当前位置： SCI文献检索 > JOURNAL OF DERMATOLOGICAL SCIENCE期刊下所有文献 > Vascular endothelial growth factor (VEGF) in the pathogenesis of psoriasis--a possible target for novel therapies?

Vascular endothelial growth factor (VEGF) in the pathogenesis of psoriasis--a possible target for novel therapies?

Abstract：

:Angiogenesis is defined as the formation of new capillaries from pre-existing blood vessels. The process of angiogenesis is tightly regulated by a balance between pro- and anti-angiogenic factors. Vascular endothelial growth factor (VEGF) is a pro-angiogenic factor and several anti-VEGF therapies are used in the treatment of diseases that are characterized by abnormal formation of blood vessels such as certain cancers and age-related macular degeneration. In addition, dysregulated angiogenesis has been observed in inflammatory diseases and might underly chronic cutaneous inflammation in psoriasis. Several experimental studies and clinical reports suggest that VEGF is involved in psoriasis pathogenesis. Among those, transgenic over-expression of VEGF in keratinocytes in mice resulted in skin inflammation and a phenotype resembling human psoriasis. In different psoriasis models, anti-VEGF antibody treatment of mice, already displaying disease symptoms, resulted in an overall improvement of the cutaneous lesions. On the molecular level human keratinocytes produce VEGF after stimulation with cytokines involved in psoriasis pathogenesis. Finally, patients with psoriasis receiving anti-VEGF treatment for cancer showed complete remission of their cutaneous symptoms. Therefore, VEGF might be an underappreciated pro-inflammatory factor in the pathogenesis of psoriasis. In this review, current knowledge on the significance of VEGF in psoriasis pathogenesis is summarized. Furthermore, current reports on treatments directed against VEGF or its receptors and their potential as future therapy for psoriasis are discussed.

journal_name

J Dermatol Sci

journal_title

Journal of dermatological science

authors

Canavese M,Altruda F,Ruzicka T,Schauber J

doi

10.1016/j.jdermsci.2010.03.023

subject

Has Abstract

pub_date

2010-06-01 00:00:00

pages

171-6

issue

3

eissn

0923-1811

issn

1873-569X

pii

S0923-1811(10)00101-5

journal_volume

58

pub_type

杂志文章,评审

相关文献

JOURNAL OF DERMATOLOGICAL SCIENCE文献大全
  • Integrated microRNA/mRNA expression profiling of the skin of psoriasis patients.

    abstract：BACKGROUND:Psoriasis is a chronic inflammatory disease characterized by demarcated, raised, and scaling skin lesions. It often serves as a model for immune-mediated disorders. Gene expression profiling of affected skin has allowed insights into psoriasis pathogenesis. However, the mechanisms leading to specific mRNA ex...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2019.11.003

    authors： Delić D,Wolk K,Schmid R,Gabrielyan O,Christou D,Rieber K,Rolser M,Jakob I,Wiech F,Griesser M,Wohnhaas C,Kokolakis G,Witte-Händel E,Baum P,Sabat R

    更新日期：2020-01-01 00:00:00

  • Analysis of antigens recognized by autoantibodies in herpes gestationis. Usefulness of immunoblotting using a fusion protein representing an extracellular domain of the 180 kD bullous pemphigoid antigen.

    abstract：:Herpes gestationis (HG) is a rare pregnancy-associated disease. The aim of this study was to compare various immunohistochemical and immunobiochemical techniques with respect to their diagnostic sensitivity for HG. We studied 43 HG sera; only half of these reacted with the basement membrane zone (BMZ) with both indire...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(96)00509-9

    authors： Murakami H,Amagai M,Higashiyama M,Hashimoto K,Chorzelski TP,Bhogal BS,Jenkins RE,Black MM,Zillikens D,Nishikawa T,Hashimoto T

    更新日期：1996-11-01 00:00:00

  • Ultraviolet irradiation-induced inhibition of histone deacetylase 4 increases the expression of matrix metalloproteinase-1 but decreases that of type I procollagen via activating JNK in human dermal fibroblasts.

