当前位置： SCI文献检索 > JOURNAL OF DERMATOLOGICAL SCIENCE期刊下所有文献 > Alterations of immune functions in barrier disrupted skin by UVB irradiation.

Alterations of immune functions in barrier disrupted skin by UVB irradiation.

Abstract：

BACKGROUND:While immunologic events elicited by acute barrier disruption or UVB irradiation have been studied in detail, the biological sequel of multiple insults to the skin is not well understood. OBJECTIVE:Since the skin would receive a variety of simultaneous stimuli in daily life, we tested the effects of sequential treatments with barrier disruption and UVB exposure on skin immunity. METHODS:Earlobes of BALB/c mice received tape-stripping and subsequently low-dose UVB exposure. Control mice were treated with either tape-stripping or UVB. The expression of surface markers and cytokine production in Langerhans cells and keratinocytes and the elicitation response of contact hypersensitivity were compared. RESULTS:By flow cytometry, tape-stripping augmented the expression of MHC class II, CD54, CD80, CD86 and CD40 on Langerhans cells, whereas UVB decreased the expression of some of these molecules. Combination of tape-stripping and UVB induced largely intermediate levels between these two. Upon stimulation with L cells expressing CD40L, Langerhans cells from tape-stripped and UVB-irradiated earlobes strongly transcribed mRNA for interleukin-1beta compared to each treatment. In keratinocytes, tape-stripping or UVB slightly upregulated tumor necrosis factor-alpha and interleukin-1alpha production at both mRNA and protein levels, whereas these two treatments synergistically increased the production of these cytokines. The in vitro hapten-presenting ability of Langerhans cells to trinitrophenyl-immune lymph node T cells ranked first in tape-stripping, second in tape-stripping plus UVB and third in UVB, and so did the intensity of elicitation responses in contact hypersensitivity to a hapten, picryl chloride. CONCLUSION:It is suggested that barrier disruption and UVB antagonize with each other in contact hypersensitivity as a reflection of their effects on Langerhans cell antigen-presenting function, but they synergize in cytokine production by both Langerhans cells and keratinocytes.

journal_name

J Dermatol Sci

journal_title

Journal of dermatological science

authors

Ito T,Seo N,Yagita H,Tsujimura K,Takigawa M,Tokura Y

doi

10.1016/s0923-1811(03)00177-4

subject

Has Abstract

pub_date

2003-12-01 00:00:00

pages

151-9

issue

3

eissn

0923-1811

issn

1873-569X

pii

S0923181103001774

journal_volume

33

pub_type

杂志文章

相关文献

JOURNAL OF DERMATOLOGICAL SCIENCE文献大全
  • Tumor-associated M2 macrophages in mycosis fungoides acquire immunomodulatory function by interferon alpha and interferon gamma.

    abstract：BACKGROUND:Tumor-associated M2 macrophages (TAMs) produce chemokines that affect the formation of cutaneous T-cell lymphoma (CTCL) by stromal factors. Since IFNs are an effective treatment for advanced-stage mycosis fungoides (MF), we hypothesized that IFNs might modulate M2 macrophages. OBJECTIVE:To prove our hypothe...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2016.05.004

    authors： Furudate S,Fujimura T,Kakizaki A,Hidaka T,Asano M,Aiba S

    更新日期：2016-09-01 00:00:00

  • Keratinocytes in atopic dermatitis express abundant ΔNp73 regulating thymic stromal lymphopoietin production via NF-κB.

    abstract：BACKGROUND:Atopic dermatitis (AD) is a chronic inflammatory skin disease that often cannot be completely controlled by modern medicine. Since multiple factors are intricately involved in the pathogenesis of AD, wide-ranging research is required for further advancement of AD treatment. Epidermal keratinocytes are the fo...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2017.06.017

    authors： Kumagai A,Kubo T,Kawata K,Kamekura R,Yamashita K,Jitsukawa S,Nagaya T,Sumikawa Y,Himi T,Yamashita T,Ichimiya S

    更新日期：2017-11-01 00:00:00

  • Non-disulfided pro alpha 1(IV) chain in B16 melanoma cell culture.

