当前位置： SCI文献检索 > JOURNAL OF DERMATOLOGICAL SCIENCE期刊下所有文献 > Induction of MHC class II antigen expression on human HMC-1 mast cells.

Induction of MHC class II antigen expression on human HMC-1 mast cells.

Abstract：

:Mast cells are not only the primary effector cells of immediate type immune reactions, but they have recently also been considered to contribute to the induction of an immune response. Data on the ability of the cells to express major histocompatibility complex (MHC) antigens and the mechanisms involved are however controversial or unclear. We have therefore studied the expression of MHCI and the induction of MHCII molecules on leukemic HMC-1 mast cells by immunohistochemistry. Cells were incubated for up to 72 h in the presence of IFN gamma, TNF alpha and IL-4, and immunohistochemical staining was done with monoclonal antibodies with specificity for HLA class I heavy chain, HLA-DQ (Tü22), HLA-DR (Tü36) and HLA-DQ, -R and -P (Tü35). All unstimulated mast cells expressed MHC class I, but almost no class II antigens. Incubation with IFN gamma caused a rapid, dose-dependent induction of MHC class II molecules, with Tü35 staining maximally one third of the cells within 24 h at the highest dose tested (100 IU/ml), with decline on extended culture. TNF alpha (2 ng/ml) was less effective but caused more persistent induction with time. IL-4 (200 ng/ml) had hardly any effects at all. Staining with Tü22 and Tü36 was always lower than with Tü35, and additive or even synergistic results were obtained when cells were stimulated with a combination of IFN gamma and TNF alpha. These findings support the concept that mast cells can facultatively participate in immune recognition processes depending on the type of pathological conditions in their microenvironment which allow expression of MHC class II molecules.

journal_name

J Dermatol Sci

journal_title

Journal of dermatological science

authors

Grabbe J,Karau L,Welker P,Ziegler A,Henz BM

doi

10.1016/s0923-1811(97)00033-9

subject

Has Abstract

pub_date

1997-11-01 00:00:00

pages

67-73

issue

1

eissn

0923-1811

issn

1873-569X

pii

S0923-1811(97)00033-9

journal_volume

16

pub_type

杂志文章

相关文献

JOURNAL OF DERMATOLOGICAL SCIENCE文献大全
  • Neural stem cells inhibit melanin production by activation of Wnt inhibitors.

    abstract：BACKGROUND:Melanin for skin pigmentation is synthesized from tyrosine via an enzymatic cascade that is controlled by tyrosinase (TYR), tyrosinase-related protein 1 (TRP1), and dopachrome tautomerase/tyrosinase related protein 2 (Dct/TRP2), which are the targets of microphthalmia-associated transcription factor (MITF). ...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2013.08.006

    authors： Hwang I,Park JH,Park HS,Choi KA,Seol KC,Oh SI,Kang S,Hong S

    更新日期：2013-12-01 00:00:00

  • Sox9 facilitates proliferation, differentiation and lipogenesis in primary cultured human sebocytes.

    abstract：BACKGROUND:The transcription factor Sox9 is pivotal in the morphogenesis of hair follicles, but its role in sebocytes is poorly understood. OBJECTIVE:We investigated the effect of Sox9 on human sebocyte proliferation, differentiation and lipogenesis. METHODS:Sox9 expression was detected by immunohistochemistry in nor...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2016.10.005

    authors： Shi G,Wang TT,Quan JH,Li SJ,Zhang MF,Liao PY,Fan YM

    更新日期：2017-01-01 00:00:00

  • Update on the mechanisms and efficacy of biological therapies for psoriasis.

    abstract：:Biologically based agents (biologics) are novel therapeutic options in the treatment of moderate-to-severe psoriasis. Unlike traditional systemic anti-psoriatic drugs, which are chemically synthesized, these agents are unique in that they are derived from living organisms and hence called "biologics." In addition, the...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章,评审

    doi：10.1016/j.jdermsci.2005.01.011

    authors： Koo J,Khera P

    更新日期：2005-05-01 00:00:00

  • New method for determining prognosis of patients with psoriasis (E-PAP).

