abstract：:Although many heavy metals are necessary for normal biological function, a subset of heavy metals have no role in human physiology, such as lead (Pb) and arsenic (As). Such elements have deleterious effects on physiology and be associated with the incidence of diabetes and related metabolic syndromes. Haemoglobin A1c ...

journal_title：Diabetes & metabolism

authors： Chang CW,Wang CW,Wu DW,Lee WH,Chen YC,Liu YH,Li CH,Tsai CC,Lin WY,Chen SC,Hung CH,Kuo CH,Su HM

更新日期：2021-01-23 00:00:00

abstract：AIM:Previous studies have reported inconsistent results regarding the association between metformin use and clinical outcomes in diabetes mellitus (DM) patients with coronavirus disease 2019 (COVID-19). This study aimed to evaluate the association between metformin use and clinical outcomes in DM patients with COVID-19...

journal_title：Diabetes & metabolism

authors： Do JY,Kim SW,Park JW,Cho KH,Kang SH

更新日期：2020-11-04 00:00:00

abstract：:Automated closed-loop (CL) insulin therapy has come of age. This major technological advance is expected to significantly improve the quality of care for adults, adolescents and children with type 1 diabetes. To improve access to this innovation for both patients and healthcare professionals (HCPs), and to promote adh...

journal_title：Diabetes & metabolism

authors： Tubiana-Rufi N,Schaepelynck P,Franc S,Chaillous L,Joubert M,Renard E,Reznik Y,Abettan C,Bismuth E,Beltrand J,Bonnemaison E,Borot S,Charpentier G,Delemer B,Desserprix A,Durain D,Farret A,Filhol N,Guerci B,Guilhem I,

更新日期：2020-11-02 00:00:00

abstract：BACKGROUND:Diabetes is a chronic disease associated with a variety of complications, and nudging may be a potential solution to improve diabetes control. Since nudging is a new concept, no review of literature on nudging diabetic patients into improving their health behaviour has been done. Therefore, we aim to collate...

journal_title：Diabetes & metabolism

authors： Kwan YH,Cheng TY,Yoon S,Ho LYC,Huang CW,Chew EH,Thumboo J,Østbye T,Low LL

更新日期：2020-11-01 00:00:00

abstract：AIM:Determine whether plasma omega-7 vaccenic acid and palmitoleic acid levels are related to homeostasis model of insulin resistance scores and incident type II diabetes, and whether race/ethnicity modifies these associations. METHODS:Plasma phospholipid fatty acids were measured by gas chromatography with flame-ioni...

journal_title：Diabetes & metabolism

authors： Weir NL,Steffen BT,Guan W,Johnson LM,Djousse L,Mukamal KJ,Tsai MY

更新日期：2020-09-01 00:00:00

abstract：AIM:The association between Liver fibrosis (LF), as assessed by either histology or Liver stiffness measurement (LSM), and the presence of Early kidney dysfunction (EKD) was investigated in this study, as was also the diagnostic performance of LSM for identifying the presence of EKD in patients with Non-alcoholic fatty...

journal_title：Diabetes & metabolism

authors： Sun DQ,Ye FZ,Kani HT,Yang JR,Zheng KI,Zhang HY,Targher G,Byrne CD,Chen YP,Yuan WJ,Yilmaz Y,Zheng MH

更新日期：2020-09-01 00:00:00

abstract：AIM:To examine the association between treatment-achieved HbA1c values and incidence of both coronary artery disease (CAD) and severe eye disease with different diabetes treatments. METHODS:Associations of treatment-achieved HbA1c were investigated in various treatment groups [diet only; insulin; sulphonylurea (SU) al...

journal_title：Diabetes & metabolism

authors： Harada M,Fujihara K,Osawa T,Yamamoto M,Kaneko M,Ishizawa M,Matsubayashi Y,Yamada T,Yamanaka N,Seida H,Kodama S,Ogawa W,Sone H

更新日期：2020-09-01 00:00:00

abstract：AIMS:Trimethylamine N-oxide (TMAO), choline and betaine serum levels have been associated with metabolic diseases including type 2 diabetes (T2D) and non-alcoholic fatty liver disease (NAFLD). These associations could be mediated by insulin resistance. However, the relationships among these metabolites, insulin resista...

