当前位置： SCI文献检索 > JOURNAL OF DERMATOLOGICAL SCIENCE期刊下所有文献 > Dermal carotenoid level and kinetics after topical and systemic administration of antioxidants: enrichment strategies in a controlled in vivo study.

Dermal carotenoid level and kinetics after topical and systemic administration of antioxidants: enrichment strategies in a controlled in vivo study.

Abstract：

BACKGROUND:High doses of sun-emitted UV-radiation induce reactive oxygen species (ROS) as major pro-oxidants thus inducing premature skin aging. The best prevention of the destructive action of free radicals in human skin is textile coverings, topical sunscreens and the development of a high antioxidative protective network. OBJECTIVE:The effects of topical, systemic and combined application of antioxidants (AO) were investigated on human skin in vivo. METHODS:Topical application of creams and systemic incorporation of tablets both containing AO was investigated in vivo by resonance Raman spectroscopy. RESULTS:Topical, systemic and combined AO-treatments induced a statistically significant increase of AO levels in human skin while placebo did not show any changes. The highest accumulation was induced by the combination of topical and systemic AO. Carotenoid-tablets combined with placebo-cream induced less carotenoid accumulation than carotenoid-tablets alone. Carotenoid levelling after the end of treatment lasted for around 2 weeks following the topical application of AOs, and up to 5 weeks after systemic administration, depending on the BMI of volunteers. CONCLUSION:Topically applied AO are stored in the SC for a short time only due to the rapid AO-depletion by desquamation, textile contact, washing and environmental stress. In contrast to topical application, the systemically applied carotenoids are stored in the body fat tissue and slowly released onto the skin surface with sweat and sebum. The combined topical and systemic application of AO represents an optimal form of protection of the AO-network.

journal_name

J Dermatol Sci

journal_title

Journal of dermatological science

authors

Darvin ME,Fluhr JW,Schanzer S,Richter H,Patzelt A,Meinke MC,Zastrow L,Golz K,Doucet O,Sterry W,Lademann J

doi

10.1016/j.jdermsci.2011.06.009

subject

Has Abstract

pub_date

2011-10-01 00:00:00

pages

53-8

issue

1

eissn

0923-1811

issn

1873-569X

pii

S0923-1811(11)00200-3

journal_volume

64

pub_type

杂志文章

相关文献

JOURNAL OF DERMATOLOGICAL SCIENCE文献大全
  • Cloning of the hamster androgen receptor gene.

    abstract：:Flank organs of male Golden Syrian hamsters contain sebaceous glands and hair follicles whose morphology and function are highly dependent on androgen, which makes these organs a useful model to study androgen action. In order to investigate molecular mechanisms of androgen action, we cloned a cDNA encoding the hamste...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(00)00172-9

    authors： Shiba K,Hamaguchi T,Kataoka K,Yamaguchi Y,Handa H,Adachi K

    更新日期：2001-07-01 00:00:00

  • Proteolytic digest derived from bovine Ligamentum Nuchae stimulates deposition of new elastin-enriched matrix in cultures and transplants of human dermal fibroblasts.

    abstract：BACKGROUND:Diverse topical products and injectable fillers used for correcting facial wrinkles induce rather short-lived effects because they target replacement of dermal collagen and hyaluronan, matrix components of limited biologic durability. OBJECTIVE:Present studies were aimed at stimulation of fully differentiat...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2005.04.002

    authors： Hinek A,Wang Y,Liu K,Mitts TF,Jimenez F

    更新日期：2005-09-01 00:00:00

  • Cicatricial pemphigoid sera specifically react with the most C-terminal portion of BP180.

    abstract：BACKGROUND:cicatricial pemphigoid and bullous pemphigoid are characterized by circulating autoantibodies to the hemidesmosomal protein, BP180. Different clinical features between cicatricial pemphigoid and bullous pemphigoid appear to correlate with distinct target epitopes on BP180. Previous studies demonstrated that ...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(03)00035-5

    authors： Lee JB,Liu Y,Hashimoto T

    更新日期：2003-06-01 00:00:00

  • The antimicrobial peptide derived from insulin-like growth factor-binding protein 5, AMP-IBP5, regulates keratinocyte functions through Mas-related gene X receptors.