    abstract：BACKGROUND:Ultraviolet (UV) irradiation is the main contributing factor for skin aging. UV irradiation induces epigenetic changes in skin. It increases the activity of histone acetylases (HATs) but decreases that of histone deacetylases (HDACs). OBJECTIVE:We aimed to investigate alterations in all classes of HDACs and...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2020.11.008

    authors： Lee Y,Shin MH,Kim MK,Park CH,Shin HS,Lee DH,Chung JH

    更新日期：2020-12-03 00:00:00

  • Sirt1 ameliorates systemic sclerosis by targeting the mTOR pathway.

    abstract：BACKGROUND:Systemic sclerosis (SSc) is a chronic autoimmune disease characterized by inflammation and fibrosis. Our previous research has indicated that Sirtuin1 (Sirt1) plays a role in the regulation of TNF-α-induced inflammation; however, whether Sirt1 may inhibit the progress of SSc by blocking inflammation remains ...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2017.04.013

    authors： Zhu X,Chu H,Jiang S,Liu Q,Liu L,Xue Y,Zheng S,Wan W,Qiu J,Wang J,Zou H

    更新日期：2017-08-01 00:00:00

  • Effects of kestose on gut mucosal immunity in an atopic dermatitis mouse model.

    abstract：BACKGROUND:Atopic dermatitis (AD) is recently increasing among populations, but the underlying mechanisms remain controversial. Interactions between the gut microbiota and mucosal immunity are considered to be a crucial etiology. Fructooligosaccharide (FOS), prebiotics have been reported as activators of the gut microb...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2017.10.006

    authors： Kim HJ,Lee SH,Go HN,Ahn JR,Kim HJ,Hong SJ

    更新日期：2018-01-01 00:00:00

  • Cutaneous manifestations of COVID-19: Report of three cases and a review of literature.

    abstract：BACKGROUND:Various cutaneous manifestations have been observed in patients with COVID-19 infection. However, overall similarities in the clinical presentation of these dermatological manifestations have not yet been summarized. OBJECTIVE:This review aims to provide an overview of various cutaneous manifestations in pa...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章,评审

    doi：10.1016/j.jdermsci.2020.04.011

    authors： Sachdeva M,Gianotti R,Shah M,Bradanini L,Tosi D,Veraldi S,Ziv M,Leshem E,Dodiuk-Gad RP

    更新日期：2020-05-01 00:00:00

  • Lymphocyte stimulation test with drug-photomodified cells in patients with quinolone photosensitivity.

    abstract：:Quinolone antibacterial agents, known to elicit photosensitive dermatitis as an adverse effect, have both phototoxicity and photoallergenicity. The latter potency is mainly derived from their photohaptenic moiety; quinolones covalently bind to protein and cells upon exposure to ultraviolet A (UVA) light. Our previous ...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(99)00011-0

    authors： Tokura Y,Seo N,Ohshima A,Yagi H,Furukawa F,Takigawa M

    更新日期：1999-09-01 00:00:00

  • Serum squamous cell carcinoma antigen (SCCA)-2 correlates with clinical severity of pediatric atopic dermatitis in Ishigaki cohort.

    abstract：BACKGROUND:We sometimes encounter difficulties in assessing the severity of pediatric atopic dermatitis (AD) using currently available biomarkers such as thymus and activation-regulated chemokine (TARC) due to the higher baseline values in non-AD children. Recent case control studies have indicated the usefulness of sq...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2019.07.005

    authors： Takeuchi S,Furusyo N,Ono J,Azuma Y,Takemura M,Esaki H,Yamamura K,Mitamura Y,Tsuji G,Kiyomatsu-Oda M,Hayashi J,Izuhara K,Furue M

    更新日期：2019-08-01 00:00:00

  • CCR7 expression correlates with subcutaneous involvement in mycosis fungoides skin lesions and promotes migration of mycosis fungoides cells (MyLa) through mTOR activation.

    abstract：BACKGROUND:The molecular pathogenesis of mycosis fungoides (MF) is currently poorly understood. The chemokine receptor CCR7 has been demonstrated to be involved in the development and progression of certain cancers, but its role in MF has rarely been investigated. OBJECTIVES:We seek to determine whether CCR7 is expres...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2013.12.003

    authors： Hu SC,Lin CL,Hong CH,Yu HS,Chen GS,Lee CH

    更新日期：2014-04-01 00:00:00

  • Genetic predisposition to bullous pemphigoid.

