The role of VEGF and thrombospondins in skin angiogenesis.

Abstract:

:The vasculature in adult skin remains normally quiescent, due to the dominant influence of endogenous angiogenesis inhibitors over angiogenic stimuli. However, skin retains the capacity for brisk initiation of angiogenesis, the growth of new blood vessels from preexisting vessels, during tissue repair and in numerous diseases, including inflammatory skin diseases such as psoriasis and skin cancers such as cutaneous squamous cell carcinomas. Moreover, cyclic vascular expansion occurs during the growth phase of the hair follicle. Recent evidence suggests vascular endothelial growth factor as the major skin angiogenesis factor. During skin angiogenesis, expression of vascular endothelial growth factor is induced in epidermal keratinocytes by several stimuli including transforming growth factor-alpha and hypoxia, leading to increased vascularization of the dermis. In contrast, vascular endothelial growth factor-C induces skin lymphangiogenesis. Thrombospondin-1 and thrombospondin-2 are endogenous inhibitors of angiogenesis that are expressed in normal skin, maintaining the quiescence of cutaneous vessels. Both inhibitors potently inhibit skin cancer growth via inhibition of tumor angiogenesis. Targeting cutaneous blood vessels represents a promising new therapeutic approach for the treatment of a variety of skin diseases.

journal_name

J Dermatol Sci

authors

Detmar M

doi

10.1016/s0923-1811(00)00145-6

subject

Has Abstract

pub_date

2000-12-01 00:00:00

pages

S78-84

eissn

0923-1811

issn

1873-569X

pii

S0923181100001456

journal_volume

24 Suppl 1

pub_type

杂志文章,评审
  • Failure to detect paramyxovirus RNA in the skin of connective tissue disease.

    abstract::Etiology of connective tissue disease is unknown. The association of infectious agents has been suspected serologically, ultrastructurally and recently by means of molecular biological techniques. We extracted RNA from lesions of 25 discoid lupus erythematosus, 9 systemic LE, and 3 systemic sclerosis biopsies, and rev...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章

    doi:10.1016/0923-1811(95)00422-x

    authors: Fujiwara H,Fujiwara K,Yotsumoto S,Hashimoto K

    更新日期:1996-01-01 00:00:00

  • Taurin-conjugated ursodeoxycholic acid has a reversible inhibitory effect on human keratinocyte growth.

    abstract::Tauroursodeoxycholic acid (TUDC) is one of the most hydrophilic taurin conjugated bile acids. TUDC has a suppressive effect on DNA synthesis in primary cultured rat hepatocytes. In this study, we investigated the growth inhibitory effect of TUDC on cultured human keratinocytes. TUDC suppressed the proliferation of ker...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章

    doi:10.1016/s0923-1811(98)00023-1

    authors: Yamaguchi Y,Itami S,Nishida K,Ando Y,Okamoto S,Hosokawa K,Yoshikawa K

    更新日期:1998-09-01 00:00:00

  • Immunohistochemical study of membrane type-matrix metalloproteinases (MT-MMPs) and matrix metalloproteinase-2 (MMP-2) in dermatofibroma and malignant fibrous histiocytoma.

    abstract::Matrix metalloproteinases (MMPs) play an important role in tumor invasion and metastasis. Enhanced expression of matrix metalloproteinase-2 (MMP-2) has been demonstrated in dermatofibroma (DF) and malignant fibrous histiocytoma (MFH). MMP-2 has been shown to be activated by membrane-type MMPs (MT-MMPs). To study the r...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章

    doi:10.1016/s0923-1811(01)00159-1

    authors: Ohnishi Y,Ito Y,Tajima S,Ishibashi A,Arai K

    更新日期:2002-02-01 00:00:00

  • Epidermal basement membrane zone components: ultrastructural distribution and molecular interactions.

    abstract::The epidermal basement membrane zone (BMZ) comprises a multiprotein complex that aids the attachment of epidermal keratinocytes to the underlying dermis. In the last 5 years, our understanding of epidermal BMZ morphology, structure and function has dramatically improved. A complex network of molecular interactions has...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章,评审

    doi:10.1016/s0923-1811(03)00045-8

    authors: McMillan JR,Akiyama M,Shimizu H

    更新日期:2003-05-01 00:00:00

  • Neither cyclosporin A nor FK506 affects adenylate cyclase responses of fetal rat keratinizing epidermal cells (FRSK cells) at concentrations that inhibit thymidine incorporation.