    abstract：:We have previously reported that two species of pro alpha 1(IV) collagen chains, disulfided (500 kDa) and non-disulfided (180 kDa), were produced by B16 melanoma cells (J Biochem (1994) 116; 1039-1043). The mechanism by which the non-disulfided pro alpha 1(IV) chain is produced was studied. No significant difference i...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/0923-1811(95)00486-6

    authors： Tajima S,Tokimitsu I

    更新日期：1996-10-01 00:00:00

  • Time course of changes in antioxidant enzymes in human skin fibroblasts after UVA irradiation.

    abstract：:Examining damage (inactivation) of antioxidant enzymes in the cells and the pattern of recovery after a single UV exposure might be a useful method for analyzing the mechanisms of chronic UV irradiation, because chronic UV irradiation means repeated single exposures. We irradiated human skin fibroblasts with a single ...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(96)00578-6

    authors： Shindo Y,Hashimoto T

    更新日期：1997-03-01 00:00:00

  • Cross-sectional survey on disease severity in Japanese patients with harlequin ichthyosis/ichthyosis: Syndromic forms and quality-of-life analysis in a subgroup.

    abstract：BACKGROUND:Congenital ichthyoses (CIs) adversely affect quality of life (QOL) in patients. However, the effects of CIs on patient QOL have not been studied sufficiently. OBJECTIVE:To investigate the association between disease severity and QOL in patients with harlequin ichthyosis (HI) and ichthyosis: syndromic forms ...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2018.08.008

    authors： Murase C,Takeichi T,Shibata A,Nakatochi M,Kinoshita F,Kubo A,Nakajima K,Ishii N,Amano H,Masuda K,Kawakami H,Kanekura T,Washio K,Asano M,Teramura K,Akasaka E,Tohyama M,Hatano Y,Ochiai T,Moriwaki S,Sato T,Ishida-Y

    更新日期：2018-11-01 00:00:00

  • Photocontact dermatitis and chloracne: two major occupational and environmental skin diseases induced by different actions of halogenated chemicals.

    abstract：:Among occupational and environmental disorders, contact or photocontact dermatitis and an acneiform eruption are two major skin disorders. Photocontact dermatitis was historically caused by various halogenated salicylanilides, while the acne is induced by halogenated aromatic hydrocarbons and thus called chloracne. Th...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章,评审

    doi：10.1016/s0923-1811(03)00097-5

    authors： Yamamoto O,Tokura Y

    更新日期：2003-08-01 00:00:00

  • Butylated hydroxyanisole blocks the inhibitory effects of tumor necrosis factor-alpha on collagen production in human dermal fibroblasts.

    abstract：:Tumor necrosis factor-alpha (TNF-alpha) has been demonstrated to selectively decrease the production of type I and type III collagens in human dermal fibroblasts. The effects of the commonly used food antioxidants, butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), alpha-tocopherol, propyl gallate, supero...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/0923-1811(95)00463-7

    authors： Taniguchi S,Furukawa M,Kono T,Hisa T,Ishii M,Hamada T

    更新日期：1996-04-01 00:00:00

  • Sirt1 ameliorates systemic sclerosis by targeting the mTOR pathway.

    abstract：BACKGROUND:Systemic sclerosis (SSc) is a chronic autoimmune disease characterized by inflammation and fibrosis. Our previous research has indicated that Sirtuin1 (Sirt1) plays a role in the regulation of TNF-α-induced inflammation; however, whether Sirt1 may inhibit the progress of SSc by blocking inflammation remains ...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2017.04.013

    authors： Zhu X,Chu H,Jiang S,Liu Q,Liu L,Xue Y,Zheng S,Wan W,Qiu J,Wang J,Zou H

    更新日期：2017-08-01 00:00:00

  • Sulfhydryl oxidase (SOx) from mouse epidermis: molecular cloning, nucleotide sequence, and expression of recombinant protein in the cultured cells.

    abstract：:Skin sulfhydryl oxidase (SOx) is an enzyme that catalyzes disulfide (S-S) cross-linking through the oxidation of sulfhydryl compounds in the skin. In this study, using the enzyme purified from rat seminal vesicle, we obtained peptide sequences for SOx by mass spectrometry. We then searched for SOx nucleotides correspo...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(02)00061-0

    authors： Matsuba S,Suga Y,Ishidoh K,Hashimoto Y,Takamori K,Kominami E,Wilhelm B,Seitz J,Ogawa H

    更新日期：2002-10-01 00:00:00

  • Occupational trichloroethylene hypersensitivity syndrome: human herpesvirus 6 reactivation and rash phenotypes.

