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Modulation of UVA light-induced oxidative stress by beta-carotene, lutein and astaxanthin in cultured fibroblasts.

Abstract：

:The ability of beta-carotene, lutein or astaxanthin to protect against UVA-induced oxidative stress in rat kidney fibroblasts (NRK) was assessed. Activities of the antioxidant enzymes catalase (CAT) and superoxide dismutase (SOD), and changes in thiobarbituric acid reactive substances (TBARS) were measured as indices of oxidative stress. Exposure to UVA light at a dose intensity of 5.6 mW/cm2 for 4 h resulted in a significant decrease in CAT and SOD activities and a significant increase in TBARS. No cytotoxicity, as indicated by lactate dehydrogenase (LDH) release, was observed. beta-Carotene (1 microM), lutein (1 microM) and astaxanthin (10 nM) protect against UVA light-induced oxidative stress in vitro with astaxanthin exhibiting superior protective properties.

journal_name

J Dermatol Sci

journal_title

Journal of dermatological science

authors

O'Connor I,O'Brien N

doi

10.1016/s0923-1811(97)00058-3

subject

Has Abstract

pub_date

1998-03-01 00:00:00

pages

226-30

issue

3

eissn

0923-1811

issn

1873-569X

pii

S0923181197000583

journal_volume

16

pub_type

杂志文章

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