    abstract::It has been reported that various anti-psoriatic agents augment the beta-adrenergic adenylate cyclase response that is defective in the psoriatic hyperproliferative epidermis. Recent evidence indicates that cyclosporin A (CsA) and FK506 show beneficial effects on psoriasis. Using fetal rat keratinizing epidermal cells...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章

    doi:10.1016/0923-1811(93)90044-p

    authors: Takahashi H,Iizuka H

    更新日期:1993-12-01 00:00:00

  • Identification of mutations in the prostaglandin transporter gene SLCO2A1 and its phenotype-genotype correlation in Japanese patients with pachydermoperiostosis.

    abstract:BACKGROUND:Pachydermoperiostosis (PDP) is a rare genetic disorder characterized by 3 major symptoms: pachydermia including cutis verticis gyrata (CVG), periostosis, and finger clubbing. Recently, a homozygous mutation in the gene HPGD, which encodes 15-hydroxyprostaglandin dehydrogenase (15-PGDH), was found to be assoc...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章

    doi:10.1016/j.jdermsci.2012.07.008

    authors: Sasaki T,Niizeki H,Shimizu A,Shiohama A,Hirakiyama A,Okuyama T,Seki A,Kabashima K,Otsuka A,Ishiko A,Tanese K,Miyakawa S,Sakabe J,Kuwahara M,Amagai M,Okano H,Suematsu M,Kudoh J

    更新日期:2012-10-01 00:00:00

  • Keratinocyte growth factor and keratin gene regulation.

    abstract::Keratinocyte growth factor (KGF) is a stromally derived paracrine mitogen that belongs to the fibroblast growth factor (FGF) family. It is secreted by dermal fibroblasts and specifically promotes keratinocyte proliferation. We have recently shown that epidermal growth factor (EGF) and transforming growth factor beta (...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章

    doi:10.1016/0923-1811(94)00350-n

    authors: Latkowski JM,Freedberg IM,Blumenberg M

    更新日期:1995-01-01 00:00:00

  • Dermatitis herpetiformis: close to unravelling a disease.

    abstract::Dermatitis herpetiformis is characterised by granular IgA precipitates in the papillary dermis. In contrast to other autoimmune blistering diseases, where tissue-deposited and circulating autoantibodies recognise the same target within the skin, in dermatitis herpetiformis a serum IgA reacting with a component of the ...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章,评审

    doi:10.1016/j.jdermsci.2003.11.004

    authors: Kárpáti S

    更新日期:2004-04-01 00:00:00

  • The mTOR-inhibitor Sirolimus decreases the cyclosporine-induced expression of the oncogene ATF3 in human keratinocytes.

    abstract:BACKGROUND:Due to their immunosuppressive therapy, organtransplant recipients (OTRs) exhibit a high incidence for the development of cutaneous squamous cell carcinoma (cSCC). Randomized studies of kidney-transplanted patients indicate a significant lower susceptibility for cSCC among patients receiving the mTOR-inhibit...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章

    doi:10.1016/j.jdermsci.2018.08.013

    authors: Schaper-Gerhardt K,Walter A,Schmitz-Rode C,Satzger I,Gutzmer R

    更新日期:2018-11-01 00:00:00

  • Analysis of antigens recognized by autoantibodies in herpes gestationis. Usefulness of immunoblotting using a fusion protein representing an extracellular domain of the 180 kD bullous pemphigoid antigen.

    abstract::Herpes gestationis (HG) is a rare pregnancy-associated disease. The aim of this study was to compare various immunohistochemical and immunobiochemical techniques with respect to their diagnostic sensitivity for HG. We studied 43 HG sera; only half of these reacted with the basement membrane zone (BMZ) with both indire...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章

    doi:10.1016/s0923-1811(96)00509-9

    authors: Murakami H,Amagai M,Higashiyama M,Hashimoto K,Chorzelski TP,Bhogal BS,Jenkins RE,Black MM,Zillikens D,Nishikawa T,Hashimoto T

    更新日期:1996-11-01 00:00:00

  • Cross-sectional survey on disease severity in Japanese patients with harlequin ichthyosis/ichthyosis: Syndromic forms and quality-of-life analysis in a subgroup.

