Spatial data analysis by epidermal Langerhans cells reveals an elegant system.

abstract：:Quinolone antibacterial agents, known to elicit photosensitive dermatitis as an adverse effect, have both phototoxicity and photoallergenicity. The latter potency is mainly derived from their photohaptenic moiety; quinolones covalently bind to protein and cells upon exposure to ultraviolet A (UVA) light. Our previous ...

journal_title：Journal of dermatological science

authors： Tokura Y,Seo N,Ohshima A,Yagi H,Furukawa F,Takigawa M

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND:The loss of subcutaneous (sc) fat is associated with aging. Inflammatory cytokines, such as interleukin-1 α (IL-1α), interleukin-11 (IL-11) and tumor necrosis factor-α (TNF-α), are known to inhibit the differentiation of preadipocytes. OBJECTIVE:This study investigated the potential role of inflammatory cyt...

journal_title：Journal of dermatological science

authors： Li WH,Pappas A,Zhang L,Ruvolo E,Cavender D

更新日期：2013-07-01 00:00:00

abstract：:Smoking tobacco is the most preventable cause of morbidity and is responsible for more than three million deaths a year worldwide. In addition to a strong association with a number of systemic diseases, smoking is also associated with many dermatological conditions, including poor wound healing, premature skin aging, ...

journal_title：Journal of dermatological science

authors： Morita A

更新日期：2007-12-01 00:00:00

abstract：:The CC-chemokine TARC is known to be a ligand for the CCR4 receptor which in turn is known to be expressed selectively on the Th(2)-subset of lymphocytes. Atopic dermatitis is generally believed to be a Th(2)-type disease, and TARC has been shown to be expressed in the skin lesions of a murine model of AD. IL-10 is an...

journal_title：Journal of dermatological science

authors： Vestergaard C,Kirstejn N,Gesser B,Mortensen JT,Matsushima K,Larsen CG

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND:Repeated exposure to ultraviolet (UV) rays damages skin connective tissue, which is thought to be associated with wrinkle formation. We hypothesized that repeated mild inflammation may cause the connective tissue alterations in photoaging. OBJECTIVE:To clarify the behavior of neutrophils and neutrophil elas...

journal_title：Journal of dermatological science

authors： Takeuchi H,Gomi T,Shishido M,Watanabe H,Suenobu N

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:The molecular pathogenesis of mycosis fungoides (MF) is currently poorly understood. The chemokine receptor CCR7 has been demonstrated to be involved in the development and progression of certain cancers, but its role in MF has rarely been investigated. OBJECTIVES:We seek to determine whether CCR7 is expres...

journal_title：Journal of dermatological science

authors： Hu SC,Lin CL,Hong CH,Yu HS,Chen GS,Lee CH

更新日期：2014-04-01 00:00:00

abstract：:This study reports on the isolation and characterization of a cDNA clone, regulated by androgen transcriptionally, in male Golden hamsters' flank organs. Previous studies have reported on the cloning of an androgen-dependent gene, FAR-17a, from the same hamster organ. After castration, the FAR-17c transcription rate d...

journal_title：Journal of dermatological science

authors： Ideta R,Seki T,Adachi K

更新日期：1995-03-01 00:00:00

abstract：:Autosomal recessive congenital ichthyoses (ARCI) include several severe subtypes including harlequin ichthyosis (HI), lamellar ichthyosis and non-bullous congenital ichthyosiform erythroderma. Patients with these severe types of ichthyoses frequently show severe hyperkeratosis and scales over a large part of the body ...

journal_title：Journal of dermatological science

authors： Akiyama M

更新日期：2006-05-01 00:00:00

abstract：:Over the last decade, animal models of atopic dermatitis (AD) have received increasing attention. They include NC/Nga mice, a hapten-induced mouse model, and transgenic and knockout mouse models. Although the pathogenesis of skin inflammation elicited in these models and that in AD are not quite the same, it is pertin...

journal_title：Journal of dermatological science

authors： Shiohara T,Hayakawa J,Mizukawa Y

更新日期：2004-10-01 00:00:00

abstract：BACKGROUND:Dry skin causes pruritus and discomfort in patients with xerosis and atopic dermatitis. General treatment for skin dryness involves the topical application of an emollient. However, more effective, simpler therapies are desired. Collagen tripeptide (CTP) is a highly purified, non-antigenic, low-allergenic co...

journal_title：Journal of dermatological science

authors： Okawa T,Yamaguchi Y,Takada S,Sakai Y,Numata N,Nakamura F,Nagashima Y,Ikezawa Z,Aihara M

更新日期：2012-05-01 00:00:00

abstract：:Isolated normal human melanocytes became enlarged and more dendritic in association with an increase in the activity of tyrosinase and the amount of b-locus protein when they were cultured with 0.1-10 microM histamine in vitro. However, histamine did not exert a proliferative effect on them. The stimulatory effect of ...

