Abstract：
AIM:Patients with diabetes have higher rates of depression than does the general population, but diabetes management mainly aims to maintain glucose stability. For this reason, our study assessed the relationship between 1-year variations in fasting plasma glucose (FPG) and risk of depression in Chinese patients with type 2 diabetes (T2D). METHODS:This retrospective cohort study was conducted on 32,829 patients aged ≥30 years who were diagnosed with T2D and who participated in the National Diabetes Case Management Program in Taiwan. Their 1-year FPG variation as a predictor was determined by coefficient of variation (CV), whereas depressive events were analyzed by Cox's proportional hazards models. RESULTS:During a mean 8.23 years of follow-up, 1041 new cases of depression were diagnosed. When patients were grouped based on quartiles of FPG-CV, incidence rates were 3.23, 3.49, 3.96 and 4.80 per 1000 person-years in the first, second, third and fourth quartile subgroups, respectively. After adjusting for traditional risk factors, baseline fasting glucose and HbA1c levels, and diabetes complications, FPG-CV was independently linked with incident depression. Hazard ratios of depression for FPG-CV in the fourth vs first quartile subgroups was 1.33 (95% CI: 1.11-1.59), respectively. CONCLUSION:Patients whose 1-year FPG variations were>42.6% had an increased risk of depression, thus suggesting that FPG variations may be a predictor of depression in patients with T2D. Also, glucose variation during outpatient visits may be an indicator for individualized diabetes management in clinical practice.
journal_name
Diabetes Metabjournal_title
Diabetes & metabolismauthors
Li CI,Liu CS,Lin CH,Lin WY,Lee YD,Yang SY,Li TC,Lin CCdoi
10.1016/j.diabet.2019.08.003subject
Has Abstractpub_date
2020-06-01 00:00:00pages
223-229issue
3eissn
1262-3636issn
1878-1780pii
S1262-3636(19)30131-4journal_volume
46pub_type
杂志文章abstract：AIM:Kidney hypoxia can predispose to the development of acute and chronic renal failure in diabetes. Ischaemia-reperfusion injury (IRI) causes inflammation, and diabetes is known to exacerbate this inflammatory response in the kidney, whereas alarmin IL-33 could act as an innate immune mediator during kidney IRI. Thus,...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2017.06.008
更新日期：2018-02-01 00:00:00
abstract：CONTEXT:In 2001 the "National Cholesterol and Education Program Expert Panel" gave a clinical definition of the metabolic syndrome. The frequency of this syndrome at baseline and its incidence and persistence at three years is studied in a French population. SUBJECTS:2109 men and 2184 women from the D.E.S.I.R. longitu...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/s1262-3636(07)70067-8
更新日期：2003-11-01 00:00:00
abstract：:Non-obese diabetic (NOD) mice spontaneously develop T-cell-mediated autoimmune diabetes. Initial work on the diabetogenic T-cell repertoire indicated that autoreactive T lymphocytes were polyclonal but that the presence of specific subsets (V beta 8 or V beta 6) might be required for induction of the disease. Further ...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：
更新日期：1997-11-01 00:00:00
abstract：AIM:As the treatment of hyperglycaemia during pregnancy with diet or insulin reduces the risk of adverse maternal outcomes and perinatal complications, screening for gestational diabetes mellitus (GDM) is included, albeit to variable extents, in all guidelines of care for pregnant women. The aim of the present investig...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2014.11.008
更新日期：2015-09-01 00:00:00
abstract：AIM:Recent guidelines for the management of type 2 diabetes (T2DM) in the elderly recommend adjusting the therapeutic target (HbA1c) according to the patient's health. Our study aimed to explore the association between achieving the recommended personalized HbA1c target and the occurrence of major clinical events under...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,多中心研究
doi：10.1016/j.diabet.2016.05.008
更新日期：2017-02-01 00:00:00
abstract：OBJECTIVES:To test the hypothesis that smokers have a higher frequency of the metabolic syndrome, and a syndrome with different characteristics than non-smokers. MATERIAL AND METHODS:The 2,569 men and 2,637 women included in the D.E.S.I.R. study, aged 30-64 years, volunteers from ten French Social Security Health Exam...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,多中心研究
doi：10.1016/s1262-3636(07)70031-9
更新日期：2003-06-01 00:00:00
abstract：:We report the case of a young insulin-dependent diabetic patient in whom acute renal failure led to detection of ureterohydronephrosis secondary to neurogenic bladder. The persistence of a high daily urine volume revealed diabetes insipidus, suggesting Wolfram syndrome, which was confirmed by the diagnosis of optic at...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：
更新日期：1998-06-01 00:00:00
