Abstract:
:Skin hyperpigmentation and itching are characteristic findings in systemic sclerosis (SSC) patients. Stem cell factor (SCF, c-kit ligand) is a multifunctional cytokine which can promote melanocyte and mast cell development. We investigated the SCF expression histopathologically in normal and SSC skin, and compared the expression with the serum SCF levels measured with a specific enzyme-linked immunosorbent assay. The epidermal and dermal immunoreactive SCF expression was markedly higher in the forearm skin of edematous phase SSC patients than in that of normal subjects. Tissue SCF expression declined from the sclerotic phase to the atrophic phase, where it was close to the normal level. In contrast, the elevated serum SCF level seen in the edematous phase samples was further increased in the sclerotic phase samples. The serum SCF level decreased in the atrophic phase, but it still remained at a level higher than that of the normal controls. Itching and increase of dermal mast cell number are characteristic of edematous phase SSC, and are in bears a parallel to the presently observed dermal SCF expression profile. Pigmentation is significant in sclerotic phase SSC and lasts to the atrophic phase, which may correspond to the serum SCF level observed here. These results indicate a contribution of the fibroblast membrane integral SCF in dermal mast cell development, and of the soluble serum SCF to melanocyte activation in SSC.
journal_name
J Dermatol Scijournal_title
Journal of dermatological scienceauthors
Kihira C,Mizutani H,Asahi K,Hamanaka H,Shimizu Mdoi
10.1016/s0923-1811(98)00077-2subject
Has Abstractpub_date
1998-05-01 00:00:00pages
72-8issue
1eissn
0923-1811issn
1873-569Xpii
S0923181198000772journal_volume
20pub_type
杂志文章abstract::Annexins (AX) or lipocortins are a family of calcium and phospholipid binding proteins that have been implicated to play a role in the regulation of inflammation and cellular differentiation. To investigate a potential role of AX in skin disorders we studied the distribution of six different AX in normal human skin (N...
journal_title:Journal of dermatological science
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journal_title:Journal of dermatological science
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journal_title:Journal of dermatological science
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journal_title:Journal of dermatological science
pub_type: 杂志文章
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更新日期:2013-07-01 00:00:00
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journal_title:Journal of dermatological science
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abstract::Etiology of connective tissue disease is unknown. The association of infectious agents has been suspected serologically, ultrastructurally and recently by means of molecular biological techniques. We extracted RNA from lesions of 25 discoid lupus erythematosus, 9 systemic LE, and 3 systemic sclerosis biopsies, and rev...
journal_title:Journal of dermatological science
pub_type: 杂志文章
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更新日期:1996-01-01 00:00:00
abstract::Crystalloid inclusion bodies (CIB) of the endothelial cells (EC) were investigated in blood vessels of human fetal skin and the umbilical cord by electron- and immunoelectron microscopy. They were found in up to 15% of the investigated EC in various types of vessels. Their sizes ranged from 0.2 microns to 0.6 microns ...
journal_title:Journal of dermatological science
pub_type: 杂志文章
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更新日期:1991-03-01 00:00:00
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journal_title:Journal of dermatological science
pub_type: 杂志文章
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更新日期:2017-11-01 00:00:00
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journal_title:Journal of dermatological science
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更新日期:2002-05-01 00:00:00
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journal_title:Journal of dermatological science
pub_type: 杂志文章,评审
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journal_title:Journal of dermatological science
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更新日期:2001-05-01 00:00:00
abstract:BACKGROUND:The inducement of Th1 cell-mediated immune response, possibly brought about through bacterial stimulation, may serve to control atopic disorders such as atopic dermatitis (AD). The streptococcal preparation, OK-432, has been shown a potent Th1 inducer through the action of IL-12. NC/Nga mice under ordinary c...
journal_title:Journal of dermatological science
pub_type: 杂志文章
doi:10.1016/j.jdermsci.2004.06.006
更新日期:2004-09-01 00:00:00
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journal_title:Journal of dermatological science
pub_type: 杂志文章
doi:10.1016/s0923-1811(98)00017-6
更新日期:1998-07-01 00:00:00
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journal_title:Journal of dermatological science
pub_type: 杂志文章
doi:10.1016/s0923-1811(98)00023-1
更新日期:1998-09-01 00:00:00
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journal_title:Journal of dermatological science
pub_type: 杂志文章
doi:10.1016/s0923-1811(00)00172-9
更新日期:2001-07-01 00:00:00
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journal_title:Journal of dermatological science
pub_type: 杂志文章
doi:10.1016/j.jdermsci.2019.06.004
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:Skin derived precursors (SKP) comprise a subset of specialized dermal cells that can be distinguished from fibroblast by their capacity for spheroidal growth. Recent investigations have shown that hair follicles constitute a niche for this cell type, but their localization and their definite function in non-...
journal_title:Journal of dermatological science
pub_type: 杂志文章
doi:10.1016/j.jdermsci.2012.10.007
更新日期:2013-02-01 00:00:00
abstract::A cell line, designated ISOS-1, was established from a tumor formed by transplantation of a human angiosarcoma into mice with severe combined immunodeficiency (SCID). The cells showed endothelial properties, based on the uptake of Dil-Ac-LDL and binding of UEA-I/GSA-I lectins, but were negative for CD11b and Pan Cytok...
journal_title:Journal of dermatological science
pub_type: 杂志文章
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更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:Infection with different species of cutaneous human papillomaviruses (cHPV) of genus alpha (cαHPVs) and associated skin disease are highly prevalent in solid organ transplant recipients (OTR), documenting the importance of the immunological control of HPV infection. OBJECTIVES:To investigate the natural cou...
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doi:10.1016/j.jdermsci.2014.11.002
更新日期:2015-01-01 00:00:00
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journal_title:Journal of dermatological science
pub_type: 杂志文章
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更新日期:2017-12-01 00:00:00
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journal_title:Journal of dermatological science
pub_type: 杂志文章
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更新日期:2017-10-01 00:00:00
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journal_title:Journal of dermatological science
pub_type: 杂志文章,评审
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更新日期:2014-05-01 00:00:00
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journal_title:Journal of dermatological science
pub_type: 杂志文章,评审
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更新日期:2020-11-01 00:00:00
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journal_title:Journal of dermatological science
pub_type: 杂志文章
doi:10.1016/j.jdermsci.2011.08.012
更新日期:2011-12-01 00:00:00
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journal_title:Journal of dermatological science
pub_type: 杂志文章
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更新日期:1992-09-01 00:00:00
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journal_title:Journal of dermatological science
pub_type: 杂志文章
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更新日期:2013-12-01 00:00:00
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journal_title:Journal of dermatological science
pub_type: 杂志文章
doi:10.1016/s0923-1811(02)00061-0
更新日期:2002-10-01 00:00:00
abstract:BACKGROUND:Main pathway in human melanocytes through which signal from the melanocortin system reaches the melanogenesis enzymes is cAMP/PKA pathway and it is modulated by Wnt and MAPK pathways. In our previous study we established significant increase of melanocortin receptor expression in unaffected skin of vitiligo ...
journal_title:Journal of dermatological science
pub_type: 杂志文章
doi:10.1016/j.jdermsci.2008.03.013
更新日期:2008-10-01 00:00:00
abstract::As we contemplate the nature of life sciences in the 21st century, we should briefly consider the changes that have occurred in the past century. Surely, the sources of progress of this science in the next century are the advances emerging now. Furthermore, the likely pace of discovery and change in life sciences in t...
journal_title:Journal of dermatological science
pub_type: 杂志文章,评审
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更新日期:2000-12-01 00:00:00