当前位置： SCI文献检索 > JOURNAL OF DERMATOLOGICAL SCIENCE期刊下所有文献 > Genetic variation at IL12B, IL23R and IL23A is associated with psoriasis severity, psoriatic arthritis and type 2 diabetes mellitus.

Genetic variation at IL12B, IL23R and IL23A is associated with psoriasis severity, psoriatic arthritis and type 2 diabetes mellitus.

Abstract：

BACKGROUND:Common DNA variants in IL12B, IL23R and IL23A have been associated with an increased susceptibility to psoriasis (Ps) and psoriatic arthritis (PsA). Metabolic comorbidities and cardiovascular risk factors have also been associated to both Ps and PsA. OBJECTIVE:To analyze the effect of single nucleotide polymorphisms (SNPs) previously linked to Ps (IL12B rs6887695 and rs3212227, IL23R rs2201841 and rs11209026, and IL23Ars2066808) in the main phenotype and metabolic/cardiovascular characteristics among Ps patients from a Northern Spanish population. METHODS:The aforementioned genetic variants were determined in a total of 405 chronic plaque Ps patients and 426 controls. Subsequent statistical analysis included stratification for psoriatic clinical characteristics (age of onset, disease severity, familial psoriasis, HLA-Cw6, nail psoriasis) plus diabetes mellitus type 2, arterial hypertension, dyslipidemia and ischemic cardiac events as comorbidities. RESULTS:An association between IL23R rs11209026-GG genotype with a more severe disease (p=0.02, OR=2.11, 95% CI=1.13-3.95). Carriers of the IL23A rs2066808-A allele were significantly more frequent among PsA patients (p=0.016, OR= 3.04, 95% CI=1.19-7.78). We found significant associations between three SNP genotypes and type 2 diabetes: IL12B rs6887695-CC (p=0.03, OR=2.90, 95% CI=1.09-7.69), IL12B rs3212227-CC (p=0.035, OR=5.90, 95% CI= 1.35-25.73) and IL23R rs2201841-GG (p= 0.027, OR=2.69, 95% CI=1.09-6.66). CONCLUSION:In our population, genetic variation at IL12B, IL23R and IL23A has an influence not only on the risk for Ps but also on disease severity and type 2 diabetes mellitus.

journal_name

J Dermatol Sci

journal_title

Journal of dermatological science

authors

Eirís N,González-Lara L,Santos-Juanes J,Queiro R,Coto E,Coto-Segura P

doi

10.1016/j.jdermsci.2014.05.010

subject

Has Abstract

pub_date

2014-09-01 00:00:00

pages

167-72

issue

3

eissn

0923-1811

issn

1873-569X

pii

S0923-1811(14)00134-0

journal_volume

75

pub_type

杂志文章

相关文献

JOURNAL OF DERMATOLOGICAL SCIENCE文献大全
  • Neutrophil elastase contributes to extracellular matrix damage induced by chronic low-dose UV irradiation in a hairless mouse photoaging model.

    abstract：BACKGROUND:Repeated exposure to ultraviolet (UV) rays damages skin connective tissue, which is thought to be associated with wrinkle formation. We hypothesized that repeated mild inflammation may cause the connective tissue alterations in photoaging. OBJECTIVE:To clarify the behavior of neutrophils and neutrophil elas...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2010.09.001

    authors： Takeuchi H,Gomi T,Shishido M,Watanabe H,Suenobu N

    更新日期：2010-12-01 00:00:00

  • Loss of skin elasticity precedes to rapid increase of wrinkle levels.

    abstract：BACKGROUND:Decreased skin elasticity is considered as a factor that promotes wrinkle formation. However, the relationship between decreased skin elasticity and the formation of wrinkles is not fully understood. OBJECTIVE:The purpose of this study is to characterize the relationship between skin elasticity and wrinkle ...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2007.05.002

    authors： Fujimura T,Haketa K,Hotta M,Kitahara T

    更新日期：2007-09-01 00:00:00

  • Epidermal turnover time.