    abstract：BACKGROUND:Trichloroethylene (TCE) is an industrial solvent which can cause severe generalized dermatitis, i.e., occupational TCE hypersensitivity syndrome. Reactivation of latent human herpesvirus 6 (HHV6) can occur in such patients, which has made TCE known as a causative chemical of drug-induced hypersensitivity syn...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2013.07.003

    authors： Kamijima M,Wang H,Yamanoshita O,Ito Y,Xia L,Yanagiba Y,Chen C,Okamura A,Huang Z,Qiu X,Song X,Cai T,Liu L,Ge Y,Deng Y,Naito H,Yoshikawa T,Tohyama M,Li L,Huang H,Nakajima T

    更新日期：2013-12-01 00:00:00

  • Clinical profiles of pediatric patients with GPP alone and with different IL36RN genotypes.

    abstract：BACKGROUND:IL36RN mutation has been identified as one pathogenesis of generalized pustular psoriasis, but the existence of GPP patients without mutation makes this controversial. OBJECTIVE:Our study aimed at assessing the differences in clinical profiles of children with GPP, with and without IL36RN mutation. METHODS...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2016.11.008

    authors： Wang Y,Cheng R,Lu Z,Guo Y,Yan M,Liang J,Huang P,Li M,Yao Z

    更新日期：2017-03-01 00:00:00

  • Immunohistochemical evaluation of tenascin in benign eccrine gland tumors: comparison with laminin and fibronectin.

    abstract：:Surgically resected specimens of skin appendage tumors, spiradenoma, poroma of eccrine glands, syringoadenoma, syringoadenoma papilliferum and mixec tumor of skin were evaluated for tenascin, as well as the basement membrane-associated protein laminin, and the extracellular matrix protein fibronectin, using immunohist...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/0923-1811(94)00369-p

    authors： Mori M,Shrestha P,Takagi H,Ogata K,Takai Y

    更新日期：1995-03-01 00:00:00

  • FK506 and cyclosporin A inhibit growth factor-stimulated human keratinocyte proliferation by blocking cells in the G0/G1 phases of the cell cycle.

    abstract：:FK506, a new immunosuppressive agent, is effective in treating patients with psoriasis. A major feature of psoriasis vulgaris is the hyperproliferation of keratinocytes together with inflammation. To determine the effect of FK506 or cyclosporin A (CsA) on the keratinocyte cell cycle, flow cytometry and the growth fact...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/0923-1811(95)00480-7

    authors： Karashima T,Hachisuka H,Sasai Y

    更新日期：1996-09-01 00:00:00

  • Preventive effect of chemical peeling on ultraviolet induced skin tumor formation.

    abstract：BACKGROUND:Chemical peeling is one of the dermatological treatments available for certain cutaneous diseases and conditions or improvement of cosmetic appearance of photoaged skin. OBJECTIVES:We assessed the photochemopreventive effect of several clinically used chemical peeling agents on the ultraviolet (UV)-irradiat...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2010.08.002

    authors： Abdel-Daim M,Funasaka Y,Kamo T,Ooe M,Matsunaka H,Yanagita E,Itoh T,Nishigori C

    更新日期：2010-10-01 00:00:00

  • Identification of a novel deletion in the ABCC6 gene leading to Pseudoxanthoma elasticum.

    abstract：BACKGROUND:Pseudoxanthoma elasticum (PXE) is an inherited systemic disorder, characterized by dermal, ocular and cardiovascular lesions. Genetic defects of the ABCC6 (MRP6) transporter are known to cause PXE. OBJECTIVES:The purpose of this study was to identify the genetic background of a PXE patient with a very early...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2005.07.010

    authors： Katona E,Aslanidis C,Remenyik E,Csikós M,Kárpáti S,Paragh G,Schmitz G

    更新日期：2005-11-01 00:00:00

  • Three dimensional structural studies of alpha-N-acetylgalactosaminidase (alpha-NAGA) in alpha-NAGA deficiency (Kanzaki disease): different gene mutations cause peculiar structural changes in alpha-NAGAs resulting in different substrate specificities and c

    abstract：BACKGROUND:Kanzaki disease (OMIM#104170) is attributable to a deficiency in alpha-N-acetylgalactosaminidase (alpha-NAGA; E.C.3.2.1.49), which hydrolyzes GalNAcalpha1-O-Ser/Thr. Missense mutations, R329W or R329Q were identified in two Japanese Kanzaki patients. Although they are on the same codon, the clinical manifest...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2004.09.005

    authors： Kanekura T,Sakuraba H,Matsuzawa F,Aikawa S,Doi H,Hirabayashi Y,Yoshii N,Fukushige T,Kanzaki T

