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Effects of x-irradiation on survival and extracellular matrix gene expression of cultured keloid fibroblasts.

Abstract：

:Survival and extracellular matrix gene expression were studied by viable cell count assay and Northern transfer analysis to compare the sensitivity of normal skin and keloid fibroblasts towards x-irradiation. As the dosage of radiation increased, the numbers of viable cells in irradiated groups were remarkably decreased exponentially, with no significant difference between normal and keloid cell lines. By Northern blot analysis, there was no change in size of the mRNAs for pro alpha 1(I) collagen, fibronectin and beta-actin. By slot-blot hybridization, pro alpha 1(I) collagen mRNA levels in x-irradiated fibroblasts were markedly decreased compared with non-irradiated controls. The amounts of fibronectin and beta-actin mRNAs were also decreased. This study suggests that both normal skin and keloid fibroblasts are sensitive to x-irradiation, and that extracellular matrix gene expression is also affected by such exposure.

journal_name

J Dermatol Sci

journal_title

Journal of dermatological science

authors

Lee KS,Jung JB,Ro YJ,Ryoo YW,Kim OB,Song JY

doi

10.1016/0923-1811(94)90318-2

subject

Has Abstract

pub_date

1994-08-01 00:00:00

pages

33-7

issue

1

eissn

0923-1811

issn

1873-569X

pii

0923-1811(94)90318-2

journal_volume

8

pub_type

杂志文章

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