journal_title：Diabetes & metabolism

authors： León-Mimila P,Villamil-Ramírez H,Li XS,Shih DM,Hui ST,Ocampo-Medina E,López-Contreras B,Morán-Ramos S,Olivares-Arevalo M,Grandini-Rosales P,Macías-Kauffer L,González-González I,Hernández-Pando R,Gómez-Pérez F,Campos-Pérez F,

更新日期：2020-08-10 00:00:00

abstract：AIM:Patients with diabetes have higher rates of depression than does the general population, but diabetes management mainly aims to maintain glucose stability. For this reason, our study assessed the relationship between 1-year variations in fasting plasma glucose (FPG) and risk of depression in Chinese patients with t...

journal_title：Diabetes & metabolism

authors： Li CI,Liu CS,Lin CH,Lin WY,Lee YD,Yang SY,Li TC,Lin CC

更新日期：2020-06-01 00:00:00

abstract：AIM:While serum fructosamine may be a good marker of glucose control in pregnant women with diabetes, its relationship with macrosomia is still uncertain. METHODS:In 130 hyperglycaemic women with singleton pregnancies (117 gestational diabetes mellitus, 13 pregestational diabetes), serum fructosamine and HbA1c levels ...

journal_title：Diabetes & metabolism

authors： Poupon P,Foussard N,Helmer C,Cougnard-Gregoire A,Rajaobelina K,Delcourt C,Lamireau T,Haissaguerre M,Blanco L,Alexandre L,Mohammedi K,Rigalleau V

更新日期：2020-06-01 00:00:00

abstract：AIM:To investigate the association between mean fasting glucose (FG) and variability in visit-to-visit FG and risk of mortality in people with type 2 diabetes (T2D). METHODS:This retrospective cohort study included 48,077 Chinese men and women with T2D. The yearly mean and coefficient of variation for fasting glucose ...

journal_title：Diabetes & metabolism

authors： Xu H,Zhang Y,Xu W,Chen L,Zhang M,Su H,Cheng Y,Zhao N,Xu D,Qin G

更新日期：2020-05-26 00:00:00

abstract：AIM:Recent prospective studies have identified distinct plasma ceramides as strong predictors of major adverse cardiovascular events in patients with established or suspected coronary artery disease (CAD). Currently, it is uncertain whether higher levels of distinct plasma ceramides are associated with greater angiogra...

journal_title：Diabetes & metabolism

authors： Mantovani A,Bonapace S,Lunardi G,Canali G,Dugo C,Vinco G,Calabria S,Barbieri E,Laaksonen R,Bonnet F,Byrne CD,Targher G

更新日期：2020-04-01 00:00:00

abstract：AIMS:Reactive dicarbonyl compounds, such as methylglyoxal (MGO), rise during an oral glucose tolerance test (OGTT), particularly in (pre)diabetes. Fasting MGO levels are associated with chronic kidney disease (CKD) and cardiovascular disease (CVD) in patients with poorly controlled type 2 diabetes mellitus (T2DM). Yet,...

journal_title：Diabetes & metabolism

authors： Hanssen NMJ,Scheijen JLJM,Houben AJHM,van de Waarenburg M,Berendschot TTJM,Webers CAB,Reesink KD,van Greevenbroek MMJ,van der Kallen C,Schaper NC,Schram MT,Henry RMA,Stehouwer CDA,Schalkwijk CG

更新日期：2020-02-10 00:00:00

abstract：BACKGROUND:In patients with type 2 diabetes (T2D), glycaemic variability (GV), another component of glycaemic abnormalities, is a novel potentially aggravating factor for coronary artery disease (CAD). OBJECTIVES:The aim of our study was to identify interactions between GV and severity of CAD in diabetes patients admi...

journal_title：Diabetes & metabolism

authors： Benalia M,Zeller M,Mouhat B,Guenancia C,Yameogo V,Greco C,Yao H,Maza M,Vergès B,Cottin Y

更新日期：2019-10-01 00:00:00

abstract：AIM:Bariatric surgery has been shown to effectively improve glycaemic control in morbidly obese subjects. However, the molecular bases of this association are still elusive and may act independently of weight loss. Here, our retrospective study has investigated the inflammatory molecule osteopontin (OPN) as a potential...

journal_title：Diabetes & metabolism

authors： Carbone F,Adami G,Liberale L,Bonaventura A,Bertolotto M,Andraghetti G,Scopinaro N,Camerini GB,Papadia FS,Cordera R,Dallegri F,Montecucco F