    abstract:BACKGROUND:Congenital ichthyoses (CIs) adversely affect quality of life (QOL) in patients. However, the effects of CIs on patient QOL have not been studied sufficiently. OBJECTIVE:To investigate the association between disease severity and QOL in patients with harlequin ichthyosis (HI) and ichthyosis: syndromic forms ...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章

    doi:10.1016/j.jdermsci.2018.08.008

    authors: Murase C,Takeichi T,Shibata A,Nakatochi M,Kinoshita F,Kubo A,Nakajima K,Ishii N,Amano H,Masuda K,Kawakami H,Kanekura T,Washio K,Asano M,Teramura K,Akasaka E,Tohyama M,Hatano Y,Ochiai T,Moriwaki S,Sato T,Ishida-Y

    更新日期:2018-11-01 00:00:00

  • Modulation of UVA light-induced oxidative stress by beta-carotene, lutein and astaxanthin in cultured fibroblasts.

    abstract::The ability of beta-carotene, lutein or astaxanthin to protect against UVA-induced oxidative stress in rat kidney fibroblasts (NRK) was assessed. Activities of the antioxidant enzymes catalase (CAT) and superoxide dismutase (SOD), and changes in thiobarbituric acid reactive substances (TBARS) were measured as indices ...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章

    doi:10.1016/s0923-1811(97)00058-3

    authors: O'Connor I,O'Brien N

    更新日期:1998-03-01 00:00:00

  • Effects of kestose on gut mucosal immunity in an atopic dermatitis mouse model.

    abstract:BACKGROUND:Atopic dermatitis (AD) is recently increasing among populations, but the underlying mechanisms remain controversial. Interactions between the gut microbiota and mucosal immunity are considered to be a crucial etiology. Fructooligosaccharide (FOS), prebiotics have been reported as activators of the gut microb...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章

    doi:10.1016/j.jdermsci.2017.10.006

    authors: Kim HJ,Lee SH,Go HN,Ahn JR,Kim HJ,Hong SJ

    更新日期:2018-01-01 00:00:00

  • Toxic epidermal necrolysis and Stevens-Johnson syndrome: soluble Fas ligand involvement in the pathomechanisms of these diseases.

    abstract::Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) are considered part of a spectrum of adverse cutaneous drug reactions showing severe and extensive skin detachment. TEN and SJS are morphologically characterized by active apoptotic keratinocyte cell death that results in the separation of the epiderm...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章,评审

    doi:10.1016/j.jdermsci.2008.06.003

    authors: Abe R

    更新日期:2008-12-01 00:00:00

  • Hydroquinone-salicylic acid conjugates as novel anti-melasma actives show superior skin targeting compared to the parent drugs.

    abstract:BACKGROUND:Hydroquinone (HQ) and salicylic acid (SA) are drugs for treating melasma through the mechanisms of tyrosinase inhibition and chemical peeling, respectively. Their high frequency of causing skin irritation has led to limited use of both drugs. OBJECTIVES:We designed the new conjugates obtained by joining HQ ...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章

    doi:10.1016/j.jdermsci.2014.08.013

    authors: Hsieh PW,Aljuffali IA,Fang CL,Chang SH,Fang JY

    更新日期:2014-11-01 00:00:00

  • Variable keratin polypeptide profile in human stratum corneum.

    abstract::Stratum corneum samples obtained from 46 members in three generations of seven families were analyzed for keratin pattern by gel electrophoresis. All these samples of apparently normal upper arm skin expressed the 55 kDa, 56.5 kDa, and 65 kDa keratin proteins; while only 28%, 20% and 48% of the samples expressed the 5...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章

    doi:10.1016/0923-1811(90)90118-w

    authors: Yaar M,Matoltsy GA,Gilchrest BA

    更新日期:1990-07-01 00:00:00

  • Granzyme B is a novel interleukin-18 converting enzyme.

    abstract:BACKGROUND:Granzyme B (GrB) is recognized to induce apoptosis; however, little is known about its possible role in other biological events. IL-18, a potent inflammatory cytokine, is produced as an inactive precursor (proIL-18). Several cells, including monocytes/macrophage lineage and non-hematopoietic cells such as ke...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章

    doi:10.1016/j.jdermsci.2010.05.004

    authors: Omoto Y,Yamanaka K,Tokime K,Kitano S,Kakeda M,Akeda T,Kurokawa I,Gabazza EC,Tsutsui H,Katayama N,Yamanishi K,Nakanishi K,Mizutani H

