当前位置： SCI文献检索 > JOURNAL OF DERMATOLOGICAL SCIENCE期刊下所有文献 > The retinoic acid-induced up-regulation of insulin-like growth factor 1 and 2 is associated with prolidase-dependent collagen synthesis in UVA-irradiated human dermal equivalents.

The retinoic acid-induced up-regulation of insulin-like growth factor 1 and 2 is associated with prolidase-dependent collagen synthesis in UVA-irradiated human dermal equivalents.

Abstract：

BACKGROUND:Ultraviolet (UV) A irradiation causes the degeneration of extracellular matrix in the skin dermis, mainly due to disrupted collagen homeostasis, resulting in the photo-aging of human skin. All-trans retinoic acid (ATRA) improves photo-aged human skin in vivo. OBJECTIVES:Although the effects of ATRA on collagen synthesis and MMP regulation are well known, the effects of ATRA on other collagen homeostasis-associated genes have not been elucidated. This study was aimed to study the factors that are pharmacologically associated with the effect of ATRA on collagen homeostasis. METHODS:The gene transcription profile of collagen homeostasis-associated genes was systematically evaluated in three-dimensional human dermal equivalents (HDEs) following UVA-irradiation and/or ATRA treatment. RESULTS:In addition to the expected changes in MMPs and collagen synthesis in HDEs in response to ATRA, prolidase, an important enzyme in the recycling of proline and hydroxyproline from degraded collagen molecules, was significantly decreased by UVA irradiation, and its down-regulation was antagonized by ATRA. Transfection with a prolidase-specific siRNA led to a significant decrease in procollagen synthesis in human fibroblasts. ATRA inhibited the UVA irradiation-induced decrease in prolidase activity through an insulin-like growth factor (IGF) receptor signaling pathway in HDEs. ARTA increased IGF1 and IGF2 production in HDEs, and neutralizing IGFs with anti-IGF antibodies abolished the effect of ATRA on proliase activity. CONCLUSIONS:These data demonstrate that ATRA regulates prolidase activity in HDEs via IGF receptor signaling, suggesting one of the pharmacological mechanisms by which improves photo-aged human skin.

journal_name

J Dermatol Sci

journal_title

Journal of dermatological science

authors

Shim JH,Shin DW,Lee TR,Kang HH,Jin SH,Noh M

doi

10.1016/j.jdermsci.2011.12.008

subject

Has Abstract

pub_date

2012-04-01 00:00:00

pages

51-9

issue

1

eissn

0923-1811

issn

1873-569X

pii

S0923-1811(11)00358-6

journal_volume

66

pub_type

杂志文章

相关文献

JOURNAL OF DERMATOLOGICAL SCIENCE文献大全
  • Exploring the imbalance of circulating follicular helper CD4+ T cells in sarcoidosis patients.

    abstract：BACKGROUND:Sarcoidosis is a systemic granulomatous disease characterized by the combination of Th1 and Th17 responses. Recently, several arguments have suggested a potential involvement of B cells as well as T cells in the pathogenesis of sarcoidosis. Follicular helper CD4+ T (TFH) cells are specialized in interacting ...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2020.02.002

    authors： Ly NTM,Ueda-Hayakawa I,Nguyen CTH,Okamoto H

    更新日期：2020-03-01 00:00:00

  • A lamellar body mimetic system for the treatment of oxazolone-induced atopic dermatitis in hairless mice.

    abstract：BACKGROUND:Atopic dermatitis is a common skin disease characterized by a Th2 cell-dominant inflammatory infiltrate, elevated serum IgE levels and impaired epidermal barrier function. It is associated to abnormal epidermal lamellar body secretion, producing alteration in lipid composition and extracellular lamellar memb...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2018.01.010

    authors： Moner V,Fernández E,Calpena AC,Garcia-Herrera A,Cócera M,López O

    更新日期：2018-05-01 00:00:00

  • Expression of monocyte chemoattractant protein-1 in the lesional skin of systemic sclerosis.

