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Failure to detect paramyxovirus RNA in the skin of connective tissue disease.

Abstract：

:Etiology of connective tissue disease is unknown. The association of infectious agents has been suspected serologically, ultrastructurally and recently by means of molecular biological techniques. We extracted RNA from lesions of 25 discoid lupus erythematosus, 9 systemic LE, and 3 systemic sclerosis biopsies, and reverse transcription-polymerase chain reaction was performed for all paramyxoviruses known to infect human beings. None of the samples yielded positive signal for any of the viruses. The existence of paramyxovirus in the skin of connective tissue disease is very unlikely.

journal_name

J Dermatol Sci

journal_title

Journal of dermatological science

authors

Fujiwara H,Fujiwara K,Yotsumoto S,Hashimoto K

doi

10.1016/0923-1811(95)00422-x

subject

Has Abstract

pub_date

1996-01-01 00:00:00

pages

70-5

issue

1

eissn

0923-1811

issn

1873-569X

pii

0923-1811(95)00422-X

journal_volume

11

pub_type

杂志文章

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