    abstract：:Epidermal turnover time is the time taken for the epidermis to replace itself. The turnover time can be subdivided; when the epidermis is divided into proliferative compartment, differentiated compartment, and stratum corneum, the total turnover time is the sum of the turnover time of each compartment. Using Weinstein...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/0923-1811(94)90057-4

    authors： Iizuka H

    更新日期：1994-12-01 00:00:00

  • Efficacy and safety of ustekinumab for the treatment of moderate-to-severe psoriasis: a phase III, randomized, placebo-controlled trial in Taiwanese and Korean patients (PEARL).

    abstract：BACKGROUND:Ustekinumab has been evaluated in Caucasian patients with psoriasis, but no studies have been conducted in Asian patients. OBJECTIVE:To assess the efficacy and safety of ustekinumab in Taiwanese and Korean patients with moderate-to-severe psoriasis. METHODS:In this 36-week, multicenter, double-blind, place...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.jdermsci.2011.05.005

    authors： Tsai TF,Ho JC,Song M,Szapary P,Guzzo C,Shen YK,Li S,Kim KJ,Kim TY,Choi JH,Youn JI,PEARL Investigators.

    更新日期：2011-09-01 00:00:00

  • Proteolytic cleavage of Livin (ML-IAP) in apoptotic melanoma cells potentially mediated by a non-canonical caspase.

    abstract：BACKGROUND:Several inhibitor of apoptosis proteins (IAPs) are cleaved during apoptosis. Studies of the melanoma-associated IAP (ML-IAP) Livin, using recombinant molecules, have implicated both caspases 3/7 and the serine protease Omi/HtrA2 in its proteolytic cleavage. OBJECTIVE:To characterize the apoptotic cleavage o...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2006.05.007

    authors： Yan H,Brouha B,Liu T,Raj D,Biddle D,Lee R,Grossman D

    更新日期：2006-09-01 00:00:00

  • Confocal Raman spectroscopy: In vivo measurement of physiological skin parameters - A pilot study.

    abstract：BACKGROUND:In vivo application of confocal Raman spectroscopy (CRS) allows non-invasive depth measurement of the skin. Thereby obtained knowledge of the skin composition is essential to reliably assess the actual skin state. Besides other components, the skin cholesterol concentration is of interest; however, little is...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2017.08.002

    authors： Binder L,SheikhRezaei S,Baierl A,Gruber L,Wolzt M,Valenta C

    更新日期：2017-12-01 00:00:00

  • Streptococci isolated from various skin lesions: the interaction with Staphylococcus aureus strains.

    abstract：:We isolated 73 streptococcus strains (41 from infections, and 32 from colonization) from various skin diseases between March, 1994, and June, 1998. In 29 out of 41 cases of infective origin, Staphylococcus aureus strains were simultaneously isolated. Twenty-four out of 28 patients with impetigo were suffering from ato...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(98)00043-7

    authors： Akiyama H,Yamasaki O,Kanzaki H,Tada J,Arata J

    更新日期：1999-01-01 00:00:00

  • Loss of factor XIIIa in pig dermis during tissue expansion.

    abstract：:Considerable evidence suggests that factor XIIIa, a blood coagulation factor, also functions in tissue repair, and specifically in the dynamic process of fibroplasia. On the other hand, the dynamic process of tissue expansion would require a loosening of the dermis, the opposite of fibroplasia. We examined the effects...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/0923-1811(91)90044-x

    authors： Penneys NS,Rademaker B,Jackson IT,Fasching MC

    更新日期：1991-01-01 00:00:00

  • Genetically engineered mouse models for skin research: taking the next step.

    abstract：:Genetically engineered mouse models are invaluable to investigators in nearly all areas of biomedical research. The use of genetically engineered mice has allowed researchers to explore fundamental functions of genes in a mammal that shares substantial similarities with human physiology and pathology. Genetically engi...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章,评审

    doi：10.1016/j.jdermsci.2008.03.012

    authors： Chen J,Roop DR

    更新日期：2008-10-01 00:00:00

  • The role of immunohistochemistry in the diagnosis of the non-lethal forms of junctional epidermolysis bullosa.

