Abstract:
BACKGROUND:The inducement of Th1 cell-mediated immune response, possibly brought about through bacterial stimulation, may serve to control atopic disorders such as atopic dermatitis (AD). The streptococcal preparation, OK-432, has been shown a potent Th1 inducer through the action of IL-12. NC/Nga mice under ordinary conditions have been found to contract dermatitis similar to human AD. OBJECTIVE:Examination was made of the therapeutic effects of OK-432 local intra- and/or subcutaneous injections on AD-like lesions in NC/Nga mice. METHODS:Immunohistochemical staining with IL-4/IL-12p40 and CD80/86 and phosphorylated STAT4/p-STAT6 and RT-PCR for IL-4/IL-12p40 and STAT6/STAT4 mRNA was conducted for the evaluation of OK-432 treatment of spontaneous AD-like lesions in NC/Nga mice. RESULTS:At 5 weeks following injection of OK-432, for treating head and back lesions in NC/Nga mice, 10 of 12 OK-432 treated NC mice were found to have clinically improved quite considerably. On the head and back skin of OK-432-treated mice, IL-12p40/CD80 positive cellular infiltration was conspicuous, in contrast to non-treated mice. IL-4/CD86 positive cellular infiltrates in OK-432-treated mice had decreased significantly more than in non-treated mice and IL-4 mRNA expression was virtually absent in OK-432-treated mice. P-STAT4 positive cells could be seen abundantly present in OK-432-treated mice, and p-STAT6 positive cells were much fewer than in non-treated mice. CONCLUSIONS:OK-432-treatment appears to induce Th1 cellular response and to down-regulate that of the Th2 pathway in AD-like lesions of NC/Nga mice. The present results demonstrate bacterial components from such Streptococcus to likely constitute an effective new therapeutic approach in the treatment of AD.
journal_name
J Dermatol Scijournal_title
Journal of dermatological scienceauthors
Horiuchi Y,Bae S,Katayama I,Nishioka Kdoi
10.1016/j.jdermsci.2004.06.006subject
Has Abstractpub_date
2004-09-01 00:00:00pages
187-97issue
3eissn
0923-1811issn
1873-569Xpii
S0923-1811(04)00131-8journal_volume
35pub_type
杂志文章abstract:BACKGROUND:Tumor-associated M2 macrophages (TAMs) produce chemokines that affect the formation of cutaneous T-cell lymphoma (CTCL) by stromal factors. Since IFNs are an effective treatment for advanced-stage mycosis fungoides (MF), we hypothesized that IFNs might modulate M2 macrophages. OBJECTIVE:To prove our hypothe...
journal_title:Journal of dermatological science
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abstract:BACKGROUND:Pachydermoperiostosis (PDP) is a rare genetic disorder characterized by 3 major symptoms: pachydermia including cutis verticis gyrata (CVG), periostosis, and finger clubbing. Recently, a homozygous mutation in the gene HPGD, which encodes 15-hydroxyprostaglandin dehydrogenase (15-PGDH), was found to be assoc...
journal_title:Journal of dermatological science
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journal_title:Journal of dermatological science
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更新日期:2007-04-01 00:00:00
abstract:BACKGROUND:Several inhibitor of apoptosis proteins (IAPs) are cleaved during apoptosis. Studies of the melanoma-associated IAP (ML-IAP) Livin, using recombinant molecules, have implicated both caspases 3/7 and the serine protease Omi/HtrA2 in its proteolytic cleavage. OBJECTIVE:To characterize the apoptotic cleavage o...
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pub_type: 杂志文章
doi:10.1016/j.jdermsci.2006.05.007
更新日期:2006-09-01 00:00:00
abstract::Kindler syndrome is an autosomal recessive genodermatosis characterized by acral blistering in neonates and diffuse, progressive poikiloderma in later life. Other clinical features include photosensitivity, premature skin ageing and severe periodontal disease. Two groups have recently shown that the molecular basis of...
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abstract:BACKGROUND:Mammalian epidermis has two diffusion barriers, the stratum corneum (SC) and tight junctions (TJs). We reported previously that a single living cell layer exists between the SC and TJ-forming keratinocytes in mice; however, the exact location of the TJ barrier in human epidermis has not been defined. OBJECT...
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journal_title:Journal of dermatological science
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更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:Cannabinoids from cannabis (Cannabis sativa) are anti-inflammatory and have inhibitory effects on the proliferation of a number of tumorigenic cell lines, some of which are mediated via cannabinoid receptors. Cannabinoid (CB) receptors are present in human skin and anandamide, an endogenous CB receptor ligan...
journal_title:Journal of dermatological science
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更新日期:2007-02-01 00:00:00
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journal_title:Journal of dermatological science
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Journal of dermatological science
pub_type: 杂志文章
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更新日期:1997-08-01 00:00:00
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journal_title:Journal of dermatological science
pub_type: 杂志文章
doi:10.1016/s0923-1811(97)00597-5
更新日期:1997-05-01 00:00:00
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journal_title:Journal of dermatological science
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更新日期:2003-08-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1016/s0923-1811(99)00048-1
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journal_title:Journal of dermatological science
pub_type: 杂志文章
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journal_title:Journal of dermatological science
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1997-03-01 00:00:00
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journal_title:Journal of dermatological science
pub_type: 杂志文章
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更新日期:2009-06-01 00:00:00
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journal_title:Journal of dermatological science
pub_type: 杂志文章
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更新日期:2010-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-10-01 00:00:00