    abstract：:Systemic sclerosis (SSc) is a connective tissue disease with unknown etiology characterized by excessive deposition of collagen in the skin as well as various internal organs. One of the characteristic histological features is the presence of infiltrating mononuclear cells in the dermis in its early stage. As well as ...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(00)00169-9

    authors： Yamamoto T,Eckes B,Hartmann K,Krieg T

    更新日期：2001-06-01 00:00:00

  • Cultured keratinocytes from plectin/HD1-deficient epidermolysis bullosa simplex showed altered ability of adhesion to the matrix.

    abstract：:Epidermolysis bullosa simplex associated with late onset of muscular dystrophy has been found to show defective expression of plectin, an intracytoplasmic protein in hemidesmosomes. In this report, we examined ability of cell-to-matrix attachment of cultured keratinocytes derived from a case with this disease by vario...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(00)00100-6

    authors： Kurose K,Mori O,Hachisuka H,Shimizu H,Owaribe K,Hashimoto T

    更新日期：2000-12-01 00:00:00

  • Reduced stratum corneum acylceramides in autosomal recessive congenital ichthyosis with a NIPAL4 mutation.

    abstract：BACKGROUND:NIPAL4, encoding the NIPA-like domain containing 4 protein (NIPAL4), is one of the causative genes of autosomal recessive congenital ichthyosis (ARCI). The physiological role of NIPAL4 and the pathogenetic mechanisms of ARCI caused by NIPAL4 mutations remain unclear. OBJECTIVE:To clarify the changes of cera...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2019.12.001

    authors： Murase Y,Takeichi T,Kawamoto A,Tanahashi K,Okuno Y,Takama H,Shimizu E,Ishikawa J,Ogi T,Akiyama M

    更新日期：2020-01-01 00:00:00

  • Effects of kestose on gut mucosal immunity in an atopic dermatitis mouse model.

    abstract：BACKGROUND:Atopic dermatitis (AD) is recently increasing among populations, but the underlying mechanisms remain controversial. Interactions between the gut microbiota and mucosal immunity are considered to be a crucial etiology. Fructooligosaccharide (FOS), prebiotics have been reported as activators of the gut microb...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2017.10.006

    authors： Kim HJ,Lee SH,Go HN,Ahn JR,Kim HJ,Hong SJ

    更新日期：2018-01-01 00:00:00

  • Taurin-conjugated ursodeoxycholic acid has a reversible inhibitory effect on human keratinocyte growth.

    abstract：:Tauroursodeoxycholic acid (TUDC) is one of the most hydrophilic taurin conjugated bile acids. TUDC has a suppressive effect on DNA synthesis in primary cultured rat hepatocytes. In this study, we investigated the growth inhibitory effect of TUDC on cultured human keratinocytes. TUDC suppressed the proliferation of ker...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(98)00023-1

    authors： Yamaguchi Y,Itami S,Nishida K,Ando Y,Okamoto S,Hosokawa K,Yoshikawa K

    更新日期：1998-09-01 00:00:00

  • Non-disulfided pro alpha 1(IV) chain in B16 melanoma cell culture.

    abstract：:We have previously reported that two species of pro alpha 1(IV) collagen chains, disulfided (500 kDa) and non-disulfided (180 kDa), were produced by B16 melanoma cells (J Biochem (1994) 116; 1039-1043). The mechanism by which the non-disulfided pro alpha 1(IV) chain is produced was studied. No significant difference i...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/0923-1811(95)00486-6

    authors： Tajima S,Tokimitsu I

    更新日期：1996-10-01 00:00:00

  • Histamine stimulates normal human melanocytes in vitro: one of the possible inducers of hyperpigmentation in urticaria pigmentosa.

    abstract：:Isolated normal human melanocytes became enlarged and more dendritic in association with an increase in the activity of tyrosinase and the amount of b-locus protein when they were cultured with 0.1-10 microM histamine in vitro. However, histamine did not exert a proliferative effect on them. The stimulatory effect of ...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/0923-1811(93)90005-a

    authors： Tomita Y,Maeda K,Tagami H

    更新日期：1993-10-01 00:00:00

  • Induction of MHC class II antigen expression on human HMC-1 mast cells.

