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Tumor-associated M2 macrophages in mycosis fungoides acquire immunomodulatory function by interferon alpha and interferon gamma.

Abstract：

BACKGROUND:Tumor-associated M2 macrophages (TAMs) produce chemokines that affect the formation of cutaneous T-cell lymphoma (CTCL) by stromal factors. Since IFNs are an effective treatment for advanced-stage mycosis fungoides (MF), we hypothesized that IFNs might modulate M2 macrophages. OBJECTIVE:To prove our hypothesis, we stimulated monocyte-derived M2 macrophages with IFN-α2a or IFN-γ and examined the mRNA expression of chemokines. METHODS:By using a microarray, we selected a series of chemokines and MMPs that were strongly connected with the IL-4 stimulation. Then, we investigated the effects of IFN-α2a and IFN-γ on these chemokines. RESULTS:IFN-α2a and IFN-γ decreased the expression and production of CCL17 and CCL18 and increased those of CXCL10 and CXCL11. Moreover, the subcutaneous administration of IFN-α2a increased the CXCL11-producing cells in the lesional skin of patients with advanced MF. CONCLUSION:Our data suggest one possible mechanism of the therapeutic effects of IFNs through TAMs for the treatment of advanced-stage MF.

journal_name

J Dermatol Sci

journal_title

Journal of dermatological science

authors

Furudate S,Fujimura T,Kakizaki A,Hidaka T,Asano M,Aiba S

doi

10.1016/j.jdermsci.2016.05.004

subject

Has Abstract

pub_date

2016-09-01 00:00:00

pages

182-9

issue

3

eissn

0923-1811

issn

1873-569X

pii

S0923-1811(16)30074-3

journal_volume

83

pub_type

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