更新日期：2019-09-01 00:00:00

abstract：AIM:To describe current practices of glucose-lowering treatments in people with diabetes and chronic kidney disease (CKD), the associated glucose control and hypoglycaemic symptoms, with an emphasis on sex differences. METHODS:Among the 3033 patients with CKD stages 3-5 recruited into the French CKD-REIN study, 645 me...

journal_title：Diabetes & metabolism

authors： Balkau B,Metzger M,Andreelli F,Frimat L,Speyer E,Combe C,Laville M,Jacquelinet C,Briançon S,Ayav C,Massy Z,Pisoni RL,Stengel B,Fouque D

更新日期：2019-04-01 00:00:00

abstract：AIM:Albuminuria is the most important indicator of diabetic nephropathy (DN). Resveratrol, a natural compound found in grape skins and red wine, has antioxidant effects. This study aimed to evaluate the effects of resveratrol on DN. METHODS:In this randomized, double-blind, placebo-controlled clinical trial, 60 patien...

journal_title：Diabetes & metabolism

authors： Sattarinezhad A,Roozbeh J,Shirazi Yeganeh B,Omrani GR,Shams M

更新日期：2019-01-01 00:00:00

abstract：AIM:Oxytocin administration to diet-induced obese (DIO) rodents, monkeys and humans decreases body weight and fat mass with concomitant improvements in glucose metabolism. Moreover, several studies show an immunomodulatory role of oxytocin in a number of settings (such as atherosclerosis, injury, sepsis). This study ai...

journal_title：Diabetes & metabolism

authors： Garrido-Urbani S,Deblon N,Poher AL,Caillon A,Ropraz P,Rohner-Jeanrenaud F,Altirriba J

更新日期：2018-06-01 00:00:00

abstract：AIM:Hepatic insulin clearance (HIC) is important in regulating plasma insulin levels. Diminished HIC causes inappropriate hyperinsulinaemia, and both obesity and fatty liver (FL), which are known to decrease HIC, can be found either together in the same patient or on their own. The mechanism by which obesity reduces HI...

journal_title：Diabetes & metabolism

authors： Matsubayashi Y,Yoshida A,Suganami H,Ishiguro H,Yamamoto M,Fujihara K,Kodama S,Tanaka S,Kaku K,Sone H

更新日期：2018-03-01 00:00:00

abstract：AIM:To investigate the effect of changes in fasting plasma glucose (FPG) variability, as assessed by 2-year trajectories of FPG variability, on mortality risk in patients with type 2 diabetes (T2D). METHODS:From 2009 to 2012, outpatients with T2D, aged>18 years, were enrolled from a medical centre. FPG was measured ev...

journal_title：Diabetes & metabolism

authors： Lee CL,Sheu WH,Lee IT,Lin SY,Liang WM,Wang JS,Li YF

更新日期：2018-03-01 00:00:00

abstract：AIMS:Type 2 diabetes is associated with insulin resistance, adipose hypertrophy and increased lipolysis. The heritability of these traits has been determined by associating them with a family history of diabetes. METHODS:Abdominal subcutaneous fat biopsies were obtained from 581 subjects in a cross-sectional study. Fa...

journal_title：Diabetes & metabolism

authors： Dahlman I,Ryden M,Arner P

更新日期：2018-03-01 00:00:00

abstract：AIM:Kidney hypoxia can predispose to the development of acute and chronic renal failure in diabetes. Ischaemia-reperfusion injury (IRI) causes inflammation, and diabetes is known to exacerbate this inflammatory response in the kidney, whereas alarmin IL-33 could act as an innate immune mediator during kidney IRI. Thus,...

journal_title：Diabetes & metabolism

authors： Sehnine M,Ferhat M,Sena S,Gombert JM,Goujon JM,Thierry A,Touchard G,Hauet T,Herbelin A,Hadjadj S

更新日期：2018-02-01 00:00:00

abstract：AIMS:To compare insulin glargine 300 U/mL (Gla-300) with glargine 100 U/mL (Gla-100) in Japanese adults with uncontrolled type 2 diabetes on basal insulin and oral anti-hyperglycaemic drugs over 12 months. METHODS:EDITION JP 2 was a randomised, open-label, phase 3 study. Following a 6-month treatment period, participa...

journal_title：Diabetes & metabolism

authors： Terauchi Y,Koyama M,Cheng X,Sumi M,Riddle MC,Bolli GB,Hirose T,EDITION JP 2 study group.

