abstract：OBJECTIVE:Increasing literature reported higher rates of psychiatric disorders in parents of children with autism spectrum disorder (ASD), as well as of autistic-like features in social and cognitive functioning. However, little attention has been paid to the association between autistic traits (AT) and global function...

journal_title：CNS spectrums

authors： Carpita B,Carmassi C,Calderoni S,Muti D,Muscarella A,Massimetti G,Cremone IM,Gesi C,Conti E,Muratori F,Dell'Osso L

更新日期：2020-12-01 00:00:00

abstract：:The rediscovery of the importance of mental illness in the risk assessment and management of those who threaten, approach, and harm public figures has led to a new way of dealing with those that threaten public figures. This approach emphasises the role of "fixation" which may be defined as an intense preoccupation pu...

journal_title：CNS spectrums

authors： Barry-Walsh J,James DV,Mullen PE

更新日期：2020-10-01 00:00:00

abstract：:Trauma-informed approaches offer a new perspective for understanding how and why individuals with serious mental illness (SMI) become entangled in the criminal justice system. There is growing awareness that many individuals with SMI have experienced significant life trauma, and factors beyond SMI that contribute to c...

journal_title：CNS spectrums

authors： Thordarson H,Rector T

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND.:Sexual response in obsessive-compulsive disorder (OCD) research and practice is overlooked. According to the Dual Control Model, satisfactory sexual response is based upon a balance of sexual excitation and inhibition. The assessment of sexual response in OCD may have clinical implications, such as the inte...

journal_title：CNS spectrums

authors： Pozza A,Marazziti D,Mucci F,Angelo NL,Prestia D,Dèttore D

更新日期：2020-07-15 00:00:00

abstract：OBJECTIVE:Gambling disorder (GD) is a common, disabling condition that often is exacerbated by stressful life events. Under stress, the sympathetic nervous system and the hypothalamic-pituitary-adrenal axis are activated. The question, therefore, arises as to whether an abnormal sympathetic response can be found in ind...

journal_title：CNS spectrums

authors： Grant JE,Chamberlain SR

更新日期：2020-06-01 00:00:00

abstract：OBJECTIVES:This study aimed to evaluate the risk of suicidal ideation and behavior associated with vortioxetine treatment in adults with major depressive disorder (MDD). METHODS:Suicide-related events were evaluated post hoc using 2 study pools: one short-term pool of 10 randomized, placebo-controlled studies (6-8 wee...

journal_title：CNS spectrums

authors： Mahableshwarkar AR,Affinito J,Reines EH,Xu J,Nomikos G,Jacobsen PL

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND.:The Leuven Affect and Pleasure Scale (LAPS) is a depression outcome measure aiming to better reflect patient treatment expectations. We investigated the evolution of the LAPS and some comparator scales during antidepressant treatment and compared scores of remitters with scores of healthy controls.Methods. ...

journal_title：CNS spectrums

authors： Demyttenaere K,Kiekens G,Bruffaerts R,Mortier P,Gorwood P,Martin L,Di Giannantonio M

更新日期：2020-05-19 00:00:00

abstract：BACKGROUND.:The current study sought to examine the relationship between documented social media use and suicidality and self-injurious behaviors in adolescents at the time of psychiatric hospitalization. METHODS.:We retrospectively identified adolescents (aged 12-17 years) hospitalized on an inpatient psychiatric uni...

journal_title：CNS spectrums

authors： Shafi RMA,Nakonezny PA,Romanowicz M,Nandakumar AL,Suarez L,Croarkin PE

更新日期：2020-04-27 00:00:00

abstract：:Rapid urbanization worldwide is associated to an increase of population in the urban settings and this is leading to new emerging mental health issues. This narrative mini-review is based on a literature search conducted through PubMed and EMBASE. A total of 113 articles published on the issue of urban mental health h...

journal_title：CNS spectrums

authors： Ventriglio A,Torales J,Castaldelli-Maia JM,De Berardis D,Bhugra D

更新日期：2020-04-06 00:00:00

abstract：:Beginning in the 1960s, a steady decline in the number of inpatient psychiatric beds has occurred across the United States, primarily as a result of stricter civil commitment criteria and a societal movement toward deinstitutionalization. Concomitant with this decrease in psychiatric beds has been a steady increase in...