    abstract：:Mast cells are not only the primary effector cells of immediate type immune reactions, but they have recently also been considered to contribute to the induction of an immune response. Data on the ability of the cells to express major histocompatibility complex (MHC) antigens and the mechanisms involved are however co...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(97)00033-9

    authors： Grabbe J,Karau L,Welker P,Ziegler A,Henz BM

    更新日期：1997-11-01 00:00:00

  • Strategies to enhance epithelial-mesenchymal interactions for human hair follicle bioengineering.

    abstract：:Hair follicle morphogenesis and regeneration depend on intensive but well-orchestrated interactions between epithelial and mesenchymal components. Accordingly, the enhancement of this crosstalk represents a promising approach to achieve successful bioengineering of human hair follicles. The present article summarizes ...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章,评审

    doi：10.1016/j.jdermsci.2013.02.004

    authors： Ohyama M,Veraitch O

    更新日期：2013-05-01 00:00:00

  • Activation of fibroblast proliferation by Werner's syndrome fibroblast-conditioned medium.

    abstract：:The effects of Werner's syndrome (WS) fibroblast-conditioned medium on cell proliferation and collagen production of normal fibroblasts were studied using four WS fibroblast strains. The conditioned medium from the WS fibroblasts brought about activation of normal fibroblast proliferation, whereas, that from late pass...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/0923-1811(94)90097-3

    authors： Hatamochi A,Arakawa M,Takeda K,Ueki H

    更新日期：1994-06-01 00:00:00

  • Assessment of in vitro percutaneous absorption of glycolic acid through human skin sections using a flow-through diffusion cell system.

    abstract：UNLABELLED:The percutaneous absorption studies were performed using a flow-through diffusion cell system with skin specimens from 24 healthy women to assess the penetration of glycolic acid (GA). Percentages of GA, based on 14C-labelled activity, found in the skin after application of 4% GA at pH 2.0 or pH 3.8, after 2...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(98)00039-5

    authors： Jiang M,Qureshi SA

    更新日期：1998-12-01 00:00:00

  • Risk of incident chronic kidney disease and end-stage renal disease in patients with psoriasis: A nationwide population-based cohort study.

    abstract：BACKGROUND:Psoriasis is a chronic inflammatory dermatosis that has been associated with various cardiovascular and metabolic comorbidities, including myocardial infarction, stroke, and diabetes mellitus. Recently, there are studies reporting the association of psoriasis with renal diseases. OBJECTIVE:To evaluate the r...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2015.03.012

    authors： Chi CC,Wang J,Chen YF,Wang SH,Chen FL,Tung TH

    更新日期：2015-06-01 00:00:00

  • Fibroblasts of neurofibromatosis type 1 showed no abnormality in p21ras-mediated response to serum in culture.

    abstract：:In order to disclose the possible disturbance in regulation of p21ras function in neurofibromatosis type 1, we investigated the recovery from the quiescent to cycling states of the cell cycle in the skin fibroblasts of the patients. When cells cultured in serum-dependent medium are deprived of the serum, these go into...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/0923-1811(94)90082-5

    authors： Kitano Y,Saito K,Okamoto E,Hashizume K

    更新日期：1994-04-01 00:00:00

  • Clinical analysis of anti-cardiolipin.beta 2 glycoprotein 1 antibody positive patients in anti-phospholipid syndrome.

    abstract：:Clinical analysis was performed on anti-cardiolipin x beta2 glycoprotein 1 (ACL x beta2 GP1) antibody positive patients with collagen vascular diseases. Nine patients out of 89 showed positive aCL x beta2 GP1 antibody which was a relatively lower percentage compared to that of othoffanti-phospholipid antibodies, such ...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/0923-1811(94)00380-w

    authors： Katayama I,Nishioka K,Otoyama K

    更新日期：1995-05-01 00:00:00

  • JSID Tanioku Memorial Lecture 1996. Genetic disorders of keratins and their associated proteins.

    abstract：:It has recently been demonstrated that genetic defects in keratin genes cause a number of different skin disorders, including epidermolysis bullosa simplex (EBS), epidermolytic hyperkeratosis (EH), the EH form of epidermal nevi, epidermolytic and non-epidermolytic forms of palmoplantar keratoderma (EPPK and PPK) and p...