    abstract：:Bullous pemphigoid (BP) is a common autoimmune blistering skin disease that mainly affects elderly patients. Although BP risk is strongly influenced by age, genetic factors are also important determinants of this disease. Many genomic regions, especially in the HLA-II region, have been found to influence BP susceptibi...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章,评审

    doi：10.1016/j.jdermsci.2020.05.010

    authors： Zhang J,Wang G

    更新日期：2020-11-01 00:00:00

  • Copper, zinc-superoxide dismutase protects from ultraviolet B-induced apoptosis of SV40-transformed human keratinocytes: the protection is associated with the increased levels of antioxidant enzymes.

    abstract：:It has been reported that cellular oxidative stress induces apoptosis. Ultraviolet radiation that generates reactive oxygen intermediates (ROIs) also induces apoptosis. Superoxide dismutase (SOD) is among the most active scavengers of ROIs, providing defense against the cellular oxidative stress. Mammalian cells expre...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(99)00060-2

    authors： Takahashi H,Hashimoto Y,Aoki N,Kinouchi M,Ishida-Yamamoto A,Iizuka H

    更新日期：2000-05-01 00:00:00

  • Cultured keratinocytes from plectin/HD1-deficient epidermolysis bullosa simplex showed altered ability of adhesion to the matrix.

    abstract：:Epidermolysis bullosa simplex associated with late onset of muscular dystrophy has been found to show defective expression of plectin, an intracytoplasmic protein in hemidesmosomes. In this report, we examined ability of cell-to-matrix attachment of cultured keratinocytes derived from a case with this disease by vario...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(00)00100-6

    authors： Kurose K,Mori O,Hachisuka H,Shimizu H,Owaribe K,Hashimoto T

    更新日期：2000-12-01 00:00:00

  • Molecular and diagnostic aspects of genetic skin fragility.

    abstract：:Genetic syndromes with skin fragility represent a heterogeneous group of very rare disorders caused by mutations in genes encoding proteins or protein subunits important for the mechanical resistance of keratinocytes and for cell-cell or cell-extracellular matrix adhesion. The common symptoms are skin blistering or pe...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章,评审

    doi：10.1016/j.jdermsci.2006.08.003

    authors： Has C,Bruckner-Tuderman L

    更新日期：2006-12-01 00:00:00

  • Hair follicle bulge: a fascinating reservoir of epithelial stem cells.

    abstract：:Hair follicles reconstitute themselves though the hair cycle, suggesting the presence of intrinsic stem cells. In contrast to the previous belief that stem cells reside in the bulbar region of hair follicles, stem cells were detected in the bulge area, a contiguous part of outer root sheath, that provides the insertio...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章,评审

    doi：10.1016/j.jdermsci.2006.12.002

    authors： Ohyama M

    更新日期：2007-05-01 00:00:00

  • Serum concentration of the soluble interleukin-2 receptor in vitiligo patients.

    abstract：:Serum levels of sIL-2R can be used to monitor in vivo immune activation and its elevation have been shown to be correlated with T cell mediated immune disease such as atopic dermatitis, psoriasis, lymphoma and systemic sclerosis. Vitiligo is the disease of depigmentation caused by destruction of melanocytes, and there...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(98)00070-x

    authors： Yeo UC,Yang YS,Park KB,Sung HT,Jung SY,Lee ES,Shin MH

    更新日期：1999-04-01 00:00:00

  • Production of epidermal sheets in a serum free culture system: a further appraisal of the role of extracellular calcium.

    abstract：:Rhenwald and Green's technique is currently the standard method for growing stratifying epidermal cell cultures. The serum free system developed in Ham's laboratory (MCDB 153) was designed to grow keratinocyte monolayers in clonogenic conditions. Our aim was to optimize conditions in serum-free MCDB 153 for culturing ...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/0923-1811(92)90044-c

    authors： Boisseau AM,Donatien P,Surlève-Bazeille JE,Amédée J,Harmand MF,Bézian JH,Maleville J,Taieb A

