View of life sciences in the 21st century.

abstract：BACKGROUND:Granzyme B (GrB) is recognized to induce apoptosis; however, little is known about its possible role in other biological events. IL-18, a potent inflammatory cytokine, is produced as an inactive precursor (proIL-18). Several cells, including monocytes/macrophage lineage and non-hematopoietic cells such as ke...

journal_title：Journal of dermatological science

authors： Omoto Y,Yamanaka K,Tokime K,Kitano S,Kakeda M,Akeda T,Kurokawa I,Gabazza EC,Tsutsui H,Katayama N,Yamanishi K,Nakanishi K,Mizutani H

更新日期：2010-08-01 00:00:00

abstract：UNLABELLED:The percutaneous absorption studies were performed using a flow-through diffusion cell system with skin specimens from 24 healthy women to assess the penetration of glycolic acid (GA). Percentages of GA, based on 14C-labelled activity, found in the skin after application of 4% GA at pH 2.0 or pH 3.8, after 2...

journal_title：Journal of dermatological science

authors： Jiang M,Qureshi SA

更新日期：1998-12-01 00:00:00

abstract：BACKGROUND:Dry skin causes pruritus and discomfort in patients with xerosis and atopic dermatitis. General treatment for skin dryness involves the topical application of an emollient. However, more effective, simpler therapies are desired. Collagen tripeptide (CTP) is a highly purified, non-antigenic, low-allergenic co...

journal_title：Journal of dermatological science

authors： Okawa T,Yamaguchi Y,Takada S,Sakai Y,Numata N,Nakamura F,Nagashima Y,Ikezawa Z,Aihara M

更新日期：2012-05-01 00:00:00

abstract：:Two different melanocyte-specific mRNAs are studied as markers for circulating melanoma cells in vitro using the human melanoma cell line G361 and in vivo using blood samples from Japanese melanoma patients at different clinical stages. These mRNAs encode tyrosinase, the most essential enzyme for melanin synthesis, an...

journal_title：Journal of dermatological science

authors： Tsukamoto K,Ueda M,Hirata S,Osada A,Kitamura R,Takahashi T,Ichihashi M,Shimada S

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND:Chemical peeling is one of the dermatological treatments available for certain cutaneous diseases and conditions or improvement of cosmetic appearance of photoaged skin. OBJECTIVES:We assessed the photochemopreventive effect of several clinically used chemical peeling agents on the ultraviolet (UV)-irradiat...

journal_title：Journal of dermatological science

authors： Abdel-Daim M,Funasaka Y,Kamo T,Ooe M,Matsunaka H,Yanagita E,Itoh T,Nishigori C

更新日期：2010-10-01 00:00:00

abstract：:Kindler syndrome is an autosomal recessive genodermatosis characterized by acral blistering in neonates and diffuse, progressive poikiloderma in later life. Other clinical features include photosensitivity, premature skin ageing and severe periodontal disease. Two groups have recently shown that the molecular basis of...

journal_title：Journal of dermatological science

authors： White SJ,McLean WH

更新日期：2005-06-01 00:00:00

abstract：BACKGROUND:In addition to their microbicidal properties, host defense peptides (HDPs) display various immunomodulatory functions, including keratinocyte production of cytokines/chemokines, proliferation, migration and wound healing. Recently, a novel HDP named AMP-IBP5 (antimicrobial peptide derived from insulin-like g...

journal_title：Journal of dermatological science

authors： Chieosilapatham P,Niyonsaba F,Kiatsurayanon C,Okumura K,Ikeda S,Ogawa H

更新日期：2017-10-01 00:00:00

abstract：:The immunomodulatory effect of the macrolide antibiotic, roxithromycin (RXM) on Langerhans cells (LC) was studied in mice. RXM inhibited the ability of LC to present superantigen and hapten to T cells at 100 microM. The superantigen-presenting activity of LC was more profoundly abrogated by RXM than the hapten-present...

journal_title：Journal of dermatological science

authors： Ohshima A,Tokura Y,Wakita H,Furukawa F,Takigawa M

更新日期：1998-07-01 00:00:00

abstract：:Alpha-N-acetylgalactosaminidase (alpha-NAGA) deficiency with angiokeratoma corporis diffusum (AKCD) is one of the lysosomal storage diseases. GalNAc(alpha))1-O-Ser/Thr (Tn) is theoretically deposited in lysosomes, but substances with attached galactose and neuraminic (sialic) acid (T and sialosyl Tn, respectively) are...

journal_title：Journal of dermatological science

authors： Kanda A,Tsuyama S,Murata F,Kodama K,Hirabayashi Y,Kanzaki T

更新日期：2002-05-01 00:00:00

abstract：:Serum levels of sIL-2R can be used to monitor in vivo immune activation and its elevation have been shown to be correlated with T cell mediated immune disease such as atopic dermatitis, psoriasis, lymphoma and systemic sclerosis. Vitiligo is the disease of depigmentation caused by destruction of melanocytes, and there...

