Loss of factor XIIIa in pig dermis during tissue expansion.


:Considerable evidence suggests that factor XIIIa, a blood coagulation factor, also functions in tissue repair, and specifically in the dynamic process of fibroplasia. On the other hand, the dynamic process of tissue expansion would require a loosening of the dermis, the opposite of fibroplasia. We examined the effects of tissue expansion on the expression of factor XIIIa in pig skin. Standard immunohistochemical procedures were used coupled with a rabbit antibody to factor XIIIa. In this report, we demonstrate that the normal expression of factor XIIIa in pig dermis is completely inhibited at the apex overlying the tissue expander. Factor XIIIa inhibition during expansion supports the thesis that this substance is important in the production and maintenance of fibroplasia.


J Dermatol Sci


Penneys NS,Rademaker B,Jackson IT,Fasching MC




Has Abstract


1991-01-01 00:00:00














  • Growth stimulation of normal melanocytes and nevocellular nevus cells by gastrin releasing peptide (GRP).

    abstract::In order to know the possible effects of gastrin releasing peptide (GRP) on nevus cells and melanocytes, we studied the effect of GRP on the proliferation of cultured human nevus cells and normal melanocytes. MTS assay showed that GRP stimulated the growth of viable melanocytes at 1000 ng/ml. GRP also stimulated the g...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章


    authors: Terashi H,Itami S,Tadokoro T,Takeyama M,Katagiri K,Takayasu S

    更新日期:1998-06-01 00:00:00

  • Expression of antimicrobial peptides in diabetic foot ulcer.

    abstract:BACKGROUND:Foot ulcers are one of the main diabetes complications due to its high frequency and difficulty of complete healing. There are several factors that participate in diabetic ulcers development and limited information exists about the role of antimicrobial peptides (AMP) in its pathogenesis. OBJECTIVE:The aim ...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章


    authors: Rivas-Santiago B,Trujillo V,Montoya A,Gonzalez-Curiel I,Castañeda-Delgado J,Cardenas A,Rincon K,Hernandez ML,Hernández-Pando R

    更新日期:2012-01-01 00:00:00

  • Genetic skin diseases related to desmosomes and corneodesmosomes.

    abstract::The integrity of the epidermis depends on the cohesion between keratinocytes, and desmosomes are the main adhesion structures. When cells become cornified, desmosomes are modified and transformed into corneodesmosomes. Mutations in the genes encoding desmosomal components underlie several skin diseases including palmo...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章,评审


    authors: Ishida-Yamamoto A,Igawa S

    更新日期:2014-05-01 00:00:00

  • Efficacy and safety of topical SR-T100 gel in treating actinic keratosis in Taiwan: A Phase III randomized double-blind vehicle-controlled parallel trial.

    abstract:BACKGROUND:Currently available topical treatments for actinic keratosis (AK) are associated with substantial side-effects. OBJECTIVES:To evaluate the efficacy and safety of topical SR-T100 gel in treating AK. METHODS:A multicenter, randomized, double-blinded phase III trial was conducted. Patients with at least two c...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Yang CC,Wong TW,Lee CH,Hong CH,Chang CH,Lai FJ,Lin SH,Chi CC,Lin TK,Yen H,Wu CH,Sheu HM,Lan CE

    更新日期:2018-06-01 00:00:00

  • Cross-sectional survey on disease severity in Japanese patients with harlequin ichthyosis/ichthyosis: Syndromic forms and quality-of-life analysis in a subgroup.

    abstract:BACKGROUND:Congenital ichthyoses (CIs) adversely affect quality of life (QOL) in patients. However, the effects of CIs on patient QOL have not been studied sufficiently. OBJECTIVE:To investigate the association between disease severity and QOL in patients with harlequin ichthyosis (HI) and ichthyosis: syndromic forms ...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章


    authors: Murase C,Takeichi T,Shibata A,Nakatochi M,Kinoshita F,Kubo A,Nakajima K,Ishii N,Amano H,Masuda K,Kawakami H,Kanekura T,Washio K,Asano M,Teramura K,Akasaka E,Tohyama M,Hatano Y,Ochiai T,Moriwaki S,Sato T,Ishida-Y

    更新日期:2018-11-01 00:00:00

  • Autoimmune reactivity against precursor form of desmoglein 1 in healthy Tunisians in the area of endemic pemphigus foliaceus.