    abstract：BACKGROUND:In addition to their microbicidal properties, host defense peptides (HDPs) display various immunomodulatory functions, including keratinocyte production of cytokines/chemokines, proliferation, migration and wound healing. Recently, a novel HDP named AMP-IBP5 (antimicrobial peptide derived from insulin-like g...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2017.05.008

    authors： Chieosilapatham P,Niyonsaba F,Kiatsurayanon C,Okumura K,Ikeda S,Ogawa H

    更新日期：2017-10-01 00:00:00

  • Both Th2 and Th1 chemokines (TARC/CCL17, MDC/CCL22, and Mig/CXCL9) are elevated in sera from patients with atopic dermatitis.

    abstract：BACKGROUND:Chemokines and their receptors are important elements for the selective attraction and activation of various subsets of leukocytes. Expression of CXCR3 ligands, such as monokine induced by IFN-gamma (Mig) leads to preferential Th1 recruitment, whereas CCR4 ligands, thymus and activation regulated chemokine (...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2004.01.001

    authors： Shimada Y,Takehara K,Sato S

    更新日期：2004-05-01 00:00:00

  • Attenuation of UVA-induced damage to human keratinocytes by silymarin.

    abstract：BACKGROUND:UV radiation from sunlight is a potent environmental risk factor in skin cancer pathogenesis. UVA is the major portion of UV light reaching the earth surface ( approximately 95%) and it is reported to lead to benign and malignant tumor formation. UVA-mediated cellular damage occurs primarily through the rele...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2006.12.009

    authors： Svobodová A,Zdarilová A,Malisková J,Mikulková H,Walterová D,Vostalová J

    更新日期：2007-04-01 00:00:00

  • High expression of Dicer reveals a negative prognostic influence in certain subtypes of primary cutaneous T cell lymphomas.

    abstract：BACKGROUND:Aberrant expression of microRNAs (miRNAs) has been implicated in oncogenesis of various tumors and primary cutaneous T cell lymphomas. Dicer, a ribonuclease III-like enzyme is essential for miRNA processing. OBJECTIVE:We initiated a retrospective study to characterize the alterations in the expression profi...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2011.08.011

    authors： Valencak J,Schmid K,Trautinger F,Wallnöfer W,Muellauer L,Soleiman A,Knobler R,Haitel A,Pehamberger H,Raderer M

    更新日期：2011-12-01 00:00:00

  • A similar local immune and oxidative stress phenotype in vitiligo and halo nevus.

    abstract：BACKGROUND:Vitiligo and halo nevus are two common T-cell-mediated skin disorders. Although autoimmunity has been suggested to be involved in both diseases, the relationship between vitiligo and halo nevus is not fully understood. OBJECTIVE:The aim of the current study was to investigate whether vitiligo and halo nevus...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2017.03.008

    authors： Yang Y,Li S,Zhu G,Zhang Q,Wang G,Gao T,Li C,Wang L,Jian Z

    更新日期：2017-07-01 00:00:00

  • Unfolded protein response in keratinocytes: impact on normal and abnormal keratinization.

    abstract：:The unfolded protein response (UPR) is a signaling pathway from the endoplasmic reticulum (ER) to the nucleus that protects cells from stress caused by misfolded or unfolded proteins. As such, ER stress is an ongoing challenge for all cells, given the central biologic importance of secretion as part of normal physiolo...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章,评审

    doi：10.1016/j.jdermsci.2012.12.002

    authors： Sugiura K

    更新日期：2013-03-01 00:00:00

  • Effect of growth factors on dermal fibroblast contraction in normal skin and hypertrophic scar.

    abstract：:We have examined the effects of four 'exogenous' growth factors, i.e. PDGF-BB (5 ng/ml), TGF-beta1 (5 ng/ml), bFGF (10 ng/ml) and EGF (10 ng/ml) on the contraction of floating collagen type I lattices populated by human normal skin (NS) and hypertrophic scar (HS) fibroblasts (FPCL). Only TGF-beta1 enhanced the contrac...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(96)00571-3

    authors： Yang CC,Lin SD,Yu HS

    更新日期：1997-02-01 00:00:00

  • DNA methylation of dermal MSCs in psoriasis: identification of epigenetically dysregulated genes.