    abstract：:Skin biopsies from four patients with similar clinical phenotypes of non-lethal junctional epidermolysis bullosa (JEB) were investigated by electron microscopy and immunohistochemistry. Electron microscopy revealed cleavage within the lamina lucida in each case, but in addition, there was considerable variability in t...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(96)00554-3

    authors： McGrath JA,Eady RA

    更新日期：1997-01-01 00:00:00

  • CCR7 expression correlates with subcutaneous involvement in mycosis fungoides skin lesions and promotes migration of mycosis fungoides cells (MyLa) through mTOR activation.

    abstract：BACKGROUND:The molecular pathogenesis of mycosis fungoides (MF) is currently poorly understood. The chemokine receptor CCR7 has been demonstrated to be involved in the development and progression of certain cancers, but its role in MF has rarely been investigated. OBJECTIVES:We seek to determine whether CCR7 is expres...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2013.12.003

    authors： Hu SC,Lin CL,Hong CH,Yu HS,Chen GS,Lee CH

    更新日期：2014-04-01 00:00:00

  • Sox9 facilitates proliferation, differentiation and lipogenesis in primary cultured human sebocytes.

    abstract：BACKGROUND:The transcription factor Sox9 is pivotal in the morphogenesis of hair follicles, but its role in sebocytes is poorly understood. OBJECTIVE:We investigated the effect of Sox9 on human sebocyte proliferation, differentiation and lipogenesis. METHODS:Sox9 expression was detected by immunohistochemistry in nor...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2016.10.005

    authors： Shi G,Wang TT,Quan JH,Li SJ,Zhang MF,Liao PY,Fan YM

    更新日期：2017-01-01 00:00:00

  • The production of superantigenic exotoxins by coagulase-negative staphylococci isolated from human skin lesions.

    abstract：:We examined the production of superantigenic exotoxins in 136 coagulase-negative staphylococci isolated from various skin lesions in humans using a reversed passive latex agglutination test (Denka Seiken). As a control we examined the same in 50 Staphylococcus aureus strains isolated from non-infective skin ulcers in ...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(00)00122-5

    authors： Akiyama H,Yamasaki O,Tada J,Arata J

    更新日期：2000-11-01 00:00:00

  • Cisplatin encapsulated in phosphatidylethanolamine liposomes enhances the in vitro cytotoxicity and in vivo intratumor drug accumulation against melanomas.

    abstract：BACKGROUND:Cisplatin is a potent anticancer drug for treating melanoma. OBJECTIVE:The aim of this study was to evaluate the possibility of using liposomes, for intratumoral distribution in a melanoma, composed of phosphatidylethanolamine (PE), for its cytotoxicity. METHOD:The in vitro drug release, in vitro cytotoxic...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2006.12.011

    authors： Hwang TL,Lee WR,Hua SC,Fang JY

    更新日期：2007-04-01 00:00:00

  • Imiquimod-induced autophagy is regulated by ER stress-mediated PKR activation in cancer cells.

    abstract：BACKGROUND:Autophagy is a highly conserved cellular catabolic pathway for degradation and recycling of intracellular components in response to nutrient starvation or environmental stress. Endoplasmic reticulum (ER) homeostasis can be disturbed by physiological and pathological influences, resulting in accumulation of m...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2017.04.011

    authors： Chang SH,Huang SW,Wang ST,Chung KC,Hsieh CW,Kao JK,Chen YJ,Wu CY,Shieh JJ

    更新日期：2017-08-01 00:00:00

  • Cannabinoids inhibit human keratinocyte proliferation through a non-CB1/CB2 mechanism and have a potential therapeutic value in the treatment of psoriasis.

    abstract：BACKGROUND:Cannabinoids from cannabis (Cannabis sativa) are anti-inflammatory and have inhibitory effects on the proliferation of a number of tumorigenic cell lines, some of which are mediated via cannabinoid receptors. Cannabinoid (CB) receptors are present in human skin and anandamide, an endogenous CB receptor ligan...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2006.10.009

    authors： Wilkinson JD,Williamson EM

    更新日期：2007-02-01 00:00:00

  • Sulfhydryl oxidase (SOx) from mouse epidermis: molecular cloning, nucleotide sequence, and expression of recombinant protein in the cultured cells.