journal_title：Journal of dermatological science

authors： Yeo UC,Yang YS,Park KB,Sung HT,Jung SY,Lee ES,Shin MH

更新日期：1999-04-01 00:00:00

abstract：:Herpes gestationis (HG) is a rare pregnancy-associated disease. The aim of this study was to compare various immunohistochemical and immunobiochemical techniques with respect to their diagnostic sensitivity for HG. We studied 43 HG sera; only half of these reacted with the basement membrane zone (BMZ) with both indire...

journal_title：Journal of dermatological science

authors： Murakami H,Amagai M,Higashiyama M,Hashimoto K,Chorzelski TP,Bhogal BS,Jenkins RE,Black MM,Zillikens D,Nishikawa T,Hashimoto T

更新日期：1996-11-01 00:00:00

abstract：:The effects of Werner's syndrome (WS) fibroblast-conditioned medium on cell proliferation and collagen production of normal fibroblasts were studied using four WS fibroblast strains. The conditioned medium from the WS fibroblasts brought about activation of normal fibroblast proliferation, whereas, that from late pass...

journal_title：Journal of dermatological science

authors： Hatamochi A,Arakawa M,Takeda K,Ueki H

更新日期：1994-06-01 00:00:00

abstract：BACKGROUND:Both lymph nodes (LNs) and lymphatic channels from primary sites to regional LNs are critical for initiation of adaptive immunity. However, as LNs are common metastatic sites in skin cancers, LN biopsies or dissections are frequently performed. In addition, reconstructive skin flaps after tumor resection may...

journal_title：Journal of dermatological science

authors： Nakamura Y,Fujisawa Y,Okiyama N,Watanabe R,Tanaka R,Ishitsuka Y,Tahara H,Fujimoto M

更新日期：2018-04-01 00:00:00

abstract：:Our previous study reported that advanced glycation end-products (AGE)-modified BSA produced active oxygen species, *O2-, H2O2, and *OH under UVA irradiation and enhanced the cytotoxicity of UVA light. We examined whether pentosidine in AGE-modified BSA was involved in one of the mechanisms generating the active oxyge...

journal_title：Journal of dermatological science

authors： Okano Y,Masaki H,Sakurai H

更新日期：2001-08-01 00:00:00

abstract：:Epidermal turnover time is the time taken for the epidermis to replace itself. The turnover time can be subdivided; when the epidermis is divided into proliferative compartment, differentiated compartment, and stratum corneum, the total turnover time is the sum of the turnover time of each compartment. Using Weinstein...

journal_title：Journal of dermatological science

authors： Iizuka H

更新日期：1994-12-01 00:00:00

abstract：:Clinical analysis was performed on anti-cardiolipin x beta2 glycoprotein 1 (ACL x beta2 GP1) antibody positive patients with collagen vascular diseases. Nine patients out of 89 showed positive aCL x beta2 GP1 antibody which was a relatively lower percentage compared to that of othoffanti-phospholipid antibodies, such ...

journal_title：Journal of dermatological science

authors： Katayama I,Nishioka K,Otoyama K

更新日期：1995-05-01 00:00:00

abstract：BACKGROUND:Diverse topical products and injectable fillers used for correcting facial wrinkles induce rather short-lived effects because they target replacement of dermal collagen and hyaluronan, matrix components of limited biologic durability. OBJECTIVE:Present studies were aimed at stimulation of fully differentiat...

journal_title：Journal of dermatological science

authors： Hinek A,Wang Y,Liu K,Mitts TF,Jimenez F

更新日期：2005-09-01 00:00:00

abstract：:Survival and extracellular matrix gene expression were studied by viable cell count assay and Northern transfer analysis to compare the sensitivity of normal skin and keloid fibroblasts towards x-irradiation. As the dosage of radiation increased, the numbers of viable cells in irradiated groups were remarkably decreas...

journal_title：Journal of dermatological science

authors： Lee KS,Jung JB,Ro YJ,Ryoo YW,Kim OB,Song JY

更新日期：1994-08-01 00:00:00

abstract：:Psoriasis is an immune-mediated disease associated with skin and joint inflammation that affects large proportions of populations worldwide. It is a heritable disease: individuals' genetic backgrounds modulate their susceptibility. In genetics, multiple human leukocyte antigen (HLA) genes are most strongly associated ...

journal_title：Journal of dermatological science

authors： Ogawa K,Okada Y

更新日期：2020-07-01 00:00:00

abstract：:Injury to vessel walls, especially microvascular damage due to free radicals, has been a focus of interest concerning the pathogenesis of systemic sclerosis. Excess reactive oxygen species may induce antioxidant defenses. We therefore measured plasma superoxide dismutase (SOD) activity in patients with systemic sclero...

