当前位置： SCI文献检索 > JOURNAL OF DERMATOLOGICAL SCIENCE期刊下所有文献 > Neither cyclosporin A nor FK506 affects adenylate cyclase responses of fetal rat keratinizing epidermal cells (FRSK cells) at concentrations that inhibit thymidine incorporation.

Neither cyclosporin A nor FK506 affects adenylate cyclase responses of fetal rat keratinizing epidermal cells (FRSK cells) at concentrations that inhibit thymidine incorporation.

Abstract：

:It has been reported that various anti-psoriatic agents augment the beta-adrenergic adenylate cyclase response that is defective in the psoriatic hyperproliferative epidermis. Recent evidence indicates that cyclosporin A (CsA) and FK506 show beneficial effects on psoriasis. Using fetal rat keratinizing epidermal cells (FRSK cells) we investigated the effects of these compounds on the adenylate cyclase system. These immunosuppressants had no effect on the adenylate cyclase responses of FRSK cells up to 1-10 microM concentration, although they significantly inhibited thymidine incorporation at concentrations more than 0.1 microM. There was no significant difference in the inhibitory effect on thymidine incorporation between CsA and FK506, despite that FK506 is a much more potent immunosuppressant than CsA.

journal_name

J Dermatol Sci

journal_title

Journal of dermatological science

authors

Takahashi H,Iizuka H

doi

10.1016/0923-1811(93)90044-p

subject

Has Abstract

pub_date

1993-12-01 00:00:00

pages

235-9

issue

3

eissn

0923-1811

issn

1873-569X

pii

0923-1811(93)90044-P

journal_volume

6

pub_type

杂志文章

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