    abstract：:We developed a new method for evaluating clinical symptoms of psoriasis during the observation period, by adding a parameter of time (the number of days) to the psoriasis area and severity index (PASI). This method was named the evaluation for prognosis with averaged PASI (E-PAP). Using this method, we assessed 14 cas...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(97)00047-9

    authors： Sugai J,Ozawa A,Kawakubo Y,Iizuka M,Miyahara M,Ohkido M

    更新日期：1998-01-01 00:00:00

  • rAAV2-mediated restoration of LEKTI in LEKTI-deficient cells from Netherton patients.

    abstract：BACKGROUND:Netherton syndrome (NS, MIM 256500) is a potential live threatening autosomal-recessive skin disorder clinically characterized by the trias of congenital erythroderma, hair shaft anomalies and atopic diathesis. It is caused by mutations in the gene SPINK5 resulting in a deficiency of its processed protein na...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2010.12.004

    authors： Roedl D,Oji V,Buters JT,Behrendt H,Braun-Falco M

    更新日期：2011-03-01 00:00:00

  • Differential phosphorylation of mitogen-activated protein kinase families by epidermal growth factor and ultraviolet B irradiation in SV40-transformed human keratinocytes.

    abstract：:SV-40 transformed human keratinocytes (SVHK cells) were stimulated with epidermal growth factor (EGF) and ultraviolet B (UVB) irradiation. Following the stimulation, cell growth, apoptosis, and the activities of mitogen-activated protein (MAP) kinase families were analyzed. EGF (100 ng/ml) increased SVHK cell number c...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(00)00123-7

    authors： Nakamura S,Takahashi H,Kinouchi M,Manabe A,Ishida-Yamamoto A,Hashimoto Y,Iizuka H

    更新日期：2001-02-01 00:00:00

  • Cicatricial pemphigoid sera specifically react with the most C-terminal portion of BP180.

    abstract：BACKGROUND:cicatricial pemphigoid and bullous pemphigoid are characterized by circulating autoantibodies to the hemidesmosomal protein, BP180. Different clinical features between cicatricial pemphigoid and bullous pemphigoid appear to correlate with distinct target epitopes on BP180. Previous studies demonstrated that ...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(03)00035-5

    authors： Lee JB,Liu Y,Hashimoto T

    更新日期：2003-06-01 00:00:00

  • Treatment with TNF-α inhibitor rectifies M1 macrophage polarization from blood CD14+ monocytes in patients with psoriasis independent of STAT1 and IRF-1 activation.

    abstract：BACKGROUND:Psoriasis is a systemic inflammatory disease with dramatic responses to TNF-α inhibitors. TNF-α is mainly produced by macrophages. However, how macrophage polarization contributes to psoriasis remains unknown. OBJECTIVE:We aimed to investigate the molecular mechanisms of macrophage polarization in psoriasis...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2018.05.009

    authors： Lin SH,Chuang HY,Ho JC,Lee CH,Hsiao CC

    更新日期：2018-09-01 00:00:00

  • Retinoid-induced beta-adrenergic inhibitory effect associated with increased thymidine incorporation of fetal rat keratinizing epidermal cells (FRSK cells).

    abstract：:Using fetal rat keratinizing epidermal cells (FRSK cells) we investigated the effects of retinoids on the cyclic AMP system. The beta-adrenergic adenylate cyclase response was significantly decreased by the treatment of cells with 1 x 10(-6) M Ro 10-1670. The effect was observed by 12 h and remained for at least 48 h....

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/0923-1811(93)90080-9

    authors： Takahashi H,Iizuka H

    更新日期：1993-04-01 00:00:00

  • Exploring the imbalance of circulating follicular helper CD4+ T cells in sarcoidosis patients.

    abstract：BACKGROUND:Sarcoidosis is a systemic granulomatous disease characterized by the combination of Th1 and Th17 responses. Recently, several arguments have suggested a potential involvement of B cells as well as T cells in the pathogenesis of sarcoidosis. Follicular helper CD4+ T (TFH) cells are specialized in interacting ...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2020.02.002

    authors： Ly NTM,Ueda-Hayakawa I,Nguyen CTH,Okamoto H

    更新日期：2020-03-01 00:00:00

  • Growth stimulation of normal melanocytes and nevocellular nevus cells by gastrin releasing peptide (GRP).