    journal_title：Journal of dermatological science

    pub_type：

    doi：10.1016/s0923-1811(96)00568-3

    authors： Fuchs E

    更新日期：1996-12-01 00:00:00

  • Identification of a novel deletion in the ABCC6 gene leading to Pseudoxanthoma elasticum.

    abstract：BACKGROUND:Pseudoxanthoma elasticum (PXE) is an inherited systemic disorder, characterized by dermal, ocular and cardiovascular lesions. Genetic defects of the ABCC6 (MRP6) transporter are known to cause PXE. OBJECTIVES:The purpose of this study was to identify the genetic background of a PXE patient with a very early...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2005.07.010

    authors： Katona E,Aslanidis C,Remenyik E,Csikós M,Kárpáti S,Paragh G,Schmitz G

    更新日期：2005-11-01 00:00:00

  • Alterations of immune functions in barrier disrupted skin by UVB irradiation.

    abstract：BACKGROUND:While immunologic events elicited by acute barrier disruption or UVB irradiation have been studied in detail, the biological sequel of multiple insults to the skin is not well understood. OBJECTIVE:Since the skin would receive a variety of simultaneous stimuli in daily life, we tested the effects of sequent...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(03)00177-4

    authors： Ito T,Seo N,Yagita H,Tsujimura K,Takigawa M,Tokura Y

    更新日期：2003-12-01 00:00:00

  • There is no influence of a temperature rise on in vivo adsorption of UV filters into the stratum corneum.

    abstract：:Temperature influences the stratum corneum adsorption of several topically applied compounds. This study was designed to evaluate the influence of the temperature on the stratum corneum adsorption of 3 UV filters. The UV filters were solubilized in two vehicles, an emulsion gel and petroleum jelly and applied at respe...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(01)00100-1

    authors： Clarys P,Gabard B,Lambrecht R,Barel A,Bieli E,Lüdi S

    更新日期：2001-10-01 00:00:00

  • TGF-beta-induced SMAD signaling and gene regulation: consequences for extracellular matrix remodeling and wound healing.

    abstract：:Members of the transforming growth factor-beta (TGF-beta) superfamily are pleiotropic cytokines that have the ability to regulate numerous cell functions, including proliferation, differentiation, apoptosis, epithelial-mesenchymal transition, and production of extracellular matrix, allowing them to play an important r...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章,评审

    doi：10.1016/j.jdermsci.2003.12.006

    authors： Schiller M,Javelaud D,Mauviel A

    更新日期：2004-08-01 00:00:00

  • Serum concentration of the soluble interleukin-2 receptor in vitiligo patients.

    abstract：:Serum levels of sIL-2R can be used to monitor in vivo immune activation and its elevation have been shown to be correlated with T cell mediated immune disease such as atopic dermatitis, psoriasis, lymphoma and systemic sclerosis. Vitiligo is the disease of depigmentation caused by destruction of melanocytes, and there...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(98)00070-x

    authors： Yeo UC,Yang YS,Park KB,Sung HT,Jung SY,Lee ES,Shin MH

    更新日期：1999-04-01 00:00:00

  • Differential regulations of matrix metalloproteinases and tissue inhibitors of metalloproteinases in dermal fibroblasts by dibutyril cyclic AMP.

    abstract：:The influence of dibutyril cyclic AMP (dbcAMP) on the gene expression of matrix metalloproteinases (MMP)-1, MMP-2, MMP-3, tissue inhibitors of metalloproteinases (TIMP)-1 and TIMP-2 was investigated in human skin fibroblasts by northern analyses. The treatment of dbcAMP increased MMP-1 and MMP-3 mRNA levels but decrea...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(97)00035-2

    authors： Kuroda K,Shinkai H

    更新日期：1997-08-01 00:00:00

  • Glutathione in human melanoma cells. Effects of cysteine, cysteine esters and glutathione isopropyl ester.

