当前位置： SCI文献检索 > JOURNAL OF DERMATOLOGICAL SCIENCE期刊下所有文献 > Depigmentation caused by application of the active brightening material, rhododendrol, is related to tyrosinase activity at a certain threshold.

Depigmentation caused by application of the active brightening material, rhododendrol, is related to tyrosinase activity at a certain threshold.

Abstract：

BACKGROUND:Tyrosinase, the rate-limiting enzyme required for melanin production, has been targeted to develop active brightening/lightening materials for skin products. Unexpected depigmentation of the skin characterized with the diverse symptoms was reported in some subjects who used a tyrosinase-competitive inhibiting quasi-drug, rhododendrol. OBJECTIVE:To investigate the mechanism underlying the depigmentation caused by rhododendrol-containing cosmetics, this study was performed. METHODS:The mechanism above was examined using more than dozen of melanocytes derived from donors of different ethnic backgrounds. The RNAi technology was utilized to confirm the effect of tyrosinase to induce the cytotoxicity of rhododendrol and liquid chromatography-tandem mass spectrometry was introduced to detect rhododendrol and its metabolites in the presence of tyrosinase. RESULTS:Melanocyte damage was related to tyrosinase activity at a certain threshold. Treatment with a tyrosinase-specific siRNA was shown to dramatically rescue the rhododendrol-induced melanocyte impairment. Hydroxyl-rhododendrol was detected only in melanocytes with higher tyrosinase activity. When an equivalent amount of hydroxyl-rhododendrol was administered, cell viability was almost equally suppressed even in melanocytes with lower tyrosinase activity. CONCLUSION:The generation of a tyrosinase-catalyzed hydroxyl-metabolite is one of the causes for the diminishment of the melanocyte viability by rhododendrol.

journal_name

J Dermatol Sci

journal_title

Journal of dermatological science

authors

Kasamatsu S,Hachiya A,Nakamura S,Yasuda Y,Fujimori T,Takano K,Moriwaki S,Hase T,Suzuki T,Matsunaga K

doi

10.1016/j.jdermsci.2014.07.001

subject

Has Abstract

pub_date

2014-10-01 00:00:00

pages

16-24

issue

1

eissn

0923-1811

issn

1873-569X

pii

S0923-1811(14)00157-1

journal_volume

76

pub_type

杂志文章

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