    abstract：:In order to know the possible effects of gastrin releasing peptide (GRP) on nevus cells and melanocytes, we studied the effect of GRP on the proliferation of cultured human nevus cells and normal melanocytes. MTS assay showed that GRP stimulated the growth of viable melanocytes at 1000 ng/ml. GRP also stimulated the g...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(97)00079-0

    authors： Terashi H,Itami S,Tadokoro T,Takeyama M,Katagiri K,Takayasu S

    更新日期：1998-06-01 00:00:00

  • Depigmentation caused by application of the active brightening material, rhododendrol, is related to tyrosinase activity at a certain threshold.

    abstract：BACKGROUND:Tyrosinase, the rate-limiting enzyme required for melanin production, has been targeted to develop active brightening/lightening materials for skin products. Unexpected depigmentation of the skin characterized with the diverse symptoms was reported in some subjects who used a tyrosinase-competitive inhibitin...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2014.07.001

    authors： Kasamatsu S,Hachiya A,Nakamura S,Yasuda Y,Fujimori T,Takano K,Moriwaki S,Hase T,Suzuki T,Matsunaga K

    更新日期：2014-10-01 00:00:00

  • Hair follicle bulge: a fascinating reservoir of epithelial stem cells.

    abstract：:Hair follicles reconstitute themselves though the hair cycle, suggesting the presence of intrinsic stem cells. In contrast to the previous belief that stem cells reside in the bulbar region of hair follicles, stem cells were detected in the bulge area, a contiguous part of outer root sheath, that provides the insertio...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章,评审

    doi：10.1016/j.jdermsci.2006.12.002

    authors： Ohyama M

    更新日期：2007-05-01 00:00:00

  • Detection of interferon-gamma mRNA in psoriatic epidermis by polymerase chain reaction.

    abstract：:Psoriatic skin lesions contain HLA-DR positive T lymphocytes, and other activation antigens, which suggest that the T cells may be producing lymphokines. Gamma interferon is produced by activated T cells, and its presence in psoriasis has been inferred by the lesional keratinocyte expression of 3 gamma interferon-indu...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/0923-1811(91)90019-t

    authors： Barker JN,Karabin GD,Stoof TJ,Sarma VJ,Dixit VM,Nickoloff BJ

    更新日期：1991-03-01 00:00:00

  • Prognostic factors in 105 Japanese cases of mycosis fungoides and Sézary syndrome: clusterin expression as a novel prognostic factor.

    abstract：BACKGROUND:The analysis of prognostic factors in Japanese cases of cutaneous T-cell lymphoma (CTCL) is scarce. Clusterin is a ubiquitous 80kDa heterodimeric glycoprotein expressed on tumor cells of systemic and primary cutaneous anaplastic large cell lymphoma. The expression of clusterin in mycosis fungoides (MF) and S...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2013.04.020

    authors： Tobisawa S,Honma M,Ishida-Yamamoto A,Saijo Y,Iizuka H

    更新日期：2013-09-01 00:00:00

  • Granzyme B is a novel interleukin-18 converting enzyme.

    abstract：BACKGROUND:Granzyme B (GrB) is recognized to induce apoptosis; however, little is known about its possible role in other biological events. IL-18, a potent inflammatory cytokine, is produced as an inactive precursor (proIL-18). Several cells, including monocytes/macrophage lineage and non-hematopoietic cells such as ke...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2010.05.004

    authors： Omoto Y,Yamanaka K,Tokime K,Kitano S,Kakeda M,Akeda T,Kurokawa I,Gabazza EC,Tsutsui H,Katayama N,Yamanishi K,Nakanishi K,Mizutani H

    更新日期：2010-08-01 00:00:00

  • Toxic epidermal necrolysis and Stevens-Johnson syndrome: soluble Fas ligand involvement in the pathomechanisms of these diseases.

