当前位置： SCI文献检索 > JOURNAL OF DERMATOLOGICAL SCIENCE期刊下所有文献 > Studies on specificity of peptidylarginine deiminase reactions using an immunochemical probe that recognizes an enzymatically deiminated partial sequence of mouse keratin K1.

Studies on specificity of peptidylarginine deiminase reactions using an immunochemical probe that recognizes an enzymatically deiminated partial sequence of mouse keratin K1.

Abstract：

:Citrulline residues are detected in keratins and filaggrin in the cornified layers of mammalian epidermis. Such citrulline residues are formed by the enzymatic deimination of arginine residues by peptidylarginine deiminases (EC 3.5.3.15). Major deiminated keratins are derived from keratin K1. Two arginine residues identified as preferred deimination sites in mouse K1 are located in its V subdomains. To develop an immunochemical probe which recognizes the deiminated peptide sequence specifically, we enzymatically deiminated an undecapeptide corresponding to the deiminated peptide sequence identified in the V2 subdomain for immunizing rabbits. An IgG fraction obtained from the antiserum was affinity-purified using an immobilized peptide column. The affinity-purified IgG showed high specificity towards partially degraded keratin K1 obtained from the cornified layer of 3-day-old mouse epidermis. It also yielded intense signals of unidentified minor components localized in the cornified layers of late embryonic and early postnatal mouse epidermis. Comparative studies using different types of the enzymes suggested that peptidylarginine deiminase type I acted on the arginine residue in the V2 subdomain of keratin K1 more readily than peptidylarginine deiminase type II. The data are discussed in conjunction with possible factors influencing the specificity of the enzyme reaction.

journal_name

J Dermatol Sci

journal_title

Journal of dermatological science

authors

Senshu T,Akiyama K,Ishigami A,Nomura K

doi

10.1016/s0923-1811(99)00026-2

subject

Has Abstract

pub_date

1999-09-01 00:00:00

pages

113-26

issue

2

eissn

0923-1811

issn

1873-569X

pii

S0923-1811(99)00026-2

journal_volume

21

pub_type

杂志文章

相关文献

JOURNAL OF DERMATOLOGICAL SCIENCE文献大全
  • Modulation of UVA light-induced oxidative stress by beta-carotene, lutein and astaxanthin in cultured fibroblasts.

    abstract：:The ability of beta-carotene, lutein or astaxanthin to protect against UVA-induced oxidative stress in rat kidney fibroblasts (NRK) was assessed. Activities of the antioxidant enzymes catalase (CAT) and superoxide dismutase (SOD), and changes in thiobarbituric acid reactive substances (TBARS) were measured as indices ...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(97)00058-3

    authors： O'Connor I,O'Brien N

    更新日期：1998-03-01 00:00:00

  • TGF-beta-induced SMAD signaling and gene regulation: consequences for extracellular matrix remodeling and wound healing.

    abstract：:Members of the transforming growth factor-beta (TGF-beta) superfamily are pleiotropic cytokines that have the ability to regulate numerous cell functions, including proliferation, differentiation, apoptosis, epithelial-mesenchymal transition, and production of extracellular matrix, allowing them to play an important r...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章,评审

    doi：10.1016/j.jdermsci.2003.12.006

    authors： Schiller M,Javelaud D,Mauviel A

    更新日期：2004-08-01 00:00:00

  • Tranexamic acid inhibits melanogenesis by activating the autophagy system in cultured melanoma cells.

    abstract：BACKGROUND:As interest in skin beauty increases, the development of new skin whitening agents has attracted substantial attention; however, the action mechanism of the agents developed so far remains largely unknown. Tranexamic acid (TXA) is commonly being used to reduce melanin synthesis in patients with melasma and a...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2017.05.019

    authors： Cho YH,Park JE,Lim DS,Lee JS

    更新日期：2017-10-01 00:00:00

  • Assessment of in vitro percutaneous absorption of glycolic acid through human skin sections using a flow-through diffusion cell system.

