当前位置： SCI文献检索 > DIABETES & METABOLISM期刊下所有文献 > Effect of canagliflozin on liver function tests in patients with type 2 diabetes.

Effect of canagliflozin on liver function tests in patients with type 2 diabetes.

Abstract：

AIMS:To report changes in liver function tests observed with canagliflozin, a sodium glucose co-transporter 2 inhibitor, across phase 3 studies in patients with type 2 diabetes, and to examine the relationship between changes in liver function tests and the weight loss and glycaemic improvements observed with canagliflozin. METHODS:Data were pooled from four 26-week, placebo-controlled studies of canagliflozin 100 and 300mg (n=2313) and two 52-week, active-controlled studies of canagliflozin 300mg versus sitagliptin 100mg (n=1488). Analysis of covariance was performed to determine the contribution of changes in body weight and HbA1c to the changes in liver function tests. RESULTS:Reductions in alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and gamma-glutamyl transferase, and increases in bilirubin were seen with canagliflozin 100 and 300mg versus placebo (nominal P<0.001 for alanine aminotransferase, aspartate aminotransferase and gamma-glutamyl transferase [both doses]; P<0.001 for alkaline phosphatase and P=0.015 for bilirubin [canagliflozin 300mg only]) at week 26 and with canagliflozin 300mg versus sitagliptin 100mg (nominal P<0.001 for alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transferase and bilirubin, and P<0.01 for alkaline phosphatase) at week 52. Few patients met predefined limits of change criteria for liver function tests, and none met Hy's law criteria. In both populations, alanine aminotransferase, aspartate aminotransferase and gamma-glutamyl transferase reductions were fully explained by HbA1c and body weight reductions. CONCLUSIONS:Canagliflozin provided improvements in liver function tests versus either placebo or sitagliptin treatments that were fully explained by the combined effects of HbA1c and body weight reductions with canagliflozin.

journal_name

Diabetes Metab

journal_title

Diabetes & metabolism

authors

Leiter LA,Forst T,Polidori D,Balis DA,Xie J,Sha S

doi

10.1016/j.diabet.2015.10.003

subject

Has Abstract

pub_date

2016-02-01 00:00:00

pages

25-32

issue

1

eissn

1262-3636

issn

1878-1780

pii

S1262-3636(15)00125-1

journal_volume

42

pub_type

杂志文章,随机对照试验

相关文献

DIABETES & METABOLISM文献大全
  • A randomised study evaluating the effects of cisapride on glucose variability and quality of life parameters in insulin-dependent diabetes mellitus patients.

    abstract：:This study evaluated the effect of cisapride on glycaemic control, well-being and treatment satisfaction in insulin-dependent diabetes mellitus (IDDM) patients with documented moderate to severe glycaemic instability. Thirty-seven patients with glycaemic instability were included in a randomized, double-blind, placebo...

    journal_title：Diabetes & metabolism

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：

    authors： Johansson UB,Wredling RA,Adamson UC,Lins PE

    更新日期：1999-09-01 00:00:00

  • When should ultrasonography be used to detect asymptomatic carotid atheroma in diabetic patients?

    abstract：INTRODUCTION:While guidelines for detection of silent myocardial and lower limb ischemia are established, data on screening asymptomatic carotid lesions remain scarce. However, such screening would be costly. Since the prevalence of diabetes increases constantly, it is necessary to keep screening costs low by setting u...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/S1262-3636(07)70321-X

    authors： Duval M,Altman JJ

    更新日期：2006-12-01 00:00:00

  • Therapeutic approach of type 2 diabetes mellitus with GLP-1 based therapies.

    abstract：:The goal of this review is to think about how to incorporate the GLP-1 based agents, represented by the dipeptidyl peptidase-4 (DPP-4) inhibitors or the glucagon-like peptide-1 (GLP-1) analogs, in the guidelines for the management of type 2 diabetes (T2DM). Orally administered DPP-4 inhibitors, such as sitagliptin and...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,评审

    doi：10.1016/S1262-3636(08)73399-8

    authors： Penfornis A,Borot S,Raccah D

    更新日期：2008-02-01 00:00:00

  • Effects of glucose-lowering agents on vascular outcomes in type 2 diabetes: a critical reappraisal.

