abstract：BACKGROUND:CAT25 (T25mononucleotide repeat of the Caspase 2 gene), is a promising DNA marker for detecting microsatellite instability (MSI) in colorectal cancer. CAT25 has the potential to be incorporated into the Bethesda panel, a commonly used panel of DNA microsatellites, or replace it in its entirety. We aimed to d...

journal_title：British journal of biomedical science

authors： Sánchez AG,Juaneda I,Eynard H,Basquiera AL,Palazzo E,Calafat P,Palla V,Romagnoli PA,Alvarellos T

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:The Fas cell surface death receptor (FAS) and Fas ligand (FASL) can participate in the apoptosis of immune cells and target cells infected with a virus through the FAS-FASL signalling pathway. The decoy receptor 3 (DCR3) can competitively inhibit the binding of FAS to FASL. Our aim is to investigate the effe...

journal_title：British journal of biomedical science

authors： Huang P,Wang CH,Zhuo LY,Xia XS,Yang S,Zhang JW,Fan HZ,Wu JJ,Yu R,Yue M,Zhang Y

更新日期：2020-07-01 00:00:00

abstract：:Background: Xanthogranulomatous pyelonephritis (XGP) is a rare chronic bacterial inflammation of the renal parenchyma and is often a diagnostic dilemma.Case Presentation: We present a challenging case of a patient with XGP. Initially thought to have had renal cell cancer she was treated accordingly with a partial neph...

journal_title：British journal of biomedical science

authors： Mohaghegh P SM,Wong RS,Rahimi M,Shih F,Bansal R

更新日期：2020-04-01 00:00:00

abstract：:Background: Cervical cancer is the second most common cancer among women after breast cancer. Its standard treatment is cisplatin-based concomitant chemoradiotherapy. Chronic inflammation in uterine cervix triggers both pro- and anti-inflammatory pathways. The unpredictability in toxicity and efficacy of treatment is ...

journal_title：British journal of biomedical science

authors： Kushwah AS,Gupta MK,Singh R,Banerjee M

更新日期：2020-04-01 00:00:00

abstract：:Background: The diagnosis of heavily pigmented melanocytic lesions is problematic. This is often compounded by lack of visibility of nuclear detail of tumour cells due to physical masking by melanin pigment. Similarly, there can be colour merging of chromogenic final reaction products with melanin, making an evidence ...

journal_title：British journal of biomedical science

authors： Orchard GE,Gabriel J,Shams M,Fernando P,Satoc J,Nwokie T,Ismail F,d'Amico C

更新日期：2019-10-01 00:00:00

abstract：INTRODUCTION:Toll-like receptors (TLRs) are pattern recognition receptors that play a role in innate immunity. Mounting evidence shows that single-nucleotide polymorphisms (SNPs) in TLRs link to various infectious diseases, including human immunodeficiency virus (HIV). We hypothesized links between two TLR4 SNPs (rs498...

journal_title：British journal of biomedical science

authors： Vidyant S,Chatterjee A,Dhole TN

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:A potential role for microRNA-935 (miR-935) has been identified in several cancers but not in non-small cell lung cancer (NSCLC). We hypothesised changes in miR-935 in NSCLC, and proposed mechanisms that may further explain its role in carcinogenesis. METHODS:NSCLC tissue and nearby normal tissue was obtain...

journal_title：British journal of biomedical science

authors： Wang C,Li S,Xu J,Niu W,Li S

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVE:Hepatic encephalopathy is a common consequence of liver cirrhosis, but diagnosis can be difficult as it is based on clinical criteria alone. We hypothesised that serum prealbumin, cholinesterase and retinol binding protein (RBP) can help support the diagnosis of hepatic encephalopathy. METHODS:We enrolled 30...

journal_title：British journal of biomedical science

authors： Tan L,Meng Y,Zeng T,Wang Q,Long T,Wu S,Guan X,Fu H,Zheng W,Tian Y,Chen J,Yu J,Wu Y,Li H,Cao L

更新日期：2019-01-01 00:00:00

abstract：:Background Hypercoagulability is a leading factor in diabetes and cardiovascular disease. Retinal vessel responses to flickering light are an important tool for assessing ocular function. We hypothesised a significant relationship between systemic markers of haemostasis and retinal vessel function. Methods Intra-ocula...

journal_title：British journal of biomedical science

authors： Heitmar R,Nicholl P,Lee B,Lau YC,Lip G

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Fibrosis markers are useful for the prediction of cirrhosis but clinical scores such as King's score, AST-Platelet ratio index (APRI), Biotechnology research center (BRC), Fibrosis routine test (FRT), Fibro-α score and Fibro-quotient (FibroQ) have limited accuracy for diagnosing significant fibrosis. We hypo...

