Objective scratch monitor evaluation of the effect of an antihistamine on nocturnal scratching in atopic dermatitis.

Abstract:

:We previously reported a simple and easy-to-use device, Scratch Monitor for evaluation of nocturnal scratching. In the present study, the effect of an antihistamine (azelastine hydrochloride) on atopic dermatitis was investigated using this device. In 40 patients with atopic dermatitis, nocturnal scratching was measured by the monitor, when taking the drug and while off medication. Neither the 'sleeping time' nor the 'pre-asleep time' differed significantly, but there was a significant difference in 'scratch rate', 'minute scratch records', 'hourly awake number' and 'awake rate', which indicated that this drug alleviated nocturnal scratching and sleep disturbance. The difference was most prominent especially in patients with a serum IgE > or = 1000 IU/ml as well as in patients with mild symptoms and normal serum lactate dehydrogenase levels. The drug was more effective for nocturnal scratching in the early period, when the 'sleeping time' was divided into three equal parts (early, mid and late periods) and each period was compared.

journal_name

J Dermatol Sci

authors

Endo K,Sano H,Fukuzumi T,Adachi J,Aoki T

doi

10.1016/s0923-1811(99)00048-1

subject

Has Abstract

pub_date

1999-12-01 00:00:00

pages

54-61

issue

1

eissn

0923-1811

issn

1873-569X

pii

S0923181199000481

journal_volume

22

pub_type

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