Telomere length of the skin in association with chronological aging and photoaging.

abstract：BACKGROUND:Extramammary Paget's disease (EMPD) is a rare skin cancer that frequently occurs in the anogenital region in the elderly. Prognosis in patients with metastatic EMPD is poor as EMPD treatment has advanced little in recent years, primarily because no EMPD cell line has been established. OBJECTIVE:We aimed to ...

journal_title：Journal of dermatological science

authors： Arita T,Kondo J,Kaneko Y,Tsutsumi M,Kanemaru M,Matsui M,Arakawa Y,Katoh N,Inoue M,Asai J

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Tight junctions (TJs) contribute to the epithelial barrier function by preventing leakage of solutes through the intercellular space. In the skin, TJs occur in the stratum granulosum (SG), where claudin-1 and claudin-4 are expressed as adhesion molecules of TJs. Claudin-1-deficient (Cldn1(-/-)) mice die with...

journal_title：Journal of dermatological science

authors： Sugawara T,Iwamoto N,Akashi M,Kojima T,Hisatsune J,Sugai M,Furuse M

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:We recently reported use of photodynamic therapy (PDT) for treating keloid disease (KD). However, in view of high recurrence rates post any treatment modality, adjuvant therapies should be considered. Additionally, we previously demonstrated the effect of a novel electrical waveform, the degenerate wave (DW)...

journal_title：Journal of dermatological science

authors： Sebastian A,Allan E,Allan D,Colthurst J,Bayat A

更新日期：2011-12-01 00:00:00

abstract：:A cell line, designated ISOS-1, was established from a tumor formed by transplantation of a human angiosarcoma into mice with severe combined immunodeficiency (SCID). The cells showed endothelial properties, based on the uptake of Dil-Ac-LDL and binding of UEA-I/GSA-I lectins, but were negative for CD11b and Pan Cytok...

journal_title：Journal of dermatological science

authors： Masuzawa M,Fujimura T,Tsubokawa M,Nishiyama S,Katsuoka K,Terada E,Kunita S,Sakurai Y,Kato H

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:Skin lesions commonly affect AIDS patients. The pathogenesis of certain dermatologic disorders primarily associated to HIV-1 is unclear, and better forms of therapy for these conditions need to be discovered. Transgenic animal models represent a novel approach for the study of these disorders and for the que...

journal_title：Journal of dermatological science

authors： Cedeno-Laurent F,Bryant J,Fishelevich R,Jones OD,Deng A,Eng ML,Gaspari AA,Trujillo JR

更新日期：2009-02-01 00:00:00

abstract：:The CC-chemokine TARC is known to be a ligand for the CCR4 receptor which in turn is known to be expressed selectively on the Th(2)-subset of lymphocytes. Atopic dermatitis is generally believed to be a Th(2)-type disease, and TARC has been shown to be expressed in the skin lesions of a murine model of AD. IL-10 is an...

journal_title：Journal of dermatological science

authors： Vestergaard C,Kirstejn N,Gesser B,Mortensen JT,Matsushima K,Larsen CG

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND:Lichen sclerosus (LS) is an acquired inflammatory mucocutaneous disease affecting the anogenital area, characterized histologically by hyalinosis and thickened vessel walls in the dermis. The presence of serum autoantibodies against extracellular matrix protein 1 (ECM1) in LS patients may suggest its involve...

journal_title：Journal of dermatological science

authors： Utsunomiya N,Utsunomiya A,Chino T,Hasegawa M,Oyama N

更新日期：2020-11-01 00:00:00

abstract：:In order to know the possible effects of gastrin releasing peptide (GRP) on nevus cells and melanocytes, we studied the effect of GRP on the proliferation of cultured human nevus cells and normal melanocytes. MTS assay showed that GRP stimulated the growth of viable melanocytes at 1000 ng/ml. GRP also stimulated the g...

journal_title：Journal of dermatological science

authors： Terashi H,Itami S,Tadokoro T,Takeyama M,Katagiri K,Takayasu S

更新日期：1998-06-01 00:00:00

abstract：BACKGROUND:Currently available topical treatments for actinic keratosis (AK) are associated with substantial side-effects. OBJECTIVES:To evaluate the efficacy and safety of topical SR-T100 gel in treating AK. METHODS:A multicenter, randomized, double-blinded phase III trial was conducted. Patients with at least two c...

journal_title：Journal of dermatological science

authors： Yang CC,Wong TW,Lee CH,Hong CH,Chang CH,Lai FJ,Lin SH,Chi CC,Lin TK,Yen H,Wu CH,Sheu HM,Lan CE

更新日期：2018-06-01 00:00:00

abstract：:In order to disclose the possible disturbance in regulation of p21ras function in neurofibromatosis type 1, we investigated the recovery from the quiescent to cycling states of the cell cycle in the skin fibroblasts of the patients. When cells cultured in serum-dependent medium are deprived of the serum, these go into...

