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Regulation of keratinocyte differentiation by O-GlcNAcylation.

Abstract：

BACKGROUND:O-linked β-N-acetylglucosamine (O-GlcNAc) modification is one of the posttranslational modification, emerging as an important regulatory mechanism in various cellular events. OBJECTIVE:We attempted to investigate whether O-GlcNAcylation is involved in keratinocyte differentiation. METHODS:Immunohistochemistry and Western blot were performed to demonstrate O-GlcNAcylation in keratinocyte differentiation. RESULTS:During calcium-induced keratinocyte differentiation, overall O-GlcNAcylation was decreased in a temporal manner. We focused our attention on transcription factor Sp-1, which is implicated in keratinocyte differentiation. Total Sp-1 level did not change during keratinocyte differentiation. However, O-GlcNAcylated Sp-1 was decreased in a keratinocyte differentiation-dependent manner. Interestingly, transcriptional activity of Sp-1, in terms of involucrin and loricrin promoter activities, was markedly increased by overexpression of O-GlcNAcase (OGA). In addition, membrane permeable non-O-GlcNAcylated Sp-1 did show transcriptional activity, while membrane permeable O-GlcNAcylated Sp-1 did not, suggesting O-GlcNAcylated Sp-1 is an inactive form in keratinocyte differentiation. CONCLUSION:Our results reveal that O-GlcNAcylation is a dynamic regulatory mechanism for keratinocyte differentiation.

journal_name

J Dermatol Sci

journal_title

Journal of dermatological science

authors

Sohn KC,Lee EJ,Shin JM,Lim EH,No Y,Lee JY,Yoon TY,Lee YH,Im M,Lee Y,Seo YJ,Lee JH,Kim CD

doi

10.1016/j.jdermsci.2014.04.010

subject

Has Abstract

pub_date

2014-07-01 00:00:00

pages

10-5

issue

1

eissn

0923-1811

issn

1873-569X

pii

S0923-1811(14)00106-6

journal_volume

75

pub_type

杂志文章

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