    abstract：:Type 2 diabetes mellitus (T2DM) is strongly associated with cardiovascular complications, especially coronary artery disease. Numerous epidemiological studies have shown a close relationship between major cardiovascular events and glycaemia, and several pathophysiological mechanisms have been described that explain ho...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,评审

    doi：10.1016/j.diabet.2014.03.004

    authors： Scheen AJ,Charbonnel B

    更新日期：2014-06-01 00:00:00

  • Screening of cardiovascular autonomic neuropathy in patients with diabetes using non-invasive quick and simple assessment of sudomotor function.

    abstract：AIM:Cardiovascular autonomic neuropathy (CAN) is a common but often overlooked complication of diabetes. Sympathetic C-fibers innervating sweat glands can be impaired early on in patients with diabetes. In this study, SUDOSCAN, a new non-invasive device that assesses sudomotor function was compared to methods generally...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2012.09.004

    authors： Yajnik CS,Kantikar V,Pande A,Deslypere JP,Dupin J,Calvet JH,Bauduceau B

    更新日期：2013-04-01 00:00:00

  • Adverse metabolic disorders during highly active antiretroviral treatments (HAART) of HIV disease.

    abstract：:Protease inhibitor treatment has dramatically improved rates of morbidity and mortality in HIV-infected patients. However, it has recently been shown that this medication is associated with long-term side effects characterized by metabolic, clinical and biological alterations. These modifications have been described i...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,评审

    doi：

    authors： Vigouroux C,Gharakhanian S,Salhi Y,Nguyên TH,Adda N,Rozenbaum W,Capeau J

    更新日期：1999-11-01 00:00:00

  • Acute consequences of hypoglycaemia in diabetic patients.

    abstract：:Strict glycaemic control is a major concern in many people with diabetes, hypoglycaemia being the most limiting factor in the daily management of patients with diabetes. Acute consequences of hypoglycaemic attacks are not precisely evaluated. Acute cardiovascular (CV) complications as myocardial ischaemia or stroke se...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,评审

    doi：10.1016/S1262-3636(10)70471-7

    authors： Halimi S

    更新日期：2010-10-01 00:00:00

  • Evaluation of perception of insulin therapy among Chinese patients with type 2 diabetes mellitus.

    abstract：AIMS:To evaluate whether perception of insulin therapy differs between patients with type 2 diabetes treated with insulin and those treated with oral hypoglycaemic agents (OHAs), and to examine whether gender, education level, injection duration and mode of injection were associated with the patients' perception of ins...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2010.12.008

    authors： Chen CC,Chang MP,Hsieh MH,Huang CY,Liao LN,Li TC

    更新日期：2011-11-01 00:00:00

  • Evidence of non-inert material in needles and cartridges following a single insulin injection with a pen.

    abstract：:Preliminary results of an observational study are described in 50 unselected diabetic patients treated with insulin pens. The study was conducted to detect the presence of unexpected material in needles and cartridges after a single insulin injection. The injection was done by a trained nurse with the patient's usual ...

    journal_title：Diabetes & metabolism

    pub_type： 临床试验,杂志文章

    doi：

    authors： Le Floch JP,Herbreteau C,Lange F,Perlemuter L

    更新日期：1997-06-01 00:00:00

  • Can fructosamine be a surrogate for HbA(1c) in evaluating the achievement of therapeutic goals in diabetes?

    abstract：OBJECTIVE:To determine if fructosamine can be used as a surrogate for HbA(1c) to monitor whether therapeutic goals in diabetes mellitus are achieved when HbA(1c) cannot be used for this purpose (hemoglobinopathies, anemia...). MATERIAL AND METHODS:Blood samples of 76 diabetic patients and 30 healthy subjects character...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：

    authors： Narbonne H,Renacco E,Pradel V,Portugal H,Vialettes B

    更新日期：2001-11-01 00:00:00

  • Glycaemic variability is associated with severity of coronary artery disease in patients with poorly controlled type 2 diabetes and acute myocardial infarction.