    abstract：UNLABELLED:The percutaneous absorption studies were performed using a flow-through diffusion cell system with skin specimens from 24 healthy women to assess the penetration of glycolic acid (GA). Percentages of GA, based on 14C-labelled activity, found in the skin after application of 4% GA at pH 2.0 or pH 3.8, after 2...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(98)00039-5

    authors： Jiang M,Qureshi SA

    更新日期：1998-12-01 00:00:00

  • Carbonylated proteins exposed to UVA and to blue light generate reactive oxygen species through a type I photosensitizing reaction.

    abstract：BACKGROUND:Carbonylated proteins (CPs) are generated by the reaction of basic amino acid residues in proteins with aldehyde compounds produced during lipid peroxidation. CPs in the stratum corneum (SC) impact skin conditions such as skin moisture functions including water content and transepidermal water loss (TEWL). I...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2016.09.016

    authors： Mizutani T,Sumida H,Sagawa Y,Okano Y,Masaki H

    更新日期：2016-12-01 00:00:00

  • TGF-beta1 increases cell rigidity by enhancing expression of smooth muscle actin: keloid-derived fibroblasts as a model for cellular mechanics.

    abstract：BACKGROUND:Mechanical transduction contributes to appropriate cell functions. Clinically, keloid, an uncontrolled fibrous overgrowth and scarring, preferentially affects skin areas subject to higher mechanical tension than others. Keloid-derived fibroblasts have exaggerated TGF-beta1-mediated responses, including smoot...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2012.06.004

    authors： Lee CH,Hong CH,Chen YT,Chen YC,Shen MR

    更新日期：2012-09-01 00:00:00

  • Cicatricial pemphigoid sera specifically react with the most C-terminal portion of BP180.

    abstract：BACKGROUND:cicatricial pemphigoid and bullous pemphigoid are characterized by circulating autoantibodies to the hemidesmosomal protein, BP180. Different clinical features between cicatricial pemphigoid and bullous pemphigoid appear to correlate with distinct target epitopes on BP180. Previous studies demonstrated that ...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(03)00035-5

    authors： Lee JB,Liu Y,Hashimoto T

    更新日期：2003-06-01 00:00:00

  • Nuclear expression of IL-33 in epidermal keratinocytes promotes wound healing in mice.

    abstract：BACKGROUND:Skin is the outermost tissue of the human body, and works as a mechanical, chemical, and biological barrier. The epidermis is the uppermost layer of the skin, and keratinocytes constitute the majority of epidermal cells. Wounds are disruptions of skin integrity, and cause tremendous disadvantages to humans; ...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2016.10.008

    authors： Oshio T,Komine M,Tsuda H,Tominaga SI,Saito H,Nakae S,Ohtsuki M

    更新日期：2017-02-01 00:00:00

  • New method for determining prognosis of patients with psoriasis (E-PAP).

    abstract：:We developed a new method for evaluating clinical symptoms of psoriasis during the observation period, by adding a parameter of time (the number of days) to the psoriasis area and severity index (PASI). This method was named the evaluation for prognosis with averaged PASI (E-PAP). Using this method, we assessed 14 cas...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(97)00047-9

    authors： Sugai J,Ozawa A,Kawakubo Y,Iizuka M,Miyahara M,Ohkido M

    更新日期：1998-01-01 00:00:00

  • Exploring the imbalance of circulating follicular helper CD4+ T cells in sarcoidosis patients.

    abstract：BACKGROUND:Sarcoidosis is a systemic granulomatous disease characterized by the combination of Th1 and Th17 responses. Recently, several arguments have suggested a potential involvement of B cells as well as T cells in the pathogenesis of sarcoidosis. Follicular helper CD4+ T (TFH) cells are specialized in interacting ...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2020.02.002

    authors： Ly NTM,Ueda-Hayakawa I,Nguyen CTH,Okamoto H

    更新日期：2020-03-01 00:00:00

  • The production of superantigenic exotoxins by coagulase-negative staphylococci isolated from human skin lesions.

