Abstract：
:Kindler syndrome is an autosomal recessive genodermatosis characterized by acral blistering in neonates and diffuse, progressive poikiloderma in later life. Other clinical features include photosensitivity, premature skin ageing and severe periodontal disease. Two groups have recently shown that the molecular basis of Kindler syndrome is loss of a novel epidermal protein, kindlin-1, encoded by the gene KIND1. Two additional kindlin proteins, kindlin-2 and kindlin-3, have also been described. Kindlin-1 is considered to be a component in the linkage of the actin cytoskeleton to the extracellular matrix and as such is proposed to have both structural and cell-signalling functions. Kindler syndrome is therefore the first skin fragility syndrome due to disruption of the actin-extracellular matrix system.
journal_name
J Dermatol Scijournal_title
Journal of dermatological scienceauthors
White SJ,McLean WHdoi
10.1016/j.jdermsci.2004.12.026subject
Has Abstractpub_date
2005-06-01 00:00:00pages
169-75issue
3eissn
0923-1811issn
1873-569Xpii
S0923-1811(05)00061-7journal_volume
38pub_type
杂志文章,评审abstract：:Crystalloid inclusion bodies (CIB) of the endothelial cells (EC) were investigated in blood vessels of human fetal skin and the umbilical cord by electron- and immunoelectron microscopy. They were found in up to 15% of the investigated EC in various types of vessels. Their sizes ranged from 0.2 microns to 0.6 microns ...
journal_title：Journal of dermatological science
pub_type： 杂志文章
doi：10.1016/0923-1811(91)90020-x
更新日期：1991-03-01 00:00:00
abstract：:In order to know the possible effects of gastrin releasing peptide (GRP) on nevus cells and melanocytes, we studied the effect of GRP on the proliferation of cultured human nevus cells and normal melanocytes. MTS assay showed that GRP stimulated the growth of viable melanocytes at 1000 ng/ml. GRP also stimulated the g...
journal_title：Journal of dermatological science
pub_type： 杂志文章
doi：10.1016/s0923-1811(97)00079-0
更新日期：1998-06-01 00:00:00
abstract：BACKGROUND:Netherton syndrome (NS, MIM 256500) is a potential live threatening autosomal-recessive skin disorder clinically characterized by the trias of congenital erythroderma, hair shaft anomalies and atopic diathesis. It is caused by mutations in the gene SPINK5 resulting in a deficiency of its processed protein na...
journal_title：Journal of dermatological science
pub_type： 杂志文章
doi：10.1016/j.jdermsci.2010.12.004
更新日期：2011-03-01 00:00:00
abstract：:Using fetal rat keratinizing epidermal cells (FRSK cells) we investigated the effects of retinoids on the cyclic AMP system. The beta-adrenergic adenylate cyclase response was significantly decreased by the treatment of cells with 1 x 10(-6) M Ro 10-1670. The effect was observed by 12 h and remained for at least 48 h....
journal_title：Journal of dermatological science
pub_type： 杂志文章
doi：10.1016/0923-1811(93)90080-9
更新日期：1993-04-01 00:00:00
abstract：:The immunomodulatory effect of the macrolide antibiotic, roxithromycin (RXM) on Langerhans cells (LC) was studied in mice. RXM inhibited the ability of LC to present superantigen and hapten to T cells at 100 microM. The superantigen-presenting activity of LC was more profoundly abrogated by RXM than the hapten-present...
journal_title：Journal of dermatological science
pub_type： 杂志文章
doi：10.1016/s0923-1811(98)00017-6
更新日期：1998-07-01 00:00:00
abstract：BACKGROUND:Canine atopic dermatitis (cAD) is a common condition in dogs that may be a naturally occurring model for human atopic dermatitis (hAD). Despite this, comparative research is limited, particularly into the genetic background of cAD. OBJECTIVES:1. Measure candidate gene expression in cAD skin using quantitati...
journal_title：Journal of dermatological science
pub_type： 杂志文章
doi：10.1016/j.jdermsci.2009.03.005
更新日期：2009-07-01 00:00:00
abstract：BACKGROUND:Ultraviolet B (UVB) radiation is a major cause of skin photodamage, including the damage associated with photodermatoses, aging, and cancer. Although many studies have shown that red light has photoprotective effects on skin, the mechanisms underlying these effects are still poorly understood. OBJECTIVE:The...
journal_title：Journal of dermatological science
pub_type： 杂志文章
doi：10.1016/j.jdermsci.2019.03.003
更新日期：2019-05-01 00:00:00
abstract：:Transdermal system(s) bearing captopril were developed using a low temperature casting method and aqueous based polymers viz., eudragit RL-100 and polyvinyl pyrrolidone (PVP). The developed system(s) were subjected to an in vitro characterization study. The results were compared with the transdermal systems of the sam...
journal_title：Journal of dermatological science
pub_type： 杂志文章
doi：10.1016/0923-1811(95)00403-f
更新日期：1995-11-01 00:00:00
abstract：:The usefulness of the Yucatan miniature pig as a screen for skin dipigmenting activity by topical application was evaluated with standard compounds. This is a naturally occurring breed of swine with light brown to dark brown skin that is relatively hairless. The skin morphology, including the pattern of pigment distri...