journal_title：Journal of dermatological science

authors： Tomita Y,Maeda K,Tagami H

更新日期：1993-10-01 00:00:00

abstract：:Extracted human terminal and vellus hair follicles were prepared by EDTA and examined by light and electron microscopes. These samples were morphologically well preserved and enabled us to observe 3-dimensional (3-D) views of the outer surfaces of hair follicles. Interestingly, the bulge areas of terminal and vellus h...

journal_title：Journal of dermatological science

authors： Narisawa Y,Hashimoto K,Kohda H

更新日期：1994-07-01 00:00:00

abstract：:Atopic dermatitis is regarded as mediated by Th2-type immunity. In fact, it frequently coincides with the elevation of immunoglobulin (Ig)-E in patients' sera. Due to the pivotal role of interleukin (IL)-4 in regulation of IgE, we hypothesized if atopic dermatitis represents a hyper-reactive condition in response to I...

journal_title：Journal of dermatological science

authors： Yamazaki F,Aragane Y,Maeda A,Matsushita K,Ueno K,Yudate T,Kawada A,Tezuka T

更新日期：2002-04-01 00:00:00

abstract：BACKGROUND:Ustekinumab has been evaluated in Caucasian patients with psoriasis, but no studies have been conducted in Asian patients. OBJECTIVE:To assess the efficacy and safety of ustekinumab in Taiwanese and Korean patients with moderate-to-severe psoriasis. METHODS:In this 36-week, multicenter, double-blind, place...

journal_title：Journal of dermatological science

authors： Tsai TF,Ho JC,Song M,Szapary P,Guzzo C,Shen YK,Li S,Kim KJ,Kim TY,Choi JH,Youn JI,PEARL Investigators.

更新日期：2011-09-01 00:00:00

abstract：:Keratinocyte growth factor (KGF) is a stromally derived paracrine mitogen that belongs to the fibroblast growth factor (FGF) family. It is secreted by dermal fibroblasts and specifically promotes keratinocyte proliferation. We have recently shown that epidermal growth factor (EGF) and transforming growth factor beta (...

journal_title：Journal of dermatological science

authors： Latkowski JM,Freedberg IM,Blumenberg M

更新日期：1995-01-01 00:00:00

abstract：:Epidermolysis bullosa simplex associated with late onset of muscular dystrophy has been found to show defective expression of plectin, an intracytoplasmic protein in hemidesmosomes. In this report, we examined ability of cell-to-matrix attachment of cultured keratinocytes derived from a case with this disease by vario...

journal_title：Journal of dermatological science

authors： Kurose K,Mori O,Hachisuka H,Shimizu H,Owaribe K,Hashimoto T

更新日期：2000-12-01 00:00:00

abstract：BACKGROUND:The CC chemokine ligand 18 (CCL18) has a higher expression in some tumors, while the CCL18 level can be a marker of tumor progression and prognosis. We previously reported that the expression of CCL18 gene was dramatically up-regulated in cutaneous malignant melanoma (CMM) and its expression levels were corr...

journal_title：Journal of dermatological science

authors： Song H,Tao Y,Ni N,Zhou X,Xiong J,Zeng X,Xu X,Qi J,Sun J

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:Mammalian epidermis has two diffusion barriers, the stratum corneum (SC) and tight junctions (TJs). We reported previously that a single living cell layer exists between the SC and TJ-forming keratinocytes in mice; however, the exact location of the TJ barrier in human epidermis has not been defined. OBJECT...

journal_title：Journal of dermatological science

authors： Yoshida K,Yokouchi M,Nagao K,Ishii K,Amagai M,Kubo A

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Th17 is a newly identified effector T cell lineage which plays a central role in many human inflammatory diseases and experimental animal models. Epicutaneous sensitization with a protein antigen has been proven to induce a Th2-predominant immune response and lead to development of atopic diseases in a murin...

journal_title：Journal of dermatological science

authors： Wang LF,Chiu HC,Hsu CJ,Liu CY,Hsueh YH,Miaw SC

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:Ultraviolet B (UVB) radiation is a major cause of skin photodamage, including the damage associated with photodermatoses, aging, and cancer. Although many studies have shown that red light has photoprotective effects on skin, the mechanisms underlying these effects are still poorly understood. OBJECTIVE:The...

journal_title：Journal of dermatological science

authors： Kim HS,Kim YJ,Kim SJ,Kang DS,Lee TR,Shin DW,Kim HJ,Seo YR

更新日期：2019-05-01 00:00:00

abstract：:We succeeded in culturing human outer root sheath cells (ORSC) in serum-free conditions without a biological feeder layer. The combination of collagen type IV substrate and modified MCDB 153 medium supplemented with bovine pituitary gland extract (K-GM medium) could support the growth of ORSC. These cells can be seria...