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    journal_title:Journal of dermatological science

    pub_type: 杂志文章


    authors: Toumi A,Saleh MA,Yamagami J,Abida O,Kallel M,Masmoudi A,Makni S,Turki H,Hachiya T,Kuroda K,Stanley JR,Masmoudi H,Amagai M

    更新日期:2013-04-01 00:00:00

  • Tobacco smoke causes premature skin aging.

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    journal_title:Journal of dermatological science

    pub_type: 杂志文章,评审


    authors: Morita A

    更新日期:2007-12-01 00:00:00

  • Three dimensional structural studies of alpha-N-acetylgalactosaminidase (alpha-NAGA) in alpha-NAGA deficiency (Kanzaki disease): different gene mutations cause peculiar structural changes in alpha-NAGAs resulting in different substrate specificities and c

    abstract:BACKGROUND:Kanzaki disease (OMIM#104170) is attributable to a deficiency in alpha-N-acetylgalactosaminidase (alpha-NAGA; E.C., which hydrolyzes GalNAcalpha1-O-Ser/Thr. Missense mutations, R329W or R329Q were identified in two Japanese Kanzaki patients. Although they are on the same codon, the clinical manifest...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章


    authors: Kanekura T,Sakuraba H,Matsuzawa F,Aikawa S,Doi H,Hirabayashi Y,Yoshii N,Fukushige T,Kanzaki T

    更新日期:2005-01-01 00:00:00

  • Vascular endothelial growth factor (VEGF) in the pathogenesis of psoriasis--a possible target for novel therapies?

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    journal_title:Journal of dermatological science

    pub_type: 杂志文章,评审


    authors: Canavese M,Altruda F,Ruzicka T,Schauber J

    更新日期:2010-06-01 00:00:00

  • Neural stem cells inhibit melanin production by activation of Wnt inhibitors.

    abstract:BACKGROUND:Melanin for skin pigmentation is synthesized from tyrosine via an enzymatic cascade that is controlled by tyrosinase (TYR), tyrosinase-related protein 1 (TRP1), and dopachrome tautomerase/tyrosinase related protein 2 (Dct/TRP2), which are the targets of microphthalmia-associated transcription factor (MITF). ...

    journal_title:Journal of dermatological science

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    authors: Hwang I,Park JH,Park HS,Choi KA,Seol KC,Oh SI,Kang S,Hong S

    更新日期:2013-12-01 00:00:00

  • The production of superantigenic exotoxins by coagulase-negative staphylococci isolated from human skin lesions.

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    journal_title:Journal of dermatological science

    pub_type: 杂志文章


    authors: Akiyama H,Yamasaki O,Tada J,Arata J

    更新日期:2000-11-01 00:00:00

  • Therapeutic effects of streptococcal preparation OK-432 on atopic dermatitis-like lesions in NC/Nga mice: possible shift from a Th2- to Th1-predominance.

    abstract:BACKGROUND:The inducement of Th1 cell-mediated immune response, possibly brought about through bacterial stimulation, may serve to control atopic disorders such as atopic dermatitis (AD). The streptococcal preparation, OK-432, has been shown a potent Th1 inducer through the action of IL-12. NC/Nga mice under ordinary c...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章


    authors: Horiuchi Y,Bae S,Katayama I,Nishioka K

    更新日期:2004-09-01 00:00:00

  • Characterization of fibroblast-derived prolidase. The presence of two forms of prolidase.

    abstract::Crude enzyme solutions of prolidase were extracted from cultured human skin fibroblasts derived from control and prolidase-deficient sisters. Two forms of prolidases (prolidase-I and II) were partially purified by high performance liquid chromatography equipped with an ion exchange column. On gel filtration, the relat...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章


    authors: Oono T,Yasutomi H,Ohhashi T,Kodama H,Arata J

    更新日期:1990-09-01 00:00:00

  • Sulfhydryl oxidase (SOx) from mouse epidermis: molecular cloning, nucleotide sequence, and expression of recombinant protein in the cultured cells.