    abstract：BACKGROUND:Mesenchymal stem cells (MSCs) are likely involved in pathological processes of immune-related diseases, including psoriasis, because of their immunoregulatory and pro-angiogenic effects. DNA methylation plays an essential role in regulating gene expression and maintaining cell function. OBJECTIVE:This study...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2013.07.002

    authors： Hou R,Yin G,An P,Wang C,Liu R,Yang Y,Yan X,Li J,Li X,Zhang K

    更新日期：2013-11-01 00:00:00

  • Cisplatin encapsulated in phosphatidylethanolamine liposomes enhances the in vitro cytotoxicity and in vivo intratumor drug accumulation against melanomas.

    abstract：BACKGROUND:Cisplatin is a potent anticancer drug for treating melanoma. OBJECTIVE:The aim of this study was to evaluate the possibility of using liposomes, for intratumoral distribution in a melanoma, composed of phosphatidylethanolamine (PE), for its cytotoxicity. METHOD:The in vitro drug release, in vitro cytotoxic...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2006.12.011

    authors： Hwang TL,Lee WR,Hua SC,Fang JY

    更新日期：2007-04-01 00:00:00

  • Role of the aryl hydrocarbon receptor signaling pathway in promoting mitochondrial biogenesis against oxidative damage in human melanocytes.

    abstract：BACKGROUND:Reactive oxygen species (ROS)-induced mitochondrial damage aggravates oxidative stress and activates mitochondrial apoptosis pathway to mediate melanocyte death. However, the repair mechanisms underlying damaged mitochondria of melanocytes remain unclear. Accumulative evidence has revealed that the aryl hydr...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2019.09.001

    authors： Wang X,Li S,Liu L,Jian Z,Cui T,Yang Y,Guo S,Yi X,Wang G,Li C,Gao T,Li K

    更新日期：2019-10-01 00:00:00

  • Induction of MHC class II antigen expression on human HMC-1 mast cells.

    abstract：:Mast cells are not only the primary effector cells of immediate type immune reactions, but they have recently also been considered to contribute to the induction of an immune response. Data on the ability of the cells to express major histocompatibility complex (MHC) antigens and the mechanisms involved are however co...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(97)00033-9

    authors： Grabbe J,Karau L,Welker P,Ziegler A,Henz BM

    更新日期：1997-11-01 00:00:00

  • Molecular and diagnostic aspects of genetic skin fragility.

    abstract：:Genetic syndromes with skin fragility represent a heterogeneous group of very rare disorders caused by mutations in genes encoding proteins or protein subunits important for the mechanical resistance of keratinocytes and for cell-cell or cell-extracellular matrix adhesion. The common symptoms are skin blistering or pe...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章,评审

    doi：10.1016/j.jdermsci.2006.08.003

    authors： Has C,Bruckner-Tuderman L

    更新日期：2006-12-01 00:00:00

  • PAK1 overexpression promotes cell proliferation in cutaneous T cell lymphoma via suppression of PUMA and p21.

    abstract：BACKGROUND:Cutaneous T cell lymphoma (CTCL) comprises a heterogeneous group of skin-homing T cell tumors. The small guanosine triphosphate effector p21-activated kinase 1 (PAK1) plays an important role in many fundamental cellular functions, including cell motility, proliferation, and apoptosis. The expression of PAK1 ...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2017.11.019

    authors： Wang Y,Gu X,Li W,Zhang Q,Zhang C

    更新日期：2018-04-01 00:00:00

  • A proinflammatory role of KLK6 protease in Netherton syndrome.

    abstract：BACKGROUND:Netherton syndrome (NS) is a rare but severe type of ichthyosis characterized by atopy, allergies, and potentially lethal skin overdesquamation associated with highly elevated proteolytic activities in LEKTI-deficient epidermis. NS symptoms are recapitulated in Spink5-/- mouse where the gene encoding Lekti h...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2019.06.004

    authors： Zingkou E,Pampalakis G,Charla E,Nauroy P,Kiritsi D,Sotiropoulou G

    更新日期：2019-07-01 00:00:00

  • In vivo optical coherence tomography of basal cell carcinoma.

