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Roxithromycin down-modulates antigen-presenting and interleukin-1 beta-producing abilities of murine Langerhans cells.

Abstract：

:The immunomodulatory effect of the macrolide antibiotic, roxithromycin (RXM) on Langerhans cells (LC) was studied in mice. RXM inhibited the ability of LC to present superantigen and hapten to T cells at 100 microM. The superantigen-presenting activity of LC was more profoundly abrogated by RXM than the hapten-presenting activity. This functional reduction was partly attributed to an RXM-induced decrease in promotion of the expression of major histocompatibility complex class II molecules on LC. On the other hand, RXM down-modulated the production of interleukin-1 beta by LC at a lower concentration of 10 microM than concentrations that inhibited antigen presentation. These results imply that RXM exerts therapeutic effectiveness via not only bacteriocidal action but also inhibitory effect on the LC ability in T-cell-mediated cutaneous diseases that can be exacerbated by skin-colonized Staphylococcus aureus.

journal_name

J Dermatol Sci

journal_title

Journal of dermatological science

authors

Ohshima A,Tokura Y,Wakita H,Furukawa F,Takigawa M

doi

10.1016/s0923-1811(98)00017-6

subject

Has Abstract

pub_date

1998-07-01 00:00:00

pages

214-22

issue

3

eissn

0923-1811

issn

1873-569X

pii

S0923181198000176

journal_volume

17

pub_type

杂志文章

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