    更新日期:2010-08-01 00:00:00

  • Functional alteration of guanine nucleotide binding proteins (Gs and Gi) in psoriatic epidermis.

    abstract::Psoriatic involved epidermis has been characterized by a defective beta-adrenergic adenylate cyclase response. It is also characterized by increased cholera toxin- and forskolin-induced cyclic AMP accumulations. Due to the fact that receptor signals are transduced to adenylate cyclase through guanine nucleotides bindi...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章

    doi:10.1016/s0923-1811(97)00069-8

    authors: Tamura T,Takahashi H,Ishida-Yamamoto A,Hashimoto Y,Iizuka H

    更新日期:1998-05-01 00:00:00

  • The role of immunohistochemistry in the diagnosis of the non-lethal forms of junctional epidermolysis bullosa.

    abstract::Skin biopsies from four patients with similar clinical phenotypes of non-lethal junctional epidermolysis bullosa (JEB) were investigated by electron microscopy and immunohistochemistry. Electron microscopy revealed cleavage within the lamina lucida in each case, but in addition, there was considerable variability in t...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章

    doi:10.1016/s0923-1811(96)00554-3

    authors: McGrath JA,Eady RA

    更新日期:1997-01-01 00:00:00

  • Oral administration of collagen tripeptide improves dryness and pruritus in the acetone-induced dry skin model.

    abstract:BACKGROUND:Dry skin causes pruritus and discomfort in patients with xerosis and atopic dermatitis. General treatment for skin dryness involves the topical application of an emollient. However, more effective, simpler therapies are desired. Collagen tripeptide (CTP) is a highly purified, non-antigenic, low-allergenic co...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章

    doi:10.1016/j.jdermsci.2012.02.004

    authors: Okawa T,Yamaguchi Y,Takada S,Sakai Y,Numata N,Nakamura F,Nagashima Y,Ikezawa Z,Aihara M

    更新日期:2012-05-01 00:00:00

  • Streptococci isolated from various skin lesions: the interaction with Staphylococcus aureus strains.

    abstract::We isolated 73 streptococcus strains (41 from infections, and 32 from colonization) from various skin diseases between March, 1994, and June, 1998. In 29 out of 41 cases of infective origin, Staphylococcus aureus strains were simultaneously isolated. Twenty-four out of 28 patients with impetigo were suffering from ato...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章

    doi:10.1016/s0923-1811(98)00043-7

    authors: Akiyama H,Yamasaki O,Kanzaki H,Tada J,Arata J

    更新日期:1999-01-01 00:00:00

  • Increased cutaneous immunoreactive stem cell factor expression and serum stem cell factor level in systemic scleroderma.

    abstract::Skin hyperpigmentation and itching are characteristic findings in systemic sclerosis (SSC) patients. Stem cell factor (SCF, c-kit ligand) is a multifunctional cytokine which can promote melanocyte and mast cell development. We investigated the SCF expression histopathologically in normal and SSC skin, and compared the...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章

    doi:10.1016/s0923-1811(98)00077-2

    authors: Kihira C,Mizutani H,Asahi K,Hamanaka H,Shimizu M

    更新日期:1998-05-01 00:00:00

  • Detection of keratinolytic proteinase in skin tissues from guinea pigs infected with Microsporum canis by an immunoperoxidase technique.

    abstract::An immunoperoxidase technique was performed to detect keratinolytic proteinase (KPase) in sections of the skin taken from guinea pigs infected with Microsporum canis and in cultured M. canis using polyclonal antisera to purified KPase. Of tissue samples from guinea pigs infected with M. canis, all sections of erythema...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章

    doi:10.1016/0923-1811(90)90015-6

    authors: Lee KH,Park HW,Lee JB

    更新日期:1990-11-01 00:00:00

  • Serum squamous cell carcinoma antigen (SCCA)-2 correlates with clinical severity of pediatric atopic dermatitis in Ishigaki cohort.