journal_title：CNS spectrums

authors： Beltrani A,Zapf PA

更新日期：2020-04-01 00:00:00

abstract：:Ethnic differences may significantly influence the outcome of psychopharmacological treatment, in terms of prescription, adherence, clinical response, emergence of side effects, as well as pharmacokinetics and pharmacodynamics. The purpose of this review was to explore the available literature in order to provide gene...

journal_title：CNS spectrums

authors： Marazziti D,Mucci F,Avella MT,Palagini L,Simoncini M,Dell'Osso L

更新日期：2020-03-02 00:00:00

abstract：OBJECTIVE:We aim to evaluate the effect of caloric restriction (CR) in cognition by comparing performance in neuropsychological tests for working memory between a group of non-obese healthy subjects doing CR for 2 years with another consuming ad libitum diet (AL). METHODS:This study was part of a larger multicenter tr...

journal_title：CNS spectrums

authors： Leclerc E,Trevizol AP,Grigolon RB,Subramaniapillai M,McIntyre RS,Brietzke E,Mansur RB

更新日期：2020-02-01 00:00:00

abstract：:The lack of predictive biomarkers for therapeutic responses to schizophrenia leads clinical procedures to be decided without taking into account the subjects' neuroanatomical features, a consideration, which could help in identifying specific pharmacological treatments for the remission of symptoms. Magnetic resonance...

journal_title：CNS spectrums

authors： Bandeira ID,Barouh JL,Bandeira ID,Quarantini L

更新日期：2020-01-10 00:00:00

abstract：:Pharmacotherapy of multiple sclerosis (MS) is evolving rapidly. Despite impressive gains over the past 2 decades in the approval of multiple drugs for MS, lack of recruitment of minorities with MS in phase 3 clinical studies is a persistent concern and skews efficacy and disability data. ...

journal_title：CNS spectrums

authors： Avasarala J

更新日期：2019-06-01 00:00:00

abstract：OBJECTIVE:Presence of negative mood (depressed mood) and anhedonia (lack of interest and pleasure) are considered core symptoms of depression, while absence of positive mood is not taken into account. It is therefore remarkable that the depression scales routinely used to assess changes during antidepressant treatment ...

journal_title：CNS spectrums

authors： Demyttenaere K,Mortier P,Kiekens G,Bruffaerts R

更新日期：2019-04-01 00:00:00

abstract：:Brain imaging techniques, especially those based on magnetic resonance imaging (MRI) and magnetoencephalography (MEG), have been increasingly applied to study multiple large-scale distributed brain networks in healthy people and neurological patients. With regard to neurodegenerative disorders, amyotrophic lateral scl...

journal_title：CNS spectrums

authors： Trojsi F,Sorrentino P,Sorrentino G,Tedeschi G

更新日期：2018-12-01 00:00:00

abstract：:The two approved treatments for tardive dyskinesia both inhibit the vesicular monoamine transporter type 2 (VMAT2) yet have pharmacologic properties that distinguish one from the other. Knowing these differences may help optimize which treatment to select for individual patients. ...

journal_title：CNS spectrums

authors： Stahl SM

更新日期：2018-08-01 00:00:00

abstract：:Congratulations to the scientific poster winners: 1 st Place: #178-Gender Differences in Prodromal Symptoms of Dementia 2 nd Place: #146-Effect of Heroin Use on Changes of Brain Functions As Measured by fMRI, a Systematic Review 3 rd Place: #185-Second Generation Antipsychotics and Catatonia: A Literature Review. ...

journal_title：CNS spectrums

authors：

更新日期：2018-02-01 00:00:00

abstract：:Drugs for psychosis and mood that bind dopamine D2 receptors can be classified not only by whether they also block serotonin 2A receptors, but by whether they also bind D3 or D1 receptors. ...

journal_title：CNS spectrums

authors： Stahl SM

更新日期：2017-10-01 00:00:00

abstract：OBJECTIVE:Evaluate the efficacy and safety of asenapine 2.5 mg twice daily (bid; n=97) or 5 mg bid (n=113) versus placebo (n=101) in adults with acute exacerbation of schizophrenia. METHODS:Adults with Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR) schizophrenia diagno...

journal_title：CNS spectrums

authors： Landbloom R,Mackle M,Wu X,Kelly L,Snow-Adami L,McIntyre RS,Mathews M,Hundt C