    abstract：BACKGROUND:Optical coherence tomography (OCT) is a promising non-invasive imaging technique that has not systematically been studied in skin cancer such as basal cell carcinoma (BCC). OBJECTIVE:We aimed, first, to describe the in vivo histologic features of BCC by using OCT, and second, to find out whether it is possi...

    journal_title：Journal of dermatological science

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.jdermsci.2006.11.012

    authors： Gambichler T,Orlikov A,Vasa R,Moussa G,Hoffmann K,Stücker M,Altmeyer P,Bechara FG

    更新日期：2007-03-01 00:00:00

  • Kojic acid-induced IL-6 production in human keratinocytes plays a role in its anti-melanogenic activity in skin.

    abstract：BACKGROUND:Kojic acid is a fungal metabolite widely used in medicinal and cosmetic formulations as a skin-lightening agent based on its de-pigmenting activity. Although in human clinical studies kojic acid has been shown to be effective in the treatment of hyper-pigmentation disorders such as melasma, the reasons for i...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2012.03.002

    authors： Choi H,Kim K,Han J,Choi H,Jin SH,Lee EK,Shin DW,Lee TR,Lee AY,Noh M

    更新日期：2012-06-01 00:00:00

  • Expression of inducible nitric oxide synthase in skin lesions of acute herpes zoster.

    abstract：:Histopathologically, the skin lesions of acute herpes zoster (AHZ) are characterized by epidermal necrotic vesicles with inflammation. Nitric oxide (NO) is generated from L-arginine by nitric oxide synthase (NOS), and immune inflammation involves the activation of NOS in both effector cells and target cells. NO can ca...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(02)00035-x

    authors： Lim YJ,Chang SE,Choi JH,Sung KJ,Bahk JH,Do SH,Lee DS

    更新日期：2002-09-01 00:00:00

  • Sialic acid cyclization of human Th homing receptor glycan associated with recurrent exacerbations of atopic dermatitis.

    abstract：BACKGROUND:The molecular pathogenesis underlying recurrent exacerbations of atopic dermatitis (AD) is unclear. Some peripheral CCR4(+) and CCR7(+) helper memory T cells express the specific homing receptor, sialyl 6-sulfo Lewis X (G152 glycan). This glycan loses receptor activity via cyclization of its sialic acid moie...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2012.09.015

    authors： Sakuma K,Furuhashi T,Kondo S,Yabe U,Ohmori K,Ito H,Aoki M,Morita A,Kannagi R

    更新日期：2012-12-01 00:00:00

  • Differential regulations of matrix metalloproteinases and tissue inhibitors of metalloproteinases in dermal fibroblasts by dibutyril cyclic AMP.

    abstract：:The influence of dibutyril cyclic AMP (dbcAMP) on the gene expression of matrix metalloproteinases (MMP)-1, MMP-2, MMP-3, tissue inhibitors of metalloproteinases (TIMP)-1 and TIMP-2 was investigated in human skin fibroblasts by northern analyses. The treatment of dbcAMP increased MMP-1 and MMP-3 mRNA levels but decrea...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(97)00035-2

    authors： Kuroda K,Shinkai H

    更新日期：1997-08-01 00:00:00

  • Hair follicle bulge: a fascinating reservoir of epithelial stem cells.

    abstract：:Hair follicles reconstitute themselves though the hair cycle, suggesting the presence of intrinsic stem cells. In contrast to the previous belief that stem cells reside in the bulbar region of hair follicles, stem cells were detected in the bulge area, a contiguous part of outer root sheath, that provides the insertio...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章,评审

    doi：10.1016/j.jdermsci.2006.12.002

    authors： Ohyama M

    更新日期：2007-05-01 00:00:00

  • Characterization of dermatitis arising spontaneously in DS-Nh mice maintained under conventional conditions: another possible model for atopic dermatitis.