    abstract：:Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) are considered part of a spectrum of adverse cutaneous drug reactions showing severe and extensive skin detachment. TEN and SJS are morphologically characterized by active apoptotic keratinocyte cell death that results in the separation of the epiderm...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章,评审

    doi：10.1016/j.jdermsci.2008.06.003

    authors： Abe R

    更新日期：2008-12-01 00:00:00

  • Cultured keratinocytes from plectin/HD1-deficient epidermolysis bullosa simplex showed altered ability of adhesion to the matrix.

    abstract：:Epidermolysis bullosa simplex associated with late onset of muscular dystrophy has been found to show defective expression of plectin, an intracytoplasmic protein in hemidesmosomes. In this report, we examined ability of cell-to-matrix attachment of cultured keratinocytes derived from a case with this disease by vario...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(00)00100-6

    authors： Kurose K,Mori O,Hachisuka H,Shimizu H,Owaribe K,Hashimoto T

    更新日期：2000-12-01 00:00:00

  • Autoimmune reactivity against precursor form of desmoglein 1 in healthy Tunisians in the area of endemic pemphigus foliaceus.

    abstract：BACKGROUND:Desmoglein 1 (Dsg1), the pemphigus foliaceus (PF) antigen, is produced as a precursor (preDsg1) and is transported to the cell surface as the mature form (matDsg1). Recent studies show that B cells from North American individuals without pemphigus can potentially produce anti-preDsg1 IgG antibodies, but ELIS...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2013.02.002

    authors： Toumi A,Saleh MA,Yamagami J,Abida O,Kallel M,Masmoudi A,Makni S,Turki H,Hachiya T,Kuroda K,Stanley JR,Masmoudi H,Amagai M

    更新日期：2013-04-01 00:00:00

  • Photocontact dermatitis and chloracne: two major occupational and environmental skin diseases induced by different actions of halogenated chemicals.

    abstract：:Among occupational and environmental disorders, contact or photocontact dermatitis and an acneiform eruption are two major skin disorders. Photocontact dermatitis was historically caused by various halogenated salicylanilides, while the acne is induced by halogenated aromatic hydrocarbons and thus called chloracne. Th...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章,评审

    doi：10.1016/s0923-1811(03)00097-5

    authors： Yamamoto O,Tokura Y

    更新日期：2003-08-01 00:00:00

  • The current landscape of psoriasis genetics in 2020.

    abstract：:Psoriasis is an immune-mediated disease associated with skin and joint inflammation that affects large proportions of populations worldwide. It is a heritable disease: individuals' genetic backgrounds modulate their susceptibility. In genetics, multiple human leukocyte antigen (HLA) genes are most strongly associated ...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章,评审

    doi：10.1016/j.jdermsci.2020.05.008

    authors： Ogawa K,Okada Y

    更新日期：2020-07-01 00:00:00

  • Sulfhydryl oxidase (SOx) from mouse epidermis: molecular cloning, nucleotide sequence, and expression of recombinant protein in the cultured cells.

    abstract：:Skin sulfhydryl oxidase (SOx) is an enzyme that catalyzes disulfide (S-S) cross-linking through the oxidation of sulfhydryl compounds in the skin. In this study, using the enzyme purified from rat seminal vesicle, we obtained peptide sequences for SOx by mass spectrometry. We then searched for SOx nucleotides correspo...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(02)00061-0

    authors： Matsuba S,Suga Y,Ishidoh K,Hashimoto Y,Takamori K,Kominami E,Wilhelm B,Seitz J,Ogawa H

    更新日期：2002-10-01 00:00:00

  • Germline mutations of the PTCH gene in Japanese patients with nevoid basal cell carcinoma syndrome.

    abstract：:Nevoid basal cell carcinoma syndrome (NBCCS) is an autosomal dominant disorder characterized by developmental and skeletal anomalies, palmo-plantar pits, odontogenic keratocysts, ectopic calcification, and occurrence of various types of tumors including basal cell carcinoma. Recent evidence has indicated that the huma...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(01)00104-9

    authors： Minami M,Urano Y,Ishigami T,Tsuda H,Kusaka J,Arase S

    更新日期：2001-09-01 00:00:00

  • APE1 promotes proliferation and migration of cutaneous squamous cell carcinoma.