    abstract::Skin sulfhydryl oxidase (SOx) is an enzyme that catalyzes disulfide (S-S) cross-linking through the oxidation of sulfhydryl compounds in the skin. In this study, using the enzyme purified from rat seminal vesicle, we obtained peptide sequences for SOx by mass spectrometry. We then searched for SOx nucleotides correspo...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章


    authors: Matsuba S,Suga Y,Ishidoh K,Hashimoto Y,Takamori K,Kominami E,Wilhelm B,Seitz J,Ogawa H

    更新日期:2002-10-01 00:00:00

  • The role of VEGF and thrombospondins in skin angiogenesis.

    abstract::The vasculature in adult skin remains normally quiescent, due to the dominant influence of endogenous angiogenesis inhibitors over angiogenic stimuli. However, skin retains the capacity for brisk initiation of angiogenesis, the growth of new blood vessels from preexisting vessels, during tissue repair and in numerous ...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章,评审


    authors: Detmar M

    更新日期:2000-12-01 00:00:00

  • Retinoid-induced beta-adrenergic inhibitory effect associated with increased thymidine incorporation of fetal rat keratinizing epidermal cells (FRSK cells).

    abstract::Using fetal rat keratinizing epidermal cells (FRSK cells) we investigated the effects of retinoids on the cyclic AMP system. The beta-adrenergic adenylate cyclase response was significantly decreased by the treatment of cells with 1 x 10(-6) M Ro 10-1670. The effect was observed by 12 h and remained for at least 48 h....

    journal_title:Journal of dermatological science

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    authors: Takahashi H,Iizuka H

    更新日期:1993-04-01 00:00:00

  • Resolvin D1 attenuates imiquimod-induced mice psoriasiform dermatitis through MAPKs and NF-κB pathways.

    abstract:BACKGROUND:Resolvin D1 (RvD1), a pro-resolution lipid mediator derived from docosahexaenoic acid (DHA), has been described to promote several kinds of inflammatory resolution. However, the effects and anti-inflammatory mechanisms of RvD1 on psoriasis have not been previously reported. OBJECTIVE:The present study aimed...

    journal_title:Journal of dermatological science

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    authors: Xu J,Duan X,Hu F,Poorun D,Liu X,Wang X,Zhang S,Gan L,He M,Zhu K,Ming Z,Chen H

    更新日期:2018-02-01 00:00:00

  • Topically applied Melaleuca alternifolia (tea tree) oil causes direct anti-cancer cytotoxicity in subcutaneous tumour bearing mice.

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    journal_title:Journal of dermatological science

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    authors: Ireland DJ,Greay SJ,Hooper CM,Kissick HT,Filion P,Riley TV,Beilharz MW

    更新日期:2012-08-01 00:00:00

  • Development of an inducible gene expression system for primary murine keratinocytes.

    abstract:BACKGROUND:The tetracycline (Tet) responsive system is a valuable tool that is routinely used in a wide variety of mammalian cells for regulatable expression of gene products. However, technical difficulties such as harsh selection conditions and extensive screening processes to identify suitably responsive clones limi...

    journal_title:Journal of dermatological science

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    authors: Nagarajan P,Sinha S

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    journal_title:Journal of dermatological science

    pub_type: 杂志文章


    authors: Ito T,Seo N,Yagita H,Tsujimura K,Takigawa M,Tokura Y

    更新日期:2003-12-01 00:00:00

  • Germline mutations of the PTCH gene in Japanese patients with nevoid basal cell carcinoma syndrome.

    abstract::Nevoid basal cell carcinoma syndrome (NBCCS) is an autosomal dominant disorder characterized by developmental and skeletal anomalies, palmo-plantar pits, odontogenic keratocysts, ectopic calcification, and occurrence of various types of tumors including basal cell carcinoma. Recent evidence has indicated that the huma...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章


    authors: Minami M,Urano Y,Ishigami T,Tsuda H,Kusaka J,Arase S

    更新日期:2001-09-01 00:00:00

  • Streptococci isolated from various skin lesions: the interaction with Staphylococcus aureus strains.

    abstract::We isolated 73 streptococcus strains (41 from infections, and 32 from colonization) from various skin diseases between March, 1994, and June, 1998. In 29 out of 41 cases of infective origin, Staphylococcus aureus strains were simultaneously isolated. Twenty-four out of 28 patients with impetigo were suffering from ato...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章


    authors: Akiyama H,Yamasaki O,Kanzaki H,Tada J,Arata J

    更新日期:1999-01-01 00:00:00

  • Expressional changes in the intracellular melanogenesis pathways and their possible role in the pathogenesis of vitiligo.