    abstract：:We examined the production of superantigenic exotoxins in 136 coagulase-negative staphylococci isolated from various skin lesions in humans using a reversed passive latex agglutination test (Denka Seiken). As a control we examined the same in 50 Staphylococcus aureus strains isolated from non-infective skin ulcers in ...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(00)00122-5

    authors： Akiyama H,Yamasaki O,Tada J,Arata J

    更新日期：2000-11-01 00:00:00

  • Genetic predisposition to bullous pemphigoid.

    abstract：:Bullous pemphigoid (BP) is a common autoimmune blistering skin disease that mainly affects elderly patients. Although BP risk is strongly influenced by age, genetic factors are also important determinants of this disease. Many genomic regions, especially in the HLA-II region, have been found to influence BP susceptibi...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章,评审

    doi：10.1016/j.jdermsci.2020.05.010

    authors： Zhang J,Wang G

    更新日期：2020-11-01 00:00:00

  • Butylated hydroxyanisole blocks the inhibitory effects of tumor necrosis factor-alpha on collagen production in human dermal fibroblasts.

    abstract：:Tumor necrosis factor-alpha (TNF-alpha) has been demonstrated to selectively decrease the production of type I and type III collagens in human dermal fibroblasts. The effects of the commonly used food antioxidants, butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), alpha-tocopherol, propyl gallate, supero...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/0923-1811(95)00463-7

    authors： Taniguchi S,Furukawa M,Kono T,Hisa T,Ishii M,Hamada T

    更新日期：1996-04-01 00:00:00

  • Analysis of T cell receptor (TCR) BV-gene clonotypes in NC/Nga mice developing dermatitis resembling human atopic dermatitis.

    abstract：BACKGROUND:Our previous study showed that T cells in skin lesions of human atopic dermatitis (AD) had oligoclonal accumulation, indicating the involvement of antigen-specific immune reactions at those sites. Recently, NC/Nga mice, which develop skin lesions similar to AD, have been proposed as a model for that disease....

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2004.11.011

    authors： Matsuoka A,Kato T,Soma Y,Takahama H,Nakamura M,Matsuoka H,Mizoguchi M

    更新日期：2005-04-01 00:00:00

  • Surgical damage to the lymphatic system promotes tumor growth via impaired adaptive immune response.

    abstract：BACKGROUND:Both lymph nodes (LNs) and lymphatic channels from primary sites to regional LNs are critical for initiation of adaptive immunity. However, as LNs are common metastatic sites in skin cancers, LN biopsies or dissections are frequently performed. In addition, reconstructive skin flaps after tumor resection may...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2017.12.016

    authors： Nakamura Y,Fujisawa Y,Okiyama N,Watanabe R,Tanaka R,Ishitsuka Y,Tahara H,Fujimoto M

    更新日期：2018-04-01 00:00:00

  • Neural stem cells inhibit melanin production by activation of Wnt inhibitors.

    abstract：BACKGROUND:Melanin for skin pigmentation is synthesized from tyrosine via an enzymatic cascade that is controlled by tyrosinase (TYR), tyrosinase-related protein 1 (TRP1), and dopachrome tautomerase/tyrosinase related protein 2 (Dct/TRP2), which are the targets of microphthalmia-associated transcription factor (MITF). ...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2013.08.006

    authors： Hwang I,Park JH,Park HS,Choi KA,Seol KC,Oh SI,Kang S,Hong S

    更新日期：2013-12-01 00:00:00

  • Cloning of the hamster androgen receptor gene.

    abstract：:Flank organs of male Golden Syrian hamsters contain sebaceous glands and hair follicles whose morphology and function are highly dependent on androgen, which makes these organs a useful model to study androgen action. In order to investigate molecular mechanisms of androgen action, we cloned a cDNA encoding the hamste...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(00)00172-9

    authors： Shiba K,Hamaguchi T,Kataoka K,Yamaguchi Y,Handa H,Adachi K

    更新日期：2001-07-01 00:00:00

  • Effects of kestose on gut mucosal immunity in an atopic dermatitis mouse model.

