当前位置： SCI文献检索 > JOURNAL OF DERMATOLOGICAL SCIENCE期刊下所有文献 > Real-time vascular imaging and photodynamic therapy efficacy with micelle-nanocarrier delivery of chlorin e6 to the microenvironment of melanoma.

Real-time vascular imaging and photodynamic therapy efficacy with micelle-nanocarrier delivery of chlorin e6 to the microenvironment of melanoma.

Abstract：

BACKGROUND:Strategies combining anti-vascular therapy and vascular imaging may facilitate the prediction of early response and outcome in cancer treatment. OBJECTIVE:The aim of this study was to investigate the relationship between the tumor-associated vasculature in melanoma and to develop an approach for melanoma treatment by utilizing the free form and micelle form of the photosensitizer (PS) chlorin e6 in photodynamic therapy (PDT). METHODS:Green fluorescence protein (GFP) expressing B16-F10 melanoma cells were implanted into the mouse ear dermis. Ce6 in free form or in micelle form was administered via the tail vein. An OV100 imaging system was used to record the red fluorescence of Ce6 to obtain real-time vascular images in the GFP tumor. RESULTS:Compared to free Ce6, Ce6 linked to the micelle-nanocarrier depicted a much clearer vascular image and had an effective vascular destruction by PDT. Micelle Ce6 was localized in lysosomes and in the endoplasmic reticulum of cultured endothelial cells, implying an active endocytosis of the nano-carrier. CONCLUSION:Micelle Ce6 can serve as a bifunctional PS for vascular imaging and PDT, which facilitates its delivery in the tumor microenvironment.

journal_name

J Dermatol Sci

journal_title

Journal of dermatological science

authors

Lee CH,Lai PS,Lu YP,Chen HY,Chai CY,Tsai RK,Fang KT,Tsai MH,Hsu CY,Hung CC,Wu DC,Yu HS,Chang CH,Tsai DP

doi

10.1016/j.jdermsci.2015.08.005

subject

Has Abstract

pub_date

2015-11-01 00:00:00

pages

124-32

issue

2

eissn

0923-1811

issn

1873-569X

pii

S0923-1811(15)30040-2

journal_volume

80

pub_type

杂志文章

相关文献

JOURNAL OF DERMATOLOGICAL SCIENCE文献大全
  • Application of FTIR microspectroscopy for characterization of biomolecular changes in human melanoma cells treated by sesamol and kojic acid.

    abstract：BACKGROUND:Hyperpigmentation is aesthetic undesirable. Sesamol and the standard antimelanogenic agent (kojic acid) were shown to hinder melanogenesis by blocking tyrosinase and reducing melanin content. OBJECTIVE:The FTIR microspectroscopy was used in an attempt to find a novel method to define biological alternation ...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2013.11.002

    authors： Srisayam M,Weerapreeyakul N,Barusrux S,Tanthanuch W,Thumanu K

    更新日期：2014-03-01 00:00:00

  • Expression of antimicrobial peptides in diabetic foot ulcer.

    abstract：BACKGROUND:Foot ulcers are one of the main diabetes complications due to its high frequency and difficulty of complete healing. There are several factors that participate in diabetic ulcers development and limited information exists about the role of antimicrobial peptides (AMP) in its pathogenesis. OBJECTIVE:The aim ...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2011.09.013

    authors： Rivas-Santiago B,Trujillo V,Montoya A,Gonzalez-Curiel I,Castañeda-Delgado J,Cardenas A,Rincon K,Hernandez ML,Hernández-Pando R

    更新日期：2012-01-01 00:00:00

  • Toxic epidermal necrolysis and Stevens-Johnson syndrome: soluble Fas ligand involvement in the pathomechanisms of these diseases.

    abstract：:Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) are considered part of a spectrum of adverse cutaneous drug reactions showing severe and extensive skin detachment. TEN and SJS are morphologically characterized by active apoptotic keratinocyte cell death that results in the separation of the epiderm...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章,评审

    doi：10.1016/j.jdermsci.2008.06.003

    authors： Abe R

    更新日期：2008-12-01 00:00:00

  • TNIP1/ANXA6 and CSMD1 variants interacting with cigarette smoking, alcohol intake affect risk of psoriasis.

