当前位置： SCI文献检索 > JOURNAL OF DERMATOLOGICAL SCIENCE期刊下所有文献 > Oral supplementation with fish oil reduces dryness and pruritus in the acetone-induced dry skin rat model.

Oral supplementation with fish oil reduces dryness and pruritus in the acetone-induced dry skin rat model.

Abstract：

BACKGROUND:Pruritus and discomfort are often present in patients with xerosis and atopic dermatitis. Several studies suggest an important role of diet in skin pathophysiology. OBJECTIVE:This study evaluated the effect of dietary fatty acids in the skin physiology via an itch-related animal model with and without supplementation with fish oil (FO), a source of polyunsaturated fatty acids (PUFA), especially omega 3 (n-3). METHODS:Male Wistar rats were divided into two groups-non-supplemented (control) and supplemented with FO (3g/kg/day) by gavage for 90 days. Every 30 days, scratching and skin parameters (transepidermal water loss (TEWL), hydration, and local blood flow) were evaluated before and after dorsal skin exposure to acetone to induce the itch-related dry skin. At the end of the study, animals were sacrificed, and skin samples collected for fatty acids composition analysis by GC-FID. RESULTS:FO supplementation reduced the TEWL and increased the skin hydration, with significant changes from day 60 on, while skin microcirculation registered no changes. It also alleviated the acetone induced skin barrier alteration, revealed by a faster resolution of TEWL and hydration, and elimination of itch-related scratching induced by dry skin. These changes were associated with the shift in the skin fatty acids incorporation pattern (richer in n-3 with n-6/n-3<5) resulting from the FO supplementation. CONCLUSION:Skin barrier dynamics seem to be influenced by FO n-3 PUFA, with suppressive effects on the scratching behaviour induced by dry skin. Hence, long-term supplementation with n-3 PUFA rich nutrients might reinforce and restore cutaneous integrity and function.

journal_name

J Dermatol Sci

journal_title

Journal of dermatological science

authors

Barcelos RC,de Mello-Sampayo C,Antoniazzi CT,Segat HJ,Silva H,Veit JC,Piccolo J,Emanuelli T,Bürger ME,Silva-Lima B,Rodrigues LM

doi

10.1016/j.jdermsci.2015.06.015

subject

Has Abstract

pub_date

2015-09-01 00:00:00

pages

298-304

issue

3

eissn

0923-1811

issn

1873-569X

pii

S0923-1811(15)30020-7

journal_volume

79

pub_type

杂志文章

相关文献

JOURNAL OF DERMATOLOGICAL SCIENCE文献大全
  • Crystalloid inclusion bodies of the endothelial cells in human fetal skin blood vessels and human umbilical cord vessels: a possible relationship to Weibel-Palade bodies?

    abstract：:Crystalloid inclusion bodies (CIB) of the endothelial cells (EC) were investigated in blood vessels of human fetal skin and the umbilical cord by electron- and immunoelectron microscopy. They were found in up to 15% of the investigated EC in various types of vessels. Their sizes ranged from 0.2 microns to 0.6 microns ...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/0923-1811(91)90020-x

    authors： Tronnier M,Hashimoto K,Setoyama M,Predeteanu GS

    更新日期：1991-03-01 00:00:00

  • Neural stem cells inhibit melanin production by activation of Wnt inhibitors.

    abstract：BACKGROUND:Melanin for skin pigmentation is synthesized from tyrosine via an enzymatic cascade that is controlled by tyrosinase (TYR), tyrosinase-related protein 1 (TRP1), and dopachrome tautomerase/tyrosinase related protein 2 (Dct/TRP2), which are the targets of microphthalmia-associated transcription factor (MITF). ...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2013.08.006

    authors： Hwang I,Park JH,Park HS,Choi KA,Seol KC,Oh SI,Kang S,Hong S

    更新日期：2013-12-01 00:00:00

  • PAK1 overexpression promotes cell proliferation in cutaneous T cell lymphoma via suppression of PUMA and p21.