    更新日期：1992-03-01 00:00:00

  • Clinical analysis of anti-cardiolipin.beta 2 glycoprotein 1 antibody positive patients in anti-phospholipid syndrome.

    abstract：:Clinical analysis was performed on anti-cardiolipin x beta2 glycoprotein 1 (ACL x beta2 GP1) antibody positive patients with collagen vascular diseases. Nine patients out of 89 showed positive aCL x beta2 GP1 antibody which was a relatively lower percentage compared to that of othoffanti-phospholipid antibodies, such ...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/0923-1811(94)00380-w

    authors： Katayama I,Nishioka K,Otoyama K

    更新日期：1995-05-01 00:00:00

  • Unfolded protein response in keratinocytes: impact on normal and abnormal keratinization.

    abstract：:The unfolded protein response (UPR) is a signaling pathway from the endoplasmic reticulum (ER) to the nucleus that protects cells from stress caused by misfolded or unfolded proteins. As such, ER stress is an ongoing challenge for all cells, given the central biologic importance of secretion as part of normal physiolo...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章,评审

    doi：10.1016/j.jdermsci.2012.12.002

    authors： Sugiura K

    更新日期：2013-03-01 00:00:00

  • miR-128 targets the CC chemokine ligand 18 gene (CCL18) in cutaneous malignant melanoma progression.

    abstract：BACKGROUND:The CC chemokine ligand 18 (CCL18) has a higher expression in some tumors, while the CCL18 level can be a marker of tumor progression and prognosis. We previously reported that the expression of CCL18 gene was dramatically up-regulated in cutaneous malignant melanoma (CMM) and its expression levels were corr...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2018.06.011

    authors： Song H,Tao Y,Ni N,Zhou X,Xiong J,Zeng X,Xu X,Qi J,Sun J

    更新日期：2018-09-01 00:00:00

  • Glutathione in human melanoma cells. Effects of cysteine, cysteine esters and glutathione isopropyl ester.

    abstract：:Thiols are of great importance for the regulation of many cellular functions including metabolism, transport and cell protection. In this study the usefulness of L-cysteine methyl and octyl esters, of N,S-diacetyl-L-cysteine methyl ester and glutathione isopropyl ester as cellular cysteine and GSH delivery systems was...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/0923-1811(90)90008-2

    authors： Karg E,Tunek A,Brötell H,Hallberg A,Rosengren E,Rorsman H

    更新日期：1990-01-01 00:00:00

  • Sulfhydryl oxidase (SOx) from mouse epidermis: molecular cloning, nucleotide sequence, and expression of recombinant protein in the cultured cells.

    abstract：:Skin sulfhydryl oxidase (SOx) is an enzyme that catalyzes disulfide (S-S) cross-linking through the oxidation of sulfhydryl compounds in the skin. In this study, using the enzyme purified from rat seminal vesicle, we obtained peptide sequences for SOx by mass spectrometry. We then searched for SOx nucleotides correspo...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(02)00061-0

    authors： Matsuba S,Suga Y,Ishidoh K,Hashimoto Y,Takamori K,Kominami E,Wilhelm B,Seitz J,Ogawa H

    更新日期：2002-10-01 00:00:00

  • Telomere length of the skin in association with chronological aging and photoaging.

    abstract：BACKGROUND:Telomere shortening has been implicated in cellular senescence, which may cause certain aging phenotypes. OBJECTIVE:To reveal whether telomere shortening is associated with chronological aging and/or photoaging of the skin, we measured telomere length in the epidermis and in the dermis from sun-protected an...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2006.02.004

    authors： Sugimoto M,Yamashita R,Ueda M

    更新日期：2006-07-01 00:00:00

  • A novel niche for skin derived precursors in non-follicular skin.

    abstract：BACKGROUND:Skin derived precursors (SKP) comprise a subset of specialized dermal cells that can be distinguished from fibroblast by their capacity for spheroidal growth. Recent investigations have shown that hair follicles constitute a niche for this cell type, but their localization and their definite function in non-...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2012.10.007

    authors： Ruetze M,Knauer T,Gallinat S,Wenck H,Achterberg V,Maerz A,Deppert W,Knott A