更新日期：2017-10-01 00:00:00

abstract：AIM:To assess the association of regular, unsupervised sports and exercise during pregnancy, by intensity level, with glycaemic control in women with gestational diabetes (GDM). METHODS:Prospective cohort study of 971 women who, shortly after being diagnosed with GDM, completed a Pregnancy Physical Activity Questionna...

journal_title：Diabetes & metabolism

authors： Ehrlich SF,Hedderson MM,Brown SD,Sternfeld B,Chasan-Taber L,Feng J,Adams J,Ching J,Crites Y,Quesenberry CP,Ferrara A

更新日期：2017-10-01 00:00:00

abstract：AIMS:Metabolic syndrome (MetS) is globally a common disorder that predisposes to both diabetes and cardiovascular disease (CVD). There is a paucity of data on fibrosis and angiogenesis in adipose tissue (AT) in patients with nascent MetS uncomplicated by diabetes or CVD. Hence, we assayed various indices of fibrosis an...

journal_title：Diabetes & metabolism

authors： Jialal I,Adams-Huet B,Major A,Devaraj S

更新日期：2017-09-01 00:00:00

abstract：AIM:To explore if efficacy and safety findings for insulin glargine 300U/mL (Gla-300) versus insulin glargine 100U/mL (Gla-100), observed over 6 months in insulin-naïve people with type 2 diabetes, are maintained after 12 months. METHODS:EDITION 3 was a phase 3a, randomized, multicentre, open-label, parallel-group, tr...

journal_title：Diabetes & metabolism

authors： Bolli GB,Riddle MC,Bergenstal RM,Wardecki M,Goyeau H,Home PD,EDITION 3 study investigators.

更新日期：2017-09-01 00:00:00

abstract：AIMS:Obstructive sleep apnea syndrome (OSAS) is associated with increased cardiovascular risk and diabetes independent of obesity. We investigated whether adipose tissue dysfunction is exacerbated due to increased tissue hypoxia. METHODS:Adipose tissue (AT) oxygenation was measured with a Clarke-type electrode (pATO2)...

journal_title：Diabetes & metabolism

authors： Thorn CE,Knight B,Pastel E,McCulloch LJ,Patel B,Shore AC,Kos K

更新日期：2017-06-01 00:00:00

abstract：AIM:Adiponectin is the most abundant adipokine and may play a key role in the interplay between obesity, inflammation, insulin resistance and the metabolic syndrome (MetS). Thus, this large population-based cohort investigated whether adiponectin at baseline and/or a decrease in adiponectin during follow-up is associat...

journal_title：Diabetes & metabolism

authors： Lindberg S,Jensen JS,Bjerre M,Frystyk J,Flyvbjerg A,Jeppesen J,Mogelvang R

更新日期：2017-04-01 00:00:00

abstract：:Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are part of the armamentarium for the treatment of type 2 diabetes (T2D), although recent guidelines have mainly recommended their use on top of oral treatments when a single or combination of two or three oral hypoglycaemic agents has failed to lower HbA1c levels b...

journal_title：Diabetes & metabolism

authors： Joubert M,Reznik Y

更新日期：2017-04-01 00:00:00

abstract：AIMS:To evaluate factors associated with reaching or not reaching target glycated haemoglobin (HbA1c) levels by analysing the respective contributions of fasting hyperglycaemia (FHG), also referred to as basal hyperglycaemia, vs postprandial hyperglycaemia (PHG) before and after initiation of a basal or premixed insuli...

journal_title：Diabetes & metabolism

authors： Scheen AJ,Schmitt H,Jiang HH,Ivanyi T

更新日期：2017-02-01 00:00:00

abstract：AIM:Recent guidelines for the management of type 2 diabetes (T2DM) in the elderly recommend adjusting the therapeutic target (HbA1c) according to the patient's health. Our study aimed to explore the association between achieving the recommended personalized HbA1c target and the occurrence of major clinical events under...

journal_title：Diabetes & metabolism

authors： Bucher S,Panjo H,Al-Salameh A,Bauduceau B,Benattar-Zibi L,Bertin P,Berrut G,Corruble E,Danchin N,Derumeaux G,Doucet J,Falissard B,Forette F,Hanon O,Ourabah R,Pasquier F,Piedvache C,Pinget M,Becquemont L,Ringa V,re

更新日期：2017-02-01 00:00:00

abstract：AIM:This study aimed to determine the association between visceral adipose tissue (VAT), liver fat (LF) content, and other markers of the metabolic syndrome (MetS) and osteoprotegerin (OPG) in dysmetabolic adults. METHODS:Subjects from the NUMEVOX cohort were included if they fulfilled at least one MetS criterion. The...