    abstract:BACKGROUND:We sometimes encounter difficulties in assessing the severity of pediatric atopic dermatitis (AD) using currently available biomarkers such as thymus and activation-regulated chemokine (TARC) due to the higher baseline values in non-AD children. Recent case control studies have indicated the usefulness of sq...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章

    doi:10.1016/j.jdermsci.2019.07.005

    authors: Takeuchi S,Furusyo N,Ono J,Azuma Y,Takemura M,Esaki H,Yamamura K,Mitamura Y,Tsuji G,Kiyomatsu-Oda M,Hayashi J,Izuhara K,Furue M

    更新日期:2019-08-01 00:00:00

  • Synergistic phototoxic effects of glycolic acid in a human keratinocyte cell line (HaCaT).

    abstract:BACKGROUND:Glycolic acid (GA) has been widely used in cosmetic agents and superficial chemical peeling in recent years. It has long been concerned that UV irradiation would enhance the photosensitivity of GA on human skin. Therefore, it is mandatory to explore the biologic effects of concomitant exposure of GA and UV i...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章

    doi:10.1016/j.jdermsci.2011.09.001

    authors: Lai WW,Hsiao YP,Chung JG,Wei YH,Cheng YW,Yang JH

    更新日期:2011-12-01 00:00:00

  • Vascular endothelial growth factor (VEGF) in the pathogenesis of psoriasis--a possible target for novel therapies?

    abstract::Angiogenesis is defined as the formation of new capillaries from pre-existing blood vessels. The process of angiogenesis is tightly regulated by a balance between pro- and anti-angiogenic factors. Vascular endothelial growth factor (VEGF) is a pro-angiogenic factor and several anti-VEGF therapies are used in the treat...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章,评审

    doi:10.1016/j.jdermsci.2010.03.023

    authors: Canavese M,Altruda F,Ruzicka T,Schauber J

    更新日期:2010-06-01 00:00:00

  • Novel ex vivo disease model for extramammary Paget's disease using the cancer tissue-originated spheroid method.

    abstract:BACKGROUND:Extramammary Paget's disease (EMPD) is a rare skin cancer that frequently occurs in the anogenital region in the elderly. Prognosis in patients with metastatic EMPD is poor as EMPD treatment has advanced little in recent years, primarily because no EMPD cell line has been established. OBJECTIVE:We aimed to ...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章

    doi:10.1016/j.jdermsci.2020.07.006

    authors: Arita T,Kondo J,Kaneko Y,Tsutsumi M,Kanemaru M,Matsui M,Arakawa Y,Katoh N,Inoue M,Asai J

    更新日期:2020-09-01 00:00:00

  • Cicatricial pemphigoid sera specifically react with the most C-terminal portion of BP180.

    abstract:BACKGROUND:cicatricial pemphigoid and bullous pemphigoid are characterized by circulating autoantibodies to the hemidesmosomal protein, BP180. Different clinical features between cicatricial pemphigoid and bullous pemphigoid appear to correlate with distinct target epitopes on BP180. Previous studies demonstrated that ...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章

    doi:10.1016/s0923-1811(03)00035-5

    authors: Lee JB,Liu Y,Hashimoto T

    更新日期:2003-06-01 00:00:00

  • Functional tight junction barrier localizes in the second layer of the stratum granulosum of human epidermis.

    abstract:BACKGROUND:Mammalian epidermis has two diffusion barriers, the stratum corneum (SC) and tight junctions (TJs). We reported previously that a single living cell layer exists between the SC and TJ-forming keratinocytes in mice; however, the exact location of the TJ barrier in human epidermis has not been defined. OBJECT...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章

    doi:10.1016/j.jdermsci.2013.04.021

    authors: Yoshida K,Yokouchi M,Nagao K,Ishii K,Amagai M,Kubo A

    更新日期:2013-08-01 00:00:00

  • Transcriptomic analysis of human dermal fibroblast cells reveals potential mechanisms underlying the protective effects of visible red light against damage from ultraviolet B light.

    abstract:BACKGROUND:Ultraviolet B (UVB) radiation is a major cause of skin photodamage, including the damage associated with photodermatoses, aging, and cancer. Although many studies have shown that red light has photoprotective effects on skin, the mechanisms underlying these effects are still poorly understood. OBJECTIVE:The...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章

    doi:10.1016/j.jdermsci.2019.03.003

    authors: Kim HS,Kim YJ,Kim SJ,Kang DS,Lee TR,Shin DW,Kim HJ,Seo YR

    更新日期:2019-05-01 00:00:00