journal_title：British journal of biomedical science

authors： Attallah AM,Omran D,Omran MM,Albannan MS,Zayed RA,Saif S,Farid A,Hassany M,Yosry A

更新日期：2018-01-01 00:00:00

abstract：:Uncertainty of measurement has become a paramount factor to consider in pathology. In the UK, consideration of uncertainty of measurement is mandatory for medical laboratories who apply to be accredited against ISO15189:2012 via the United Kingdom Accreditation Service. This guideline intends to help those working wit...

journal_title：British journal of biomedical science

authors： Sanders D,Fensome-Rimmer S,Woodward B

更新日期：2017-10-01 00:00:00

abstract：:The impact of warfarin therapy on the functions of extrahepatic vitamin K-dependent proteins (VKDP) is less clearly understood and less widely recognised in clinical practice than that on the hepatic counterparts (clotting factors II, VII, IX and X). Warfarin inhibits osteocalcin, an abundant extrahepatic VKDP involve...

journal_title：British journal of biomedical science

authors： Donaldson CJ,Harrington DJ

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND AND AIMS:miR-199a-3p may play an important role in tumour inhibition. The aim of the present study was to determine any link between miR-199a-3p expression in thyroid tissues and clinicopathologic features, as well as to assess potential usefulness of miR-199a-3p in prediction for invasion and metastasis of ...

journal_title：British journal of biomedical science

authors： Liu C,Xing M,Wang L,Zhang K

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND AND AIMS:miRNA-124 (miR-124) expression was known to be downregulated in patients with pancreatic ductal adenocarcinoma (PDAC). Downregulation of miR-124 was significantly associated with poor prognosis in patients with PDAC. Recent studies have shown that circulating miRNAs could be the potential biomarkers...

journal_title：British journal of biomedical science

authors： Sun B,Liu X,Gao Y,Li L,Dong Z

更新日期：2016-10-01 00:00:00

abstract：:In 2015, the British Journal of Biomedical Science published 47 reports on topics relating to the various disciplines within biomedical science. Of these, the majority were in infection science (15 in microbiology and two in virology) and blood science (seven in biochemistry, four in haematology, three in immunology a...

journal_title：British journal of biomedical science

authors： Blann A,Nation B

更新日期：2016-01-01 00:00:00

abstract：:The incidence of chronic kidney disease (CKD) is increasing with the prevalence of obesity, diabetes mellitus, elevated blood pressure and other cardiovascular-renal risk factors. Wider point-of-care testing (POCT) strategies in the community setting are needed to prevent CKD and delay progressive loss of renal functi...

journal_title：British journal of biomedical science

authors： Muhammad S

更新日期：2015-01-01 00:00:00

abstract：:Psoriasis is a T-helper-1 (Th1)/Th17-mediated chronic inflammatory skin disease, characterised by hyperproliferation of keratinocytes. Psoriasis and cardiovascular disease share similar pathogenic mechanisms such as vascular endothelial cell dysfunction, oxidative stress and metabolic syndrome. 25-hydroxy vitamin D is...

journal_title：British journal of biomedical science

authors： Chandrashekar L,Kumarit GR,Rajappa M,Revathy G,Munisamy M,Thappa DM

更新日期：2015-01-01 00:00:00

abstract：:The current study aimed to investigate the prevalence of vancomycin-resistant Enterococcus in E. faecalis and E. faecium and antimicrobial susceptibility patterns, then dominant genes responsible for vancomycin resistance were determined. For this propose, 180 clinical isolates of Enterococcus were subjected for ident...

journal_title：British journal of biomedical science

authors： Mohammadi F,Ghafourian S,Mohebi R,Taherikalani M,Pakzad I,Valadbeigi H,Hatami V,Sadeghifard N

更新日期：2015-01-01 00:00:00

abstract：:This study aims to determine the asymptomatic bacteriuria in pregnancy due to GBS and its antimicrobial sensitivity pattern for planning strategy for the management of these cases and also to determine the relationship between asymptomatic bacteriuria and pyuria. A total of 3863 consecutive urine specimens were collec...

journal_title：British journal of biomedical science

authors： Ahmad S

更新日期：2015-01-01 00:00:00

abstract：:Reports of Helicobacter pylori in biliary tract diseases in humans are very fragmentary, and therefore there is a need for further investigations. This study aims to detect H. pylori in the bile and gall bladder (GB) of patients with chronic calcular cholecystitis (CCC), and to determine the association of H. pylori i...