    abstract：:Skin sulfhydryl oxidase (SOx) is an enzyme that catalyzes disulfide (S-S) cross-linking through the oxidation of sulfhydryl compounds in the skin. In this study, using the enzyme purified from rat seminal vesicle, we obtained peptide sequences for SOx by mass spectrometry. We then searched for SOx nucleotides correspo...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(02)00061-0

    authors： Matsuba S,Suga Y,Ishidoh K,Hashimoto Y,Takamori K,Kominami E,Wilhelm B,Seitz J,Ogawa H

    更新日期：2002-10-01 00:00:00

  • Application of FTIR microspectroscopy for characterization of biomolecular changes in human melanoma cells treated by sesamol and kojic acid.

    abstract：BACKGROUND:Hyperpigmentation is aesthetic undesirable. Sesamol and the standard antimelanogenic agent (kojic acid) were shown to hinder melanogenesis by blocking tyrosinase and reducing melanin content. OBJECTIVE:The FTIR microspectroscopy was used in an attempt to find a novel method to define biological alternation ...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2013.11.002

    authors： Srisayam M,Weerapreeyakul N,Barusrux S,Tanthanuch W,Thumanu K

    更新日期：2014-03-01 00:00:00

  • Simultaneous and separated culture of keratinocytes and fibroblasts on each side of a collagen membrane.

    abstract：:We have developed a new cell culture system which is of benefit for the research of dermal-epidermal interaction. In this system, normal human keratinocytes are cultured on the upper surface of a permeable collagen membrane, on the undersurface of which human fibroblasts are simultaneously and separately cultured in a...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/0923-1811(93)90099-b

    authors： Mitsuhashi Y,Mikami Y,Mikami H,Ishikawa H,Tamai K,Hashimoto I

    更新日期：1993-02-01 00:00:00

  • Glycolic acid induces keratinocyte proliferation in a skin equivalent model via TRPV1 activation.

    abstract：BACKGROUND:Glycolic acid (GA) is the most commonly used alpha-hydroxy acid (AHA) for dermatologic applications, and is considered as a versatile superficial peeling agent for facial rejuvenation. Its therapeutic effect includes acceleration of epidermal turnover without apparent inflammation, and its action is pH-depen...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2009.11.007

    authors： Denda S,Denda M,Inoue K,Hibino T

    更新日期：2010-02-01 00:00:00

  • Analysis of T cell receptor (TCR) BV-gene clonotypes in NC/Nga mice developing dermatitis resembling human atopic dermatitis.

    abstract：BACKGROUND:Our previous study showed that T cells in skin lesions of human atopic dermatitis (AD) had oligoclonal accumulation, indicating the involvement of antigen-specific immune reactions at those sites. Recently, NC/Nga mice, which develop skin lesions similar to AD, have been proposed as a model for that disease....

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2004.11.011

    authors： Matsuoka A,Kato T,Soma Y,Takahama H,Nakamura M,Matsuoka H,Mizoguchi M

    更新日期：2005-04-01 00:00:00

  • Tight junction dysfunction in the stratum granulosum leads to aberrant stratum corneum barrier function in claudin-1-deficient mice.

    abstract：BACKGROUND:Tight junctions (TJs) contribute to the epithelial barrier function by preventing leakage of solutes through the intercellular space. In the skin, TJs occur in the stratum granulosum (SG), where claudin-1 and claudin-4 are expressed as adhesion molecules of TJs. Claudin-1-deficient (Cldn1(-/-)) mice die with...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2013.01.002

    authors： Sugawara T,Iwamoto N,Akashi M,Kojima T,Hisatsune J,Sugai M,Furuse M

    更新日期：2013-04-01 00:00:00

  • Clinical analysis of anti-cardiolipin.beta 2 glycoprotein 1 antibody positive patients in anti-phospholipid syndrome.

    abstract：:Clinical analysis was performed on anti-cardiolipin x beta2 glycoprotein 1 (ACL x beta2 GP1) antibody positive patients with collagen vascular diseases. Nine patients out of 89 showed positive aCL x beta2 GP1 antibody which was a relatively lower percentage compared to that of othoffanti-phospholipid antibodies, such ...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/0923-1811(94)00380-w

    authors： Katayama I,Nishioka K,Otoyama K

    更新日期：1995-05-01 00:00:00

  • Thrombospondin-1 promotes fibroblast-mediated collagen gel contraction caused by activation of latent transforming growth factor beta-1.