    abstract：BACKGROUND:Psoriasis is a common multi-factorial skin disease, in which gene-gene and gene-environment interactions may affect the onset, manifestation and clinical course. OBJECTIVE:To investigate the underlying gene-environment interaction among several established susceptibility genes, cigarette smoking and alcohol...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2013.02.006

    authors： Yin XY,Cheng H,Wang WJ,Wang WJ,Fu HY,Liu LH,Zhang FY,Yang S,Zhang XJ

    更新日期：2013-05-01 00:00:00

  • Cutaneous manifestations of COVID-19: Report of three cases and a review of literature.

    abstract：BACKGROUND:Various cutaneous manifestations have been observed in patients with COVID-19 infection. However, overall similarities in the clinical presentation of these dermatological manifestations have not yet been summarized. OBJECTIVE:This review aims to provide an overview of various cutaneous manifestations in pa...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章,评审

    doi：10.1016/j.jdermsci.2020.04.011

    authors： Sachdeva M,Gianotti R,Shah M,Bradanini L,Tosi D,Veraldi S,Ziv M,Leshem E,Dodiuk-Gad RP

    更新日期：2020-05-01 00:00:00

  • Serum concentration of the soluble interleukin-2 receptor in vitiligo patients.

    abstract：:Serum levels of sIL-2R can be used to monitor in vivo immune activation and its elevation have been shown to be correlated with T cell mediated immune disease such as atopic dermatitis, psoriasis, lymphoma and systemic sclerosis. Vitiligo is the disease of depigmentation caused by destruction of melanocytes, and there...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(98)00070-x

    authors： Yeo UC,Yang YS,Park KB,Sung HT,Jung SY,Lee ES,Shin MH

    更新日期：1999-04-01 00:00:00

  • Depigmentation caused by application of the active brightening material, rhododendrol, is related to tyrosinase activity at a certain threshold.

    abstract：BACKGROUND:Tyrosinase, the rate-limiting enzyme required for melanin production, has been targeted to develop active brightening/lightening materials for skin products. Unexpected depigmentation of the skin characterized with the diverse symptoms was reported in some subjects who used a tyrosinase-competitive inhibitin...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2014.07.001

    authors： Kasamatsu S,Hachiya A,Nakamura S,Yasuda Y,Fujimori T,Takano K,Moriwaki S,Hase T,Suzuki T,Matsunaga K

    更新日期：2014-10-01 00:00:00

  • JAK inhibitor JTE-052 regulates contact hypersensitivity by downmodulating T cell activation and differentiation.

    abstract：BACKGROUND:Using JAK inhibitors to inhibit cytokine signaling is presumed to be a possible means of treating skin inflammatory disorders such as contact dermatitis. OBJECTIVE:To clarify the action site of JAK inhibitors in skin inflammatory disorders. METHODS:We analyzed the mechanism of action of the JAK inhibitor J...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2016.09.007

    authors： Amano W,Nakajima S,Yamamoto Y,Tanimoto A,Matsushita M,Miyachi Y,Kabashima K

    更新日期：2016-12-01 00:00:00

  • Immunoelectron microscopic analysis of lysosomal deposits in alpha-N-acetylgalactosaminidase deficiency with angiokeratoma corporis diffusum.

    abstract：:Alpha-N-acetylgalactosaminidase (alpha-NAGA) deficiency with angiokeratoma corporis diffusum (AKCD) is one of the lysosomal storage diseases. GalNAc(alpha))1-O-Ser/Thr (Tn) is theoretically deposited in lysosomes, but substances with attached galactose and neuraminic (sialic) acid (T and sialosyl Tn, respectively) are...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(02)00005-1

    authors： Kanda A,Tsuyama S,Murata F,Kodama K,Hirabayashi Y,Kanzaki T

    更新日期：2002-05-01 00:00:00

  • High expression of Dicer reveals a negative prognostic influence in certain subtypes of primary cutaneous T cell lymphomas.

    abstract：BACKGROUND:Aberrant expression of microRNAs (miRNAs) has been implicated in oncogenesis of various tumors and primary cutaneous T cell lymphomas. Dicer, a ribonuclease III-like enzyme is essential for miRNA processing. OBJECTIVE:We initiated a retrospective study to characterize the alterations in the expression profi...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2011.08.011

    authors： Valencak J,Schmid K,Trautinger F,Wallnöfer W,Muellauer L,Soleiman A,Knobler R,Haitel A,Pehamberger H,Raderer M