    abstract：BACKGROUND:Atopic dermatitis (AD) is recently increasing among populations, but the underlying mechanisms remain controversial. Interactions between the gut microbiota and mucosal immunity are considered to be a crucial etiology. Fructooligosaccharide (FOS), prebiotics have been reported as activators of the gut microb...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2017.10.006

    authors： Kim HJ,Lee SH,Go HN,Ahn JR,Kim HJ,Hong SJ

    更新日期：2018-01-01 00:00:00

  • The current landscape of psoriasis genetics in 2020.

    abstract：:Psoriasis is an immune-mediated disease associated with skin and joint inflammation that affects large proportions of populations worldwide. It is a heritable disease: individuals' genetic backgrounds modulate their susceptibility. In genetics, multiple human leukocyte antigen (HLA) genes are most strongly associated ...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章,评审

    doi：10.1016/j.jdermsci.2020.05.008

    authors： Ogawa K,Okada Y

    更新日期：2020-07-01 00:00:00

  • Occupational trichloroethylene hypersensitivity syndrome: human herpesvirus 6 reactivation and rash phenotypes.

    abstract：BACKGROUND:Trichloroethylene (TCE) is an industrial solvent which can cause severe generalized dermatitis, i.e., occupational TCE hypersensitivity syndrome. Reactivation of latent human herpesvirus 6 (HHV6) can occur in such patients, which has made TCE known as a causative chemical of drug-induced hypersensitivity syn...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2013.07.003

    authors： Kamijima M,Wang H,Yamanoshita O,Ito Y,Xia L,Yanagiba Y,Chen C,Okamura A,Huang Z,Qiu X,Song X,Cai T,Liu L,Ge Y,Deng Y,Naito H,Yoshikawa T,Tohyama M,Li L,Huang H,Nakajima T

    更新日期：2013-12-01 00:00:00

  • The retinoic acid-induced up-regulation of insulin-like growth factor 1 and 2 is associated with prolidase-dependent collagen synthesis in UVA-irradiated human dermal equivalents.

    abstract：BACKGROUND:Ultraviolet (UV) A irradiation causes the degeneration of extracellular matrix in the skin dermis, mainly due to disrupted collagen homeostasis, resulting in the photo-aging of human skin. All-trans retinoic acid (ATRA) improves photo-aged human skin in vivo. OBJECTIVES:Although the effects of ATRA on colla...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2011.12.008

    authors： Shim JH,Shin DW,Lee TR,Kang HH,Jin SH,Noh M

    更新日期：2012-04-01 00:00:00

  • Hydroquinone-salicylic acid conjugates as novel anti-melasma actives show superior skin targeting compared to the parent drugs.

    abstract：BACKGROUND:Hydroquinone (HQ) and salicylic acid (SA) are drugs for treating melasma through the mechanisms of tyrosinase inhibition and chemical peeling, respectively. Their high frequency of causing skin irritation has led to limited use of both drugs. OBJECTIVES:We designed the new conjugates obtained by joining HQ ...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2014.08.013

    authors： Hsieh PW,Aljuffali IA,Fang CL,Chang SH,Fang JY

    更新日期：2014-11-01 00:00:00

  • Vascular endothelial growth factor (VEGF) in the pathogenesis of psoriasis--a possible target for novel therapies?

    abstract：:Angiogenesis is defined as the formation of new capillaries from pre-existing blood vessels. The process of angiogenesis is tightly regulated by a balance between pro- and anti-angiogenic factors. Vascular endothelial growth factor (VEGF) is a pro-angiogenic factor and several anti-VEGF therapies are used in the treat...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章,评审

    doi：10.1016/j.jdermsci.2010.03.023

    authors： Canavese M,Altruda F,Ruzicka T,Schauber J

    更新日期：2010-06-01 00:00:00

  • Photocontact dermatitis and chloracne: two major occupational and environmental skin diseases induced by different actions of halogenated chemicals.

    abstract：:Among occupational and environmental disorders, contact or photocontact dermatitis and an acneiform eruption are two major skin disorders. Photocontact dermatitis was historically caused by various halogenated salicylanilides, while the acne is induced by halogenated aromatic hydrocarbons and thus called chloracne. Th...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章,评审

    doi：10.1016/s0923-1811(03)00097-5

    authors： Yamamoto O,Tokura Y

    更新日期：2003-08-01 00:00:00

  • An attempt to develop mouse model for anti-laminin γ1 pemphigoid.