    abstract：BACKGROUND:In patients with type 2 diabetes (T2D), glycaemic variability (GV), another component of glycaemic abnormalities, is a novel potentially aggravating factor for coronary artery disease (CAD). OBJECTIVES:The aim of our study was to identify interactions between GV and severity of CAD in diabetes patients admi...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2019.01.012

    authors： Benalia M,Zeller M,Mouhat B,Guenancia C,Yameogo V,Greco C,Yao H,Maza M,Vergès B,Cottin Y

    更新日期：2019-10-01 00:00:00

  • Hypoglycaemic episodes in patients with type 2 diabetes--risk factors and associations with patient-reported outcomes: The PANORAMA Study.

    abstract：AIM:To explore the frequency of hypoglycaemic episodes, their risk factors, and associations with patient-reported outcomes in patients with type 2 diabetes enrolled in the PANORAMA cross-sectional study. METHODS:Five thousand seven hundred and eighty-three patients aged ≥ 40 years with type 2 diabetes duration ≥ 1 ye...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2015.08.007

    authors： Simon D,de Pablos-Velasco P,Parhofer KG,Gönder-Frederick L,Duprat Lomon I,Vandenberghe H,Eschwège E,Bradley C

    更新日期：2015-12-01 00:00:00

  • Renal involvement is related to body height in newly diagnosed diabetic women aged 40 years or over.

    abstract：:We scrutinized the relation between body height and renal involvement in a large population-based sample of newly diagnosed diabetic patients aged 40 years or over. The urinary albumin concentration (UAC) was measured in freshly voided morning urine in 1,284 newly diagnosed diabetic patients. The course of insulin tre...

    journal_title：Diabetes & metabolism

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：

    authors： Olivarius Nde F,Vestbo E,Andreasen AH,Mogensen CE

    更新日期：2001-02-01 00:00:00

  • Impaired endothelial function is not associated with arterial stiffness in adults with type 1 diabetes.

    abstract：AIM:This study investigated the relationship between endothelial dysfunction (ED) and arterial stiffness (AS) in adults with type 1 diabetes and no clinical cardiovascular (CV) disease. METHODS:A total of 68 patients with type 1 diabetes and 68 age- and gender-matched healthy (non-diabetic) subjects were evaluated. ED...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2013.03.006

    authors： Llauradó G,Ceperuelo-Mallafré V,Vilardell C,Simó R,Albert L,Berlanga E,Vendrell J,González-Clemente JM

    更新日期：2013-09-01 00:00:00

  • Review and case report of idiopathic lower extremity compartment syndrome and its treatment in diabetic patients.

    abstract：:Diabetic muscle infarction is a rare complication of diabetes mellitus. However, idiopathic compartment syndrome in the diabetic patient is even a rarer disease, which has been reported only in three cases up to date. The disease seems to occur in patients affected by type 1 diabetes mellitus with a history of poorly ...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,评审

    doi：

    authors： Pamoukian VN,Rubino F,Iraci JC

    更新日期：2000-12-01 00:00:00

  • The metabolic syndrome: prevalence, main characteristics and association with socio-economic status in adults living in Great Tunis.

    abstract：AIMS:This study aimed to determine the prevalence of the metabolic syndrome (MetS) and its association with socio-economic status in the population of Great Tunis. METHODS:The study included 2712 subjects (1228 men and 1484 women), aged 35-70 years and living in the Great Tunis region, all of whom were recruited betwe...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2009.11.009

    authors： Allal-Elasmi M,Haj Taieb S,Hsairi M,Zayani Y,Omar S,Sanhaji H,Jemaa R,Feki M,Elati J,Mebazaa A,Kaabachi N

    更新日期：2010-06-01 00:00:00

  • Hypoglycaemia unawareness.

    abstract：:Hypoglycaemia unawareness, a frequent syndrome in insulin-dependent diabetes mellitus (IDDM), involves a decrease or absence of perception of specific symptoms which normally inform the subject that plasma glucose is decreasing to dangerous levels leading to neuroglycopenia. Without warning symptoms, IDDM patients are...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,评审

    doi：

    authors： Bolli GB

    更新日期：1997-09-01 00:00:00

  • Accuracy assessment of online glucose monitoring by a subcutaneous enzymatic glucose sensor during exercise in patients with type 1 diabetes treated by continuous subcutaneous insulin infusion.