journal_title：Journal of dermatological science

authors： Arase S,Katoh S,Sadamoto Y,Nakanishi H,Urano Y,Fujie K,Takeda K

更新日期：1991-01-01 00:00:00

abstract：UNLABELLED:The percutaneous absorption studies were performed using a flow-through diffusion cell system with skin specimens from 24 healthy women to assess the penetration of glycolic acid (GA). Percentages of GA, based on 14C-labelled activity, found in the skin after application of 4% GA at pH 2.0 or pH 3.8, after 2...

journal_title：Journal of dermatological science

authors： Jiang M,Qureshi SA

更新日期：1998-12-01 00:00:00

abstract：:Kindler syndrome is an autosomal recessive genodermatosis characterized by acral blistering in neonates and diffuse, progressive poikiloderma in later life. Other clinical features include photosensitivity, premature skin ageing and severe periodontal disease. Two groups have recently shown that the molecular basis of...

journal_title：Journal of dermatological science

authors： White SJ,McLean WH

更新日期：2005-06-01 00:00:00

abstract：BACKGROUND:Common DNA variants in IL12B, IL23R and IL23A have been associated with an increased susceptibility to psoriasis (Ps) and psoriatic arthritis (PsA). Metabolic comorbidities and cardiovascular risk factors have also been associated to both Ps and PsA. OBJECTIVE:To analyze the effect of single nucleotide poly...

journal_title：Journal of dermatological science

authors： Eirís N,González-Lara L,Santos-Juanes J,Queiro R,Coto E,Coto-Segura P

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:1 alpha,25-Dihydroxyvitamin D3 (1 alpha,25(OH)2D3), the active form of vitamin D, suppresses keratinocyte proliferation, promotes keratinocyte differentiation, and induces involucrin expression. Peroxisome proliferation-activated receptors (PPARs) are ligand-activated transcription factors. It has been repor...

journal_title：Journal of dermatological science

authors： Dai X,Sayama K,Shirakata Y,Tokumaru S,Yang L,Tohyama M,Hirakawa S,Hanakawa Y,Hashimoto K

更新日期：2008-04-01 00:00:00

abstract：:Serum levels of sIL-2R can be used to monitor in vivo immune activation and its elevation have been shown to be correlated with T cell mediated immune disease such as atopic dermatitis, psoriasis, lymphoma and systemic sclerosis. Vitiligo is the disease of depigmentation caused by destruction of melanocytes, and there...

journal_title：Journal of dermatological science

authors： Yeo UC,Yang YS,Park KB,Sung HT,Jung SY,Lee ES,Shin MH

更新日期：1999-04-01 00:00:00

abstract：BACKGROUND:Candidiasis is caused by several Candida species, of which Candida stellatoidea and C. dubliniensis are phenotypically close to C. albicans. Although current molecular biology-based techniques can distinguish between C. albicans and C. dubliniensis, a convenient tool that can distinguish C. stellatoidea from...

journal_title：Journal of dermatological science

authors： Kanbe T,Kurimoto K,Hattori H,Iwata T,Kikuchi A

更新日期：2005-10-01 00:00:00

abstract：:Large numbers of pigmented melanocytes are located in human hair follicles, predominantly around the dermal papillae, and the number of melanocytes and the melanogenic activity of the hair follicles are closely related to the hair cycle. We found that cultured human dermal papilla cells secreted a melanocyte chemoattr...

journal_title：Journal of dermatological science

authors： Ideta R,Soma T,Tsunenaga M,Ifuku O

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Foot ulcers are one of the main diabetes complications due to its high frequency and difficulty of complete healing. There are several factors that participate in diabetic ulcers development and limited information exists about the role of antimicrobial peptides (AMP) in its pathogenesis. OBJECTIVE:The aim ...

journal_title：Journal of dermatological science

authors： Rivas-Santiago B,Trujillo V,Montoya A,Gonzalez-Curiel I,Castañeda-Delgado J,Cardenas A,Rincon K,Hernandez ML,Hernández-Pando R

更新日期：2012-01-01 00:00:00

abstract：:DS-Nh (DS Nh/+) mice spontaneously develop dermatitis when they are housed in a conventional environment. In this study, we analyzed the clinical and histopathological features of dermatitis in DS-Nh mice, which is characterized by erythema, edema, and erosion on the face, neck, chest and flexor surfaces of their fore...

journal_title：Journal of dermatological science

authors： Hikita I,Yoshioka T,Mizoguchi T,Tsukahara K,Tsuru K,Nagai H,Hirasawa T,Tsuruta Y,Suzuki R,Ichihashi M,Horikawa T

更新日期：2002-11-01 00:00:00