    abstract：BACKGROUND:Cutaneous T cell lymphoma (CTCL) comprises a heterogeneous group of skin-homing T cell tumors. The small guanosine triphosphate effector p21-activated kinase 1 (PAK1) plays an important role in many fundamental cellular functions, including cell motility, proliferation, and apoptosis. The expression of PAK1 ...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2017.11.019

    authors： Wang Y,Gu X,Li W,Zhang Q,Zhang C

    更新日期：2018-04-01 00:00:00

  • Hair follicle bulge: a fascinating reservoir of epithelial stem cells.

    abstract：:Hair follicles reconstitute themselves though the hair cycle, suggesting the presence of intrinsic stem cells. In contrast to the previous belief that stem cells reside in the bulbar region of hair follicles, stem cells were detected in the bulge area, a contiguous part of outer root sheath, that provides the insertio...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章,评审

    doi：10.1016/j.jdermsci.2006.12.002

    authors： Ohyama M

    更新日期：2007-05-01 00:00:00

  • Modulation of UVA light-induced oxidative stress by beta-carotene, lutein and astaxanthin in cultured fibroblasts.

    abstract：:The ability of beta-carotene, lutein or astaxanthin to protect against UVA-induced oxidative stress in rat kidney fibroblasts (NRK) was assessed. Activities of the antioxidant enzymes catalase (CAT) and superoxide dismutase (SOD), and changes in thiobarbituric acid reactive substances (TBARS) were measured as indices ...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(97)00058-3

    authors： O'Connor I,O'Brien N

    更新日期：1998-03-01 00:00:00

  • Treatment with TNF-α inhibitor rectifies M1 macrophage polarization from blood CD14+ monocytes in patients with psoriasis independent of STAT1 and IRF-1 activation.

    abstract：BACKGROUND:Psoriasis is a systemic inflammatory disease with dramatic responses to TNF-α inhibitors. TNF-α is mainly produced by macrophages. However, how macrophage polarization contributes to psoriasis remains unknown. OBJECTIVE:We aimed to investigate the molecular mechanisms of macrophage polarization in psoriasis...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2018.05.009

    authors： Lin SH,Chuang HY,Ho JC,Lee CH,Hsiao CC

    更新日期：2018-09-01 00:00:00

  • Alterations of immune functions in barrier disrupted skin by UVB irradiation.

    abstract：BACKGROUND:While immunologic events elicited by acute barrier disruption or UVB irradiation have been studied in detail, the biological sequel of multiple insults to the skin is not well understood. OBJECTIVE:Since the skin would receive a variety of simultaneous stimuli in daily life, we tested the effects of sequent...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(03)00177-4

    authors： Ito T,Seo N,Yagita H,Tsujimura K,Takigawa M,Tokura Y

    更新日期：2003-12-01 00:00:00

  • Vascular endothelial growth factor (VEGF) in the pathogenesis of psoriasis--a possible target for novel therapies?

    abstract：:Angiogenesis is defined as the formation of new capillaries from pre-existing blood vessels. The process of angiogenesis is tightly regulated by a balance between pro- and anti-angiogenic factors. Vascular endothelial growth factor (VEGF) is a pro-angiogenic factor and several anti-VEGF therapies are used in the treat...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章,评审

    doi：10.1016/j.jdermsci.2010.03.023

    authors： Canavese M,Altruda F,Ruzicka T,Schauber J

    更新日期：2010-06-01 00:00:00

  • Variable keratin polypeptide profile in human stratum corneum.

    abstract：:Stratum corneum samples obtained from 46 members in three generations of seven families were analyzed for keratin pattern by gel electrophoresis. All these samples of apparently normal upper arm skin expressed the 55 kDa, 56.5 kDa, and 65 kDa keratin proteins; while only 28%, 20% and 48% of the samples expressed the 5...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/0923-1811(90)90118-w

    authors： Yaar M,Matoltsy GA,Gilchrest BA

    更新日期：1990-07-01 00:00:00

  • Proteolytic cleavage of Livin (ML-IAP) in apoptotic melanoma cells potentially mediated by a non-canonical caspase.

