Abstract:
OBJECTIVE:Accumulating evidence has linked elevated parathyroid hormone (PTH) with insulin resistance, beta cell dysfunction and dysglycaemia, however, its role in the development of diabetes is largely unclear, particularly among non-whites. We sought to examine the association of PTH with the incidence of diabetes. METHODS:We studied 8066 white and 2034 black adults aged 46-70 years at baseline (1990-92) from the ARIC Study with follow-up for incident diabetes ascertained during study visits conducted in 1993-95 and 1996-98. Hazard ratios (HR) and their 95% CIs for diabetes adjusted for demographics, lifestyle, and 25-hydroxyvitamin D were estimated according to PTH measured at baseline. RESULTS:PTH was higher among blacks than whites (median [IQR], 43.8 [35.0-55.8] vs. 37.9 [30.4-47.3] pg/mL; P<0.001). During a median follow-up of 6 years, 498 white and 167 black participants developed diabetes. The association of PTH with diabetes varied significantly by race (P-interaction 0.02). PTH was not associated with risk for diabetes among black adults. Among whites, HRs according to quintiles of PTH were 1 (referent), 0.95 (0.71, 1.29), 0.95 (0.70, 1.28), 1.12 (0.84, 1.51), and 1.31 (0.98, 1.76) (P-trend 0.03). When a clinical cut-point for PTH was applied (≥65pg/mL; 5.7% of whites), the HR for diabetes among whites was 1.38 (1.01, 1.88). Results were similar when restricted to participants with normal baseline kidney function. CONCLUSION:In this large, population-based study, elevated PTH was independently associated with risk for diabetes among white, but not black adults. Further studies are needed to elucidate the mechanisms that may underlie this differential association of PTH with diabetes across race groups.
journal_name
Diabetes Metabjournal_title
Diabetes & metabolismauthors
Reis JP,Selvin E,Pankow JS,Michos ED,Rebholz CM,Lutsey PLdoi
10.1016/j.diabet.2015.12.004subject
Has Abstractpub_date
2016-06-01 00:00:00pages
162-9issue
3eissn
1262-3636issn
1878-1780pii
S1262-3636(15)00171-8journal_volume
42pub_type
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journal_title:Diabetes & metabolism
pub_type: 杂志文章
doi:10.1016/j.diabet.2007.01.005
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journal_title:Diabetes & metabolism
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doi:10.1016/j.diabet.2007.10.001
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更新日期:2001-12-01 00:00:00
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journal_title:Diabetes & metabolism
pub_type: 杂志文章
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journal_title:Diabetes & metabolism
pub_type: 杂志文章,评审
doi:10.1016/j.diabet.2012.04.003
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pub_type: 临床试验,杂志文章
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journal_title:Diabetes & metabolism
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Diabetes & metabolism
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journal_title:Diabetes & metabolism
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更新日期:2000-09-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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journal_title:Diabetes & metabolism
pub_type: 杂志文章
doi:10.1016/j.diabet.2016.12.004
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journal_title:Diabetes & metabolism
pub_type: 杂志文章,评审
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更新日期:1998-11-01 00:00:00
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journal_title:Diabetes & metabolism
pub_type: 杂志文章
doi:10.1016/j.diabet.2013.03.006
更新日期:2013-09-01 00:00:00
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journal_title:Diabetes & metabolism
pub_type: 杂志文章
doi:
更新日期:2002-09-01 00:00:00
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journal_title:Diabetes & metabolism
pub_type: 杂志文章,评审
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更新日期:1997-11-01 00:00:00
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journal_title:Diabetes & metabolism
pub_type: 临床试验,杂志文章
doi:
更新日期:1997-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/S1262-3636(08)74604-4
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更新日期:2011-02-01 00:00:00
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doi:10.1016/s1262-3636(07)70274-4
更新日期:2006-06-01 00:00:00
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journal_title:Diabetes & metabolism
pub_type: 杂志文章,评审
doi:
更新日期:1996-07-01 00:00:00
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journal_title:Diabetes & metabolism
pub_type: 评论,杂志文章,评审
doi:
更新日期:2002-12-01 00:00:00
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journal_title:Diabetes & metabolism
pub_type: 杂志文章
doi:
更新日期:2000-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/s1262-3636(07)70303-8
更新日期:2006-11-01 00:00:00
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journal_title:Diabetes & metabolism
pub_type: 杂志文章,评审
doi:10.1016/S1262-3636(11)70965-X
更新日期:2011-12-01 00:00:00
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journal_title:Diabetes & metabolism
pub_type: 杂志文章
doi:
更新日期:2000-05-01 00:00:00
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journal_title:Diabetes & metabolism
pub_type: 杂志文章
doi:
更新日期:1997-11-01 00:00:00
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journal_title:Diabetes & metabolism
pub_type: 杂志文章
doi:10.1016/j.diabet.2015.04.006
更新日期:2015-12-01 00:00:00
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journal_title:Diabetes & metabolism
pub_type: 杂志文章
doi:
更新日期:2000-04-01 00:00:00