abstract：:Diabetes Mellitus frankly increases the prevalence of sexual problems in men, mainly in the form of erectile dysfunctions. Its effects on sexual function of the diabetic women have been less objectively studied, due to cultural reasons and methodological difficulties. The different phases of the sexual cycle, as well ...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,评审
doi：
更新日期：2001-09-01 00:00:00
abstract：:Glucagon-like peptide (GLP)-1 action involves both endocrine and neural pathways to control peripheral tissues. In diabetes the impairment of either pathway may define different subsets of patients: some may be better treated with GLP-1 receptor agonists that are more likely to directly stimulate beta-cells and extrap...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2013.02.005
更新日期：2013-04-01 00:00:00
abstract：:The management of type 2 diabetes continues to evolve as new data emerge. Although glycaemic control is still important, other risk factors--such as hypertension, dyslipidaemia and obesity--must also be addressed in order to reduce the long-term risks of cardiovascular complications and mortality. In this context, tar...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,评审
doi：10.1016/j.diabet.2012.04.003
更新日期：2012-10-01 00:00:00
abstract：:We scrutinized the relation between body height and renal involvement in a large population-based sample of newly diagnosed diabetic patients aged 40 years or over. The urinary albumin concentration (UAC) was measured in freshly voided morning urine in 1,284 newly diagnosed diabetic patients. The course of insulin tre...
journal_title：Diabetes & metabolism
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：
更新日期：2001-02-01 00:00:00
abstract：:The prevalence of diabetes in African communities is increasing with ageing of the population and lifestyle changes associated with rapid urbanisation and westernisation. Traditional rural communities still have very low prevalence, at most 1-2%, except in some specific high-risk groups, whereas 1-13% or more adults i...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,评审
doi：
更新日期：2001-12-01 00:00:00
abstract：:Type 2 diabetes mellitus (T2DM) is strongly associated with cardiovascular complications, especially coronary artery disease. Numerous epidemiological studies have shown a close relationship between major cardiovascular events and glycaemia, and several pathophysiological mechanisms have been described that explain ho...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,评审
doi：10.1016/j.diabet.2014.03.004
更新日期：2014-06-01 00:00:00
abstract：AIM:This report highlights the metabolic, endocrine and cardiovascular comorbidities in a case of familial partial lipodystrophy (FPLD), and also evaluates the efficacy and safety of metformin therapy. METHODS:Mutational analysis was carried out of the LMNA gene in a teenage girl with an FPLD phenotype. Insulin resist...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2013.12.008
更新日期：2014-06-01 00:00:00
abstract：:The timely series of state-of-the-art reviews contained within this supplement provide a valuable overview of the current state of diabetes care, and the pharmacological interventions we have available. Our experts agree that one of the most important lessons to emerge recently concerns the magnitude of the malign inf...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/s1262-3636(03)72797-9
更新日期：2003-09-01 00:00:00
abstract：AIM:Cholesterol intake is associated with the risk for type 2 diabetes mellitus, but no previous studies have evaluated its role regarding the risk of gestational diabetes mellitus (GDM). We investigate the relation between cholesterol intake and GDM. METHODS:At screening for GDM, 335 pregnant women were evaluated for...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2006.07.002
更新日期：2007-02-01 00:00:00
abstract：AIM:The association between Liver fibrosis (LF), as assessed by either histology or Liver stiffness measurement (LSM), and the presence of Early kidney dysfunction (EKD) was investigated in this study, as was also the diagnostic performance of LSM for identifying the presence of EKD in patients with Non-alcoholic fatty...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2019.11.003
更新日期：2020-09-01 00:00:00
abstract：:Brown adipose tissue (BAT) is able to convert calories into heat rather than storing them. Therefore, activated BAT could be a potential target in the battle against obesity and type 2 diabetes. This review focuses on the role of the autonomic nervous system in the activation of human BAT. Although the number of studi...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,评审
doi：10.1016/j.diabet.2015.08.005
更新日期：2015-12-01 00:00:00
abstract：:Insulin-requiring diabetes (IRD) is a condition of permanent blood glucose imbalance which occurs despite a regulated diet and treatment with maximum doses of oral anti-diabetic drugs (glibenclamide 15 mg/d + metformin 1,700 mg/d). This report describes the results of a 2-year prospective study in 75 IRD patients trea...
