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Effects of UVB on fascin expression in dendritic cells and Langerhans cells.

Abstract：

BACKGROUND:Fascin is an actin-binding protein that regulates the rearrangement of cytoskeletal elements and their interactions with the cell membrane. Previous studies have indicated that fascin expression is enhanced in DC upon maturation and plays a critical role in T cell activation. Ultraviolet irradiation exerts immunosuppressive effects. OBJECTIVE:We examined the effects of UVB irradiation on the interaction of DC/LC with T cells through fascin. METHOD:Murine bone marrow-derived DC (BM-DC) were induced by recombinant murine GM-CSF and LPS, and UVB irradiation was applied prior to supplementation with LPS. I-A(+) cells (Langerhans cells (LC)) in the epidermal cell suspensions were exposed to UVB irradiation at the beginning of the 24-h culture. BM-DC and LC were analysed by immunohistochemical staining and flow cytometric analyses. To evaluate the effects of UVB irradiation on DC-T cell binding, we examined the clustering of BM-DC with allogeneic CD4(+) T cells under a confocal microscope. RESULTS:Fascin expression in BM-DC and LC was decreased by UVB irradiation. Furthermore, UVB irradiation reduced the ability of BM-DC to cluster with allogeneic CD4(+) T cells. Polarization of fascin and filamentous actin (F-actin) at the point of contact of BM-DC with T cells was also disturbed by UVB irradiation. CONCLUSION:These results suggest that the suppression of fascin expression by UVB irradiation down-regulates the rearrangement of the cytoskeleton and, thereby, antigen presentation in DC/LC.

journal_name

J Dermatol Sci

journal_title

Journal of dermatological science

authors

Sugihara A,Okamoto H,Horio T

doi

10.1016/j.jdermsci.2005.05.004

subject

Has Abstract

pub_date

2005-12-01 00:00:00

pages

177-85

issue

3

eissn

0923-1811

issn

1873-569X

pii

S0923-1811(05)00144-1

journal_volume

40

pub_type

杂志文章

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