    abstract：:Thiols are of great importance for the regulation of many cellular functions including metabolism, transport and cell protection. In this study the usefulness of L-cysteine methyl and octyl esters, of N,S-diacetyl-L-cysteine methyl ester and glutathione isopropyl ester as cellular cysteine and GSH delivery systems was...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/0923-1811(90)90008-2

    authors： Karg E,Tunek A,Brötell H,Hallberg A,Rosengren E,Rorsman H

    更新日期：1990-01-01 00:00:00

  • Similarly potent action of 1,25-dihydroxyvitamin D3 and its analogues, tacalcitol, calcipotriol, and maxacalcitol on normal human keratinocyte proliferation and differentiation.

    abstract：BACKGROUND:The active vitamin D3 regulates proliferation and differentiation of epidermal keratinocytes. Recently topical vitamin D3, tacalcitol, calcipotriol, and maxacalcitol are widely used for psoriasis. OBJECTIVE:To examine the effect of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) on cultured normal keratinocytes (NHK...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(02)00136-6

    authors： Takahashi H,Ibe M,Kinouchi M,Ishida-Yamamoto A,Hashimoto Y,Iizuka H

    更新日期：2003-02-01 00:00:00

  • Growth stimulation of normal melanocytes and nevocellular nevus cells by gastrin releasing peptide (GRP).

    abstract：:In order to know the possible effects of gastrin releasing peptide (GRP) on nevus cells and melanocytes, we studied the effect of GRP on the proliferation of cultured human nevus cells and normal melanocytes. MTS assay showed that GRP stimulated the growth of viable melanocytes at 1000 ng/ml. GRP also stimulated the g...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(97)00079-0

    authors： Terashi H,Itami S,Tadokoro T,Takeyama M,Katagiri K,Takayasu S

    更新日期：1998-06-01 00:00:00

  • Mechanism of action of androgen in hair follicles.

    abstract：:In order to investigate the mode of action of testosterone (T) on human hair follicles we studied the metabolism of T and localization of androgen receptors in outer root sheath cells (ORSC) and dermal papilla cells (DPC) from different body sites. T was principally metabolized to androstenedione (delta 4) even in bea...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/0923-1811(94)90040-x

    authors： Itami S,Sonoda T,Kurata S,Takayasu S

    更新日期：1994-07-01 00:00:00

  • Oral supplementation with fish oil reduces dryness and pruritus in the acetone-induced dry skin rat model.

    abstract：BACKGROUND:Pruritus and discomfort are often present in patients with xerosis and atopic dermatitis. Several studies suggest an important role of diet in skin pathophysiology. OBJECTIVE:This study evaluated the effect of dietary fatty acids in the skin physiology via an itch-related animal model with and without suppl...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2015.06.015

    authors： Barcelos RC,de Mello-Sampayo C,Antoniazzi CT,Segat HJ,Silva H,Veit JC,Piccolo J,Emanuelli T,Bürger ME,Silva-Lima B,Rodrigues LM

    更新日期：2015-09-01 00:00:00

  • Effect of dopa-loading on glutathione metabolising enzymes and tyrosinase in relation to 5-S-cysteinyl-dopa genesis in cultured B-16 melanoma cells.

    abstract：:The effect of DOPA and glutathione (GSH) on enzyme systems for 5-S-cysteinyl-DOPA (5SCD) genesis in murine melanoma cells cultured in tyrosine- and cystine-free medium were studied. DOPA at its optimum concentration (10(-5) M) when added alone did not alter tyrosinase, glutathione-S-transferase or gamma-glutamyl trans...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/0923-1811(91)90025-s

    authors： Chakraborty AK,Ichihashi M,Mishima Y

    更新日期：1991-09-01 00:00:00

  • Proteolytic cleavage of Livin (ML-IAP) in apoptotic melanoma cells potentially mediated by a non-canonical caspase.

    abstract：BACKGROUND:Several inhibitor of apoptosis proteins (IAPs) are cleaved during apoptosis. Studies of the melanoma-associated IAP (ML-IAP) Livin, using recombinant molecules, have implicated both caspases 3/7 and the serine protease Omi/HtrA2 in its proteolytic cleavage. OBJECTIVE:To characterize the apoptotic cleavage o...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2006.05.007

    authors： Yan H,Brouha B,Liu T,Raj D,Biddle D,Lee R,Grossman D

    更新日期：2006-09-01 00:00:00