更新日期：2017-08-01 00:00:00

abstract：:Research on deep brain stimulation (DBS) for treatment-resistant psychiatric disorders has established preliminary efficacy signals for treatment-resistant depression. There are only few studies on DBS that included patients suffering from bipolar disorder. This article gives an overview of these studies concerning DB...

journal_title：CNS spectrums

authors： Gippert SM,Switala C,Bewernick BH,Kayser S,Bräuer A,Coenen VA,Schlaepfer TE

更新日期：2017-06-01 00:00:00

abstract：:Mixed affective states, defined as the coexistence of depressive and manic symptoms, are complex presentations of manic-depressive illness that represent a challenge for clinicians at the levels of diagnosis, classification, and pharmacological treatment. The evidence shows that patients with bipolar disorder who have...

journal_title：CNS spectrums

authors： Solé E,Garriga M,Valentí M,Vieta E

更新日期：2017-04-01 00:00:00

abstract：:During the past two decades, a number of studies have found that depressed patients frequently have manic symptoms intermixed with depressive symptoms. While the frequency of mixed syndromes are more common in bipolar than in unipolar depressives, mixed states are also common in patients with major depressive disorder...

journal_title：CNS spectrums

authors： Zimmerman M

更新日期：2017-04-01 00:00:00

abstract：:A significant minority of people presenting with a major depressive episode (MDE) experience co-occurring subsyndromal hypo/manic symptoms. As this presentation may have important prognostic and treatment implications, the DSM-5 codified a new nosological entity, the "mixed features specifier," referring to individual...

journal_title：CNS spectrums

authors： Stahl SM,Morrissette DA,Faedda G,Fava M,Goldberg JF,Keck PE,Lee Y,Malhi G,Marangoni C,McElroy SL,Ostacher M,Rosenblat JD,Solé E,Suppes T,Takeshima M,Thase ME,Vieta E,Young A,Zimmerman M,McIntyre RS

更新日期：2017-04-01 00:00:00

abstract：:Restless legs syndrome (RLS) is a common neurological movement disorder, characterized by restless and unpleasant sensations in the deep inside of legs. The symptoms of RLS are less noticeable during daytime, but more prevalent at night. Therefore, the disorder can induce low quality of life, insomnia, and impairment ...

journal_title：CNS spectrums

authors： Sahli ZT,Jo J,Mousa SA,Tarazi FI

更新日期：2017-02-01 00:00:00

abstract：:Obsessive-compulsive disorder (OCD) has been recognized as mainly characterized by compulsivity rather than anxiety and, therefore, was removed from the anxiety disorders chapter and given its own in both the American Psychiatric Association (APA) Diagnostic and Statistical Manual of Mental Disorders (DSM-5) and the B...

journal_title：CNS spectrums

authors： Marras A,Fineberg N,Pallanti S

更新日期：2016-08-01 00:00:00

abstract：:Pimavanserin, a novel agent approved for the treatment of Parkinson's disease psychosis, has potent actions as an antagonist/inverse agonist at serotonin 5HT2A receptors and less potent antagonist/inverse agonist actions at 5HT2C receptors. ...

journal_title：CNS spectrums

authors： Stahl SM

更新日期：2016-08-01 00:00:00

abstract：:Psychogenic nonepileptic seizures (PNES) are a functional neurological disorder/conversion disorder subtype, which are neurobehavioral conditions at the interface of neurology and psychiatry. Significant advancements over the past decade have been made in the diagnosis, management, and neurobiological understanding of...

journal_title：CNS spectrums

authors： Perez DL,LaFrance WC Jr

更新日期：2016-06-01 00:00:00

abstract：:Neuropsychiatry has had different meanings at different times in the history of clinical neuroscience. In this article, the origins of what has become today's neuropsychiatry are briefly explored, hopefully revealing a number of pioneers of the discipline, some of the names being familiar to many readers, others howev...

journal_title：CNS spectrums

authors： Trimble M

更新日期：2016-06-01 00:00:00

abstract：OBJECTIVE/INTRODUCTION:There is a close functional and neuroanatomical relationship between olfactory ability and emotional processing. The present study seeks to explore the association between olfactory ability and social cognition, especially facial emotion perception, in euthymic bipolar patients. METHODS:Thirty-n...

journal_title：CNS spectrums

authors： Lahera G,Ruiz-Murugarren S,Fernández-Liria A,Saiz-Ruiz J,Buck BE,Penn DL

