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Elevated plasma superoxide dismutase activity in patients with systemic sclerosis.

Abstract：

:Injury to vessel walls, especially microvascular damage due to free radicals, has been a focus of interest concerning the pathogenesis of systemic sclerosis. Excess reactive oxygen species may induce antioxidant defenses. We therefore measured plasma superoxide dismutase (SOD) activity in patients with systemic sclerosis and found average SOD activity of plasma in 16 patients with systemic sclerosis (5.00 +/- 3.10 U/ml) to be significantly (P < 0.001) higher than those in 89 healthy volunteers (1.56 +/- 0.234 U/ml). Patients with Raynaud's phenomenon and/or skin sclerosis had particularly high SOD activity. These findings suggest that plasma SOD activity may serve as a useful parameter for assessment of sclerotic progression and the presence of Raynaud's phenomenon.

journal_name

J Dermatol Sci

journal_title

Journal of dermatological science

authors

Morita A,Minami H,Sakakibara N,Sato K,Tsuji T

doi

10.1016/0923-1811(95)00441-6

subject

Has Abstract

pub_date

1996-03-01 00:00:00

pages

196-201

issue

3

eissn

0923-1811

issn

1873-569X

pii

0923-1811(95)00441-6

journal_volume

11

pub_type

杂志文章

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