    abstract：BACKGROUND:Human Apurinic/Apyrimidinic Endonuclease 1 (APE1/REF-1/HAP1) is a multifunction protein involved in the progression of cancer. But the role of APE1 in cutaneous squamous cell carcinoma (cSCC) is unclear. OBJECTIVE:This study is aimed to investigate the basic modulatory mechanism of APE1 in cSCC development ...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2020.08.012

    authors： Deng X,Zhen P,Niu X,Dai Y,Wang Y,Zhou M

    更新日期：2020-10-01 00:00:00

  • Serum squamous cell carcinoma antigen (SCCA)-2 correlates with clinical severity of pediatric atopic dermatitis in Ishigaki cohort.

    abstract：BACKGROUND:We sometimes encounter difficulties in assessing the severity of pediatric atopic dermatitis (AD) using currently available biomarkers such as thymus and activation-regulated chemokine (TARC) due to the higher baseline values in non-AD children. Recent case control studies have indicated the usefulness of sq...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2019.07.005

    authors： Takeuchi S,Furusyo N,Ono J,Azuma Y,Takemura M,Esaki H,Yamamura K,Mitamura Y,Tsuji G,Kiyomatsu-Oda M,Hayashi J,Izuhara K,Furue M

    更新日期：2019-08-01 00:00:00

  • Expression of monocyte chemoattractant protein-1 in the lesional skin of systemic sclerosis.

    abstract：:Systemic sclerosis (SSc) is a connective tissue disease with unknown etiology characterized by excessive deposition of collagen in the skin as well as various internal organs. One of the characteristic histological features is the presence of infiltrating mononuclear cells in the dermis in its early stage. As well as ...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(00)00169-9

    authors： Yamamoto T,Eckes B,Hartmann K,Krieg T

    更新日期：2001-06-01 00:00:00

  • Efficacy and safety of ustekinumab for the treatment of moderate-to-severe psoriasis: a phase III, randomized, placebo-controlled trial in Taiwanese and Korean patients (PEARL).

    abstract：BACKGROUND:Ustekinumab has been evaluated in Caucasian patients with psoriasis, but no studies have been conducted in Asian patients. OBJECTIVE:To assess the efficacy and safety of ustekinumab in Taiwanese and Korean patients with moderate-to-severe psoriasis. METHODS:In this 36-week, multicenter, double-blind, place...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.jdermsci.2011.05.005

    authors： Tsai TF,Ho JC,Song M,Szapary P,Guzzo C,Shen YK,Li S,Kim KJ,Kim TY,Choi JH,Youn JI,PEARL Investigators.

    更新日期：2011-09-01 00:00:00

  • Genetic predisposition to bullous pemphigoid.

    abstract：:Bullous pemphigoid (BP) is a common autoimmune blistering skin disease that mainly affects elderly patients. Although BP risk is strongly influenced by age, genetic factors are also important determinants of this disease. Many genomic regions, especially in the HLA-II region, have been found to influence BP susceptibi...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章,评审

    doi：10.1016/j.jdermsci.2020.05.010

    authors： Zhang J,Wang G

    更新日期：2020-11-01 00:00:00

  • Telomerase in cutaneous carcinogenesis.

    abstract：:Telomerase is a ribonucleoprotein enzyme that catalyses the addition of telomeric repeats to telomeres. Since the shortening of telomeres is thought to act as a mitotic clock, activation of telomerase is crucial for the continued growth of cancer cells. Telomerase is frequently activated in premalignant and malignant ...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章,评审

    doi：10.1016/s0923-1811(99)00075-4

    authors： Ueda M

    更新日期：2000-03-01 00:00:00

  • Characterization of fibroblast-derived prolidase. The presence of two forms of prolidase.

    abstract：:Crude enzyme solutions of prolidase were extracted from cultured human skin fibroblasts derived from control and prolidase-deficient sisters. Two forms of prolidases (prolidase-I and II) were partially purified by high performance liquid chromatography equipped with an ion exchange column. On gel filtration, the relat...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/0923-1811(90)90588-5

    authors： Oono T,Yasutomi H,Ohhashi T,Kodama H,Arata J

    更新日期：1990-09-01 00:00:00