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TGF-beta-induced SMAD signaling and gene regulation: consequences for extracellular matrix remodeling and wound healing.

Abstract：

:Members of the transforming growth factor-beta (TGF-beta) superfamily are pleiotropic cytokines that have the ability to regulate numerous cell functions, including proliferation, differentiation, apoptosis, epithelial-mesenchymal transition, and production of extracellular matrix, allowing them to play an important role during embryonic development and for maintenance of tissue homeostasis. Three TGF-beta isoforms have been identified in mammals. They propagate their signal via a signal transduction network involving receptor serine/threonine kinases at the cell surface and their substrates, the SMAD proteins. Upon phosphorylation and oligomerization, the latter move into the nucleus to regulate transcription of target genes. This review will summarize recent advances in the understanding of the mechanisms underlying SMAD modulation of extracellular matrix gene expression in the context of wound healing and tissue fibrosis.

journal_name

J Dermatol Sci

journal_title

Journal of dermatological science

authors

Schiller M,Javelaud D,Mauviel A

doi

10.1016/j.jdermsci.2003.12.006

subject

Has Abstract

pub_date

2004-08-01 00:00:00

pages

83-92

issue

2

eissn

0923-1811

issn

1873-569X

pii

S0923181104000076

journal_volume

35

pub_type

杂志文章,评审

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