    abstract：BACKGROUND:Grafting of cultured epithelium has become a useful technique for the treatment of epithelial defects, since grafted epithelial cells secrete factors promoting wound healing. We identified one such factor produced by cultured oral epithelial cells as thrombospondin-1 (TSP-1). Recently, TSP-1 was reported to ...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(02)00150-0

    authors： Sakai K,Sumi Y,Muramatsu H,Hata K,Muramatsu T,Ueda M

    更新日期：2003-04-01 00:00:00

  • Characterization of itch-associated responses of NC mice with mite-induced chronic dermatitis.

    abstract：:To clarify the behavioral and pathological features of spontaneous scratching of NC mice with mite-induced chronic dermatitis, we investigated the spontaneous and pruritogen-evoked scratching of NC mice. Although the frequency of scratching of NC mouse did not increase under specific pathogen-free environment, it grad...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(00)00099-2

    authors： Yamaguchi T,Maekawa T,Nishikawa Y,Nojima H,Kaneko M,Kawakita T,Miyamoto T,Kuraishi Y

    更新日期：2001-01-01 00:00:00

  • Hair growth-stimulating effects of cyclosporin A and FK506, potent immunosuppressants.

    abstract：:Cyclosporin A (CsA), a cyclic endecapeptide, is a T cell-specific immunosuppressant and is successfully used in the field of organ transplantation. Another T cell-specific immunosuppressant, FK506, a more recently discovered macrolide antibiotic, is effective against graft rejection at much lower doses than CsA. Altho...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章,评审

    doi：10.1016/0923-1811(94)90035-3

    authors： Yamamoto S,Kato R

    更新日期：1994-07-01 00:00:00

  • Pilot study on novel skin care method by augmentation with Staphylococcus epidermidis, an autologous skin microbe--A blinded randomized clinical trial.

    abstract：BACKGROUND AND OBJECTIVE:Staphylococcus epidermidis is an autologous bacterium that is beneficial to skin health. Our goal was to develop a novel, personalized basic cosmetic that exploits this characteristic. METHODS:We conducted a double-blinded, randomized clinical trial on augmentation with S. epidermidis as a pil...

    journal_title：Journal of dermatological science

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.jdermsci.2015.05.001

    authors： Nodake Y,Matsumoto S,Miura R,Honda H,Ishibashi G,Matsumoto S,Dekio I,Sakakibara R

    更新日期：2015-08-01 00:00:00

  • Expression of inducible nitric oxide synthase in skin lesions of acute herpes zoster.

    abstract：:Histopathologically, the skin lesions of acute herpes zoster (AHZ) are characterized by epidermal necrotic vesicles with inflammation. Nitric oxide (NO) is generated from L-arginine by nitric oxide synthase (NOS), and immune inflammation involves the activation of NOS in both effector cells and target cells. NO can ca...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(02)00035-x

    authors： Lim YJ,Chang SE,Choi JH,Sung KJ,Bahk JH,Do SH,Lee DS

    更新日期：2002-09-01 00:00:00

  • Malignant blue nevus: a report of eight cases.

    abstract：:Malignant blue nevus is uncommon compared to its benign counterpart and is regarded as a rare form of malignant melanoma. We report the clinical and histological findings in eight cases. Histologically, all eight specimens showed no epidermal involvement and had contained within or were adjacent to portions of blue ne...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/0923-1811(92)90018-7

    authors： Mehregan DA,Gibson LE,Mehregan AH

    更新日期：1992-11-01 00:00:00

  • Serum concentration of the soluble interleukin-2 receptor in vitiligo patients.

    abstract：:Serum levels of sIL-2R can be used to monitor in vivo immune activation and its elevation have been shown to be correlated with T cell mediated immune disease such as atopic dermatitis, psoriasis, lymphoma and systemic sclerosis. Vitiligo is the disease of depigmentation caused by destruction of melanocytes, and there...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(98)00070-x

    authors： Yeo UC,Yang YS,Park KB,Sung HT,Jung SY,Lee ES,Shin MH

    更新日期：1999-04-01 00:00:00