    更新日期：2011-12-01 00:00:00

  • Modulation of UVA light-induced oxidative stress by beta-carotene, lutein and astaxanthin in cultured fibroblasts.

    abstract：:The ability of beta-carotene, lutein or astaxanthin to protect against UVA-induced oxidative stress in rat kidney fibroblasts (NRK) was assessed. Activities of the antioxidant enzymes catalase (CAT) and superoxide dismutase (SOD), and changes in thiobarbituric acid reactive substances (TBARS) were measured as indices ...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(97)00058-3

    authors： O'Connor I,O'Brien N

    更新日期：1998-03-01 00:00:00

  • Integrated microRNA/mRNA expression profiling of the skin of psoriasis patients.

    abstract：BACKGROUND:Psoriasis is a chronic inflammatory disease characterized by demarcated, raised, and scaling skin lesions. It often serves as a model for immune-mediated disorders. Gene expression profiling of affected skin has allowed insights into psoriasis pathogenesis. However, the mechanisms leading to specific mRNA ex...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2019.11.003

    authors： Delić D,Wolk K,Schmid R,Gabrielyan O,Christou D,Rieber K,Rolser M,Jakob I,Wiech F,Griesser M,Wohnhaas C,Kokolakis G,Witte-Händel E,Baum P,Sabat R

    更新日期：2020-01-01 00:00:00

  • Similarly potent action of 1,25-dihydroxyvitamin D3 and its analogues, tacalcitol, calcipotriol, and maxacalcitol on normal human keratinocyte proliferation and differentiation.

    abstract：BACKGROUND:The active vitamin D3 regulates proliferation and differentiation of epidermal keratinocytes. Recently topical vitamin D3, tacalcitol, calcipotriol, and maxacalcitol are widely used for psoriasis. OBJECTIVE:To examine the effect of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) on cultured normal keratinocytes (NHK...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(02)00136-6

    authors： Takahashi H,Ibe M,Kinouchi M,Ishida-Yamamoto A,Hashimoto Y,Iizuka H

    更新日期：2003-02-01 00:00:00

  • Sox9 facilitates proliferation, differentiation and lipogenesis in primary cultured human sebocytes.

    abstract：BACKGROUND:The transcription factor Sox9 is pivotal in the morphogenesis of hair follicles, but its role in sebocytes is poorly understood. OBJECTIVE:We investigated the effect of Sox9 on human sebocyte proliferation, differentiation and lipogenesis. METHODS:Sox9 expression was detected by immunohistochemistry in nor...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2016.10.005

    authors： Shi G,Wang TT,Quan JH,Li SJ,Zhang MF,Liao PY,Fan YM

    更新日期：2017-01-01 00:00:00

  • Proteolytic digest derived from bovine Ligamentum Nuchae stimulates deposition of new elastin-enriched matrix in cultures and transplants of human dermal fibroblasts.

    abstract：BACKGROUND:Diverse topical products and injectable fillers used for correcting facial wrinkles induce rather short-lived effects because they target replacement of dermal collagen and hyaluronan, matrix components of limited biologic durability. OBJECTIVE:Present studies were aimed at stimulation of fully differentiat...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2005.04.002

    authors： Hinek A,Wang Y,Liu K,Mitts TF,Jimenez F

    更新日期：2005-09-01 00:00:00

  • Cannabinoids inhibit human keratinocyte proliferation through a non-CB1/CB2 mechanism and have a potential therapeutic value in the treatment of psoriasis.

    abstract：BACKGROUND:Cannabinoids from cannabis (Cannabis sativa) are anti-inflammatory and have inhibitory effects on the proliferation of a number of tumorigenic cell lines, some of which are mediated via cannabinoid receptors. Cannabinoid (CB) receptors are present in human skin and anandamide, an endogenous CB receptor ligan...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2006.10.009

    authors： Wilkinson JD,Williamson EM

    更新日期：2007-02-01 00:00:00

  • The mTOR-inhibitor Sirolimus decreases the cyclosporine-induced expression of the oncogene ATF3 in human keratinocytes.