    abstract：BACKGROUND:We recently reported that the autoantibodies of anti-p200 pemphigoid sera react with laminin γ1 and renamed this entity as anti-laminin γ1 pemphigoid. However, it has not been clarified whether the anti-laminin γ1 autoantibodies, particularly those to the C-terminal integrin binding site, affect the dermoepi...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2013.01.001

    authors： Koga H,Ishii N,Dainichi T,Tsuruta D,Hamada T,Ohata C,Karashima T,Furumura M,Hashimoto T

    更新日期：2013-05-01 00:00:00

  • Influences of keratinocyte-fibroblast interaction on the expression of epimorphin by fibroblasts in vitro.

    abstract：:Epimorphin was demonstrated to be a mesenchymal signal factor modulating epithelial morphogenesis of skin, lung and liver in vitro. Most of the previous studies were performed biochemically and functionally. In the present study, expression of epimorphin was immunohistochemically compared between cultured fibroblasts ...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/s0923-1811(98)00081-4

    authors： Zhang L,Ishikawa O,Takeuchi Y,Yokoyama Y,Miyachi Y

    更新日期：1999-07-01 00:00:00

  • Kojic acid-induced IL-6 production in human keratinocytes plays a role in its anti-melanogenic activity in skin.

    abstract：BACKGROUND:Kojic acid is a fungal metabolite widely used in medicinal and cosmetic formulations as a skin-lightening agent based on its de-pigmenting activity. Although in human clinical studies kojic acid has been shown to be effective in the treatment of hyper-pigmentation disorders such as melasma, the reasons for i...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2012.03.002

    authors： Choi H,Kim K,Han J,Choi H,Jin SH,Lee EK,Shin DW,Lee TR,Lee AY,Noh M

    更新日期：2012-06-01 00:00:00

  • Keratinocyte-derived TGFβ is not required to maintain skin immune homeostasis.

    abstract：BACKGROUND:Transforming growth factor beta 1 (TGFβ) is known to be a regulator of autoimmunity. Loss of TGFβ leads to severe multi-organ autoimmunity in mice. In skin, role of TGFβ in suppressing autoimmunity is unclear. OBJECTIVE:Determine whether Keratinocyte (KC)-derived TGFβ is required for skin immune homeostasis...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2019.04.008

    authors： Yang Y,Zenke Y,Hirai T,Kaplan DH

    更新日期：2019-05-01 00:00:00

  • Zinc deficiency exacerbates pressure ulcers by increasing oxidative stress and ATP in the skin.

    abstract：BACKGROUND:Zinc deficiency is believed to be a predisposing factor for the development and intractable healing of pressure ulcers (PUs); however, the mechanisms of this association have not been elucidated. OBJECTIVE:Objective was to elucidate the mechanisms of the formation of severe and prolonged PUs under the zinc ...

    journal_title：Journal of dermatological science

    pub_type： 杂志文章

    doi：10.1016/j.jdermsci.2019.07.004

    authors： Nakamura H,Sekiguchi A,Ogawa Y,Kawamura T,Akai R,Iwawaki T,Makiguchi T,Yokoo S,Ishikawa O,Motegi SI

    更新日期：2019-08-01 00:00:00

  • In vivo optical coherence tomography of basal cell carcinoma.

    abstract：BACKGROUND:Optical coherence tomography (OCT) is a promising non-invasive imaging technique that has not systematically been studied in skin cancer such as basal cell carcinoma (BCC). OBJECTIVE:We aimed, first, to describe the in vivo histologic features of BCC by using OCT, and second, to find out whether it is possi...

    journal_title：Journal of dermatological science

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.jdermsci.2006.11.012

    authors： Gambichler T,Orlikov A,Vasa R,Moussa G,Hoffmann K,Stücker M,Altmeyer P,Bechara FG

    更新日期：2007-03-01 00:00:00