Abstract:
:Telomeres, which exist in eukaryotic chromosome ends in specialized G-rich TTAGGG structure, protect the ends from degradation or fusion. On the other hand, telomerase is a ribonucleoprotein complex enzyme that synthesizes TTAGGG repeat sequences at the ends of eukaryotic chromosomes. Previous studies suggested that telomere length and telomerase activity cooperate in aging and immortalization of cells. Here, we examined telomere length and telomerase activity in keratinocytes from seven human subjects, including a patient with Werner's syndrome. Telomere length in keratinocytes from healthy individuals was shortened with aging. However, telomerase activity from an individual aged 42 years was reduced, compared with that from a 0 year old individual. Passages of keratinocytes reduced telomerase activity significantly in F2 and F3 keratinocytes from 0 and 42 year old individuals. Withdrawal of either EGF or amphiregulin from medium resulted in down-regulation of telomerase activity. These results suggest that telomere length and telomerase activity in primary cultured keratinocytes may be one of the parameters for cell senescence. However, there remain obscure factors such as ultraviolet-B radiation and growth factors.
journal_name
J Dermatol Scijournal_title
Journal of dermatological scienceauthors
Matsui M,Miyasaka J,Hamada K,Ogawa Y,Hiramoto M,Fujimori R,Aioi Adoi
10.1016/s0923-1811(99)00049-3subject
Has Abstractpub_date
2000-02-01 00:00:00pages
80-7issue
2eissn
0923-1811issn
1873-569Xpii
S0923-1811(99)00049-3journal_volume
22pub_type
杂志文章abstract::Transdermal system(s) bearing captopril were developed using a low temperature casting method and aqueous based polymers viz., eudragit RL-100 and polyvinyl pyrrolidone (PVP). The developed system(s) were subjected to an in vitro characterization study. The results were compared with the transdermal systems of the sam...
journal_title:Journal of dermatological science
pub_type: 杂志文章
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journal_title:Journal of dermatological science
pub_type: 杂志文章
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journal_title:Journal of dermatological science
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journal_title:Journal of dermatological science
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journal_title:Journal of dermatological science
pub_type: 杂志文章
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journal_title:Journal of dermatological science
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更新日期:2001-01-01 00:00:00
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journal_title:Journal of dermatological science
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更新日期:2017-05-01 00:00:00
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journal_title:Journal of dermatological science
pub_type: 杂志文章
doi:10.1016/0923-1811(94)90097-3
更新日期:1994-06-01 00:00:00
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journal_title:Journal of dermatological science
pub_type: 杂志文章
doi:10.1016/j.jdermsci.2005.04.002
更新日期:2005-09-01 00:00:00
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journal_title:Journal of dermatological science
pub_type: 杂志文章
doi:10.1016/s0923-1811(99)00060-2
更新日期:2000-05-01 00:00:00
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更新日期:2014-03-01 00:00:00
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journal_title:Journal of dermatological science
pub_type: 杂志文章
doi:10.1016/j.jdermsci.2012.07.008
更新日期:2012-10-01 00:00:00
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journal_title:Journal of dermatological science
pub_type: 杂志文章
doi:10.1016/j.jdermsci.2018.04.010
更新日期:2018-07-01 00:00:00
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journal_title:Journal of dermatological science
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journal_title:Journal of dermatological science
pub_type: 杂志文章
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journal_title:Journal of dermatological science
pub_type: 杂志文章
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journal_title:Journal of dermatological science
pub_type: 杂志文章,随机对照试验
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更新日期:2013-03-01 00:00:00
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journal_title:Journal of dermatological science
pub_type: 杂志文章
doi:10.1016/j.jdermsci.2009.11.007
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journal_title:Journal of dermatological science
pub_type: 杂志文章
doi:10.1016/j.jdermsci.2019.11.003
更新日期:2020-01-01 00:00:00
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journal_title:Journal of dermatological science
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journal_title:Journal of dermatological science
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更新日期:2003-08-01 00:00:00
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journal_title:Journal of dermatological science
pub_type: 杂志文章
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更新日期:2012-04-01 00:00:00
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journal_title:Journal of dermatological science
pub_type: 杂志文章
doi:10.1016/0923-1811(95)00394-8
更新日期:1995-09-01 00:00:00
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journal_title:Journal of dermatological science
pub_type: 杂志文章
doi:10.1016/j.jdermsci.2012.05.005
更新日期:2012-08-01 00:00:00