当前位置： SCI文献检索 > JOURNAL OF DERMATOLOGICAL SCIENCE期刊下所有文献 > Propionibacterium acnes-induced IL-8 production may be mediated by NF-kappaB activation in human monocytes.

Propionibacterium acnes-induced IL-8 production may be mediated by NF-kappaB activation in human monocytes.

Abstract：

:Propionibacterium acnes (P. acnes) causes an inflammatory acne that is characterized by massive neutrophilic infiltration. IL-8 is thought to play an important role in the pathophysiology of P. acnes, although the mechanisms by which P. acnes up-regulates the release of IL-8, a neutrophilic chemokine, from target cells is not well understood. In this study, we investigated the mechanisms through which heat-killed P. acnes induces IL-8 production in THP-1 cells (a human monocytic cell line). We found that P. acnes is able to directly induce IL-8 production and IL-8 mRNA expression in human monocytic cells in a dose- and time-dependent manner through a mechanism requiring transcription factor NF-kappaB activation. Additionally, P. acnes-induced IL-8 secretion was inhibited by roxithromycin, a macrolide antibiotic, and its inhibitory effect seemed to be partially associated with the inhibition of P. acnes-induced NF-kappaB activation. This is the first study to show that NF-kappaB activation is involved in the IL-8 production of monocytic cells stimulated by P. acnes.

journal_name

J Dermatol Sci

journal_title

Journal of dermatological science

authors

Chen Q,Koga T,Uchi H,Hara H,Terao H,Moroi Y,Urabe K,Furue M

doi

10.1016/s0923-1811(02)00013-0

subject

Has Abstract

pub_date

2002-08-01 00:00:00

pages

97-103

issue

2

eissn

0923-1811

issn

1873-569X

pii

S0923181102000130

journal_volume

29

pub_type

杂志文章

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