journal_title：Journal of dermatological science
pub_type： 杂志文章
doi：10.1016/0923-1811(91)90007-k
更新日期：1991-12-01 00:00:00
abstract：:Skin biopsies from four patients with similar clinical phenotypes of non-lethal junctional epidermolysis bullosa (JEB) were investigated by electron microscopy and immunohistochemistry. Electron microscopy revealed cleavage within the lamina lucida in each case, but in addition, there was considerable variability in t...
journal_title：Journal of dermatological science
pub_type： 杂志文章
doi：10.1016/s0923-1811(96)00554-3
更新日期：1997-01-01 00:00:00
abstract：:DS-Nh (DS Nh/+) mice spontaneously develop dermatitis when they are housed in a conventional environment. In this study, we analyzed the clinical and histopathological features of dermatitis in DS-Nh mice, which is characterized by erythema, edema, and erosion on the face, neck, chest and flexor surfaces of their fore...
journal_title：Journal of dermatological science
pub_type： 杂志文章
doi：10.1016/s0923-1811(02)00070-1
更新日期：2002-11-01 00:00:00
abstract：:Large numbers of pigmented melanocytes are located in human hair follicles, predominantly around the dermal papillae, and the number of melanocytes and the melanogenic activity of the hair follicles are closely related to the hair cycle. We found that cultured human dermal papilla cells secreted a melanocyte chemoattr...
journal_title：Journal of dermatological science
pub_type： 杂志文章
doi：10.1016/s0923-1811(01)00145-1
更新日期：2002-01-01 00:00:00
abstract：BACKGROUND:Chemokines and their receptors are important elements for the selective attraction and activation of various subsets of leukocytes. Expression of CXCR3 ligands, such as monokine induced by IFN-gamma (Mig) leads to preferential Th1 recruitment, whereas CCR4 ligands, thymus and activation regulated chemokine (...
journal_title：Journal of dermatological science
pub_type： 杂志文章
doi：10.1016/j.jdermsci.2004.01.001
更新日期：2004-05-01 00:00:00
abstract：:Over the last decade, animal models of atopic dermatitis (AD) have received increasing attention. They include NC/Nga mice, a hapten-induced mouse model, and transgenic and knockout mouse models. Although the pathogenesis of skin inflammation elicited in these models and that in AD are not quite the same, it is pertin...
journal_title：Journal of dermatological science
pub_type： 杂志文章,评审
doi：10.1016/j.jdermsci.2004.02.013
更新日期：2004-10-01 00:00:00
abstract：:Among occupational and environmental disorders, contact or photocontact dermatitis and an acneiform eruption are two major skin disorders. Photocontact dermatitis was historically caused by various halogenated salicylanilides, while the acne is induced by halogenated aromatic hydrocarbons and thus called chloracne. Th...
journal_title：Journal of dermatological science
pub_type： 杂志文章,评审
doi：10.1016/s0923-1811(03)00097-5
更新日期：2003-08-01 00:00:00
abstract：BACKGROUND:Mammalian epidermis has two diffusion barriers, the stratum corneum (SC) and tight junctions (TJs). We reported previously that a single living cell layer exists between the SC and TJ-forming keratinocytes in mice; however, the exact location of the TJ barrier in human epidermis has not been defined. OBJECT...
journal_title：Journal of dermatological science
pub_type： 杂志文章
doi：10.1016/j.jdermsci.2013.04.021
更新日期：2013-08-01 00:00:00
abstract：:Citrulline residues are detected in keratins and filaggrin in the cornified layers of mammalian epidermis. Such citrulline residues are formed by the enzymatic deimination of arginine residues by peptidylarginine deiminases (EC 3.5.3.15). Major deiminated keratins are derived from keratin K1. Two arginine residues ide...
journal_title：Journal of dermatological science
pub_type： 杂志文章
doi：10.1016/s0923-1811(99)00026-2
更新日期：1999-09-01 00:00:00
abstract：:Survival and extracellular matrix gene expression were studied by viable cell count assay and Northern transfer analysis to compare the sensitivity of normal skin and keloid fibroblasts towards x-irradiation. As the dosage of radiation increased, the numbers of viable cells in irradiated groups were remarkably decreas...
journal_title：Journal of dermatological science
pub_type： 杂志文章
doi：10.1016/0923-1811(94)90318-2
更新日期：1994-08-01 00:00:00
abstract：BACKGROUND:The effects of hyaluronic acid (HA) injection on tissue collagen anabolism are suggested to be related to the induction of mechanical stress, causing biochemical changes in skin physiology. OBJECTIVES:To ascertain the association between dermal mechanics modulated by a hyaluronic acid-based filler effect an...
journal_title：Journal of dermatological science
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jdermsci.2012.12.006
更新日期：2013-03-01 00:00:00
abstract：:We examined the production of superantigenic exotoxins in 136 coagulase-negative staphylococci isolated from various skin lesions in humans using a reversed passive latex agglutination test (Denka Seiken). As a control we examined the same in 50 Staphylococcus aureus strains isolated from non-infective skin ulcers in ...