    更新日期：2005-01-01 00:00:00

  • Effect of cyclosporin A on suppressor T cells.

    abstract：:The effect of cyclosporin A (CsA) on suppressor T cells (Ts) was evaluated by in vitro incubation with afferent-phase Ts (Ts-aff) and efferent-phase Ts (Ts-eff). 2,4-Dinitro-1-fluorobenzene (DNFB) and hen egg-white lysozyme (HEL) were used as antigens. Both Ts-aff and Ts-eff were resistant to high- and low-dose CsA tr...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/0923-1811(90)90218-3

    authors： Ishii N,Ishii H,Ono H,Horiuchi Y,Nakajima H,Aoki I

    更新日期：1990-03-01 00:00:00

  • Induction of MHC class II antigen expression on human HMC-1 mast cells.

    abstract：:Mast cells are not only the primary effector cells of immediate type immune reactions, but they have recently also been considered to contribute to the induction of an immune response. Data on the ability of the cells to express major histocompatibility complex (MHC) antigens and the mechanisms involved are however co...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(97)00033-9

    authors： Grabbe J,Karau L,Welker P,Ziegler A,Henz BM

    更新日期：1997-11-01 00:00:00

  • Both Th2 and Th1 chemokines (TARC/CCL17, MDC/CCL22, and Mig/CXCL9) are elevated in sera from patients with atopic dermatitis.

    abstract：BACKGROUND:Chemokines and their receptors are important elements for the selective attraction and activation of various subsets of leukocytes. Expression of CXCR3 ligands, such as monokine induced by IFN-gamma (Mig) leads to preferential Th1 recruitment, whereas CCR4 ligands, thymus and activation regulated chemokine (...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2004.01.001

    authors： Shimada Y,Takehara K,Sato S

    更新日期：2004-05-01 00:00:00

  • Dermatitis herpetiformis: close to unravelling a disease.

    abstract：:Dermatitis herpetiformis is characterised by granular IgA precipitates in the papillary dermis. In contrast to other autoimmune blistering diseases, where tissue-deposited and circulating autoantibodies recognise the same target within the skin, in dermatitis herpetiformis a serum IgA reacting with a component of the ...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章,评审

    doi：10.1016/j.jdermsci.2003.11.004

    authors： Kárpáti S

    更新日期：2004-04-01 00:00:00

  • TNIP1/ANXA6 and CSMD1 variants interacting with cigarette smoking, alcohol intake affect risk of psoriasis.

    abstract：BACKGROUND:Psoriasis is a common multi-factorial skin disease, in which gene-gene and gene-environment interactions may affect the onset, manifestation and clinical course. OBJECTIVE:To investigate the underlying gene-environment interaction among several established susceptibility genes, cigarette smoking and alcohol...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2013.02.006

    authors： Yin XY,Cheng H,Wang WJ,Wang WJ,Fu HY,Liu LH,Zhang FY,Yang S,Zhang XJ

    更新日期：2013-05-01 00:00:00

  • Detection of interferon-gamma mRNA in psoriatic epidermis by polymerase chain reaction.

    abstract：:Psoriatic skin lesions contain HLA-DR positive T lymphocytes, and other activation antigens, which suggest that the T cells may be producing lymphokines. Gamma interferon is produced by activated T cells, and its presence in psoriasis has been inferred by the lesional keratinocyte expression of 3 gamma interferon-indu...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/0923-1811(91)90019-t

    authors： Barker JN,Karabin GD,Stoof TJ,Sarma VJ,Dixit VM,Nickoloff BJ

    更新日期：1991-03-01 00:00:00

  • Histamine stimulates normal human melanocytes in vitro: one of the possible inducers of hyperpigmentation in urticaria pigmentosa.

    abstract：:Isolated normal human melanocytes became enlarged and more dendritic in association with an increase in the activity of tyrosinase and the amount of b-locus protein when they were cultured with 0.1-10 microM histamine in vitro. However, histamine did not exert a proliferative effect on them. The stimulatory effect of ...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/0923-1811(93)90005-a

    authors： Tomita Y,Maeda K,Tagami H

    更新日期：1993-10-01 00:00:00

  • Effects of kestose on gut mucosal immunity in an atopic dermatitis mouse model.

