A study of anti-carbonic anhydrase II antibodies in rheumatic autoimmune diseases.

abstract：:In order to know the possible effects of gastrin releasing peptide (GRP) on nevus cells and melanocytes, we studied the effect of GRP on the proliferation of cultured human nevus cells and normal melanocytes. MTS assay showed that GRP stimulated the growth of viable melanocytes at 1000 ng/ml. GRP also stimulated the g...

journal_title：Journal of dermatological science

authors： Terashi H,Itami S,Tadokoro T,Takeyama M,Katagiri K,Takayasu S

更新日期：1998-06-01 00:00:00

abstract：:Members of the transforming growth factor-beta (TGF-beta) superfamily are pleiotropic cytokines that have the ability to regulate numerous cell functions, including proliferation, differentiation, apoptosis, epithelial-mesenchymal transition, and production of extracellular matrix, allowing them to play an important r...

journal_title：Journal of dermatological science

authors： Schiller M,Javelaud D,Mauviel A

更新日期：2004-08-01 00:00:00

abstract：BACKGROUND:Kojic acid is a fungal metabolite widely used in medicinal and cosmetic formulations as a skin-lightening agent based on its de-pigmenting activity. Although in human clinical studies kojic acid has been shown to be effective in the treatment of hyper-pigmentation disorders such as melasma, the reasons for i...

journal_title：Journal of dermatological science

authors： Choi H,Kim K,Han J,Choi H,Jin SH,Lee EK,Shin DW,Lee TR,Lee AY,Noh M

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Currently available topical treatments for actinic keratosis (AK) are associated with substantial side-effects. OBJECTIVES:To evaluate the efficacy and safety of topical SR-T100 gel in treating AK. METHODS:A multicenter, randomized, double-blinded phase III trial was conducted. Patients with at least two c...

journal_title：Journal of dermatological science

authors： Yang CC,Wong TW,Lee CH,Hong CH,Chang CH,Lai FJ,Lin SH,Chi CC,Lin TK,Yen H,Wu CH,Sheu HM,Lan CE

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Several inhibitor of apoptosis proteins (IAPs) are cleaved during apoptosis. Studies of the melanoma-associated IAP (ML-IAP) Livin, using recombinant molecules, have implicated both caspases 3/7 and the serine protease Omi/HtrA2 in its proteolytic cleavage. OBJECTIVE:To characterize the apoptotic cleavage o...

journal_title：Journal of dermatological science

authors： Yan H,Brouha B,Liu T,Raj D,Biddle D,Lee R,Grossman D

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:Aquaporin 3 (AQP3) is the predominant aquaporin in the skin and is overexpressed in hyperplastic epidermal disorders. Upregulation of AQP3 contributes to keratinocyte proliferation and epidermal hyperplasia. Resveratrol, a natural polyphenol, has an anti-proliferative effect on normal human epidermal keratin...

journal_title：Journal of dermatological science

authors： Wu Z,Uchi H,Morino-Koga S,Shi W,Furue M

更新日期：2014-07-01 00:00:00

abstract：:The epidermal basement membrane zone (BMZ) comprises a multiprotein complex that aids the attachment of epidermal keratinocytes to the underlying dermis. In the last 5 years, our understanding of epidermal BMZ morphology, structure and function has dramatically improved. A complex network of molecular interactions has...

journal_title：Journal of dermatological science

authors： McMillan JR,Akiyama M,Shimizu H

更新日期：2003-05-01 00:00:00

abstract：:Stratum corneum samples obtained from 46 members in three generations of seven families were analyzed for keratin pattern by gel electrophoresis. All these samples of apparently normal upper arm skin expressed the 55 kDa, 56.5 kDa, and 65 kDa keratin proteins; while only 28%, 20% and 48% of the samples expressed the 5...

journal_title：Journal of dermatological science

authors： Yaar M,Matoltsy GA,Gilchrest BA

更新日期：1990-07-01 00:00:00

abstract：BACKGROUND:Pseudoxanthoma elasticum (PXE) is an autosomal recessive metabolic disorder with ectopic mineralization in the skin, eyes and cardiovascular system. PXE is caused by mutations in ABCC6. OBJECTIVE:To examine 54 unrelated South African PXE patients for ABCC6 PXE causing mutations. METHODS:Patients were scree...

journal_title：Journal of dermatological science

authors： Ramsay M,Greenberg T,Lombard Z,Labrum R,Lubbe S,Aron S,Marais AS,Terry S,Bercovitch L,Viljoen D