journal_title：Journal of dermatological science

authors： Kitano Y,Saito K,Okamoto E,Hashizume K

更新日期：1994-04-01 00:00:00

abstract：BACKGROUND:Cisplatin is a potent anticancer drug for treating melanoma. OBJECTIVE:The aim of this study was to evaluate the possibility of using liposomes, for intratumoral distribution in a melanoma, composed of phosphatidylethanolamine (PE), for its cytotoxicity. METHOD:The in vitro drug release, in vitro cytotoxic...

journal_title：Journal of dermatological science

authors： Hwang TL,Lee WR,Hua SC,Fang JY

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND:Diverse topical products and injectable fillers used for correcting facial wrinkles induce rather short-lived effects because they target replacement of dermal collagen and hyaluronan, matrix components of limited biologic durability. OBJECTIVE:Present studies were aimed at stimulation of fully differentiat...

journal_title：Journal of dermatological science

authors： Hinek A,Wang Y,Liu K,Mitts TF,Jimenez F

更新日期：2005-09-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) play an important role in tumor invasion and metastasis. Enhanced expression of matrix metalloproteinase-2 (MMP-2) has been demonstrated in dermatofibroma (DF) and malignant fibrous histiocytoma (MFH). MMP-2 has been shown to be activated by membrane-type MMPs (MT-MMPs). To study the r...

journal_title：Journal of dermatological science

authors： Ohnishi Y,Ito Y,Tajima S,Ishibashi A,Arai K

更新日期：2002-02-01 00:00:00

abstract：BACKGROUND:NIPAL4, encoding the NIPA-like domain containing 4 protein (NIPAL4), is one of the causative genes of autosomal recessive congenital ichthyosis (ARCI). The physiological role of NIPAL4 and the pathogenetic mechanisms of ARCI caused by NIPAL4 mutations remain unclear. OBJECTIVE:To clarify the changes of cera...

journal_title：Journal of dermatological science

authors： Murase Y,Takeichi T,Kawamoto A,Tanahashi K,Okuno Y,Takama H,Shimizu E,Ishikawa J,Ogi T,Akiyama M

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Psoriasis is a common multi-factorial skin disease, in which gene-gene and gene-environment interactions may affect the onset, manifestation and clinical course. OBJECTIVE:To investigate the underlying gene-environment interaction among several established susceptibility genes, cigarette smoking and alcohol...

journal_title：Journal of dermatological science

authors： Yin XY,Cheng H,Wang WJ,Wang WJ,Fu HY,Liu LH,Zhang FY,Yang S,Zhang XJ

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Mammalian epidermis has two diffusion barriers, the stratum corneum (SC) and tight junctions (TJs). We reported previously that a single living cell layer exists between the SC and TJ-forming keratinocytes in mice; however, the exact location of the TJ barrier in human epidermis has not been defined. OBJECT...

journal_title：Journal of dermatological science

authors： Yoshida K,Yokouchi M,Nagao K,Ishii K,Amagai M,Kubo A

更新日期：2013-08-01 00:00:00

abstract：:We have examined the effects of four 'exogenous' growth factors, i.e. PDGF-BB (5 ng/ml), TGF-beta1 (5 ng/ml), bFGF (10 ng/ml) and EGF (10 ng/ml) on the contraction of floating collagen type I lattices populated by human normal skin (NS) and hypertrophic scar (HS) fibroblasts (FPCL). Only TGF-beta1 enhanced the contrac...

journal_title：Journal of dermatological science

authors： Yang CC,Lin SD,Yu HS

更新日期：1997-02-01 00:00:00

abstract：:We have previously reported that two species of pro alpha 1(IV) collagen chains, disulfided (500 kDa) and non-disulfided (180 kDa), were produced by B16 melanoma cells (J Biochem (1994) 116; 1039-1043). The mechanism by which the non-disulfided pro alpha 1(IV) chain is produced was studied. No significant difference i...

journal_title：Journal of dermatological science

authors： Tajima S,Tokimitsu I

更新日期：1996-10-01 00:00:00

abstract：:The vasculature in adult skin remains normally quiescent, due to the dominant influence of endogenous angiogenesis inhibitors over angiogenic stimuli. However, skin retains the capacity for brisk initiation of angiogenesis, the growth of new blood vessels from preexisting vessels, during tissue repair and in numerous ...

journal_title：Journal of dermatological science

authors： Detmar M

更新日期：2000-12-01 00:00:00

abstract：BACKGROUND:Cutaneous T cell lymphoma (CTCL) comprises a heterogeneous group of skin-homing T cell tumors. The small guanosine triphosphate effector p21-activated kinase 1 (PAK1) plays an important role in many fundamental cellular functions, including cell motility, proliferation, and apoptosis. The expression of PAK1 ...