journal_title：Diabetes & metabolism
pub_type： 临床试验,杂志文章
doi：
更新日期：1997-02-01 00:00:00
abstract：:The capacity of cardiac myocyte to regulate ATP production to face any change in energy demand is a major determinant of cardiac function. Because FA is the main heart fuel (although the most expensive one in oxygen, and prompt to induce deleterious effects), this process is based on a balanced fatty acid (FA) metabol...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：
更新日期：2001-11-01 00:00:00
abstract：:Serum glycated apolipoprotein B (apo B-G) levels were determined in 31 non-insulin-dependent diabetic patients and 13 control subjects by an enzyme-linked immunosorbent assay. Apo B-G was increased in diabetic patients compared to non-diabetic subjects, whether expressed as a serum concentration (57.7 vs 36.1 mg/l) or...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：
更新日期：1998-04-01 00:00:00
abstract：:Strict glycaemic control is a major concern in many people with diabetes, hypoglycaemia being the most limiting factor in the daily management of patients with diabetes. Acute consequences of hypoglycaemic attacks are not precisely evaluated. Acute cardiovascular (CV) complications as myocardial ischaemia or stroke se...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,评审
doi：10.1016/S1262-3636(10)70471-7
更新日期：2010-10-01 00:00:00
abstract：AIMS:The metabolic syndrome (MetS) is a risk factor for cancer. However, it is not known if the MetS confers a greater cancer risk than the sum of its individual components, which components drive the association, or if the MetS predicts future cancer risk. MATERIALS AND METHODS:We linked 20,648 participants from the ...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2015.04.006
更新日期：2015-12-01 00:00:00
abstract：:Non-islet cell tumor-related hypoglycemia is a rare phenomenon. We report the case of a 63 Year-old man admitted for hemiparesia and a capillary blood glucose of 20 mg/dL. The presence of an immature form of IGF-II that can mimic the effect of insulin, namely "big IGF-II", explained this patient's hypoglycaemia. A mod...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/s1262-3636(07)70119-2
更新日期：2004-06-01 00:00:00
abstract：BACKGROUND:Recent studies suggest that HbA1c is an important predictor of the glycometabolic state of patients admitted for acute myocardial infarction (AMI). OBJECTIVE:We aimed at comparing the results of HbA1c concentrations obtained by 2 different methods in patients with AMI. RESEARCH DESIGN AND METHODS:In a firs...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/s1262-3636(07)70196-9
更新日期：2005-06-01 00:00:00
abstract：OBJECTIVE:Recently, the association of the natural variants rs1260326 and rs780094 of the glucokinase regulatory protein (GCKR) gene with increased fasting triglycerides and decreased fasting plasma glucose in diabetic adults was reported; the minor alleles were also found to reduce the risk of type 2 diabetes. The pre...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2011.02.003
更新日期：2011-11-01 00:00:00
abstract：:Insulin resistance represents a major public health problem, as it plays a major role in the pathophysiology of type 2 diabetes mellitus; it is also associated with increased cardiovascular risk and atherogenic dyslipidaemia, and is a central component of the cluster of metabolic abnormalities that comprise the metabo...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,评审
doi：10.1016/j.diabet.2011.01.002
更新日期：2011-06-01 00:00:00
abstract：:ATP-sensitive potassium channels (K(ATP)) couple cell metabolism to electrical activity by regulating potassium movement across the membrane. These channels are octameric complex with two kind of subunits: four regulatory sulfonylurea receptor (SUR) embracing four poreforming inwardly rectifying potassium channel (Kir...
journal_title：Diabetes & metabolism
pub_type： 杂志文章,评审
doi：10.1016/S1262-3636(07)70311-7
更新日期：2006-12-01 00:00:00
abstract：:We report a rare case of hypothermia with acute renal failure in a patient suffering from diabetic nephropathy. A 71-year-old male who had been receiving insulin therapy for the treatment of diabetes mellitus complicated with advanced diabetic nephropathy since 1998 was malnourished with an extremely decreased muscle ...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：
更新日期：2000-04-01 00:00:00
abstract：:Although many heavy metals are necessary for normal biological function, a subset of heavy metals have no role in human physiology, such as lead (Pb) and arsenic (As). Such elements have deleterious effects on physiology and be associated with the incidence of diabetes and related metabolic syndromes. Haemoglobin A1c ...
journal_title：Diabetes & metabolism
pub_type： 杂志文章
doi：10.1016/j.diabet.2021.101233
更新日期：2021-01-23 00:00:00