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:Common DNA variants in IL12B, IL23R and IL23A have been associated with an increased susceptibility to psoriasis (Ps) and psoriatic arthritis (PsA). Metabolic comorbidities and cardiovascular risk factors have also been associated to both Ps and PsA. OBJECTIVE:To analyze the effect of single nucleotide poly...

journal_title：Journal of dermatological science

authors： Eirís N,González-Lara L,Santos-Juanes J,Queiro R,Coto E,Coto-Segura P

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:UV radiation is the major environmental factor related to development of cutaneous melanoma. Besides sun exposure and the influence of latitude, some host characteristics such as skin phototype and hair and eye color are also risk factors for melanoma. Polymorphisms in DNA repair genes could be good candidat...

journal_title：Journal of dermatological science

authors： Gonçalves FT,Francisco G,de Souza SP,Luiz OC,Festa-Neto C,Sanches JA,Chammas R,Gattas GJ,Eluf-Neto J

更新日期：2011-10-01 00:00:00

abstract：:We have developed a new cell culture system which is of benefit for the research of dermal-epidermal interaction. In this system, normal human keratinocytes are cultured on the upper surface of a permeable collagen membrane, on the undersurface of which human fibroblasts are simultaneously and separately cultured in a...

journal_title：Journal of dermatological science

authors： Mitsuhashi Y,Mikami Y,Mikami H,Ishikawa H,Tamai K,Hashimoto I

更新日期：1993-02-01 00:00:00

abstract：:An immunoperoxidase technique was performed to detect keratinolytic proteinase (KPase) in sections of the skin taken from guinea pigs infected with Microsporum canis and in cultured M. canis using polyclonal antisera to purified KPase. Of tissue samples from guinea pigs infected with M. canis, all sections of erythema...

journal_title：Journal of dermatological science

authors： Lee KH,Park HW,Lee JB

更新日期：1990-11-01 00:00:00

abstract：BACKGROUND:Transforming growth factor beta 1 (TGFβ) is known to be a regulator of autoimmunity. Loss of TGFβ leads to severe multi-organ autoimmunity in mice. In skin, role of TGFβ in suppressing autoimmunity is unclear. OBJECTIVE:Determine whether Keratinocyte (KC)-derived TGFβ is required for skin immune homeostasis...

journal_title：Journal of dermatological science

authors： Yang Y,Zenke Y,Hirai T,Kaplan DH

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:As interest in skin beauty increases, the development of new skin whitening agents has attracted substantial attention; however, the action mechanism of the agents developed so far remains largely unknown. Tranexamic acid (TXA) is commonly being used to reduce melanin synthesis in patients with melasma and a...

journal_title：Journal of dermatological science

authors： Cho YH,Park JE,Lim DS,Lee JS

更新日期：2017-10-01 00:00:00

abstract：:Over the last decade, animal models of atopic dermatitis (AD) have received increasing attention. They include NC/Nga mice, a hapten-induced mouse model, and transgenic and knockout mouse models. Although the pathogenesis of skin inflammation elicited in these models and that in AD are not quite the same, it is pertin...

journal_title：Journal of dermatological science

authors： Shiohara T,Hayakawa J,Mizukawa Y

更新日期：2004-10-01 00:00:00

abstract：BACKGROUND:The loss of subcutaneous (sc) fat is associated with aging. Inflammatory cytokines, such as interleukin-1 α (IL-1α), interleukin-11 (IL-11) and tumor necrosis factor-α (TNF-α), are known to inhibit the differentiation of preadipocytes. OBJECTIVE:This study investigated the potential role of inflammatory cyt...

journal_title：Journal of dermatological science

authors： Li WH,Pappas A,Zhang L,Ruvolo E,Cavender D

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:The appearance and function of human skin are dramatically altered with aging, resulting in higher rates of severe xerosis and other skin complaints. The outermost layer of the epidermis, the stratum corneum (SC), is responsible for the biomechanical barrier function of skin and is also adversely transformed...

journal_title：Journal of dermatological science

authors： Biniek K,Kaczvinsky J,Matts P,Dauskardt RH

更新日期：2015-11-01 00:00:00

abstract：:As we contemplate the nature of life sciences in the 21st century, we should briefly consider the changes that have occurred in the past century. Surely, the sources of progress of this science in the next century are the advances emerging now. Furthermore, the likely pace of discovery and change in life sciences in t...

journal_title：Journal of dermatological science

authors： Sharp PA

更新日期：2000-12-01 00:00:00

abstract：:The effect of DOPA and glutathione (GSH) on enzyme systems for 5-S-cysteinyl-DOPA (5SCD) genesis in murine melanoma cells cultured in tyrosine- and cystine-free medium were studied. DOPA at its optimum concentration (10(-5) M) when added alone did not alter tyrosinase, glutathione-S-transferase or gamma-glutamyl trans...