journal_title：Journal of dermatological science

authors： Morita A,Minami H,Sakakibara N,Sato K,Tsuji T

更新日期：1996-03-01 00:00:00

abstract：BACKGROUND:Our previous study showed that T cells in skin lesions of human atopic dermatitis (AD) had oligoclonal accumulation, indicating the involvement of antigen-specific immune reactions at those sites. Recently, NC/Nga mice, which develop skin lesions similar to AD, have been proposed as a model for that disease....

journal_title：Journal of dermatological science

authors： Matsuoka A,Kato T,Soma Y,Takahama H,Nakamura M,Matsuoka H,Mizoguchi M

更新日期：2005-04-01 00:00:00

abstract：:Epidermolysis bullosa simplex associated with late onset of muscular dystrophy has been found to show defective expression of plectin, an intracytoplasmic protein in hemidesmosomes. In this report, we examined ability of cell-to-matrix attachment of cultured keratinocytes derived from a case with this disease by vario...

journal_title：Journal of dermatological science

authors： Kurose K,Mori O,Hachisuka H,Shimizu H,Owaribe K,Hashimoto T

更新日期：2000-12-01 00:00:00

abstract：:Mast cells are not only the primary effector cells of immediate type immune reactions, but they have recently also been considered to contribute to the induction of an immune response. Data on the ability of the cells to express major histocompatibility complex (MHC) antigens and the mechanisms involved are however co...

journal_title：Journal of dermatological science

authors： Grabbe J,Karau L,Welker P,Ziegler A,Henz BM

更新日期：1997-11-01 00:00:00

abstract：:Using fetal rat keratinizing epidermal cells (FRSK cells) we investigated the effects of retinoids on the cyclic AMP system. The beta-adrenergic adenylate cyclase response was significantly decreased by the treatment of cells with 1 x 10(-6) M Ro 10-1670. The effect was observed by 12 h and remained for at least 48 h....

journal_title：Journal of dermatological science

authors： Takahashi H,Iizuka H

更新日期：1993-04-01 00:00:00

abstract：:Temperature influences the stratum corneum adsorption of several topically applied compounds. This study was designed to evaluate the influence of the temperature on the stratum corneum adsorption of 3 UV filters. The UV filters were solubilized in two vehicles, an emulsion gel and petroleum jelly and applied at respe...

journal_title：Journal of dermatological science

authors： Clarys P,Gabard B,Lambrecht R,Barel A,Bieli E,Lüdi S

更新日期：2001-10-01 00:00:00

abstract：:Psoriatic skin lesions contain HLA-DR positive T lymphocytes, and other activation antigens, which suggest that the T cells may be producing lymphokines. Gamma interferon is produced by activated T cells, and its presence in psoriasis has been inferred by the lesional keratinocyte expression of 3 gamma interferon-indu...

journal_title：Journal of dermatological science

authors： Barker JN,Karabin GD,Stoof TJ,Sarma VJ,Dixit VM,Nickoloff BJ

更新日期：1991-03-01 00:00:00

abstract：BACKGROUND:Recent studies suggest that large (>1 cm) diameter circular cutaneous wounds induce follicular neogenesis in mice. However, the effects of non-circular wounds or smaller circular wounds on the hair follicle cycle remain poorly understood. OBJECTIVE:We investigated whether non-circular wounds or smaller (≤1 ...

journal_title：Journal of dermatological science

authors： Jiang S,Zhao L,Teklemariam T,Hantash BM

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:1 alpha,25-Dihydroxyvitamin D3 (1 alpha,25(OH)2D3), the active form of vitamin D, suppresses keratinocyte proliferation, promotes keratinocyte differentiation, and induces involucrin expression. Peroxisome proliferation-activated receptors (PPARs) are ligand-activated transcription factors. It has been repor...

journal_title：Journal of dermatological science

authors： Dai X,Sayama K,Shirakata Y,Tokumaru S,Yang L,Tohyama M,Hirakawa S,Hanakawa Y,Hashimoto K

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND:The exact mechanism of the inflammatory changes occurring during the development of Behçet's disease (BD) remains unclear. OBJECTIVE:We investigated the role of classical (M1) and alternative (M2) activation of macrophages in a herpes simplex virus (HSV)-induced BD mouse model. METHODS:The classical vs. al...

journal_title：Journal of dermatological science

authors： Anower AK,Shim JA,Choi B,Kwon HJ,Sohn S

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Aberrant expression of microRNAs (miRNAs) has been implicated in oncogenesis of various tumors and primary cutaneous T cell lymphomas. Dicer, a ribonuclease III-like enzyme is essential for miRNA processing. OBJECTIVE:We initiated a retrospective study to characterize the alterations in the expression profi...

journal_title：Journal of dermatological science

authors： Valencak J,Schmid K,Trautinger F,Wallnöfer W,Muellauer L,Soleiman A,Knobler R,Haitel A,Pehamberger H,Raderer M

更新日期：2011-12-01 00:00:00