Objective scratch monitor evaluation of the effect of an antihistamine on nocturnal scratching in atopic dermatitis.


:We previously reported a simple and easy-to-use device, Scratch Monitor for evaluation of nocturnal scratching. In the present study, the effect of an antihistamine (azelastine hydrochloride) on atopic dermatitis was investigated using this device. In 40 patients with atopic dermatitis, nocturnal scratching was measured by the monitor, when taking the drug and while off medication. Neither the 'sleeping time' nor the 'pre-asleep time' differed significantly, but there was a significant difference in 'scratch rate', 'minute scratch records', 'hourly awake number' and 'awake rate', which indicated that this drug alleviated nocturnal scratching and sleep disturbance. The difference was most prominent especially in patients with a serum IgE > or = 1000 IU/ml as well as in patients with mild symptoms and normal serum lactate dehydrogenase levels. The drug was more effective for nocturnal scratching in the early period, when the 'sleeping time' was divided into three equal parts (early, mid and late periods) and each period was compared.


J Dermatol Sci


Endo K,Sano H,Fukuzumi T,Adachi J,Aoki T




Has Abstract


1999-12-01 00:00:00














  • Cannabinoids inhibit human keratinocyte proliferation through a non-CB1/CB2 mechanism and have a potential therapeutic value in the treatment of psoriasis.

    abstract:BACKGROUND:Cannabinoids from cannabis (Cannabis sativa) are anti-inflammatory and have inhibitory effects on the proliferation of a number of tumorigenic cell lines, some of which are mediated via cannabinoid receptors. Cannabinoid (CB) receptors are present in human skin and anandamide, an endogenous CB receptor ligan...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章


    authors: Wilkinson JD,Williamson EM

    更新日期:2007-02-01 00:00:00

  • Expression of antimicrobial peptides in diabetic foot ulcer.

    abstract:BACKGROUND:Foot ulcers are one of the main diabetes complications due to its high frequency and difficulty of complete healing. There are several factors that participate in diabetic ulcers development and limited information exists about the role of antimicrobial peptides (AMP) in its pathogenesis. OBJECTIVE:The aim ...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章


    authors: Rivas-Santiago B,Trujillo V,Montoya A,Gonzalez-Curiel I,Castañeda-Delgado J,Cardenas A,Rincon K,Hernandez ML,Hernández-Pando R

    更新日期:2012-01-01 00:00:00

  • Elevated plasma superoxide dismutase activity in patients with systemic sclerosis.

    abstract::Injury to vessel walls, especially microvascular damage due to free radicals, has been a focus of interest concerning the pathogenesis of systemic sclerosis. Excess reactive oxygen species may induce antioxidant defenses. We therefore measured plasma superoxide dismutase (SOD) activity in patients with systemic sclero...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章


    authors: Morita A,Minami H,Sakakibara N,Sato K,Tsuji T

    更新日期:1996-03-01 00:00:00

  • TGF-beta-induced SMAD signaling and gene regulation: consequences for extracellular matrix remodeling and wound healing.

    abstract::Members of the transforming growth factor-beta (TGF-beta) superfamily are pleiotropic cytokines that have the ability to regulate numerous cell functions, including proliferation, differentiation, apoptosis, epithelial-mesenchymal transition, and production of extracellular matrix, allowing them to play an important r...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章,评审


    authors: Schiller M,Javelaud D,Mauviel A

    更新日期:2004-08-01 00:00:00

  • The role of VEGF and thrombospondins in skin angiogenesis.

    abstract::The vasculature in adult skin remains normally quiescent, due to the dominant influence of endogenous angiogenesis inhibitors over angiogenic stimuli. However, skin retains the capacity for brisk initiation of angiogenesis, the growth of new blood vessels from preexisting vessels, during tissue repair and in numerous ...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章,评审


    authors: Detmar M

    更新日期:2000-12-01 00:00:00

  • Correlation of Merkel cell polyomavirus positivity with PDGFRα mutations and survivin expression in Merkel cell carcinoma.

    abstract:BACKGROUND:Merkel cell carcinoma (MCC) is a neuroendocrine cancer of the skin postulated to originate through Merkel cell polyomavirus (MCPyV) oncogenesis and/or by mutations in molecules implicated in the regulation of cell growth and survival. Despite the fact that MCPvV is detected more broadly within the population...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章


    authors: Batinica M,Akgül B,Silling S,Mauch C,Zigrino P

    更新日期:2015-07-01 00:00:00

  • Studies on specificity of peptidylarginine deiminase reactions using an immunochemical probe that recognizes an enzymatically deiminated partial sequence of mouse keratin K1.