    abstract：BACKGROUND:Due to their immunosuppressive therapy, organtransplant recipients (OTRs) exhibit a high incidence for the development of cutaneous squamous cell carcinoma (cSCC). Randomized studies of kidney-transplanted patients indicate a significant lower susceptibility for cSCC among patients receiving the mTOR-inhibit...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2018.08.013

    authors： Schaper-Gerhardt K,Walter A,Schmitz-Rode C,Satzger I,Gutzmer R

    更新日期：2018-11-01 00:00:00

  • Copper, zinc-superoxide dismutase protects from ultraviolet B-induced apoptosis of SV40-transformed human keratinocytes: the protection is associated with the increased levels of antioxidant enzymes.

    abstract：:It has been reported that cellular oxidative stress induces apoptosis. Ultraviolet radiation that generates reactive oxygen intermediates (ROIs) also induces apoptosis. Superoxide dismutase (SOD) is among the most active scavengers of ROIs, providing defense against the cellular oxidative stress. Mammalian cells expre...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(99)00060-2

    authors： Takahashi H,Hashimoto Y,Aoki N,Kinouchi M,Ishida-Yamamoto A,Iizuka H

    更新日期：2000-05-01 00:00:00

  • Epidermal turnover time.

    abstract：:Epidermal turnover time is the time taken for the epidermis to replace itself. The turnover time can be subdivided; when the epidermis is divided into proliferative compartment, differentiated compartment, and stratum corneum, the total turnover time is the sum of the turnover time of each compartment. Using Weinstein...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/0923-1811(94)90057-4

    authors： Iizuka H

    更新日期：1994-12-01 00:00:00

  • Efficacy and safety of ustekinumab for the treatment of moderate-to-severe psoriasis: a phase III, randomized, placebo-controlled trial in Taiwanese and Korean patients (PEARL).

    abstract：BACKGROUND:Ustekinumab has been evaluated in Caucasian patients with psoriasis, but no studies have been conducted in Asian patients. OBJECTIVE:To assess the efficacy and safety of ustekinumab in Taiwanese and Korean patients with moderate-to-severe psoriasis. METHODS:In this 36-week, multicenter, double-blind, place...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.jdermsci.2011.05.005

    authors： Tsai TF,Ho JC,Song M,Szapary P,Guzzo C,Shen YK,Li S,Kim KJ,Kim TY,Choi JH,Youn JI,PEARL Investigators.

    更新日期：2011-09-01 00:00:00

  • Functional alteration of guanine nucleotide binding proteins (Gs and Gi) in psoriatic epidermis.

    abstract：:Psoriatic involved epidermis has been characterized by a defective beta-adrenergic adenylate cyclase response. It is also characterized by increased cholera toxin- and forskolin-induced cyclic AMP accumulations. Due to the fact that receptor signals are transduced to adenylate cyclase through guanine nucleotides bindi...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(97)00069-8

    authors： Tamura T,Takahashi H,Ishida-Yamamoto A,Hashimoto Y,Iizuka H

    更新日期：1998-05-01 00:00:00

  • Clinical profiles of pediatric patients with GPP alone and with different IL36RN genotypes.

    abstract：BACKGROUND:IL36RN mutation has been identified as one pathogenesis of generalized pustular psoriasis, but the existence of GPP patients without mutation makes this controversial. OBJECTIVE:Our study aimed at assessing the differences in clinical profiles of children with GPP, with and without IL36RN mutation. METHODS...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2016.11.008

    authors： Wang Y,Cheng R,Lu Z,Guo Y,Yan M,Liang J,Huang P,Li M,Yao Z

    更新日期：2017-03-01 00:00:00

  • PCR and PCR-RFLP techniques targeting the DNA topoisomerase II gene for rapid clinical diagnosis of the etiologic agent of dermatophytosis.

    abstract：BACKGROUND:We have focused on the DNA topoisomerase II genes of several pathogenic fungi, and developed polymerase chain reaction (PCR) and PCR-restriction fragment length polymorphism (RFLP) methods targeting this gene for identification of dermatophytes. OBJECTIVE:To assess the availability of the PCR-based identifi...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2003.10.007

    authors： Kamiya A,Kikuchi A,Tomita Y,Kanbe T

    更新日期：2004-02-01 00:00:00

  • Zinc deficiency exacerbates pressure ulcers by increasing oxidative stress and ATP in the skin.