    abstract：BACKGROUND:Atopic dermatitis (AD) is recently increasing among populations, but the underlying mechanisms remain controversial. Interactions between the gut microbiota and mucosal immunity are considered to be a crucial etiology. Fructooligosaccharide (FOS), prebiotics have been reported as activators of the gut microb...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2017.10.006

    authors： Kim HJ,Lee SH,Go HN,Ahn JR,Kim HJ,Hong SJ

    更新日期：2018-01-01 00:00:00

  • Taurin-conjugated ursodeoxycholic acid has a reversible inhibitory effect on human keratinocyte growth.

    abstract：:Tauroursodeoxycholic acid (TUDC) is one of the most hydrophilic taurin conjugated bile acids. TUDC has a suppressive effect on DNA synthesis in primary cultured rat hepatocytes. In this study, we investigated the growth inhibitory effect of TUDC on cultured human keratinocytes. TUDC suppressed the proliferation of ker...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(98)00023-1

    authors： Yamaguchi Y,Itami S,Nishida K,Ando Y,Okamoto S,Hosokawa K,Yoshikawa K

    更新日期：1998-09-01 00:00:00

  • Pilot study on novel skin care method by augmentation with Staphylococcus epidermidis, an autologous skin microbe--A blinded randomized clinical trial.

    abstract：BACKGROUND AND OBJECTIVE:Staphylococcus epidermidis is an autologous bacterium that is beneficial to skin health. Our goal was to develop a novel, personalized basic cosmetic that exploits this characteristic. METHODS:We conducted a double-blinded, randomized clinical trial on augmentation with S. epidermidis as a pil...

    journal_title：Journal of dermatological science

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.jdermsci.2015.05.001

    authors： Nodake Y,Matsumoto S,Miura R,Honda H,Ishibashi G,Matsumoto S,Dekio I,Sakakibara R

    更新日期：2015-08-01 00:00:00

  • Serum concentration of the soluble interleukin-2 receptor in vitiligo patients.

    abstract：:Serum levels of sIL-2R can be used to monitor in vivo immune activation and its elevation have been shown to be correlated with T cell mediated immune disease such as atopic dermatitis, psoriasis, lymphoma and systemic sclerosis. Vitiligo is the disease of depigmentation caused by destruction of melanocytes, and there...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(98)00070-x

    authors： Yeo UC,Yang YS,Park KB,Sung HT,Jung SY,Lee ES,Shin MH

    更新日期：1999-04-01 00:00:00

  • Characterization of itch-associated responses of NC mice with mite-induced chronic dermatitis.

    abstract：:To clarify the behavioral and pathological features of spontaneous scratching of NC mice with mite-induced chronic dermatitis, we investigated the spontaneous and pruritogen-evoked scratching of NC mice. Although the frequency of scratching of NC mouse did not increase under specific pathogen-free environment, it grad...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(00)00099-2

    authors： Yamaguchi T,Maekawa T,Nishikawa Y,Nojima H,Kaneko M,Kawakita T,Miyamoto T,Kuraishi Y

    更新日期：2001-01-01 00:00:00

  • Depigmentation caused by application of the active brightening material, rhododendrol, is related to tyrosinase activity at a certain threshold.

    abstract：BACKGROUND:Tyrosinase, the rate-limiting enzyme required for melanin production, has been targeted to develop active brightening/lightening materials for skin products. Unexpected depigmentation of the skin characterized with the diverse symptoms was reported in some subjects who used a tyrosinase-competitive inhibitin...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2014.07.001

    authors： Kasamatsu S,Hachiya A,Nakamura S,Yasuda Y,Fujimori T,Takano K,Moriwaki S,Hase T,Suzuki T,Matsunaga K

    更新日期：2014-10-01 00:00:00

  • The role of VEGF and thrombospondins in skin angiogenesis.

    abstract：:The vasculature in adult skin remains normally quiescent, due to the dominant influence of endogenous angiogenesis inhibitors over angiogenic stimuli. However, skin retains the capacity for brisk initiation of angiogenesis, the growth of new blood vessels from preexisting vessels, during tissue repair and in numerous ...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章,评审

    doi：10.1016/s0923-1811(00)00145-6

    authors： Detmar M

    更新日期：2000-12-01 00:00:00