    abstract::Citrulline residues are detected in keratins and filaggrin in the cornified layers of mammalian epidermis. Such citrulline residues are formed by the enzymatic deimination of arginine residues by peptidylarginine deiminases (EC Major deiminated keratins are derived from keratin K1. Two arginine residues ide...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章


    authors: Senshu T,Akiyama K,Ishigami A,Nomura K

    更新日期:1999-09-01 00:00:00

  • Genetic skin diseases related to desmosomes and corneodesmosomes.

    abstract::The integrity of the epidermis depends on the cohesion between keratinocytes, and desmosomes are the main adhesion structures. When cells become cornified, desmosomes are modified and transformed into corneodesmosomes. Mutations in the genes encoding desmosomal components underlie several skin diseases including palmo...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章,评审


    authors: Ishida-Yamamoto A,Igawa S

    更新日期:2014-05-01 00:00:00

  • Mechanism of action of androgen in hair follicles.

    abstract::In order to investigate the mode of action of testosterone (T) on human hair follicles we studied the metabolism of T and localization of androgen receptors in outer root sheath cells (ORSC) and dermal papilla cells (DPC) from different body sites. T was principally metabolized to androstenedione (delta 4) even in bea...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章


    authors: Itami S,Sonoda T,Kurata S,Takayasu S

    更新日期:1994-07-01 00:00:00

  • Neutrophil elastase contributes to extracellular matrix damage induced by chronic low-dose UV irradiation in a hairless mouse photoaging model.

    abstract:BACKGROUND:Repeated exposure to ultraviolet (UV) rays damages skin connective tissue, which is thought to be associated with wrinkle formation. We hypothesized that repeated mild inflammation may cause the connective tissue alterations in photoaging. OBJECTIVE:To clarify the behavior of neutrophils and neutrophil elas...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章


    authors: Takeuchi H,Gomi T,Shishido M,Watanabe H,Suenobu N

    更新日期:2010-12-01 00:00:00

  • Keratinocyte growth factor and keratin gene regulation.

    abstract::Keratinocyte growth factor (KGF) is a stromally derived paracrine mitogen that belongs to the fibroblast growth factor (FGF) family. It is secreted by dermal fibroblasts and specifically promotes keratinocyte proliferation. We have recently shown that epidermal growth factor (EGF) and transforming growth factor beta (...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章


    authors: Latkowski JM,Freedberg IM,Blumenberg M

    更新日期:1995-01-01 00:00:00

  • Expression of inducible nitric oxide synthase in skin lesions of acute herpes zoster.

    abstract::Histopathologically, the skin lesions of acute herpes zoster (AHZ) are characterized by epidermal necrotic vesicles with inflammation. Nitric oxide (NO) is generated from L-arginine by nitric oxide synthase (NOS), and immune inflammation involves the activation of NOS in both effector cells and target cells. NO can ca...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章


    authors: Lim YJ,Chang SE,Choi JH,Sung KJ,Bahk JH,Do SH,Lee DS

    更新日期:2002-09-01 00:00:00

  • Treatment with TNF-α inhibitor rectifies M1 macrophage polarization from blood CD14+ monocytes in patients with psoriasis independent of STAT1 and IRF-1 activation.

    abstract:BACKGROUND:Psoriasis is a systemic inflammatory disease with dramatic responses to TNF-α inhibitors. TNF-α is mainly produced by macrophages. However, how macrophage polarization contributes to psoriasis remains unknown. OBJECTIVE:We aimed to investigate the molecular mechanisms of macrophage polarization in psoriasis...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章


    authors: Lin SH,Chuang HY,Ho JC,Lee CH,Hsiao CC

    更新日期:2018-09-01 00:00:00

  • Harlequin ichthyosis and other autosomal recessive congenital ichthyoses: the underlying genetic defects and pathomechanisms.

    abstract::Autosomal recessive congenital ichthyoses (ARCI) include several severe subtypes including harlequin ichthyosis (HI), lamellar ichthyosis and non-bullous congenital ichthyosiform erythroderma. Patients with these severe types of ichthyoses frequently show severe hyperkeratosis and scales over a large part of the body ...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章,评审


    authors: Akiyama M

    更新日期:2006-05-01 00:00:00

  • Telomerase in cutaneous carcinogenesis.