    abstract：:DS-Nh (DS Nh/+) mice spontaneously develop dermatitis when they are housed in a conventional environment. In this study, we analyzed the clinical and histopathological features of dermatitis in DS-Nh mice, which is characterized by erythema, edema, and erosion on the face, neck, chest and flexor surfaces of their fore...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(02)00070-1

    authors： Hikita I,Yoshioka T,Mizoguchi T,Tsukahara K,Tsuru K,Nagai H,Hirasawa T,Tsuruta Y,Suzuki R,Ichihashi M,Horikawa T

    更新日期：2002-11-01 00:00:00

  • The retinoic acid-induced up-regulation of insulin-like growth factor 1 and 2 is associated with prolidase-dependent collagen synthesis in UVA-irradiated human dermal equivalents.

    abstract：BACKGROUND:Ultraviolet (UV) A irradiation causes the degeneration of extracellular matrix in the skin dermis, mainly due to disrupted collagen homeostasis, resulting in the photo-aging of human skin. All-trans retinoic acid (ATRA) improves photo-aged human skin in vivo. OBJECTIVES:Although the effects of ATRA on colla...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2011.12.008

    authors： Shim JH,Shin DW,Lee TR,Kang HH,Jin SH,Noh M

    更新日期：2012-04-01 00:00:00

  • Simultaneous and separated culture of keratinocytes and fibroblasts on each side of a collagen membrane.

    abstract：:We have developed a new cell culture system which is of benefit for the research of dermal-epidermal interaction. In this system, normal human keratinocytes are cultured on the upper surface of a permeable collagen membrane, on the undersurface of which human fibroblasts are simultaneously and separately cultured in a...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/0923-1811(93)90099-b

    authors： Mitsuhashi Y,Mikami Y,Mikami H,Ishikawa H,Tamai K,Hashimoto I

    更新日期：1993-02-01 00:00:00

  • The promoter of an androgen dependent gene in the hamster flank organ.

    abstract：:Hamster flank organs are useful for studying androgen-dependent growth of hair follicles and sebaceous glands. A cDNA clone (FAR-17a) was isolated from the hamster flank organ, whose expression was highly sensitive to androgen. The mRNA level of this gene was reduced after castration but reappeared after testosterone ...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(97)00597-5

    authors： Aoki H,Seki T,Sawada J,Handa H,Adachi K

    更新日期：1997-05-01 00:00:00

  • The role of immunohistochemistry in the diagnosis of the non-lethal forms of junctional epidermolysis bullosa.

    abstract：:Skin biopsies from four patients with similar clinical phenotypes of non-lethal junctional epidermolysis bullosa (JEB) were investigated by electron microscopy and immunohistochemistry. Electron microscopy revealed cleavage within the lamina lucida in each case, but in addition, there was considerable variability in t...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(96)00554-3

    authors： McGrath JA,Eady RA

    更新日期：1997-01-01 00:00:00

  • Localization of annexins in normal and diseased human skin.

    abstract：:Annexins (AX) or lipocortins are a family of calcium and phospholipid binding proteins that have been implicated to play a role in the regulation of inflammation and cellular differentiation. To investigate a potential role of AX in skin disorders we studied the distribution of six different AX in normal human skin (N...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/0923-1811(93)90043-o

    authors： Bastian BC,van der Piepen U,Römisch J,Pâques EP,Bröcker EB

    更新日期：1993-12-01 00:00:00

  • Serum squamous cell carcinoma antigen (SCCA)-2 correlates with clinical severity of pediatric atopic dermatitis in Ishigaki cohort.

    abstract：BACKGROUND:We sometimes encounter difficulties in assessing the severity of pediatric atopic dermatitis (AD) using currently available biomarkers such as thymus and activation-regulated chemokine (TARC) due to the higher baseline values in non-AD children. Recent case control studies have indicated the usefulness of sq...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2019.07.005

    authors： Takeuchi S,Furusyo N,Ono J,Azuma Y,Takemura M,Esaki H,Yamamura K,Mitamura Y,Tsuji G,Kiyomatsu-Oda M,Hayashi J,Izuhara K,Furue M

    更新日期：2019-08-01 00:00:00