Abstract:
:Psoriatic involved epidermis has been characterized by a defective beta-adrenergic adenylate cyclase response. It is also characterized by increased cholera toxin- and forskolin-induced cyclic AMP accumulations. Due to the fact that receptor signals are transduced to adenylate cyclase through guanine nucleotides binding proteins (G-proteins), that affect cholera toxin- and forskolin-induced cyclic AMP accumulations, possible alterations of G-proteins of psoriatic involved and perilesional uninvolved epidermis by using toxin-catalyzed ADP-ribosylation and immunoblot analyses was investigated. Cholera toxin catalyzes ADP-ribosylation of stimulatory guanine nucleotides binding protein (Gs) in either trimeric (inactive) or monomeric (active) form, while islet activating protein (IAP) catalyzes ADP ribosylation of inhibitory guanine nucleotide binding protein (Gi) in only trimeric (inactive) form. Results indicate that although the psoriatic involved epidermis shows increased cholera toxin- and IAP-catalyzed ADP-ribosylations, the amounts of immunoreactive Gs alpha or Gi alpha are not significantly altered. The increase in IAP-catalyzed ADP-ribosylation indicates increased inactive Gi, explaining the increased forskolin-induced cyclic AMP accumulation. The increase in cholera toxin-catalyzed ADP-ribosylation of Gs explains the increased cholera toxin-induced cyclic AMP accumulation in the psoriatic involved epidermis.
journal_name
J Dermatol Scijournal_title
Journal of dermatological scienceauthors
Tamura T,Takahashi H,Ishida-Yamamoto A,Hashimoto Y,Iizuka Hdoi
10.1016/s0923-1811(97)00069-8subject
Has Abstractpub_date
1998-05-01 00:00:00pages
61-6issue
1eissn
0923-1811issn
1873-569Xpii
S0923181197000698journal_volume
17pub_type
杂志文章abstract::Systemic sclerosis (SSc) is a connective tissue disease with unknown etiology characterized by excessive deposition of collagen in the skin as well as various internal organs. One of the characteristic histological features is the presence of infiltrating mononuclear cells in the dermis in its early stage. As well as ...
journal_title:Journal of dermatological science
pub_type: 杂志文章
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abstract::Etiology of connective tissue disease is unknown. The association of infectious agents has been suspected serologically, ultrastructurally and recently by means of molecular biological techniques. We extracted RNA from lesions of 25 discoid lupus erythematosus, 9 systemic LE, and 3 systemic sclerosis biopsies, and rev...
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pub_type: 杂志文章,评审
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journal_title:Journal of dermatological science
pub_type: 杂志文章
doi:10.1016/j.jdermsci.2015.10.005
更新日期:2015-12-01 00:00:00
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doi:10.1016/j.jdermsci.2005.05.004
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journal_title:Journal of dermatological science
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journal_title:Journal of dermatological science
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2015-08-01 00:00:00
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