journal_title：Journal of dermatological science

authors： Wang Y,Gu X,Li W,Zhang Q,Zhang C

更新日期：2018-04-01 00:00:00

abstract：:To clarify the behavioral and pathological features of spontaneous scratching of NC mice with mite-induced chronic dermatitis, we investigated the spontaneous and pruritogen-evoked scratching of NC mice. Although the frequency of scratching of NC mouse did not increase under specific pathogen-free environment, it grad...

journal_title：Journal of dermatological science

authors： Yamaguchi T,Maekawa T,Nishikawa Y,Nojima H,Kaneko M,Kawakita T,Miyamoto T,Kuraishi Y

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Ustekinumab has been evaluated in Caucasian patients with psoriasis, but no studies have been conducted in Asian patients. OBJECTIVE:To assess the efficacy and safety of ustekinumab in Taiwanese and Korean patients with moderate-to-severe psoriasis. METHODS:In this 36-week, multicenter, double-blind, place...

journal_title：Journal of dermatological science

authors： Tsai TF,Ho JC,Song M,Szapary P,Guzzo C,Shen YK,Li S,Kim KJ,Kim TY,Choi JH,Youn JI,PEARL Investigators.

更新日期：2011-09-01 00:00:00

abstract：:We examined the adherence characteristics and susceptibility to various antimicrobial agents of 130 strains of Staphylococcus aureus isolated from infective skin lesions and 135 strains of S. aureus isolated from non-infective eczematous lesions of atopic dermatitis (AD) patients. The isolation rate of methicillin-res...

journal_title：Journal of dermatological science

authors： Akiyama H,Yamasaki O,Tada J,Arata J

更新日期：2000-08-01 00:00:00

abstract：BACKGROUND:Skin derived precursors (SKP) comprise a subset of specialized dermal cells that can be distinguished from fibroblast by their capacity for spheroidal growth. Recent investigations have shown that hair follicles constitute a niche for this cell type, but their localization and their definite function in non-...

journal_title：Journal of dermatological science

authors： Ruetze M,Knauer T,Gallinat S,Wenck H,Achterberg V,Maerz A,Deppert W,Knott A

更新日期：2013-02-01 00:00:00

abstract：:Smoking tobacco is the most preventable cause of morbidity and is responsible for more than three million deaths a year worldwide. In addition to a strong association with a number of systemic diseases, smoking is also associated with many dermatological conditions, including poor wound healing, premature skin aging, ...

journal_title：Journal of dermatological science

authors： Morita A

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:Foot ulcers are one of the main diabetes complications due to its high frequency and difficulty of complete healing. There are several factors that participate in diabetic ulcers development and limited information exists about the role of antimicrobial peptides (AMP) in its pathogenesis. OBJECTIVE:The aim ...

journal_title：Journal of dermatological science

authors： Rivas-Santiago B,Trujillo V,Montoya A,Gonzalez-Curiel I,Castañeda-Delgado J,Cardenas A,Rincon K,Hernandez ML,Hernández-Pando R

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Trichloroethylene (TCE) is an industrial solvent which can cause severe generalized dermatitis, i.e., occupational TCE hypersensitivity syndrome. Reactivation of latent human herpesvirus 6 (HHV6) can occur in such patients, which has made TCE known as a causative chemical of drug-induced hypersensitivity syn...

journal_title：Journal of dermatological science

authors： Kamijima M,Wang H,Yamanoshita O,Ito Y,Xia L,Yanagiba Y,Chen C,Okamura A,Huang Z,Qiu X,Song X,Cai T,Liu L,Ge Y,Deng Y,Naito H,Yoshikawa T,Tohyama M,Li L,Huang H,Nakajima T

更新日期：2013-12-01 00:00:00

abstract：:We developed a new method for evaluating clinical symptoms of psoriasis during the observation period, by adding a parameter of time (the number of days) to the psoriasis area and severity index (PASI). This method was named the evaluation for prognosis with averaged PASI (E-PAP). Using this method, we assessed 14 cas...

journal_title：Journal of dermatological science

authors： Sugai J,Ozawa A,Kawakubo Y,Iizuka M,Miyahara M,Ohkido M

更新日期：1998-01-01 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) plays important roles not only in the morphogenesis but also in wound repair, tissue fibrosis and cancer progression. Recently, regulatory mechanism of this process has been elaborately elucidated. EMT can be a new therapeutic target for treating skin ulcer, fibrosing alopecia, ...

journal_title：Journal of dermatological science

authors： Nakamura M,Tokura Y

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Several inhibitor of apoptosis proteins (IAPs) are cleaved during apoptosis. Studies of the melanoma-associated IAP (ML-IAP) Livin, using recombinant molecules, have implicated both caspases 3/7 and the serine protease Omi/HtrA2 in its proteolytic cleavage. OBJECTIVE:To characterize the apoptotic cleavage o...

journal_title：Journal of dermatological science

authors： Yan H,Brouha B,Liu T,Raj D,Biddle D,Lee R,Grossman D

更新日期：2006-09-01 00:00:00