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    journal_title:Journal of dermatological science

    pub_type: 杂志文章


    authors: Kingo K,Aunin E,Karelson M,Rätsep R,Silm H,Vasar E,Kõks S

    更新日期:2008-10-01 00:00:00

  • Objective scratch monitor evaluation of the effect of an antihistamine on nocturnal scratching in atopic dermatitis.

    abstract::We previously reported a simple and easy-to-use device, Scratch Monitor for evaluation of nocturnal scratching. In the present study, the effect of an antihistamine (azelastine hydrochloride) on atopic dermatitis was investigated using this device. In 40 patients with atopic dermatitis, nocturnal scratching was measur...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章


    authors: Endo K,Sano H,Fukuzumi T,Adachi J,Aoki T

    更新日期:1999-12-01 00:00:00

  • Propionibacterium acnes-induced iNOS and COX-2 protein expression via ROS-dependent NF-κB and AP-1 activation in macrophages.

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    journal_title:Journal of dermatological science

    pub_type: 杂志文章


    authors: Tsai HH,Lee WR,Wang PH,Cheng KT,Chen YC,Shen SC

    更新日期:2013-02-01 00:00:00

  • Multi-layered environmental regulation on the homeostasis of stem cells: the saga of hair growth and alopecia.

    abstract::Stem cells are fascinating because of their potential in regenerative medicine. Stem cell homeostasis has been thought to be mainly regulated by signals from their adjacent micro-environment named the "stem cell niche". However, recent studies reveal that there can be multiple layers of environmental controls. Here we...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章,评审


    authors: Chen CC,Chuong CM

    更新日期:2012-04-01 00:00:00

  • Occupational trichloroethylene hypersensitivity syndrome: human herpesvirus 6 reactivation and rash phenotypes.

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    journal_title:Journal of dermatological science

    pub_type: 杂志文章


    authors: Kamijima M,Wang H,Yamanoshita O,Ito Y,Xia L,Yanagiba Y,Chen C,Okamura A,Huang Z,Qiu X,Song X,Cai T,Liu L,Ge Y,Deng Y,Naito H,Yoshikawa T,Tohyama M,Li L,Huang H,Nakajima T

    更新日期:2013-12-01 00:00:00

  • An attempt to develop mouse model for anti-laminin γ1 pemphigoid.

    abstract:BACKGROUND:We recently reported that the autoantibodies of anti-p200 pemphigoid sera react with laminin γ1 and renamed this entity as anti-laminin γ1 pemphigoid. However, it has not been clarified whether the anti-laminin γ1 autoantibodies, particularly those to the C-terminal integrin binding site, affect the dermoepi...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章


    authors: Koga H,Ishii N,Dainichi T,Tsuruta D,Hamada T,Ohata C,Karashima T,Furumura M,Hashimoto T

    更新日期:2013-05-01 00:00:00

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    journal_title:Journal of dermatological science

    pub_type: 杂志文章


    authors: Akiyama H,Yamasaki O,Tada J,Arata J

    更新日期:2000-08-01 00:00:00

  • Establishment of a new murine-phenotypic angiosarcoma cell line (ISOS-1).

    abstract::A cell line, designated ISOS-1, was established from a tumor formed by transplantation of a human angiosarcoma into mice with severe combined immunodeficiency (SCID). The cells showed endothelial properties, based on the uptake of Dil-Ac-LDL and binding of UEA-I/GSA-I lectins, but were negative for CD11b and Pan Cytok...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章


    authors: Masuzawa M,Fujimura T,Tsubokawa M,Nishiyama S,Katsuoka K,Terada E,Kunita S,Sakurai Y,Kato H

    更新日期:1998-01-01 00:00:00