journal_title：British journal of biomedical science

authors： Helaly GF,El-Ghazzawi EF,Kazem AH,Dowidar NL,Anwar MM,Attia NM

更新日期：2014-01-01 00:00:00

abstract：:Streptococcus pseudopneumoniae is a distinct pathogen and the available evidence suggests its significance in lower respiratory tract infections. The purpose of this study is to investigate the occurrence of this new species in patients presenting with community-acquired pneumonia in a university hospital setting usin...

journal_title：British journal of biomedical science

authors： Alnimr AM

更新日期：2014-01-01 00:00:00

abstract：:Recombinant full-length urease gene cluster and seven 100% deletion recombinant variants of urease subunits genes, (ureG, ureH, ureA, ureB, ureC, ureE and ureF) were constructed in vitro from the Campylobacter sputorum biovar paraureolyticus LMG17591 strain and expressed in Escherichia coli JM109 cells. A urease-posit...

journal_title：British journal of biomedical science

authors： Nakajima T,Kuribayashi T,Yamamoto S,Moore JE,Millar BC,Matsuda M

更新日期：2014-01-01 00:00:00

abstract：:Bladder cancer cells appear to have an altered lipid metabolism as evidenced by modulated lipogenic enzymes. The aim of this study is to investigate differences in tissue fat composition between malignant and adjacent normal urinary bladder tissue. Normal-appearing and malignant bladder tissues were collected from 31 ...

journal_title：British journal of biomedical science

authors： Miryaghoubzadeh J,Darabi M,Madaen K,Shaaker M,Mehdizadeh A,Hajihosseini R

更新日期：2013-01-01 00:00:00

abstract：:This study aims to assess whether or not incomplete filling of primary lithium heparin tubes may influence the activity of creatine kinase (CK), alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma-glutamyltransferase (GGT). Blood was drawn from 20 healthy volunteer using an identical sequence of...

journal_title：British journal of biomedical science

authors： Lippi G,Avanzini P,Cosmai M,Aloe R,Ernst D

更新日期：2012-01-01 00:00:00

abstract：:In the present study, Slovenian honey samples produced from different floral sources are evaluated for their antibacterial and antifungal properties. The peroxide contribution to antibacterial activity is also determined. Minimum inhibitory concentration (MIC) of the honeys was assessed against four bacterial species ...

journal_title：British journal of biomedical science

authors： Kuncic MK,Jaklic D,Lapanje A,Gunde-Cimerman N

更新日期：2012-01-01 00:00:00

abstract：:Streptococcus pneumoniae is the leading cause of community-acquired pneumonia (CAP). Currently, empirical treatment with quinolones is being used due to the emergence of beta-lactam and macrolide resistance in S. pneumonaie. Although the prevalence of quinolone-resistant S. pneumoniae remains low, increasing numbers o...

journal_title：British journal of biomedical science

authors： Kakinuma Y,Maeda Y,Mason C,Goldsmith CE,Coulter WA,Matsuda M,Dooley JS,Lowery CJ,Moore JE

更新日期：2012-01-01 00:00:00

abstract：:The Qiagen QIAsymphony SP is a high-throughput (up to 96 samples per run), fully-automated nucleic acid isolation system. It was implemented in the authors' laboratory to cope with the high demand for pandemic H1N1 influenza testing in 2009. This study evaluated the QIAsymphony SP for viral nucleic acid isolation from...

journal_title：British journal of biomedical science

authors： Parham NJ,Parmar SA,Kumar N,Aliyu S,Curran MD,Zhang H

更新日期：2012-01-01 00:00:00

abstract：:Forty-eight isolates of viridans-group streptococci (VGS) from adults and children in the community are examined for their resistance to ciprofloxacin phenotypically by determination of the minimum inhibitory concentration (MIC). In addition, the parC gene locus is amplified and sequenced in all isolates and mutations...

journal_title：British journal of biomedical science

authors： Murayama M,Maeda Y,Goldsmith CE,Coulter WA,Masons C,Millar BC,Matsuda M,Moore JE

更新日期：2011-01-01 00:00:00

abstract：:Otitis externa is a ubiquitous inflammatory disease; although it arises most commonly from an infection, there is no consensus in the UK for the reporting of ear swab culture results. This study aims to review current microbiology laboratory reporting of ear swab specimens to primary care and reach an evidence-based c...

journal_title：British journal of biomedical science

authors： Geyer M,Howell-Jones R,Cunningham R,McNulty C,Health Protection Agency GP Microbiology Laboratory Use Group.