    abstract::Telomerase is a ribonucleoprotein enzyme that catalyses the addition of telomeric repeats to telomeres. Since the shortening of telomeres is thought to act as a mitotic clock, activation of telomerase is crucial for the continued growth of cancer cells. Telomerase is frequently activated in premalignant and malignant ...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章,评审


    authors: Ueda M

    更新日期:2000-03-01 00:00:00

  • Epicutaneous sensitization with a protein antigen induces Th17 cells.

    abstract:BACKGROUND:Th17 is a newly identified effector T cell lineage which plays a central role in many human inflammatory diseases and experimental animal models. Epicutaneous sensitization with a protein antigen has been proven to induce a Th2-predominant immune response and lead to development of atopic diseases in a murin...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章


    authors: Wang LF,Chiu HC,Hsu CJ,Liu CY,Hsueh YH,Miaw SC

    更新日期:2009-06-01 00:00:00

  • Epidermal turnover time.

    abstract::Epidermal turnover time is the time taken for the epidermis to replace itself. The turnover time can be subdivided; when the epidermis is divided into proliferative compartment, differentiated compartment, and stratum corneum, the total turnover time is the sum of the turnover time of each compartment. Using Weinstein...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章


    authors: Iizuka H

    更新日期:1994-12-01 00:00:00

  • Novel ex vivo disease model for extramammary Paget's disease using the cancer tissue-originated spheroid method.

    abstract:BACKGROUND:Extramammary Paget's disease (EMPD) is a rare skin cancer that frequently occurs in the anogenital region in the elderly. Prognosis in patients with metastatic EMPD is poor as EMPD treatment has advanced little in recent years, primarily because no EMPD cell line has been established. OBJECTIVE:We aimed to ...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章


    authors: Arita T,Kondo J,Kaneko Y,Tsutsumi M,Kanemaru M,Matsui M,Arakawa Y,Katoh N,Inoue M,Asai J

    更新日期:2020-09-01 00:00:00

  • Three dimensional structural studies of alpha-N-acetylgalactosaminidase (alpha-NAGA) in alpha-NAGA deficiency (Kanzaki disease): different gene mutations cause peculiar structural changes in alpha-NAGAs resulting in different substrate specificities and c

    abstract:BACKGROUND:Kanzaki disease (OMIM#104170) is attributable to a deficiency in alpha-N-acetylgalactosaminidase (alpha-NAGA; E.C., which hydrolyzes GalNAcalpha1-O-Ser/Thr. Missense mutations, R329W or R329Q were identified in two Japanese Kanzaki patients. Although they are on the same codon, the clinical manifest...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章


    authors: Kanekura T,Sakuraba H,Matsuzawa F,Aikawa S,Doi H,Hirabayashi Y,Yoshii N,Fukushige T,Kanzaki T

    更新日期:2005-01-01 00:00:00

  • Histamine stimulates normal human melanocytes in vitro: one of the possible inducers of hyperpigmentation in urticaria pigmentosa.

    abstract::Isolated normal human melanocytes became enlarged and more dendritic in association with an increase in the activity of tyrosinase and the amount of b-locus protein when they were cultured with 0.1-10 microM histamine in vitro. However, histamine did not exert a proliferative effect on them. The stimulatory effect of ...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章


    authors: Tomita Y,Maeda K,Tagami H

    更新日期:1993-10-01 00:00:00

  • Dermal carotenoid level and kinetics after topical and systemic administration of antioxidants: enrichment strategies in a controlled in vivo study.

    abstract:BACKGROUND:High doses of sun-emitted UV-radiation induce reactive oxygen species (ROS) as major pro-oxidants thus inducing premature skin aging. The best prevention of the destructive action of free radicals in human skin is textile coverings, topical sunscreens and the development of a high antioxidative protective ne...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章


    authors: Darvin ME,Fluhr JW,Schanzer S,Richter H,Patzelt A,Meinke MC,Zastrow L,Golz K,Doucet O,Sterry W,Lademann J

    更新日期:2011-10-01 00:00:00

  • Establishment of a new murine-phenotypic angiosarcoma cell line (ISOS-1).

    abstract::A cell line, designated ISOS-1, was established from a tumor formed by transplantation of a human angiosarcoma into mice with severe combined immunodeficiency (SCID). The cells showed endothelial properties, based on the uptake of Dil-Ac-LDL and binding of UEA-I/GSA-I lectins, but were negative for CD11b and Pan Cytok...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章


    authors: Masuzawa M,Fujimura T,Tsubokawa M,Nishiyama S,Katsuoka K,Terada E,Kunita S,Sakurai Y,Kato H

    更新日期:1998-01-01 00:00:00

  • Cytokine modulation of retinoic acid-inducible gene-I (RIG-I) expression in human epidermal keratinocytes.