    更新日期：2013-02-01 00:00:00

  • Localization of fibronectin in the initial lymphatics and blood vessels of normal human skin: an immunoelectron microscopic investigation.

    abstract：:The initial lymphatics of the human skin do not possess a basal lamina, but a subendothelial fibrous network, of which we do not know the biochemical and immunohistological composition. We investigated the wall of blood vessels and initial lymphatics in normal human skin for the presence of fibronectin by immunoelectr...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/0923-1811(92)90060-o

    authors： Lubach D,Nissen S,Marghescu S

    更新日期：1992-09-01 00:00:00

  • Immunohistochemical evaluation of tenascin in benign eccrine gland tumors: comparison with laminin and fibronectin.

    abstract：:Surgically resected specimens of skin appendage tumors, spiradenoma, poroma of eccrine glands, syringoadenoma, syringoadenoma papilliferum and mixec tumor of skin were evaluated for tenascin, as well as the basement membrane-associated protein laminin, and the extracellular matrix protein fibronectin, using immunohist...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/0923-1811(94)00369-p

    authors： Mori M,Shrestha P,Takagi H,Ogata K,Takai Y

    更新日期：1995-03-01 00:00:00

  • Expression of inducible nitric oxide synthase in skin lesions of acute herpes zoster.

    abstract：:Histopathologically, the skin lesions of acute herpes zoster (AHZ) are characterized by epidermal necrotic vesicles with inflammation. Nitric oxide (NO) is generated from L-arginine by nitric oxide synthase (NOS), and immune inflammation involves the activation of NOS in both effector cells and target cells. NO can ca...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(02)00035-x

    authors： Lim YJ,Chang SE,Choi JH,Sung KJ,Bahk JH,Do SH,Lee DS

    更新日期：2002-09-01 00:00:00

  • Characterization of itch-associated responses of NC mice with mite-induced chronic dermatitis.

    abstract：:To clarify the behavioral and pathological features of spontaneous scratching of NC mice with mite-induced chronic dermatitis, we investigated the spontaneous and pruritogen-evoked scratching of NC mice. Although the frequency of scratching of NC mouse did not increase under specific pathogen-free environment, it grad...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(00)00099-2

    authors： Yamaguchi T,Maekawa T,Nishikawa Y,Nojima H,Kaneko M,Kawakita T,Miyamoto T,Kuraishi Y

    更新日期：2001-01-01 00:00:00

  • Characterization of dermatitis arising spontaneously in DS-Nh mice maintained under conventional conditions: another possible model for atopic dermatitis.

    abstract：:DS-Nh (DS Nh/+) mice spontaneously develop dermatitis when they are housed in a conventional environment. In this study, we analyzed the clinical and histopathological features of dermatitis in DS-Nh mice, which is characterized by erythema, edema, and erosion on the face, neck, chest and flexor surfaces of their fore...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(02)00070-1

    authors： Hikita I,Yoshioka T,Mizoguchi T,Tsukahara K,Tsuru K,Nagai H,Hirasawa T,Tsuruta Y,Suzuki R,Ichihashi M,Horikawa T

    更新日期：2002-11-01 00:00:00

  • The promoter of an androgen dependent gene in the hamster flank organ.

    abstract：:Hamster flank organs are useful for studying androgen-dependent growth of hair follicles and sebaceous glands. A cDNA clone (FAR-17a) was isolated from the hamster flank organ, whose expression was highly sensitive to androgen. The mRNA level of this gene was reduced after castration but reappeared after testosterone ...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(97)00597-5

    authors： Aoki H,Seki T,Sawada J,Handa H,Adachi K

    更新日期：1997-05-01 00:00:00

  • Correlation of Merkel cell polyomavirus positivity with PDGFRα mutations and survivin expression in Merkel cell carcinoma.

    abstract：BACKGROUND:Merkel cell carcinoma (MCC) is a neuroendocrine cancer of the skin postulated to originate through Merkel cell polyomavirus (MCPyV) oncogenesis and/or by mutations in molecules implicated in the regulation of cell growth and survival. Despite the fact that MCPvV is detected more broadly within the population...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2015.04.002

    authors： Batinica M,Akgül B,Silling S,Mauch C,Zigrino P

    更新日期：2015-07-01 00:00:00