    abstract：BACKGROUND:Several inhibitor of apoptosis proteins (IAPs) are cleaved during apoptosis. Studies of the melanoma-associated IAP (ML-IAP) Livin, using recombinant molecules, have implicated both caspases 3/7 and the serine protease Omi/HtrA2 in its proteolytic cleavage. OBJECTIVE:To characterize the apoptotic cleavage o...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2006.05.007

    authors： Yan H,Brouha B,Liu T,Raj D,Biddle D,Lee R,Grossman D

    更新日期：2006-09-01 00:00:00

  • Exploring the imbalance of circulating follicular helper CD4+ T cells in sarcoidosis patients.

    abstract：BACKGROUND:Sarcoidosis is a systemic granulomatous disease characterized by the combination of Th1 and Th17 responses. Recently, several arguments have suggested a potential involvement of B cells as well as T cells in the pathogenesis of sarcoidosis. Follicular helper CD4+ T (TFH) cells are specialized in interacting ...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2020.02.002

    authors： Ly NTM,Ueda-Hayakawa I,Nguyen CTH,Okamoto H

    更新日期：2020-03-01 00:00:00

  • Zinc deficiency exacerbates pressure ulcers by increasing oxidative stress and ATP in the skin.

    abstract：BACKGROUND:Zinc deficiency is believed to be a predisposing factor for the development and intractable healing of pressure ulcers (PUs); however, the mechanisms of this association have not been elucidated. OBJECTIVE:Objective was to elucidate the mechanisms of the formation of severe and prolonged PUs under the zinc ...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2019.07.004

    authors： Nakamura H,Sekiguchi A,Ogawa Y,Kawamura T,Akai R,Iwawaki T,Makiguchi T,Yokoo S,Ishikawa O,Motegi SI

    更新日期：2019-08-01 00:00:00

  • Time course of changes in antioxidant enzymes in human skin fibroblasts after UVA irradiation.

    abstract：:Examining damage (inactivation) of antioxidant enzymes in the cells and the pattern of recovery after a single UV exposure might be a useful method for analyzing the mechanisms of chronic UV irradiation, because chronic UV irradiation means repeated single exposures. We irradiated human skin fibroblasts with a single ...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(96)00578-6

    authors： Shindo Y,Hashimoto T

    更新日期：1997-03-01 00:00:00

  • The atopic dermatitis-like lesion and the associated MRSA infection and barrier dysfunction can be alleviated by 2,4-dimethoxy-6-methylbenzene-1,3-diol from Antrodia camphorata.

    abstract：BACKGROUND:Atopic dermatitis (AD) is an inflammatory skin disease with an associated barrier dysfunction and Staphylococcus aureus infection. The mainstay steroid and calcineurin inhibitor therapy shows some adverse effects. 2,4-Dimethoxy-6-methylbenzene-1,3-diol (DMD) is a benzenoid isolated from Antrodia camphorata. ...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2018.09.002

    authors： Yang SC,Huang TH,Chiu CH,Chou WL,Alalaiwe A,Yeh YC,Su KW,Fang JY

    更新日期：2018-11-01 00:00:00

  • Ultraviolet irradiation-induced inhibition of histone deacetylase 4 increases the expression of matrix metalloproteinase-1 but decreases that of type I procollagen via activating JNK in human dermal fibroblasts.

    abstract：BACKGROUND:Ultraviolet (UV) irradiation is the main contributing factor for skin aging. UV irradiation induces epigenetic changes in skin. It increases the activity of histone acetylases (HATs) but decreases that of histone deacetylases (HDACs). OBJECTIVE:We aimed to investigate alterations in all classes of HDACs and...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2020.11.008

    authors： Lee Y,Shin MH,Kim MK,Park CH,Shin HS,Lee DH,Chung JH

    更新日期：2020-12-03 00:00:00

  • Germline mutations of the PTCH gene in Japanese patients with nevoid basal cell carcinoma syndrome.

    abstract：:Nevoid basal cell carcinoma syndrome (NBCCS) is an autosomal dominant disorder characterized by developmental and skeletal anomalies, palmo-plantar pits, odontogenic keratocysts, ectopic calcification, and occurrence of various types of tumors including basal cell carcinoma. Recent evidence has indicated that the huma...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(01)00104-9

    authors： Minami M,Urano Y,Ishigami T,Tsuda H,Kusaka J,Arase S

    更新日期：2001-09-01 00:00:00

  • Autoimmune reactivity against precursor form of desmoglein 1 in healthy Tunisians in the area of endemic pemphigus foliaceus.