    abstract：BACKGROUND:Zinc deficiency is believed to be a predisposing factor for the development and intractable healing of pressure ulcers (PUs); however, the mechanisms of this association have not been elucidated. OBJECTIVE:Objective was to elucidate the mechanisms of the formation of severe and prolonged PUs under the zinc ...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2019.07.004

    authors： Nakamura H,Sekiguchi A,Ogawa Y,Kawamura T,Akai R,Iwawaki T,Makiguchi T,Yokoo S,Ishikawa O,Motegi SI

    更新日期：2019-08-01 00:00:00

  • Pilot study on novel skin care method by augmentation with Staphylococcus epidermidis, an autologous skin microbe--A blinded randomized clinical trial.

    abstract：BACKGROUND AND OBJECTIVE:Staphylococcus epidermidis is an autologous bacterium that is beneficial to skin health. Our goal was to develop a novel, personalized basic cosmetic that exploits this characteristic. METHODS:We conducted a double-blinded, randomized clinical trial on augmentation with S. epidermidis as a pil...

    journal_title：Journal of dermatological science

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.jdermsci.2015.05.001

    authors： Nodake Y,Matsumoto S,Miura R,Honda H,Ishibashi G,Matsumoto S,Dekio I,Sakakibara R

    更新日期：2015-08-01 00:00:00

  • New method for determining prognosis of patients with psoriasis (E-PAP).

    abstract：:We developed a new method for evaluating clinical symptoms of psoriasis during the observation period, by adding a parameter of time (the number of days) to the psoriasis area and severity index (PASI). This method was named the evaluation for prognosis with averaged PASI (E-PAP). Using this method, we assessed 14 cas...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(97)00047-9

    authors： Sugai J,Ozawa A,Kawakubo Y,Iizuka M,Miyahara M,Ohkido M

    更新日期：1998-01-01 00:00:00

  • Efficacy and safety of topical SR-T100 gel in treating actinic keratosis in Taiwan: A Phase III randomized double-blind vehicle-controlled parallel trial.

    abstract：BACKGROUND:Currently available topical treatments for actinic keratosis (AK) are associated with substantial side-effects. OBJECTIVES:To evaluate the efficacy and safety of topical SR-T100 gel in treating AK. METHODS:A multicenter, randomized, double-blinded phase III trial was conducted. Patients with at least two c...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.jdermsci.2018.02.015

    authors： Yang CC,Wong TW,Lee CH,Hong CH,Chang CH,Lai FJ,Lin SH,Chi CC,Lin TK,Yen H,Wu CH,Sheu HM,Lan CE

    更新日期：2018-06-01 00:00:00

  • Gene expression in canine atopic dermatitis and correlation with clinical severity scores.

    abstract：BACKGROUND:Canine atopic dermatitis (cAD) is a common condition in dogs that may be a naturally occurring model for human atopic dermatitis (hAD). Despite this, comparative research is limited, particularly into the genetic background of cAD. OBJECTIVES:1. Measure candidate gene expression in cAD skin using quantitati...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2009.03.005

    authors： Wood SH,Clements DN,Ollier WE,Nuttall T,McEwan NA,Carter SD

    更新日期：2009-07-01 00:00:00

  • Loss of factor XIIIa in pig dermis during tissue expansion.

    abstract：:Considerable evidence suggests that factor XIIIa, a blood coagulation factor, also functions in tissue repair, and specifically in the dynamic process of fibroplasia. On the other hand, the dynamic process of tissue expansion would require a loosening of the dermis, the opposite of fibroplasia. We examined the effects...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/0923-1811(91)90044-x

    authors： Penneys NS,Rademaker B,Jackson IT,Fasching MC

    更新日期：1991-01-01 00:00:00

  • Resolvin D1 attenuates imiquimod-induced mice psoriasiform dermatitis through MAPKs and NF-κB pathways.

    abstract：BACKGROUND:Resolvin D1 (RvD1), a pro-resolution lipid mediator derived from docosahexaenoic acid (DHA), has been described to promote several kinds of inflammatory resolution. However, the effects and anti-inflammatory mechanisms of RvD1 on psoriasis have not been previously reported. OBJECTIVE:The present study aimed...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2017.10.016

    authors： Xu J,Duan X,Hu F,Poorun D,Liu X,Wang X,Zhang S,Gan L,He M,Zhu K,Ming Z,Chen H

    更新日期：2018-02-01 00:00:00