    abstract：AIM:Online continuous glucose monitoring (CGM) during physical exercise would be highly useful in patients with insulin-treated diabetes. For this reason, this study assessed whether such a goal could be reached with a subcutaneous 'needle-type' enzymatic sensor. METHODS:Ten patients (five women/five men), aged 51 ± 1...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2012.12.004

    authors： Radermecker RP,Fayolle C,Brun JF,Bringer J,Renard E

    更新日期：2013-05-01 00:00:00

  • Activities of cyclooxygenases, and levels of prostaglandins E2 and F2alpha, in fetopathy associated with experimental diabetic gestation.

    abstract：AIM:The present study investigated the cyclooxygenase (COX) pathway to elucidate any changes that may be involved in the mechanism(s) underlying diabetic fetopathy. METHODS:Diabetes was induced in female rats (n=12) by two successive daily injections of 55 mg/kg streptozotocin, while control animals (n=10) were inject...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2009.06.009

    authors： Al-Matubsi HY,Salim MD,El-Sharaky AS,Kamel MA,Oriquat GA,Helmy MH,El-Bassiouni EA,Shourbaji M

    更新日期：2010-02-01 00:00:00

  • LMNA gene mutation as a model of cardiometabolic dysfunction: from genetic analysis to treatment response.

    abstract：AIM:This report highlights the metabolic, endocrine and cardiovascular comorbidities in a case of familial partial lipodystrophy (FPLD), and also evaluates the efficacy and safety of metformin therapy. METHODS:Mutational analysis was carried out of the LMNA gene in a teenage girl with an FPLD phenotype. Insulin resist...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2013.12.008

    authors： Chirico V,Ferraù V,Loddo I,Briuglia S,Amorini M,Salpietro V,Lacquaniti A,Salpietro C,Arrigo T

    更新日期：2014-06-01 00:00:00

  • Efficacy of periodontal treatment on glycaemic control in diabetic patients: A meta-analysis of interventional studies.

    abstract：AIM:There is growing evidence that periodontal disease may favour the incidence or aggravation of diabetes and its complications. To investigate the issue, we conducted a meta-analysis of the effect of periodontal therapy on glycaemic control in diabetic patients. METHODS:A literature search was carried out using seve...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.diabet.2008.03.006

    authors： Darré L,Vergnes JN,Gourdy P,Sixou M

    更新日期：2008-11-01 00:00:00

  • Plasma levels of tumor necrosis factor-alpha (TNF-alpha) are essentially dependent on visceral fat amount in type 2 diabetic patients.

    abstract：:TNF-alpha is considered as one of the potential determinants of insulin resistance. However several data suggest that TNF-alpha expression itself, could be modulated by the degree of adiposity and/or plasma insulin levels. To clarify the determinants of plasma TNF-alpha levels in type 2 diabetes mellitus, we studied t...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：

    authors： Bertin E,Nguyen P,Guenounou M,Durlach V,Potron G,Leutenegger M

    更新日期：2000-05-01 00:00:00

  • Moderate intensity sports and exercise is associated with glycaemic control in women with gestational diabetes.

    abstract：AIM:To assess the association of regular, unsupervised sports and exercise during pregnancy, by intensity level, with glycaemic control in women with gestational diabetes (GDM). METHODS:Prospective cohort study of 971 women who, shortly after being diagnosed with GDM, completed a Pregnancy Physical Activity Questionna...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2017.01.006

    authors： Ehrlich SF,Hedderson MM,Brown SD,Sternfeld B,Chasan-Taber L,Feng J,Adams J,Ching J,Crites Y,Quesenberry CP,Ferrara A

    更新日期：2017-10-01 00:00:00

  • Vascular placental abnormalities and newborn death in a pregnant diabetic woman with familial partial lipodystrophy type 3: a possible role for peroxisome proliferator-activated receptor γ.