更新日期：2016-02-01 00:00:00

abstract：:This narrative review provides an overview of the epidemiology of binge eating disorder (BED), highlighting the medical history of this disorder and its entry as an independent condition in the Feeding and Eating Disorders section of the recently published Diagnostic and Statistical Manual of Mental Disorders, Fifth E...

journal_title：CNS spectrums

authors： Davis C

更新日期：2015-12-01 00:00:00

abstract：:Binge eating disorder (BED) is the most common of eating disorders and is characterized by excessive, out-of-control, rapid food intake. This review focuses on cognitive impairments in BED, which represent an endophenotype that mediates brain function and behavior. Here we focus on reviewing impulsivity, compulsivity,...

journal_title：CNS spectrums

authors： Voon V

更新日期：2015-12-01 00:00:00

abstract：OBJECTIVE:Pediatric obsessive-compulsive disorder (OCD) and tic disorders (TD) are often associated with attention-deficit hyperactivity disorder (ADHD). In order to clarify the role of attention and inhibitory control in pediatric OCD and TD, a continuous performance test (CPT) was administered to a cohort of children...

journal_title：CNS spectrums

authors： Lucke IM,Lin C,Conteh F,Federline A,Sung H,Specht M,Grados MA

更新日期：2015-10-01 00:00:00

abstract：:Vortioxetine is an antidepressant with multiple pharmacologic modes of action at targets where serotonin neurons connect with other neurons. These actions modify the release of both glutamate and GABA (gamma amino butyric acid) within various brain circuits. ...

journal_title：CNS spectrums

authors： Stahl SM

更新日期：2015-08-01 00:00:00

abstract：:Almost no literature addresses treatment planning for the forensic psychiatric patient. In the absence of such guidance, recovery-oriented multifocal treatment planning has been imported into forensic mental health systems from community psychiatric settings, despite the fact that conditions of admission and discharge...

journal_title：CNS spectrums

authors： Schaufenbil RJ,Kornbluh R,Stahl SM,Warburton KD

更新日期：2015-06-01 00:00:00

abstract：:Although addictive syndromes have been traditionally related to substance-use disorders, during the last few decades a novel addictive group, including the so-called "behavioral or no-drug addictions," has been recognized and has attracted increasing attention for its relevant social impact. This group includes pathol...

journal_title：CNS spectrums

authors： Marazziti D,Presta S,Baroni S,Silvestri S,Dell'Osso L

更新日期：2014-12-01 00:00:00

abstract：INTRODUCTION:Efficacy of depression treatments, including adjunctive antipsychotic treatment, has not been explored for patients with worsening symptoms after antidepressant therapy (ADT). METHODS:This post-hoc analysis utilized pooled data from 3 similarly designed, randomized, double-blind, placebo-controlled trials...

journal_title：CNS spectrums

authors： Nelson JC,Rahman Z,Laubmeier KK,Eudicone JM,McQuade RD,Berman RM,Marcus RN,Baker RA,Sheehan JJ

更新日期：2014-12-01 00:00:00

abstract：ISSUE:Many individuals with total blindness can develop a circadian rhythm disorder-called non-24 sleep wake syndrome-because they cannot detect light to resynchronize their sleep-wake cycles. A new melatonin 1 and melatonin 2 agonist tasimelteon improves sleep in these patients, resetting their circadian sleep-wake cl...

journal_title：CNS spectrums

authors： Stahl SM

更新日期：2014-12-01 00:00:00

abstract：UNLABELLED:The serotoninergic system as a target for add-on treatment seems to be a promising approach in patients with schizophrenia. OBJECTIVE:To clarify if selective 5HT-6 antagonist AVN-211 (CD-008-0173) adds clinical and cognitive effects to stable antipsychotic treatment. METHODS:A randomized, double-blind, pla...

journal_title：CNS spectrums

authors： Morozova MA,Lepilkina TA,Rupchev GE,Beniashvily AG,Burminskiy DS,Potanin SS,Bondarenko EV,Kazey VI,Lavrovsky Y,Ivachtchenko AV

更新日期：2014-08-01 00:00:00

abstract：:There is some evidence indicating that psychotropic medications might lead to health-related quality of life (QOL) improvements among children and adolescents with psychiatric disorders. The aim of this systematic review is to assess evidence regarding whether antidepressant treatment improves QOL among children and a...

journal_title：CNS spectrums

authors： Stevanovic D,Tadic I,Knez R

更新日期：2014-04-01 00:00:00