journal_title：Diabetes & metabolism

authors： Monseu M,Dubois S,Boursier J,Aubé C,Gagnadoux F,Lefthériotis G,Ducluzeau PH

更新日期：2016-11-01 00:00:00

abstract：AIMS:To examine the seasonality and effects of temperature on levels of fasting plasma glucose (FPG). METHODS:We collected health data from the Kailuan cohort study. FPG, blood pressure and individual information including age, gender, body mass index, smoking status, drinking habit, physical activities, income, work ...

journal_title：Diabetes & metabolism

authors： Li S,Zhou Y,Williams G,Jaakkola JJ,Ou C,Chen S,Yao T,Qin T,Wu S,Guo Y

更新日期：2016-09-01 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) has become the leading cause of chronic liver diseases worldwide, causing considerable liver-related mortality and morbidity. Over the last 10years, it has also become increasingly evident that NAFLD is a multisystem disease, affecting many extra-hepatic organ systems and inte...

journal_title：Diabetes & metabolism

authors： Targher G,Marchesini G,Byrne CD

更新日期：2016-06-01 00:00:00

abstract：OBJECTIVE:Accumulating evidence has linked elevated parathyroid hormone (PTH) with insulin resistance, beta cell dysfunction and dysglycaemia, however, its role in the development of diabetes is largely unclear, particularly among non-whites. We sought to examine the association of PTH with the incidence of diabetes. ...

journal_title：Diabetes & metabolism

authors： Reis JP,Selvin E,Pankow JS,Michos ED,Rebholz CM,Lutsey PL

更新日期：2016-06-01 00:00:00

abstract：AIMS:To report changes in liver function tests observed with canagliflozin, a sodium glucose co-transporter 2 inhibitor, across phase 3 studies in patients with type 2 diabetes, and to examine the relationship between changes in liver function tests and the weight loss and glycaemic improvements observed with canaglifl...

journal_title：Diabetes & metabolism

authors： Leiter LA,Forst T,Polidori D,Balis DA,Xie J,Sha S

更新日期：2016-02-01 00:00:00

abstract：AIM:To explore the frequency of hypoglycaemic episodes, their risk factors, and associations with patient-reported outcomes in patients with type 2 diabetes enrolled in the PANORAMA cross-sectional study. METHODS:Five thousand seven hundred and eighty-three patients aged ≥ 40 years with type 2 diabetes duration ≥ 1 ye...

journal_title：Diabetes & metabolism

authors： Simon D,de Pablos-Velasco P,Parhofer KG,Gönder-Frederick L,Duprat Lomon I,Vandenberghe H,Eschwège E,Bradley C

更新日期：2015-12-01 00:00:00

abstract：:Brown adipose tissue (BAT) is able to convert calories into heat rather than storing them. Therefore, activated BAT could be a potential target in the battle against obesity and type 2 diabetes. This review focuses on the role of the autonomic nervous system in the activation of human BAT. Although the number of studi...

journal_title：Diabetes & metabolism

authors： Bahler L,Molenaars RJ,Verberne HJ,Holleman F

更新日期：2015-12-01 00:00:00

abstract：AIMS:The metabolic syndrome (MetS) is a risk factor for cancer. However, it is not known if the MetS confers a greater cancer risk than the sum of its individual components, which components drive the association, or if the MetS predicts future cancer risk. MATERIALS AND METHODS:We linked 20,648 participants from the ...

journal_title：Diabetes & metabolism

authors： Harding J,Sooriyakumaran M,Anstey KJ,Adams R,Balkau B,Briffa T,Davis TM,Davis WA,Dobson A,Giles GG,Grant J,Knuiman M,Luszcz M,Mitchell P,Pasco JA,Reid C,Simmons D,Simons L,Tonkin A,Woodward M,Shaw JE,Magliano DJ

更新日期：2015-12-01 00:00:00

abstract：:Our society is currently facing an epidemic of diabetes and heart failure. Historically, certain cardiology treatments, mainly beta-blockers, have been considered 'dangerous' in diabetic patients, but the time has come for personalized medicine to be applied in the field of cardiology, especially in heart failure (HF)...

journal_title：Diabetes & metabolism

authors： Girerd N,Zannad F,Rossignol P

更新日期：2015-12-01 00:00:00