    abstract：:The peroxisome proliferator-activated receptor protein gamma (PPARγ), a nuclear receptor involved in adipocyte differentiation, energy homoeostasis and fat storage, can lead, in rare cases of coding mutations, to familial partial lipodystrophy type 3 (FPLD3) with severe insulin resistance. PPARγ is also highly express...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2012.02.012

    authors： Castell AL,Hiéronimus S,Lascols O,Fournier T,Fénichel P

    更新日期：2012-10-01 00:00:00

  • Pancreas transplantation: results and indications.

    abstract：:Pancreatic transplantation is the best method of replacing the endocrine function of the gland in Type 1 insulin-dependent diabetic patients. At the end of 1996, 9,000 pancreas transplants had been reported to the international Pancreas Transplant Registry. For 1994-1996, one-year pancreas survival rates were 81% for ...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,评审

    doi：

    authors： Dubernard JM,Tajra LC,Lefrançois N,Dawahra M,Martin C,Thivolet C,Martin X

    更新日期：1998-06-01 00:00:00

  • [Role of bariatric surgery in the obese diabetic].

    abstract：:Bariatric surgery can be proposed to address severe obesity associated with comorbid conditions, when medical treatment has failed. Three surgical techniques are currently available, including 2 using coelioscopy. Short term results are encouraging regarding weight loss, which is linked with a reduction in comorbid co...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,评审

    doi：

    authors： Simon C

    更新日期：2000-06-01 00:00:00

  • Multicenter randomized evaluation of a nutritional education software in obese patients.

    abstract：OBJECTIVE:To study the efficacy of the nutritional education software, Nutri-Expert, in the management of obese adult patients. MATERIAL AND METHODS:Two groups of obese patients were followed up over one year in a randomized study: the first group received close traditional management (seven nutritional visits over th...

    journal_title：Diabetes & metabolism

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：

    authors： Turnin MC,Bourgeois O,Cathelineau G,Leguerrier AM,Halimi S,Sandre-Banon D,Coliche V,Breux M,Verlet E,Labrousse F,Bensoussan D,Grenier JL,Poncet MF,Tordjmann F,Brun JM,Blickle JF,Mattei C,Bolzonella C,Buisson JC,Fabr

    更新日期：2001-04-01 00:00:00

  • Association of treatment-achieved HbA1c with incidence of coronary artery disease and severe eye disease in diabetes patients.

    abstract：AIM:To examine the association between treatment-achieved HbA1c values and incidence of both coronary artery disease (CAD) and severe eye disease with different diabetes treatments. METHODS:Associations of treatment-achieved HbA1c were investigated in various treatment groups [diet only; insulin; sulphonylurea (SU) al...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2018.08.009

    authors： Harada M,Fujihara K,Osawa T,Yamamoto M,Kaneko M,Ishizawa M,Matsubayashi Y,Yamada T,Yamanaka N,Seida H,Kodama S,Ogawa W,Sone H

    更新日期：2020-09-01 00:00:00

  • Diabetes and hypoglycaemia in young children and mutations in the Kir6.2 subunit of the potassium channel: therapeutic consequences.

    abstract：:ATP-sensitive potassium channels (K(ATP)) couple cell metabolism to electrical activity by regulating potassium movement across the membrane. These channels are octameric complex with two kind of subunits: four regulatory sulfonylurea receptor (SUR) embracing four poreforming inwardly rectifying potassium channel (Kir...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,评审

    doi：10.1016/S1262-3636(07)70311-7

    authors： Flechtner I,de Lonlay P,Polak M

    更新日期：2006-12-01 00:00:00

  • Seasonality and temperature effects on fasting plasma glucose: A population-based longitudinal study in China.

    abstract：AIMS:To examine the seasonality and effects of temperature on levels of fasting plasma glucose (FPG). METHODS:We collected health data from the Kailuan cohort study. FPG, blood pressure and individual information including age, gender, body mass index, smoking status, drinking habit, physical activities, income, work ...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2016.01.002

    authors： Li S,Zhou Y,Williams G,Jaakkola JJ,Ou C,Chen S,Yao T,Qin T,Wu S,Guo Y

    更新日期：2016-09-01 00:00:00