journal_title：Journal of dermatological science
pub_type： 杂志文章
doi：10.1016/s0923-1811(00)00122-5
更新日期：2000-11-01 00:00:00
abstract：BACKGROUND:Psoriasis is a common multi-factorial skin disease, in which gene-gene and gene-environment interactions may affect the onset, manifestation and clinical course. OBJECTIVE:To investigate the underlying gene-environment interaction among several established susceptibility genes, cigarette smoking and alcohol...
journal_title：Journal of dermatological science
pub_type： 杂志文章
doi：10.1016/j.jdermsci.2013.02.006
更新日期：2013-05-01 00:00:00
abstract：:The prick test is a useful skin test for diagnosing immediate hypersensitivity response. Sometimes it is necessary to perform prick tests on patients who have already received antihistamines or corticosteroids. It is, however, occasionally uncertain whether the results of prick tests are reliable. In this study, the i...
journal_title：Journal of dermatological science
pub_type： 杂志文章
doi：10.1016/s0923-1811(02)00069-5
更新日期：2002-12-01 00:00:00
abstract：:p53, A tumor suppressor gene, has been documented as the most frequently mutated gene in human cancers including non-melanoma skin tumors. It has been controversial whether the p53 gene mutation plays a major role for melanoma genesis. To examine the role of p53 in human malignant melanoma carcinogenesis, we performed...
journal_title：Journal of dermatological science
pub_type： 杂志文章
doi：10.1016/0923-1811(95)00465-3
更新日期：1996-06-01 00:00:00
abstract：BACKGROUND:UV radiation is the major environmental factor related to development of cutaneous melanoma. Besides sun exposure and the influence of latitude, some host characteristics such as skin phototype and hair and eye color are also risk factors for melanoma. Polymorphisms in DNA repair genes could be good candidat...
journal_title：Journal of dermatological science
pub_type： 杂志文章
doi：10.1016/j.jdermsci.2011.06.003
更新日期：2011-10-01 00:00:00
abstract：:The epidermal basement membrane zone (BMZ) comprises a multiprotein complex that aids the attachment of epidermal keratinocytes to the underlying dermis. In the last 5 years, our understanding of epidermal BMZ morphology, structure and function has dramatically improved. A complex network of molecular interactions has...
journal_title：Journal of dermatological science
pub_type： 杂志文章,评审
doi：10.1016/s0923-1811(03)00045-8
更新日期：2003-05-01 00:00:00
abstract：:Tauroursodeoxycholic acid (TUDC) is one of the most hydrophilic taurin conjugated bile acids. TUDC has a suppressive effect on DNA synthesis in primary cultured rat hepatocytes. In this study, we investigated the growth inhibitory effect of TUDC on cultured human keratinocytes. TUDC suppressed the proliferation of ker...
journal_title：Journal of dermatological science
pub_type： 杂志文章
doi：10.1016/s0923-1811(98)00023-1
更新日期：1998-09-01 00:00:00
abstract：:Stratum corneum samples obtained from 46 members in three generations of seven families were analyzed for keratin pattern by gel electrophoresis. All these samples of apparently normal upper arm skin expressed the 55 kDa, 56.5 kDa, and 65 kDa keratin proteins; while only 28%, 20% and 48% of the samples expressed the 5...
journal_title：Journal of dermatological science
pub_type： 杂志文章
doi：10.1016/0923-1811(90)90118-w
更新日期：1990-07-01 00:00:00
abstract：BACKGROUND:IL36RN mutation has been identified as one pathogenesis of generalized pustular psoriasis, but the existence of GPP patients without mutation makes this controversial. OBJECTIVE:Our study aimed at assessing the differences in clinical profiles of children with GPP, with and without IL36RN mutation. METHODS...
journal_title：Journal of dermatological science
pub_type： 杂志文章
doi：10.1016/j.jdermsci.2016.11.008
更新日期：2017-03-01 00:00:00
abstract：BACKGROUND:Ultraviolet (UV) irradiation is the main contributing factor for skin aging. UV irradiation induces epigenetic changes in skin. It increases the activity of histone acetylases (HATs) but decreases that of histone deacetylases (HDACs). OBJECTIVE:We aimed to investigate alterations in all classes of HDACs and...
journal_title：Journal of dermatological science
pub_type： 杂志文章
doi：10.1016/j.jdermsci.2020.11.008
更新日期：2020-12-03 00:00:00
abstract：BACKGROUND:Atopic dermatitis (AD) is characterized by impaired skin barrier function and immune system dysfunction. The expression and role of Yes-associated protein (YAP) in AD are unclear. OBJECTIVE:To characterize the role of the YAP in T cell imbalance and epidermal keratinocyte dysfunction in the pathogenesis of ...
journal_title：Journal of dermatological science
pub_type： 杂志文章
doi：10.1016/j.jdermsci.2020.12.004
更新日期：2020-12-18 00:00:00
