata C,Karashima T,Furumura M,Hashimoto T

更新日期：2013-05-01 00:00:00

abstract：:Psoriatic skin lesions contain HLA-DR positive T lymphocytes, and other activation antigens, which suggest that the T cells may be producing lymphokines. Gamma interferon is produced by activated T cells, and its presence in psoriasis has been inferred by the lesional keratinocyte expression of 3 gamma interferon-indu...

journal_title：Journal of dermatological science

authors： Barker JN,Karabin GD,Stoof TJ,Sarma VJ,Dixit VM,Nickoloff BJ

更新日期：1991-03-01 00:00:00

abstract：:Serum levels of sIL-2R can be used to monitor in vivo immune activation and its elevation have been shown to be correlated with T cell mediated immune disease such as atopic dermatitis, psoriasis, lymphoma and systemic sclerosis. Vitiligo is the disease of depigmentation caused by destruction of melanocytes, and there...

journal_title：Journal of dermatological science

authors： Yeo UC,Yang YS,Park KB,Sung HT,Jung SY,Lee ES,Shin MH

更新日期：1999-04-01 00:00:00

abstract：:Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) are considered part of a spectrum of adverse cutaneous drug reactions showing severe and extensive skin detachment. TEN and SJS are morphologically characterized by active apoptotic keratinocyte cell death that results in the separation of the epiderm...

journal_title：Journal of dermatological science

authors： Abe R

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:The active vitamin D3 regulates proliferation and differentiation of epidermal keratinocytes. Recently topical vitamin D3, tacalcitol, calcipotriol, and maxacalcitol are widely used for psoriasis. OBJECTIVE:To examine the effect of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) on cultured normal keratinocytes (NHK...

journal_title：Journal of dermatological science

authors： Takahashi H,Ibe M,Kinouchi M,Ishida-Yamamoto A,Hashimoto Y,Iizuka H

更新日期：2003-02-01 00:00:00

abstract：:Cyclosporin A (CsA), a cyclic endecapeptide, is a T cell-specific immunosuppressant and is successfully used in the field of organ transplantation. Another T cell-specific immunosuppressant, FK506, a more recently discovered macrolide antibiotic, is effective against graft rejection at much lower doses than CsA. Altho...

journal_title：Journal of dermatological science

authors： Yamamoto S,Kato R

更新日期：1994-07-01 00:00:00

abstract：:A cell line, designated ISOS-1, was established from a tumor formed by transplantation of a human angiosarcoma into mice with severe combined immunodeficiency (SCID). The cells showed endothelial properties, based on the uptake of Dil-Ac-LDL and binding of UEA-I/GSA-I lectins, but were negative for CD11b and Pan Cytok...

journal_title：Journal of dermatological science

authors： Masuzawa M,Fujimura T,Tsubokawa M,Nishiyama S,Katsuoka K,Terada E,Kunita S,Sakurai Y,Kato H

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:In addition to their microbicidal properties, host defense peptides (HDPs) display various immunomodulatory functions, including keratinocyte production of cytokines/chemokines, proliferation, migration and wound healing. Recently, a novel HDP named AMP-IBP5 (antimicrobial peptide derived from insulin-like g...

journal_title：Journal of dermatological science

authors： Chieosilapatham P,Niyonsaba F,Kiatsurayanon C,Okumura K,Ikeda S,Ogawa H

更新日期：2017-10-01 00:00:00

abstract：:We developed a new method for evaluating clinical symptoms of psoriasis during the observation period, by adding a parameter of time (the number of days) to the psoriasis area and severity index (PASI). This method was named the evaluation for prognosis with averaged PASI (E-PAP). Using this method, we assessed 14 cas...

journal_title：Journal of dermatological science

authors： Sugai J,Ozawa A,Kawakubo Y,Iizuka M,Miyahara M,Ohkido M

更新日期：1998-01-01 00:00:00

abstract：:Stem cells are fascinating because of their potential in regenerative medicine. Stem cell homeostasis has been thought to be mainly regulated by signals from their adjacent micro-environment named the "stem cell niche". However, recent studies reveal that there can be multiple layers of environmental controls. Here we...

journal_title：Journal of dermatological science

authors： Chen CC,Chuong CM

更新日期：2012-04-01 00:00:00

abstract：:We previously reported a simple and easy-to-use device, Scratch Monitor for evaluation of nocturnal scratching. In the present study, the effect of an antihistamine (azelastine hydrochloride) on atopic dermatitis was investigated using this device. In 40 patients with atopic dermatitis, nocturnal scratching was measur...

journal_title：Journal of dermatological science

authors： Endo K,Sano H,Fukuzumi T,Adachi J,Aoki T

更新日期：1999-12-01 00:00:00

abstract：BACKGROUND:Chemical peeling is one of the dermatological treatments available for certain cutaneous diseases and conditions or improvement of cosmetic appearance of photoaged skin. OBJECTIVES:We assessed the photochemopreventive effect of several clinically used chemical peeling agents on the ultraviolet (UV)-irradiat...

journal_title：Journal of dermatological science

authors： Abdel-Daim M,Funasaka Y,Kamo T,Ooe M,Matsunaka H,Yanagita E,Itoh T,Nishigori C

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:The capacity of photosensitizing chemicals with ultraviolet A light (UVA) to induce apoptosis is one of the methods to assess their phototoxic and potentially photoallergic properties, since apoptotic cells may be easily presented by antigen-presenting cells. OBJECTIVES:We examined the photoaggravated abili...

journal_title：Journal of dermatological science

authors： Kurita M,Shimauchi T,Kobayashi M,Atarashi K,Mori K,Tokura Y

更新日期：2007-02-01 00:00:00

abstract：:Histopathologically, the skin lesions of acute herpes zoster (AHZ) are characterized by epidermal necrotic vesicles with inflammation. Nitric oxide (NO) is generated from L-arginine by nitric oxide synthase (NOS), and immune inflammation involves the activation of NOS in both effector cells and target cells. NO can ca...

journal_title：Journal of dermatological science

authors： Lim YJ,Chang SE,Choi JH,Sung KJ,Bahk JH,Do SH,Lee DS

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:The CC chemokine ligand 18 (CCL18) has a higher expression in some tumors, while the CCL18 level can be a marker of tumor progression and prognosis. We previously reported that the expression of CCL18 gene was dramatically up-regulated in cutaneous malignant melanoma (CMM) and its expression levels were corr...

journal_title：Journal of dermatological science

authors： Song H,Tao Y,Ni N,Zhou X,Xiong J,Zeng X,Xu X,Qi J,Sun J

更新日期：2018-09-01 00:00:00

abstract：:The epidermal basement membrane zone (BMZ) comprises a multiprotein complex that aids the attachment of epidermal keratinocytes to the underlying dermis. In the last 5 years, our understanding of epidermal BMZ morphology, structure and function has dramatically improved. A complex network of molecular interactions has...

journal_title：Journal of dermatological science

authors： McMillan JR,Akiyama M,Shimizu H

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:Resolvin D1 (RvD1), a pro-resolution lipid mediator derived from docosahexaenoic acid (DHA), has been described to promote several kinds of inflammatory resolution. However, the effects and anti-inflammatory mechanisms of RvD1 on psoriasis have not been previously reported. OBJECTIVE:The present study aimed...

journal_title：Journal of dermatological science

authors： Xu J,Duan X,Hu F,Poorun D,Liu X,Wang X,Zhang S,Gan L,He M,Zhu K,Ming Z,Chen H

更新日期：2018-02-01 00:00:00