更新日期：2011-01-01 00:00:00

abstract：:Human platelet antibodies are often implicated in conditions such as neonatal alloimmune thrombocytopenia (NAIT), idiopathic thrombocytopenic purpura (ITP) and platelet refractoriness; however, the frequency of such alloantibodies has not been reported in Nigeria and West Africa. A cross section of apparently healthy ...

journal_title：British journal of biomedical science

authors： Jeremiah ZA,Oburu JE,Erhabor O,Buseri FI

更新日期：2011-01-01 00:00:00

abstract：:Prediabetes is a condition that requires early intervention against diabetic macrovascular complications. This study aims to assess whether or not the likelihood of diabetes macrovascular complications occurring in prediabetes can be better estimated by a model combining a set of conventional and emerging biomarkers, ...

journal_title：British journal of biomedical science

authors： Nwose EU,Richards RS,McDonald S,Jelinek HF,Kerr RG,Tinley R

更新日期：2010-01-01 00:00:00

abstract：:A total of 186 Helicobacter pylori isolates and 532 gastric biopsies recovered from 532 patients with varying degrees of gastroduodenal pathology are subjected to in vitro antibiotic susceptibility testing using the disc-diffusion method, Etest (MIC breakpoints) and molecular testing using the polymerase chain reactio...

journal_title：British journal of biomedical science

authors： Oyedeji KS,Smith SI,Coker AO,Arigbabu AO

更新日期：2009-01-01 00:00:00

abstract：:Proteolytic enzymes can be extremely useful for the identification of clinically significant antibodies in blood grouping; however, they can also be destructive to certain agglutination reactions. ABO antibodies are the most clinically significant. A review of the literature reveals little research involving proteolyt...

journal_title：British journal of biomedical science

authors： Rookard LE,Edmondson O,Greenwell P

更新日期：2009-01-01 00:00:00

abstract：:Phenobarbital, a long-acting barbiturate, is generally considered to be a fairly safe and effective drug; however, hepatotoxicity is an infrequent but potentially fatal adverse effect and there is little information on the serum activity of liver enzymes in patients on stable, long-term monotherapy. The serum activity...

journal_title：British journal of biomedical science

authors： Lippi G,Montagnana M,Salvagno GL,Guidi GC

更新日期：2008-01-01 00:00:00

abstract：:Isolates (n = 51) of Pseudomonas aeruginosa obtained from the sputa of 29 adult patients attending the Regional Cystic Fibrosis Centre in Northern Ireland were compared using an enterobacterial repetitive intergenic consensus sequence (ERIC2) primer in a random amplification of polymorphic DNA (RAPD) polymerase chain ...

journal_title：British journal of biomedical science

authors： Clarke L,Moore JE,Millar BC,Crowe M,Xu J,Goldsmith CE,Murphy RG,Dooley JS,Rendall J,Elborn JS

更新日期：2008-01-01 00:00:00

abstract：:Ethanol is the most frequently abused drug and causes a variety of pathological disturbances. It causes toxicity to tissues by generating free radicals during the course of its metabolism that can damage cellular structure and function, especially in hepatocytes. This study investigates the preventive and protective e...

journal_title：British journal of biomedical science

authors： George S,Chaturvedi P

更新日期：2008-01-01 00:00:00

abstract：:Mupirocin is an antimicrobial agent commonly used to treat staphylococcal infection or to eliminate persistent carriage. To date, interpretive criteria have not been established to define susceptibility or resistance when performing mupirocin susceptibility testing. In this evaluation, using CLSI guidelines, a total o...

journal_title：British journal of biomedical science

authors： Creagh S,Lucey B

更新日期：2007-01-01 00:00:00

abstract：:This study compares the Mycoplasma Duo kit for the detection of genital mycoplasmas with conventional culture using A7 differential agar for the detection of Mycoplasma hominis and Ureaplasma urealyticum in clinical samples. Detection of the mycoplasmas is based on the specific metabolic properties of each organism to...

journal_title：British journal of biomedical science

authors： Evans GE,Anderson TP,Seaward LM,Murdoch DR

更新日期：2007-01-01 00:00:00

abstract：:In this study the association between beta3-adrenoceptor gene polymorphism and serum concentration of leptin with body mass index (BMI) is investigated. Using subjects in the Tehran Lipid and Glucose Study, genotyping of the Trp64Arg polymorphism of the beta3-adrenoreceptor gene was performed using a restriction fragm...

journal_title：British journal of biomedical science

authors： Eshraghi P,Hedayati M,Daneshpour MS,Mirmiran P,Azizi F

更新日期：2007-01-01 00:00:00

abstract：:This study aims to determine the in vitro susceptibility of Helicobacter pylori to clarithromycin, metronidazole, amoxycillin and tetracycline, the four antibiotics commonly used in eradication therapies. These data are used to evaluate the efficacy of current empiric treatment of H. pylori infection in the Southern R...

journal_title：British journal of biomedical science

authors： Hooton C,Dempsey C,Keohane J,O'Mahony S,Crosbie O,Lucey B

更新日期：2006-01-01 00:00:00