    abstract：BACKGROUND:Desmoglein 1 (Dsg1), the pemphigus foliaceus (PF) antigen, is produced as a precursor (preDsg1) and is transported to the cell surface as the mature form (matDsg1). Recent studies show that B cells from North American individuals without pemphigus can potentially produce anti-preDsg1 IgG antibodies, but ELIS...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2013.02.002

    authors： Toumi A,Saleh MA,Yamagami J,Abida O,Kallel M,Masmoudi A,Makni S,Turki H,Hachiya T,Kuroda K,Stanley JR,Masmoudi H,Amagai M

    更新日期：2013-04-01 00:00:00

  • Depigmentation caused by application of the active brightening material, rhododendrol, is related to tyrosinase activity at a certain threshold.

    abstract：BACKGROUND:Tyrosinase, the rate-limiting enzyme required for melanin production, has been targeted to develop active brightening/lightening materials for skin products. Unexpected depigmentation of the skin characterized with the diverse symptoms was reported in some subjects who used a tyrosinase-competitive inhibitin...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2014.07.001

    authors： Kasamatsu S,Hachiya A,Nakamura S,Yasuda Y,Fujimori T,Takano K,Moriwaki S,Hase T,Suzuki T,Matsunaga K

    更新日期：2014-10-01 00:00:00

  • Development of an inducible gene expression system for primary murine keratinocytes.

    abstract：BACKGROUND:The tetracycline (Tet) responsive system is a valuable tool that is routinely used in a wide variety of mammalian cells for regulatable expression of gene products. However, technical difficulties such as harsh selection conditions and extensive screening processes to identify suitably responsive clones limi...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2007.09.003

    authors： Nagarajan P,Sinha S

    更新日期：2008-01-01 00:00:00

  • Confocal Raman spectroscopy: In vivo measurement of physiological skin parameters - A pilot study.

    abstract：BACKGROUND:In vivo application of confocal Raman spectroscopy (CRS) allows non-invasive depth measurement of the skin. Thereby obtained knowledge of the skin composition is essential to reliably assess the actual skin state. Besides other components, the skin cholesterol concentration is of interest; however, little is...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2017.08.002

    authors： Binder L,SheikhRezaei S,Baierl A,Gruber L,Wolzt M,Valenta C

    更新日期：2017-12-01 00:00:00

  • Regulation of keratinocyte differentiation by O-GlcNAcylation.

    abstract：BACKGROUND:O-linked β-N-acetylglucosamine (O-GlcNAc) modification is one of the posttranslational modification, emerging as an important regulatory mechanism in various cellular events. OBJECTIVE:We attempted to investigate whether O-GlcNAcylation is involved in keratinocyte differentiation. METHODS:Immunohistochemis...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2014.04.010

    authors： Sohn KC,Lee EJ,Shin JM,Lim EH,No Y,Lee JY,Yoon TY,Lee YH,Im M,Lee Y,Seo YJ,Lee JH,Kim CD

    更新日期：2014-07-01 00:00:00

  • Telomere length of the skin in association with chronological aging and photoaging.

    abstract：BACKGROUND:Telomere shortening has been implicated in cellular senescence, which may cause certain aging phenotypes. OBJECTIVE:To reveal whether telomere shortening is associated with chronological aging and/or photoaging of the skin, we measured telomere length in the epidermis and in the dermis from sun-protected an...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2006.02.004

    authors： Sugimoto M,Yamashita R,Ueda M

    更新日期：2006-07-01 00:00:00

  • Therapeutic effects of streptococcal preparation OK-432 on atopic dermatitis-like lesions in NC/Nga mice: possible shift from a Th2- to Th1-predominance.

    abstract：BACKGROUND:The inducement of Th1 cell-mediated immune response, possibly brought about through bacterial stimulation, may serve to control atopic disorders such as atopic dermatitis (AD). The streptococcal preparation, OK-432, has been shown a potent Th1 inducer through the action of IL-12. NC/Nga mice under ordinary c...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2004.06.006

    authors： Horiuchi Y,Bae S,Katayama I,Nishioka K

    更新日期：2004-09-01 00:00:00

  • Preventive effect of chemical peeling on ultraviolet induced skin tumor formation.