journal_title：Journal of dermatological science

authors： Chakraborty AK,Ichihashi M,Mishima Y

更新日期：1991-09-01 00:00:00

abstract：BACKGROUND:Resolvin D1 (RvD1), a pro-resolution lipid mediator derived from docosahexaenoic acid (DHA), has been described to promote several kinds of inflammatory resolution. However, the effects and anti-inflammatory mechanisms of RvD1 on psoriasis have not been previously reported. OBJECTIVE:The present study aimed...

journal_title：Journal of dermatological science

authors： Xu J,Duan X,Hu F,Poorun D,Liu X,Wang X,Zhang S,Gan L,He M,Zhu K,Ming Z,Chen H

更新日期：2018-02-01 00:00:00

abstract：:Kindler syndrome is an autosomal recessive genodermatosis characterized by acral blistering in neonates and diffuse, progressive poikiloderma in later life. Other clinical features include photosensitivity, premature skin ageing and severe periodontal disease. Two groups have recently shown that the molecular basis of...

journal_title：Journal of dermatological science

authors： White SJ,McLean WH

更新日期：2005-06-01 00:00:00

abstract：:Dermatitis herpetiformis is characterised by granular IgA precipitates in the papillary dermis. In contrast to other autoimmune blistering diseases, where tissue-deposited and circulating autoantibodies recognise the same target within the skin, in dermatitis herpetiformis a serum IgA reacting with a component of the ...

journal_title：Journal of dermatological science

authors： Kárpáti S

更新日期：2004-04-01 00:00:00

abstract：BACKGROUND:Mammalian epidermis has two diffusion barriers, the stratum corneum (SC) and tight junctions (TJs). We reported previously that a single living cell layer exists between the SC and TJ-forming keratinocytes in mice; however, the exact location of the TJ barrier in human epidermis has not been defined. OBJECT...

journal_title：Journal of dermatological science

authors： Yoshida K,Yokouchi M,Nagao K,Ishii K,Amagai M,Kubo A

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Telomere shortening has been implicated in cellular senescence, which may cause certain aging phenotypes. OBJECTIVE:To reveal whether telomere shortening is associated with chronological aging and/or photoaging of the skin, we measured telomere length in the epidermis and in the dermis from sun-protected an...

journal_title：Journal of dermatological science

authors： Sugimoto M,Yamashita R,Ueda M

更新日期：2006-07-01 00:00:00

abstract：:We have previously reported that two species of pro alpha 1(IV) collagen chains, disulfided (500 kDa) and non-disulfided (180 kDa), were produced by B16 melanoma cells (J Biochem (1994) 116; 1039-1043). The mechanism by which the non-disulfided pro alpha 1(IV) chain is produced was studied. No significant difference i...

journal_title：Journal of dermatological science

authors： Tajima S,Tokimitsu I

更新日期：1996-10-01 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) plays important roles not only in the morphogenesis but also in wound repair, tissue fibrosis and cancer progression. Recently, regulatory mechanism of this process has been elaborately elucidated. EMT can be a new therapeutic target for treating skin ulcer, fibrosing alopecia, ...

journal_title：Journal of dermatological science

authors： Nakamura M,Tokura Y

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:While immunologic events elicited by acute barrier disruption or UVB irradiation have been studied in detail, the biological sequel of multiple insults to the skin is not well understood. OBJECTIVE:Since the skin would receive a variety of simultaneous stimuli in daily life, we tested the effects of sequent...

journal_title：Journal of dermatological science

authors： Ito T,Seo N,Yagita H,Tsujimura K,Takigawa M,Tokura Y

更新日期：2003-12-01 00:00:00

abstract：:DS-Nh (DS Nh/+) mice spontaneously develop dermatitis when they are housed in a conventional environment. In this study, we analyzed the clinical and histopathological features of dermatitis in DS-Nh mice, which is characterized by erythema, edema, and erosion on the face, neck, chest and flexor surfaces of their fore...

journal_title：Journal of dermatological science

authors： Hikita I,Yoshioka T,Mizoguchi T,Tsukahara K,Tsuru K,Nagai H,Hirasawa T,Tsuruta Y,Suzuki R,Ichihashi M,Horikawa T

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND:Diverse topical products and injectable fillers used for correcting facial wrinkles induce rather short-lived effects because they target replacement of dermal collagen and hyaluronan, matrix components of limited biologic durability. OBJECTIVE:Present studies were aimed at stimulation of fully differentiat...

journal_title：Journal of dermatological science

authors： Hinek A,Wang Y,Liu K,Mitts TF,Jimenez F

更新日期：2005-09-01 00:00:00