Abstract:
BACKGROUND:The effects of hyaluronic acid (HA) injection on tissue collagen anabolism are suggested to be related to the induction of mechanical stress, causing biochemical changes in skin physiology. OBJECTIVES:To ascertain the association between dermal mechanics modulated by a hyaluronic acid-based filler effect and metabolism. METHODS:Sixty females were randomised to receive a 0.5mL injection of HA gel or isotonic sodium chloride (control) in the arm. Skin biopsies were taken at baseline and after 1, 3 and 6 months. Protein and gene expression of procollagen, matrix metalloproteinases (MMP) and MMP tissue inhibitors (TIMP1) were measured blind by ELISA and qPCR, respectively. Injected volumes were measured by high-frequency ultrasound and radiofrequency analysis. Skin layer effects of injections were analysed by finite element digital modelling. RESULTS:One month after injection, the filler induced an increase in procollagen (p=0.0016) and TIMP-1 (p=0.0485) levels and relative gene expression of procollagen III and I isoforms compared with the controls. After 3 months, procollagen levels remained greater than in the controls (p=0.0005), whereas procollagen expression and TIMP-1 and MMP content were no longer different. Forty-three percent of the injected filler volume was found at 1 month, 26% after 3 months and 20% after 6 months. LIMITATIONS:The ultrasound imaging technique limited the scope of the investigation and precluded an evaluation of the action of the filler at the hypodermic level. CONCLUSIONS:Integrating both mechanical and biological aspects, our results suggest that mechanical stress generated by cross-linked HA plays a role in dermal cell biochemical response.
journal_name
J Dermatol Scijournal_title
Journal of dermatological scienceauthors
Turlier V,Delalleau A,Casas C,Rouquier A,Bianchi P,Alvarez S,Josse G,Briant A,Dahan S,Saint-Martory C,Theunis J,Bensafi-Benaouda A,Degouy A,Schmitt AM,Redoulès Ddoi
10.1016/j.jdermsci.2012.12.006subject
Has Abstractpub_date
2013-03-01 00:00:00pages
187-94issue
3eissn
0923-1811issn
1873-569Xpii
S0923-1811(13)00002-9journal_volume
69pub_type
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