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Taurin-conjugated ursodeoxycholic acid has a reversible inhibitory effect on human keratinocyte growth.

Abstract：

:Tauroursodeoxycholic acid (TUDC) is one of the most hydrophilic taurin conjugated bile acids. TUDC has a suppressive effect on DNA synthesis in primary cultured rat hepatocytes. In this study, we investigated the growth inhibitory effect of TUDC on cultured human keratinocytes. TUDC suppressed the proliferation of keratinocytes in a dose dependent fashion, as measured by both cell counts and 5-bromo-2'-deoxyuridine (BrdU) uptake. Keratinocytes reproliferated and reached almost the same cell number as control after removal of TUDC from the medium. TUDC (1 mM) had no effect on the cell viability, as measured by the dye exclusion test. Epidermal sheets stratified in the presence of TUDC appeared thinner than those stratified without TUDC. These results suggest that TUDC has a reversible growth suppressive effect on human keratinocytes through the mechanism other than cytotoxicity and would be applicable for the treatment of hyperproliferative skin disorders such as psoriasis.

journal_name

J Dermatol Sci

journal_title

Journal of dermatological science

authors

Yamaguchi Y,Itami S,Nishida K,Ando Y,Okamoto S,Hosokawa K,Yoshikawa K

doi

10.1016/s0923-1811(98)00023-1

subject

Has Abstract

pub_date

1998-09-01 00:00:00

pages

35-42

issue

1

eissn

0923-1811

issn

1873-569X

pii

S0923181198000231

journal_volume

18

pub_type

杂志文章

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