    abstract:BACKGROUND:Retinoic acid-inducible gene-I (RIG-I) is a member of the DExH/D box family proteins and designated as a putative RNA helicase, which plays various roles in gene expression and cellular functions in response to a variety of RNA viruses. OBJECTIVE:The present study was designed to investigate the effects of ...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章


    authors: Kitamura H,Matsuzaki Y,Kimura K,Nakano H,Imaizumi T,Satoh K,Hanada K

    更新日期:2007-02-01 00:00:00

  • Surgical damage to the lymphatic system promotes tumor growth via impaired adaptive immune response.

    abstract:BACKGROUND:Both lymph nodes (LNs) and lymphatic channels from primary sites to regional LNs are critical for initiation of adaptive immunity. However, as LNs are common metastatic sites in skin cancers, LN biopsies or dissections are frequently performed. In addition, reconstructive skin flaps after tumor resection may...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章


    authors: Nakamura Y,Fujisawa Y,Okiyama N,Watanabe R,Tanaka R,Ishitsuka Y,Tahara H,Fujimoto M

    更新日期:2018-04-01 00:00:00

  • Pilot study on novel skin care method by augmentation with Staphylococcus epidermidis, an autologous skin microbe--A blinded randomized clinical trial.

    abstract:BACKGROUND AND OBJECTIVE:Staphylococcus epidermidis is an autologous bacterium that is beneficial to skin health. Our goal was to develop a novel, personalized basic cosmetic that exploits this characteristic. METHODS:We conducted a double-blinded, randomized clinical trial on augmentation with S. epidermidis as a pil...

    journal_title:Journal of dermatological science

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Nodake Y,Matsumoto S,Miura R,Honda H,Ishibashi G,Matsumoto S,Dekio I,Sakakibara R

    更新日期:2015-08-01 00:00:00

  • Non-disulfided pro alpha 1(IV) chain in B16 melanoma cell culture.

    abstract::We have previously reported that two species of pro alpha 1(IV) collagen chains, disulfided (500 kDa) and non-disulfided (180 kDa), were produced by B16 melanoma cells (J Biochem (1994) 116; 1039-1043). The mechanism by which the non-disulfided pro alpha 1(IV) chain is produced was studied. No significant difference i...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章


    authors: Tajima S,Tokimitsu I

    更新日期:1996-10-01 00:00:00

  • Increased SS bonds in chronic solar elastosis: a study with N-(7-dimethylamino-4-methyl-3-coumarinyl) maleimide (DACM) stain.

    abstract::We have studied the distribution of SH groups and SS linkages in solar elastosis, in comparison with that in aged and juvenile sun-unexposed skin, using N-(7-dimethylamino-4-methyl-3-coumarinyl) maleimide (DACM) stain. In heavy solar elastosis we found increased fluorescence for SS bonds in the upper and middle reticu...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章


    authors: Pravatà G,Noto G,Aricò M

    更新日期:1994-02-01 00:00:00

  • Kindler surprise: mutations in a novel actin-associated protein cause Kindler syndrome.

    abstract::Kindler syndrome is an autosomal recessive genodermatosis characterized by acral blistering in neonates and diffuse, progressive poikiloderma in later life. Other clinical features include photosensitivity, premature skin ageing and severe periodontal disease. Two groups have recently shown that the molecular basis of...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章,评审


    authors: White SJ,McLean WH

    更新日期:2005-06-01 00:00:00

  • Activation of fibroblast proliferation by Werner's syndrome fibroblast-conditioned medium.

    abstract::The effects of Werner's syndrome (WS) fibroblast-conditioned medium on cell proliferation and collagen production of normal fibroblasts were studied using four WS fibroblast strains. The conditioned medium from the WS fibroblasts brought about activation of normal fibroblast proliferation, whereas, that from late pass...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章


    authors: Hatamochi A,Arakawa M,Takeda K,Ueki H

    更新日期:1994-06-01 00:00:00

  • Cicatricial pemphigoid sera specifically react with the most C-terminal portion of BP180.

    abstract:BACKGROUND:cicatricial pemphigoid and bullous pemphigoid are characterized by circulating autoantibodies to the hemidesmosomal protein, BP180. Different clinical features between cicatricial pemphigoid and bullous pemphigoid appear to correlate with distinct target epitopes on BP180. Previous studies demonstrated that ...

    journal_title:Journal of dermatological science

    pub_type: 杂志文章


    authors: Lee JB,Liu Y,Hashimoto T

    更新日期:2003-06-01 00:00:00