    abstract：BACKGROUND:Chemical peeling is one of the dermatological treatments available for certain cutaneous diseases and conditions or improvement of cosmetic appearance of photoaged skin. OBJECTIVES:We assessed the photochemopreventive effect of several clinically used chemical peeling agents on the ultraviolet (UV)-irradiat...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2010.08.002

    authors： Abdel-Daim M,Funasaka Y,Kamo T,Ooe M,Matsunaka H,Yanagita E,Itoh T,Nishigori C

    更新日期：2010-10-01 00:00:00

  • Elevated plasma superoxide dismutase activity in patients with systemic sclerosis.

    abstract：:Injury to vessel walls, especially microvascular damage due to free radicals, has been a focus of interest concerning the pathogenesis of systemic sclerosis. Excess reactive oxygen species may induce antioxidant defenses. We therefore measured plasma superoxide dismutase (SOD) activity in patients with systemic sclero...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/0923-1811(95)00441-6

    authors： Morita A,Minami H,Sakakibara N,Sato K,Tsuji T

    更新日期：1996-03-01 00:00:00

  • Clinical profiles of pediatric patients with GPP alone and with different IL36RN genotypes.

    abstract：BACKGROUND:IL36RN mutation has been identified as one pathogenesis of generalized pustular psoriasis, but the existence of GPP patients without mutation makes this controversial. OBJECTIVE:Our study aimed at assessing the differences in clinical profiles of children with GPP, with and without IL36RN mutation. METHODS...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2016.11.008

    authors： Wang Y,Cheng R,Lu Z,Guo Y,Yan M,Liang J,Huang P,Li M,Yao Z

    更新日期：2017-03-01 00:00:00

  • Adherence characteristics of Staphylococcus aureus and coagulase-negative staphylococci isolated from various skin lesions.

    abstract：:We investigated the adherence characteristics of Staphylococcus aureus and coagulase-negative staphylococci (CNS) isolated from various skin lesions by examining hydrophobicity, negative charge, tube adherence, slime production, and promotion of adherence to coverslips by blood proteins. Our results in the present stu...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(98)00036-x

    authors： Akiyama H,Yamasaki O,Kanzaki H,Tada J,Arata J

    更新日期：1998-11-01 00:00:00

  • Immunohistochemical evaluation of tenascin in benign eccrine gland tumors: comparison with laminin and fibronectin.

    abstract：:Surgically resected specimens of skin appendage tumors, spiradenoma, poroma of eccrine glands, syringoadenoma, syringoadenoma papilliferum and mixec tumor of skin were evaluated for tenascin, as well as the basement membrane-associated protein laminin, and the extracellular matrix protein fibronectin, using immunohist...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/0923-1811(94)00369-p

    authors： Mori M,Shrestha P,Takagi H,Ogata K,Takai Y

    更新日期：1995-03-01 00:00:00

  • Characterization of fibroblast-derived prolidase. The presence of two forms of prolidase.

    abstract：:Crude enzyme solutions of prolidase were extracted from cultured human skin fibroblasts derived from control and prolidase-deficient sisters. Two forms of prolidases (prolidase-I and II) were partially purified by high performance liquid chromatography equipped with an ion exchange column. On gel filtration, the relat...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/0923-1811(90)90588-5

    authors： Oono T,Yasutomi H,Ohhashi T,Kodama H,Arata J

    更新日期：1990-09-01 00:00:00

  • Tumor-associated M2 macrophages in mycosis fungoides acquire immunomodulatory function by interferon alpha and interferon gamma.

    abstract：BACKGROUND:Tumor-associated M2 macrophages (TAMs) produce chemokines that affect the formation of cutaneous T-cell lymphoma (CTCL) by stromal factors. Since IFNs are an effective treatment for advanced-stage mycosis fungoides (MF), we hypothesized that IFNs might modulate M2 macrophages. OBJECTIVE:To prove our hypothe...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2016.05.004

    authors： Furudate S,Fujimura T,Kakizaki A,Hidaka T,Asano M,Aiba S

    更新日期：2016-09-01 00:00:00